Loretta Georgina Que, MD

Professor of Medicine
Campus mail 279 Msrb1, Durham, NC 27710
Phone (919) 681-8551
Email address loretta.que@duke.edu

My research interests focus on studying the role of nitric oxide and related enzymes in the pathogenesis of lung disease, specifically that caused by nitrosative/oxidative stress. Proposed studies are performed in cell culture and applied to animal models of disease, then examined in human disease where relevant. It is our hope that by better understanding the role of NO and reactive nitrogen species in mediating inflammation, and regulating cell signaling, that we will not only help to unravel the basic mechanisms of NO related lung disease, but also provide a rationale for targeted therapeutic use of NO.

Key words: nitrosative defense, lung injury, nitric oxide

Education and Training

  • Pulmonary Fellow, Medicine, Duke University, 1993 - 1996
  • Clinical Instructor, Medicine, Yale University, 1992 - 1993
  • Medical Resident, Medicine, Yale University, 1989 - 1992
  • M.D., The University of Chicago, 1989

Grants

Publications

Lugogo, Njira L., Geoffrey S. Ginsburg, and Loretta G. Que. “Genetic profiling and tailored therapy in asthma: are we there yet?” Curr Opin Mol Ther 9, no. 6 (December 2007): 528–37.

PMID
18041663
Scholars@Duke

Whalen, Erin J., Matthew W. Foster, Akio Matsumoto, Kentaro Ozawa, Jonathan D. Violin, Loretta G. Que, Chris D. Nelson, et al. “Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2.” Cell 129, no. 3 (May 4, 2007): 511–22. https://doi.org/10.1016/j.cell.2007.02.046.

PMID
17482545
Full Text

Clay, Alison S., Loretta Que, Emil R. Petrusa, Mark Sebastian, and Joseph Govert. “Debriefing in the intensive care unit: a feedback tool to facilitate bedside teaching.” Crit Care Med 35, no. 3 (March 2007): 738–54. https://doi.org/10.1097/01.CCM.0000257329.22025.18.

PMID
17255866
Full Text

Que, Loretta G., Limin Liu, Yun Yan, Gregory S. Whitehead, Stephen H. Gavett, David A. Schwartz, and Jonathan S. Stamler. “Protection from experimental asthma by an endogenous bronchodilator.” Science 308, no. 5728 (June 10, 2005): 1618–21. https://doi.org/10.1126/science.1108228.

PMID
15919956
Full Text

Liu, L. M., Y. Yan, M. Zeng, J. Zhang, M. A. Hanes, G. Ahearn, T. J. McMahon, et al. “Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock.” In Nitric Oxide Biology and Chemistry, 11:39–39. ACADEMIC PRESS INC ELSEVIER SCIENCE, 2004.

Scholars@Duke

Liu, Limin, Yun Yan, Ming Zeng, Jian Zhang, Martha A. Hanes, Gregory Ahearn, Timothy J. McMahon, et al. “Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock.” Cell 116, no. 4 (February 20, 2004): 617–28. https://doi.org/10.1016/s0092-8674(04)00131-x.

PMID
14980227
Full Text

Marshall, H. E., L. G. Que, J. S. Stamler, and B. Gaston. “S-nitrosothiols in lung inflammation.” In Therapeutic Targets in Airway Inflammation, 123–42, 2003.

Scholars@Duke

Yu, Qing, Loretta G. Que, and Don C. Rockey. “Adenovirus-mediated gene transfer to nonparenchymal cells in normal and injured liver.” Am J Physiol Gastrointest Liver Physiol 282, no. 3 (March 2002): G565–72. https://doi.org/10.1152/ajpgi.00512.2000.

PMID
11842008
Full Text

Que, Loretta G., Samuel E. George, Tomomi Gotoh, Masataka Mori, and Yuh-Chin T. Huang. “Effects of arginase isoforms on NO Production by nNOS.” Nitric Oxide 6, no. 1 (February 2002): 1–8. https://doi.org/10.1006/niox.2001.0355.

PMID
11829529
Full Text

Pages