Lori Ann Orlando, MD

Associate Professor of Medicine
Campus mail 102906, Aesthetic Center 2nd Floor, Durham, NC 27705
Phone (919) 660-6606
Email address orlan002@duke.edu

Dr. Lori A. Orlando, MD MHS is an Associate Professor of Medicine and Director of the Precision Medicine Program in the Center for Applied Genomics and Precision Medicine at Duke University. She attended Tulane Medical Center for both medical school (1994-1998) and Internal Medicine residency (1998-2000). There she finished AOA and received a number of awards for teaching and clinical care from the medical school and the residency programs, including the Musser-Burch-Puschett award in 2000 for academic excellence. After completing her residency, she served as Chief Medical Resident in Internal Medicine (2001) and then completed a Health Services Research Fellowship at Duke University Medical Center (2002-2004). In 2004 she also received her MHS from the Clinical Research Training Program at Duke University and joined the academic faculty at Duke. In 2005 she received the Milton W. Hamolsky Award for Outstanding Junior Faculty by the Society of General Internal Medicine. Her major research interests are decision making and patient preferences, implementation research, risk stratification for targeting preventive health services, and decision modeling. From 2004-2009 she worked with Dr. David Matchar in the Center for Clinical Heath Policy Research (CCHPR), where she specialized in decision modeling, decision making, and technology assessments. In 2009 she began working with Dr. Geoffrey Ginsburg in what is now the Center for Applied Genomics and Precision Medicine (CAGPM) and in 2014 she became the director of the Center’s Precision Medicine Program. Since joining the CAGPM she has been leading the development and implementation of MeTree, a patient-facing family health history based risk assessment and clinical decision support program designed to facilitate the uptake of risk stratified evidence-based guidelines. MeTree was designed to overcome the major barriers to collecting and using high quality family health histories to guide clinical care and has been shown to be highly effective when integrated into primary care practices. This effort started with the Genomic Medicine Model, a multi-institutional project, whose goal was to implement personalized medicine in primary care practices. The success of that project has led to funding as part of NHGRI’s IGNITE (Implementing Genomics in Clinical Practice) network. She is currently testing methods for integrating patient preferences and decision making processes into clinical decision support recommendations for patients and providers to facilitate management of patients’ risk for chronic disease using mHealth and other behavioral interventions.

Education and Training

  • Fellow in General Internal Medicine, Medicine, Duke University, 2002 - 2004
  • Chief Medical Resident, Medicine, Tulane University, 2001 - 2002
  • Medical Resident, Mecicine, Tulane University, 1998 - 2001
  • M.H.S., Duke University, 2004
  • M.D., Tulane University, 1998

Publications

Weitzel, KW, Alexander, M, Bernhardt, BA, Calman, N, Carey, DJ, Cavallari, LH, Field, JR, Hauser, D, Junkins, HA, Levin, PA, Levy, K, Madden, EB, Manolio, TA, Odgis, J, Orlando, LA, Pyeritz, R, Wu, RR, Shuldiner, AR, Bottinger, EP, Denny, JC, Dexter, PR, Flockhart, DA, Horowitz, CR, Johnson, JA, Kimmel, SE, Levy, MA, Pollin, TI, Ginsburg, GS, and IGNITE Network, . "The IGNITE network: a model for genomic medicine implementation and research." Bmc Medical Genomics 9 (January 5, 2016): 1-null.

PMID
26729011
Full Text

Wu, RR, Myers, RA, McCarty, CA, Dimmock, D, Farrell, M, Cross, D, Chinevere, TD, Ginsburg, GS, Orlando, LA, and Family Health History Network, . "Protocol for the "Implementation, adoption, and utility of family history in diverse care settings" study." Implementation Science : Is 10 (November 24, 2015): 163-null.

PMID
26597091
Full Text

Wu, RR, and Orlando, LA. "Implementation of health risk assessments with family health history: barriers and benefits." Postgraduate medical journal 91, no. 1079 (September 2015): 508-513. (Review)

PMID
26268266
Full Text

Wu, RR, Himmel, T, Myers, RA, Hauser, E, Vorderstrasse, A, Ginsburg, G, and Orlando, LA. "EFFECT OF FAMILY HISTORY AND GENETIC RISK COUNSELLING FOR TYPE 2 DIABETES ON PERCEPTIONS OF RISK AND CONTROL: SECONDARY ANALYSIS OF A RANDOMIZED CONTROLLED TRIAL." April 2015.

Scholars@Duke

Buchanan, AH, Christianson, CA, Himmel, T, Powell, KP, Agbaje, A, Ginsburg, GS, Henrich, VC, and Orlando, LA. "Use of a patient-entered family health history tool with decision support in primary care: impact of identification of increased risk patients on genetic counseling attendance." Journal of genetic counseling 24, no. 1 (February 2015): 179-188.

PMID
25120038
Full Text

Gallagher, P, King, HA, Haga, SB, Orlando, LA, Joy, SV, Trujillo, GM, Scott, WM, Bembe, M, Creighton, DL, Cho, AH, Ginsburg, GS, and Vorderstrasse, A. "Patient beliefs and behaviors about genomic risk for type 2 diabetes: Implications for prevention." Journal of Health Communication 20, no. 6 (January 1, 2015): 728-735.

Full Text

Mather, RC, Garrett, WE, Cole, BJ, Hussey, K, Bolognesi, MP, Lassiter, T, and Orlando, LA. "Cost-effectiveness analysis of the diagnosis of meniscus tears." The American Journal of Sports Medicine 43, no. 1 (January 2015): 128-137.

PMID
25451791
Full Text

Gallagher, P, King, HA, Haga, SB, Orlando, LA, Joy, SV, Trujillo, GM, Scott, WM, Bembe, M, Creighton, DL, Cho, AH, Ginsburg, GS, and Vorderstrasse, A. "Patient beliefs and behaviors about genomic risk for type 2 diabetes: implications for prevention." Journal of health communication 20, no. 6 (January 2015): 728-735.

PMID
25844569
Full Text

Bartlett, G, Rahimzadeh, V, Longo, C, Orlando, LA, Dawes, M, Lachaine, J, Bochud, M, Paccaud, F, Bergman, H, Crimi, L, and Issa, AM. "The future of genomic testing in primary care: the changing face of personalized medicine." Personalized Medicine 11, no. 5 (July 2014): 477-486.

Full Text

Beadles, CA, Ryanne Wu, R, Himmel, T, Buchanan, AH, Powell, KP, Hauser, E, Henrich, VC, Ginsburg, GS, and Orlando, LA. "Providing patient education: impact on quantity and quality of family health history collection." Familial cancer 13, no. 2 (June 2014): 325-332.

PMID
24515581
Full Text

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