Lori Ann Orlando, MD

Professor of Medicine
Associate Director of Duke Center for Applied Genomics and Precision Medicine
Campus mail 102906, Aesthetic Center 2nd Floor, Durham, NC 27705
Phone (919) 660-6606
Email address orlan002@duke.edu

Dr. Lori A. Orlando, MD MHS MMCI is a Professor of Medicine and Director of the Precision Medicine Program in the Center for Applied Genomics and Precision Medicine at Duke University. She attended Tulane Medical Center for both medical school (1994-1998) and Internal Medicine residency (1998-2000). There she finished AOA and received a number of awards for teaching and clinical care from the medical school and the residency programs, including the Musser-Burch-Puschett award in 2000 for academic excellence. After completing her residency, she served as Chief Medical Resident in Internal Medicine (2001) and then completed a Health Services Research Fellowship at Duke University Medical Center (2002-2004). In 2004 she also received her MHS from the Clinical Research Training Program at Duke University and joined the academic faculty at Duke. In 2005 she received the Milton W. Hamolsky Award for Outstanding Junior Faculty by the Society of General Internal Medicine. Her major research interests are decision making and patient preferences, implementation research, risk stratification for targeting preventive health services, and decision modeling. From 2004-2009 she worked with Dr. David Matchar in the Center for Clinical Heath Policy Research (CCHPR), where she specialized in decision modeling, decision making, and technology assessments. In 2009 she began working with Dr. Geoffrey Ginsburg in what is now the Center for Applied Genomics and Precision Medicine (CAGPM) and in 2014 she became the director of the Center’s Precision Medicine Program. Since joining the CAGPM she has been leading the development and implementation of MeTree, a patient-facing family health history based risk assessment and clinical decision support program designed to facilitate the uptake of risk stratified evidence-based guidelines. MeTree was designed to overcome the major barriers to collecting and using high quality family health histories to guide clinical care and has been shown to be highly effective when integrated into primary care practices. This effort started with the Genomic Medicine Model, a multi-institutional project, whose goal was to implement personalized medicine in primary care practices. The success of that project has led to funding as part of NHGRI’s IGNITE (Implementing Genomics in Clinical Practice) network. She is currently testing methods for integrating patient preferences and decision making processes into clinical decision support recommendations for patients and providers to facilitate management of patients’ risk for chronic disease using mHealth and other behavioral interventions.

Education and Training

  • Fellow in General Internal Medicine, Medicine, Duke University, 2002 - 2004
  • Chief Medical Resident, Medicine, Tulane University, 2001 - 2002
  • Medical Resident, Medicine, Tulane University, 1998 - 2001
  • M.M.C.i., Duke University, Fuqua School of Business, 2019
  • M.H.S., Duke University, 2004
  • M.D., Tulane University, 1998

Publications

Yoon, Sungwon, Hendra Goh, Si Ming Fung, Shihui Tang, David Matchar, Geoffrey S. Ginsburg, Lori A. Orlando, Joanne Ngeow, and Rebekah Ryanne Wu. “Experience and Perceptions of a Family Health History Risk Assessment Tool among Multi-Ethnic Asian Breast Cancer Patients.” J Pers Med 11, no. 10 (October 19, 2021). https://doi.org/10.3390/jpm11101046.

PMID
34683187
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Levy, Kenneth D., Kathryn Blake, Colette Fletcher-Hoppe, James Franciosi, Daisuke Goto, James K. Hicks, Ann M. Holmes, et al. “Correction: Opportunities to implement a sustainable genomic medicine program: lessons learned from the IGNITE Network.” Genet Med 23, no. 10 (October 2021): 2020. https://doi.org/10.1038/s41436-020-01054-0.

PMID
33288881
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Chung, Wendy K., Kyle Brothers, Angela Bradbury, Sirisak Chanprasert, Lori Orlando, Ali Torkamani, Heather Zierhut, et al. “Genomic medicine implementation protocols in the PhenX Toolkit: tools for standardized data collection.” Genet Med 23, no. 9 (September 2021): 1783–88. https://doi.org/10.1038/s41436-021-01183-0.

PMID
33972721
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Sperber, Nina R., Olivia M. Dong, Megan C. Roberts, Paul Dexter, Amanda R. Elsey, Geoffrey S. Ginsburg, Carol R. Horowitz, et al. “Strategies to Integrate Genomic Medicine into Clinical Care: Evidence from the IGNITE Network.” J Pers Med 11, no. 7 (July 8, 2021). https://doi.org/10.3390/jpm11070647.

PMID
34357114
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Bylstra, Yasmin, Weng Khong Lim, Sylvia Kam, Koei Wan Tham, R Ryanne Wu, Jing Xian Teo, Sonia Davila, et al. “Correction to: Family history assessment significantly enhances delivery of precision medicine in the genomics era.” Genome Med 13, no. 1 (July 5, 2021): 109. https://doi.org/10.1186/s13073-021-00916-9.

PMID
34225778
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Ginsburg, Geoffrey S., Larisa H. Cavallari, Hrishikesh Chakraborty, Rhonda M. Cooper-DeHoff, Paul R. Dexter, Michael T. Eadon, Bart S. Ferket, et al. “Establishing the value of genomics in medicine: the IGNITE Pragmatic Trials Network.” Genet Med 23, no. 7 (July 2021): 1185–91. https://doi.org/10.1038/s41436-021-01118-9.

PMID
33782552
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Schneider, Thomas M., Michael T. Eadon, Rhonda M. Cooper-DeHoff, Kerri L. Cavanaugh, Khoa A. Nguyen, Meghan J. Arwood, Emma M. Tillman, et al. “Multi-Institutional Implementation of Clinical Decision Support for APOL1, NAT2, and YEATS4 Genotyping in Antihypertensive Management.” J Pers Med 11, no. 6 (May 27, 2021). https://doi.org/10.3390/jpm11060480.

PMID
34071920
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Fung, Si Ming, R Ryanne Wu, Rachel A. Myers, Jasper Goh, Geoffrey S. Ginsburg, David Matchar, Lori A. Orlando, and Joanne Ngeow. “Clinical implementation of an oncology-specific family health history risk assessment tool.” Hered Cancer Clin Pract 19, no. 1 (March 20, 2021): 20. https://doi.org/10.1186/s13053-021-00177-y.

PMID
33743786
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Bylstra, Yasmin, Weng Khong Lim, Sylvia Kam, Koei Wan Tham, R Ryanne Wu, Jing Xian Teo, Sonia Davila, et al. “Family history assessment significantly enhances delivery of precision medicine in the genomics era.” Genome Med 13, no. 1 (January 7, 2021): 3. https://doi.org/10.1186/s13073-020-00819-1.

PMID
33413596
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Lau, Brian C., Carolyn A. Hutyra, Benjamin Streufert, Shelby D. Reed, Lori A. Orlando, Joel C. Huber, Dean C. Taylor, and Richard C. Mather. “Surgeon Applications of Patient Preferences in Treatment Decision Making for First-Time Anterior Shoulder Dislocation.” Orthop J Sports Med 8, no. 12 (December 2020): 2325967120966145. https://doi.org/10.1177/2325967120966145.

PMID
33330735
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