Lori Ann Orlando, MD

Professor of Medicine
Associate Director of Duke Center for Applied Genomics and Precision Medicine
Campus mail 102906, Aesthetic Center 2nd Floor, Durham, NC 27705
Phone (919) 660-6606
Email address orlan002@duke.edu

Dr. Lori A. Orlando, MD MHS MMCI is a Professor of Medicine and Director of the Precision Medicine Program in the Center for Applied Genomics and Precision Medicine at Duke University. She attended Tulane Medical Center for both medical school (1994-1998) and Internal Medicine residency (1998-2000). There she finished AOA and received a number of awards for teaching and clinical care from the medical school and the residency programs, including the Musser-Burch-Puschett award in 2000 for academic excellence. After completing her residency, she served as Chief Medical Resident in Internal Medicine (2001) and then completed a Health Services Research Fellowship at Duke University Medical Center (2002-2004). In 2004 she also received her MHS from the Clinical Research Training Program at Duke University and joined the academic faculty at Duke. In 2005 she received the Milton W. Hamolsky Award for Outstanding Junior Faculty by the Society of General Internal Medicine. Her major research interests are decision making and patient preferences, implementation research, risk stratification for targeting preventive health services, and decision modeling. From 2004-2009 she worked with Dr. David Matchar in the Center for Clinical Heath Policy Research (CCHPR), where she specialized in decision modeling, decision making, and technology assessments. In 2009 she began working with Dr. Geoffrey Ginsburg in what is now the Center for Applied Genomics and Precision Medicine (CAGPM) and in 2014 she became the director of the Center’s Precision Medicine Program. Since joining the CAGPM she has been leading the development and implementation of MeTree, a patient-facing family health history based risk assessment and clinical decision support program designed to facilitate the uptake of risk stratified evidence-based guidelines. MeTree was designed to overcome the major barriers to collecting and using high quality family health histories to guide clinical care and has been shown to be highly effective when integrated into primary care practices. This effort started with the Genomic Medicine Model, a multi-institutional project, whose goal was to implement personalized medicine in primary care practices. The success of that project has led to funding as part of NHGRI’s IGNITE (Implementing Genomics in Clinical Practice) network. She is currently testing methods for integrating patient preferences and decision making processes into clinical decision support recommendations for patients and providers to facilitate management of patients’ risk for chronic disease using mHealth and other behavioral interventions.

Education and Training

  • Fellow in General Internal Medicine, Medicine, Duke University, 2002 - 2004
  • Chief Medical Resident, Medicine, Tulane University, 2001 - 2002
  • Medical Resident, Medicine, Tulane University, 1998 - 2001
  • M.M.C.i., Duke University, Fuqua School of Business, 2019
  • M.H.S., Duke University, 2004
  • M.D., Tulane University, 1998

Publications

Ginsburg, Geoffrey S., Larisa H. Cavallari, Hrishikesh Chakraborty, Rhonda M. Cooper-DeHoff, Paul R. Dexter, Michael T. Eadon, Bart S. Ferket, et al. “Establishing the value of genomics in medicine: the IGNITE Pragmatic Trials Network.” Genet Med, March 29, 2021. https://doi.org/10.1038/s41436-021-01118-9.

PMID
33782552
Full Text

Fung, Si Ming, R Ryanne Wu, Rachel A. Myers, Jasper Goh, Geoffrey S. Ginsburg, David Matchar, Lori A. Orlando, and Joanne Ngeow. “Clinical implementation of an oncology-specific family health history risk assessment tool.” Hered Cancer Clin Pract 19, no. 1 (March 20, 2021): 20. https://doi.org/10.1186/s13053-021-00177-y.

PMID
33743786
Full Text

Bylstra, Yasmin, Weng Khong Lim, Sylvia Kam, Koei Wan Tham, R Ryanne Wu, Jing Xian Teo, Sonia Davila, et al. “Family history assessment significantly enhances delivery of precision medicine in the genomics era.” Genome Med 13, no. 1 (January 7, 2021): 3. https://doi.org/10.1186/s13073-020-00819-1.

PMID
33413596
Full Text

Levy, Kenneth D., Kathryn Blake, Colette Fletcher-Hoppe, James Franciosi, Daisuke Goto, James K. Hicks, Ann M. Holmes, et al. “Correction: Opportunities to implement a sustainable genomic medicine program: lessons learned from the IGNITE Network.” Genet Med, December 7, 2020. https://doi.org/10.1038/s41436-020-01054-0.

PMID
33288881
Full Text

Lau, Brian C., Carolyn A. Hutyra, Benjamin Streufert, Shelby D. Reed, Lori A. Orlando, Joel C. Huber, Dean C. Taylor, and Richard C. Mather. “Surgeon Applications of Patient Preferences in Treatment Decision Making for First-Time Anterior Shoulder Dislocation.” Orthop J Sports Med 8, no. 12 (December 2020): 2325967120966145. https://doi.org/10.1177/2325967120966145.

PMID
33330735
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Orlando, Lori A., R Ryanne Wu, Rachel A. Myers, Joan Neuner, Catherine McCarty, Irina V. Haller, Melissa Harry, et al. “At the intersection of precision medicine and population health: an implementation-effectiveness study of family health history based systematic risk assessment in primary care.” Bmc Health Serv Res 20, no. 1 (November 7, 2020): 1015. https://doi.org/10.1186/s12913-020-05868-1.

PMID
33160339
Full Text

Luvsantseren, Sally, Michelle Whirl-Carrillo, Katrin Sangkuhl, Nancy Shin, Alice Wen, Philip Empey, Benish Alam, et al. “Variant Interpretation in Current Pharmacogenetic Testing.” J Pers Med 10, no. 4 (October 31, 2020). https://doi.org/10.3390/jpm10040204.

PMID
33142667
Full Text

Orlando, Lori A., Nina R. Sperber, Corrine Voils, Marshall Nichols, Rachel A. Myers, R Ryanne Wu, Tejinder Rakhra-Burris, et al. “Correction: Developing a common framework for evaluating the implementation of genomic medicine interventions in clinical care: the IGNITE Network's Common Measures Working Group.” Genet Med 22, no. 10 (October 2020): 1729. https://doi.org/10.1038/s41436-020-0910-6.

PMID
32719392
Full Text

Levy, Kenneth D., Kathryn Blake, Colette Fletcher-Hoppe, James Franciosi, Diasuke Goto, James K. Hicks, Ann M. Holmes, et al. “Correction: Opportunities to implement a sustainable genomic medicine program: lessons learned from the IGNITE Network.” Genet Med 22, no. 10 (October 2020): 1730. https://doi.org/10.1038/s41436-020-0911-5.

PMID
32719393
Full Text

Wu, R Ryanne, Rehena Sultana, Yasmin Bylstra, Saumya Jamuar, Sonia Davila, Weng Khong Lim, Geoffrey S. Ginsburg, et al. “Evaluation of family health history collection methods impact on data and risk assessment outcomes.” Prev Med Rep 18 (June 2020): 101072. https://doi.org/10.1016/j.pmedr.2020.101072.

PMID
32181122
Full Text

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