Lori Ann Orlando, MD

Associate Professor of Medicine
Campus mail 102906, Aesthetic Center 2nd Floor, Durham, NC 27705
Phone (919) 660-6606
Email address orlan002@duke.edu

Dr. Lori A. Orlando, MD MHS is an Associate Professor of Medicine and Associate Director of the Precision Medicine Program in the Center for Applied Genomics and Precision Medicine at Duke University. She attended Tulane Medical Center for both medical school (1994-1998) and Internal Medicine residency (1998-2000). There she finished AOA and received a number of awards for teaching and clinical care from the medical school and the residency programs, including the Musser-Burch-Puschett award in 2000 for academic excellence. After completing her residency, she served as Chief Medical Resident in Internal Medicine (2001) and then completed a Health Services Research Fellowship at Duke University Medical Center (2002-2004). In 2004 she also received her MHS from the Clinical Research Training Program at Duke University and joined the academic faculty at Duke. In 2005 she received the Milton W. Hamolsky Award for Outstanding Junior Faculty by the Society of General Internal Medicine. Her major research interests are decision making and patient preferences, implementation research, risk stratification for targeting preventive health services, and decision modeling. From 2004-2009 she worked with Dr. David Matchar in the Center for Clinical Heath Policy Research (CCHPR), where she specialized in decision modeling, decision making, and technology assessments. In 2009 she began working with Dr. Geoffrey Ginsburg in what is now the Center for Applied Genomics and Precision Medicine (CAGPM) and in 2014 she became the director of the Center’s Precision Medicine Program. Since joining the CAGPM she has been leading the development and implementation of MeTree, a patient-facing family health history based risk assessment and clinical decision support program designed to facilitate the uptake of risk stratified evidence-based guidelines. MeTree was designed to overcome the major barriers to collecting and using high quality family health histories to guide clinical care and has been shown to be highly effective when integrated into primary care practices. This effort started with the Genomic Medicine Model, a multi-institutional project, whose goal was to implement personalized medicine in primary care practices. The success of that project has led to funding as part of NHGRI’s IGNITE (Implementing Genomics in Clinical Practice) network. She is currently testing methods for integrating patient preferences and decision making processes into clinical decision support recommendations for patients and providers to facilitate management of patients’ risk for chronic disease using mHealth and other behavioral interventions.

Education and Training

  • Fellow in General Internal Medicine, Medicine, Duke University, 2002 - 2004
  • Chief Medical Resident, Medicine, Tulane University, 2001 - 2002
  • Medical Resident, Mecicine, Tulane University, 1998 - 2001
  • M.H.S., Duke University, 2004
  • M.D., Tulane University, 1998

Publications

Wu, RR, Myers, RA, Sperber, N, Voils, CI, Neuner, J, McCarty, CA, Haller, IV, Harry, M, Fulda, KG, Cross, D, Dimmock, D, Rakhra-Burris, T, Buchanan, AH, Ginsburg, GS, and Orlando, LA. "Implementation, adoption, and utility of family health history risk assessment in diverse care settings: evaluating implementation processes and impact with an implementation framework." Genetics in Medicine : Official Journal of the American College of Medical Genetics (June 6, 2018).

PMID
29875427
Full Text

Orlando, LA, and Wu, RR. "Family Health History and Health Risk Assessment For Cardiovascular Disease in Health Care." In Genomic and Precision Medicine: Cardiovascular Disease: Third Edition, 1-16. November 13, 2017.

Full Text

Phillips, KA, Deverka, PA, Sox, HC, Khoury, MJ, Sandy, LG, Ginsburg, GS, Tunis, SR, Orlando, LA, and Douglas, MP. "Making genomic medicine evidence-based and patient-centered: a structured review and landscape analysis of comparative effectiveness research." Genetics in Medicine : Official Journal of the American College of Medical Genetics 19, no. 10 (October 2017): 1081-1091. (Review)

PMID
28406488
Full Text

Orlando, LA, Sperber, NR, Voils, C, Nichols, M, Myers, RA, Wu, RR, Rakhra-Burris, T, Levy, KD, Levy, M, Pollin, TI, Guan, Y, Horowitz, CR, Ramos, M, Kimmel, SE, McDonough, CW, Madden, EB, and Damschroder, LJ. "Developing a common framework for evaluating the implementation of genomic medicine interventions in clinical care: the IGNITE Network's Common Measures Working Group." Genetics in medicine : official journal of the American College of Medical Genetics (September 14, 2017).

PMID
28914267
Full Text

Sperber, NR, Carpenter, JS, Cavallari, LH, J Damschroder, L, Cooper-DeHoff, RM, Denny, JC, Ginsburg, GS, Guan, Y, Horowitz, CR, Levy, KD, Levy, MA, Madden, EB, Matheny, ME, Pollin, TI, Pratt, VM, Rosenman, M, Voils, CI, W Weitzel, K, Wilke, RA, Ryanne Wu, R, and Orlando, LA. "Challenges and strategies for implementing genomic services in diverse settings: experiences from the Implementing GeNomics In pracTicE (IGNITE) network." Bmc Medical Genomics 10, no. 1 (May 22, 2017): 35-null.

PMID
28532511
Full Text

Streufert, B, Reed, SD, Orlando, LA, Taylor, DC, Huber, JC, and Mather, RC. "Understanding Preferences for Treatment After Hypothetical First-Time Anterior Shoulder Dislocation: Surveying an Online Panel Utilizing a Novel Shared Decision-Making Tool." Orthopaedic journal of sports medicine 5, no. 3 (March 20, 2017): 2325967117695788-.

PMID
28377932
Full Text

Wu, RR, Myers, RA, Hauser, ER, Vorderstrasse, A, Cho, A, Ginsburg, GS, and Orlando, LA. "Impact of Genetic Testing and Family Health History Based Risk Counseling on Behavior Change and Cognitive Precursors for Type 2 Diabetes." Journal of genetic counseling 26, no. 1 (February 2017): 133-140.

PMID
27296809
Full Text

Orlando, LA, and Wu, RR. "Family Health History and Health Risk Assessment in Health Care." In Genomic and Precision Medicine: Foundations, Translation, and Implementation: Third Edition, 189-204. December 15, 2016.

Full Text

Orlando, LA, Wu, RR, Myers, RA, Buchanan, AH, Henrich, VC, Hauser, ER, and Ginsburg, GS. "Clinical utility of a Web-enabled risk-assessment and clinical decision support program." Genetics in Medicine : Official Journal of the American College of Medical Genetics 18, no. 10 (October 2016): 1020-1028.

PMID
26938783
Full Text

Henrich, VC, and Orlando, LA. "Family health history: an essential starting point for personalized risk assessment and disease prevention." Personalized Medicine 13, no. 5 (September 2016): 499-510.

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