Loretta Georgina Que, MD

Professor of Medicine
Campus mail 279 Msrb1, Durham, NC 27710
Phone (919) 681-8551
Email address loretta.que@duke.edu

My research interests focus on studying the role of nitric oxide and related enzymes in the pathogenesis of lung disease, specifically that caused by nitrosative/oxidative stress. Proposed studies are performed in cell culture and applied to animal models of disease, then examined in human disease where relevant. It is our hope that by better understanding the role of NO and reactive nitrogen species in mediating inflammation, and regulating cell signaling, that we will not only help to unravel the basic mechanisms of NO related lung disease, but also provide a rationale for targeted therapeutic use of NO.

Key words: nitrosative defense, lung injury, nitric oxide

Education and Training

  • Pulmonary Fellow, Medicine, Duke University, 1993 - 1996
  • Clinical Instructor, Medicine, Yale University, 1992 - 1993
  • Medical Resident, Medicine, Yale University, 1989 - 1992
  • M.D., The University of Chicago, 1989

Publications

Foster, M. W., E. N. Potts, E. J. Soderblom, Z. Yang, D. M. Gooden, M. A. Moseley, W. M. Foster, and L. G. Que. “Systemic And/Or Local Aerosol Inhibition Of S-Nitrosoglutathione Reductase (GSNOR) Ameliorates Physiologic, Biologic, And Proteomic Phenotypes In An Allergic Mouse Model Of Inflammatory Airway Disease.” In American Journal of Respiratory and Critical Care Medicine, Vol. 183. AMER THORACIC SOC, 2011.

Scholars@Duke

Potts, E. N., Z. Yang, M. W. Foster, W. M. Foster, and L. G. Que. “Aerosolized Nitrosothiol Therapy Ameliorates Biologic And Physiologic Phenotypes Associated With Allergic Asthma.” In American Journal of Respiratory and Critical Care Medicine, Vol. 183. AMER THORACIC SOC, 2011.

Scholars@Duke

Norfolk, Stephanie G., Caroline L. Hollingsworth, Cameron R. Wolfe, Joseph A. Govert, Loretta G. Que, Ira M. Cheifetz, and John W. Hollingsworth. “Rescue therapy in adult and pediatric patients with pH1N1 influenza infection: a tertiary center intensive care unit experience from April to October 2009.” Crit Care Med 38, no. 11 (November 2010): 2103–7. https://doi.org/10.1097/CCM.0b013e3181f268f1.

PMID
20711068
Full Text

Huang, Yuh-Chin T., Michael Schmitt, Zhonghui Yang, Loretta G. Que, Judith C. Stewart, Mark W. Frampton, and Robert B. Devlin. “Gene expression profile in circulating mononuclear cells after exposure to ultrafine carbon particles.” Inhal Toxicol 22, no. 10 (August 2010): 835–46. https://doi.org/10.3109/08958378.2010.486419.

PMID
20507211
Full Text

Choudhry, Shweta, Loretta G. Que, Zhonghui Yang, Limin Liu, Celeste Eng, Sung O. Kim, Gunjan Kumar, et al. “GSNO reductase and beta2-adrenergic receptor gene-gene interaction: bronchodilator responsiveness to albuterol.” Pharmacogenet Genomics 20, no. 6 (June 2010): 351–58. https://doi.org/10.1097/FPC.0b013e328337f992.

PMID
20335826
Full Text

Wahidi, Momen M., Gerard A. Silvestri, Raymond D. Coakley, J Scott Ferguson, R Wesley Shepherd, Leonard Moses, John Conforti, et al. “A prospective multicenter study of competency metrics and educational interventions in the learning of bronchoscopy among new pulmonary fellows.” Chest 137, no. 5 (May 2010): 1040–49. https://doi.org/10.1378/chest.09-1234.

PMID
19858234
Full Text

Pastva, A. M., J. K. L. Walker, S. Mukherjee, C. Giamberardino, B. J. Hsia, E. Potts, J. P. Eu, W. M. Foster, L. G. Que, and J. R. Wright. “In A Model Of Innate Immunity The Interaction Between Inducible Nitric Oxide Synthase And Surfactant Protein-A Regulates Airway Responsiveness.” American Journal of Respiratory and Critical Care Medicine 181 (2010).

Scholars@Duke

Que, Loretta G., Zhonghui Yang, Jonathan S. Stamler, Njira L. Lugogo, and Monica Kraft. “S-nitrosoglutathione reductase: an important regulator in human asthma.” Am J Respir Crit Care Med 180, no. 3 (August 1, 2009): 226–31. https://doi.org/10.1164/rccm.200901-0158OC.

PMID
19395503
Full Text

Brown, B. J., A. M. Pastva, B. Lo, W. M. Foster, P. Eu, L. G. Que, S. N. Abraham, J. R. Wright, and D. W. Zaas. “AHR Is Attenuated in Caveolin-1 Deficient Mice.” American Journal of Respiratory and Critical Care Medicine 179 (January 1, 2009).

Scholars@Duke

Que, L. G., Z. Yang, T. D. Church, D. M. Beaver, D. Jinwright, N. L. Lugogo, and M. Kraft. “GSNO Reductase Expression and Activity Are Increased in Asthmatic Airway Macrophages.” American Journal of Respiratory and Critical Care Medicine 179 (January 1, 2009).

Scholars@Duke

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