Lori Ann Orlando, MD

Associate Professor of Medicine
Associate Director of Duke Center for Applied Genomics and Precision Medicine
Campus mail 102906, Aesthetic Center 2nd Floor, Durham, NC 27705
Phone (919) 660-6606
Email address orlan002@duke.edu

Dr. Lori A. Orlando, MD MHS is an Associate Professor of Medicine and Director of the Precision Medicine Program in the Center for Applied Genomics and Precision Medicine at Duke University. She attended Tulane Medical Center for both medical school (1994-1998) and Internal Medicine residency (1998-2000). There she finished AOA and received a number of awards for teaching and clinical care from the medical school and the residency programs, including the Musser-Burch-Puschett award in 2000 for academic excellence. After completing her residency, she served as Chief Medical Resident in Internal Medicine (2001) and then completed a Health Services Research Fellowship at Duke University Medical Center (2002-2004). In 2004 she also received her MHS from the Clinical Research Training Program at Duke University and joined the academic faculty at Duke. In 2005 she received the Milton W. Hamolsky Award for Outstanding Junior Faculty by the Society of General Internal Medicine. Her major research interests are decision making and patient preferences, implementation research, risk stratification for targeting preventive health services, and decision modeling. From 2004-2009 she worked with Dr. David Matchar in the Center for Clinical Heath Policy Research (CCHPR), where she specialized in decision modeling, decision making, and technology assessments. In 2009 she began working with Dr. Geoffrey Ginsburg in what is now the Center for Applied Genomics and Precision Medicine (CAGPM) and in 2014 she became the director of the Center’s Precision Medicine Program. Since joining the CAGPM she has been leading the development and implementation of MeTree, a patient-facing family health history based risk assessment and clinical decision support program designed to facilitate the uptake of risk stratified evidence-based guidelines. MeTree was designed to overcome the major barriers to collecting and using high quality family health histories to guide clinical care and has been shown to be highly effective when integrated into primary care practices. This effort started with the Genomic Medicine Model, a multi-institutional project, whose goal was to implement personalized medicine in primary care practices. The success of that project has led to funding as part of NHGRI’s IGNITE (Implementing Genomics in Clinical Practice) network. She is currently testing methods for integrating patient preferences and decision making processes into clinical decision support recommendations for patients and providers to facilitate management of patients’ risk for chronic disease using mHealth and other behavioral interventions.

Education and Training

  • Fellow in General Internal Medicine, Medicine, Duke University, 2002 - 2004
  • Chief Medical Resident, Medicine, Tulane University, 2001 - 2002
  • Medical Resident, Mecicine, Tulane University, 1998 - 2001
  • M.H.S., Duke University, 2004
  • M.D., Tulane University, 1998

Publications

Zebrowski, Alexis M., Darcy E. Ellis, Frances K. Barg, Nina R. Sperber, Barbara A. Bernhardt, Joshua C. Denny, Paul R. Dexter, et al. “Qualitative study of system-level factors related to genomic implementation..” Genet Med 21, no. 7 (July 2019): 1534–40. https://doi.org/10.1038/s41436-018-0378-9.

PMID
30467402
Full Text

Levy, Kenneth D., Kathryn Blake, Colette Fletcher-Hoppe, James Franciosi, Diasuke Goto, James K. Hicks, Ann M. Holmes, et al. “Correction: Opportunities to implement a sustainable genomic medicine program: lessons learned from the IGNITE Network..” Genet Med 21, no. 7 (July 2019). https://doi.org/10.1038/s41436-018-0280-5.

PMID
30158693
Full Text

Horowitz, Carol R., Lori A. Orlando, Anne M. Slavotinek, Josh Peterson, Frank Angelo, Barbara Biesecker, Vence L. Bonham, et al. “The Genomic Medicine Integrative Research Framework: A Conceptual Framework for Conducting Genomic Medicine Research..” Am J Hum Genet 104, no. 6 (June 6, 2019): 1088–96. https://doi.org/10.1016/j.ajhg.2019.04.006.

PMID
31104772
Full Text

Orlando, Lori A., Corrine Voils, Carol R. Horowitz, Rachel A. Myers, Meghan J. Arwood, Emily J. Cicali, Caitrin W. McDonough, et al. “IGNITE network: Response of patients to genomic medicine interventions..” Mol Genet Genomic Med 7, no. 5 (May 2019). https://doi.org/10.1002/mgg3.636.

PMID
30895746
Full Text

Hutyra, Carolyn A., Stephen Smiley, Dean C. Taylor, Lori A. Orlando, and Richard C. Mather. “Efficacy of a Preference-Based Decision Tool on Treatment Decisions for a First-Time Anterior Shoulder Dislocation: A Randomized Controlled Trial of At-Risk Patients..” Med Decis Making 39, no. 3 (April 2019): 253–63. https://doi.org/10.1177/0272989X19832915.

PMID
30834817
Full Text

Levy, Kenneth D., Kathryn Blake, Colette Fletcher-Hoppe, James Franciosi, Diasuke Goto, James K. Hicks, Ann M. Holmes, et al. “Opportunities to implement a sustainable genomic medicine program: lessons learned from the IGNITE Network..” Genet Med 21, no. 3 (March 2019): 743–47. https://doi.org/10.1038/s41436-018-0080-y.

PMID
29997387
Full Text

Wu, R Ryanne, Rachel A. Myers, Adam H. Buchanan, David Dimmock, Kimberly G. Fulda, Irina V. Haller, Susanne B. Haga, et al. “Effect of Sociodemographic Factors on Uptake of a Patient-Facing Information Technology Family Health History Risk Assessment Platform..” Appl Clin Inform 10, no. 2 (March 2019): 180–88. https://doi.org/10.1055/s-0039-1679926.

PMID
30866001
Full Text

Wu, R Ryanne, Rachel A. Myers, Nina Sperber, Corrine I. Voils, Joan Neuner, Catherine A. McCarty, Irina V. Haller, et al. “Implementation, adoption, and utility of family health history risk assessment in diverse care settings: evaluating implementation processes and impact with an implementation framework..” Genet Med 21, no. 2 (February 2019): 331–38. https://doi.org/10.1038/s41436-018-0049-x.

PMID
29875427
Full Text

Hutyra, Carolyn A., Benjamin Streufert, Cary S. Politzer, Perez Agaba, Elka Rubin, Lori A. Orlando, Dean C. Taylor, and Richard C. Mather. “Assessing the Effectiveness of Evidence-Based Medicine in Practice: A Case Study of First-Time Anterior Shoulder Dislocations..” J Bone Joint Surg Am 101, no. 2 (January 16, 2019). https://doi.org/10.2106/JBJS.17.01588.

PMID
30653051
Full Text

Tillekeratne, L Gayani, Champica Bodinayake, Ajith Nagahawatte, Ruvini Kurukulasooriya, Lori A. Orlando, Ryan A. Simmons, Lawrence P. Park, Christopher W. Woods, and Shelby D. Reed. “Use of clinical algorithms and rapid influenza testing to manage influenza-like illness: a cost-effectiveness analysis in Sri Lanka..” Bmj Global Health 4, no. 2 (January 2019). https://doi.org/10.1136/bmjgh-2018-001291.

PMID
30997171
Full Text

Pages