Marilyn Jo Telen, MD

Professor of Medicine
Wellcome Clinical Distinguished Professor of Medicine in Honor of R. Wayne Rundles, M.D.
Associate Professor of Pathology
Member of the Duke Cancer Institute
Affiliate, Duke Global Health Institute
Campus mail 333 Med Sci Res Bldg, Durham, NC 27710
Phone (919) 684-5378
Email address marilyn.telen@duke.edu

Dr. Telen is recognized as an expert in the biochemistry and molecular genetics of blood group antigens and the pathophysiological mechanisms of vaso-occlusion in sickle cell disease. She is the Director of the Duke Comprehensive Sickle Cell Center.

Dr. Telen's laboratory focuses on structure/function analysis of membrane proteins expressed by erythroid cells, as well as the role of these proteins in non-erythroid cells. Proteins are also studied in transfectant systems, and research focuses especially on adhesion receptors. The goals of this work are (1) to understand the mechanism and role of red cell adhesion to leukocytes and endothelium in sickle cell disease; (2) to understand the signaling mechanisms leading to activation (and inactivation) of red cell adhesion molecules; (3) to understand the molecular basis of blood group antigen expression, and (4) to understand the interactions of erythroid membrane proteins with other cells and with extracellular matrix..

Recent investigations have focused on the role of signaling pathways in the upregulation of sickle red cell adhesion. Present studies include (1) investigation of beta-adrenergic signaling pathway responsible for activation of B-CAM/LU and LW adhesion receptors; (2) understanding how nitric oxide and ATP downregulate sickle red cell adhesion; (3) studying the effect of these processes in animal models.

Dr. Telen is also involved in a large multicenter study looking for genetic polymorphisms that affect clinical outcomes in sickle cell disease, as well as a multi-center study investigating the mechanisms and treatment of pulmonary hypertension in sickle cell disease.

Key Words:

Adhesion molecules
Erythrocyte membrane
Sickle cell disease
Transfusion medicine
Immunohematology
CD44
B-CAM/LU
Genetic polymorphisms

Education and Training

  • Fellowship, Hematology/ Oncology, Duke University School of Medicine, 1980 - 1983
  • Resident, Medicine, State University of New York - Buffalo, 1977 - 1980
  • Intern, Medicine, State University of New York - Buffalo, 1977 - 1978
  • M.D., New York University, 1977

Publications

Narine, Kalindi Yajnik, Jennifer Minjia Chang, Jude Jonassaint, Marilyn J. Telen, and Nirmish Shah. “Use of Mobile Technology to Monitor Pain and Reduce Outpatient, Emergency Department (ED), and Hospital Visits for Sickle Cell Pain Crisis.” In Blood, 128:2390–2390. American Society of Hematology, 2016. https://doi.org/10.1182/blood.v128.22.2390.2390.

Full Text

Chang, Jennifer Minjia, Martha Delahunty, Milena Batchvarova, Karen L. Soldano, J Michael Cook, and Marilyn J. Telen. “Effect of FXIII Polymorphism on Formation of Heterocellular Aggregates in SCD.” In Blood, 128:3648–3648. American Society of Hematology, 2016. https://doi.org/10.1182/blood.v128.22.3648.3648.

Full Text

Telen, Marilyn J., Milena Batchvarova, Siqing Shan, Petra H. Bovee-Geurts, Rahima Zennadi, Anna Leitgeb, Roland Brock, and Maria Lindgren. “Sevuparin binds to multiple adhesive ligands and reduces sickle red blood cell-induced vaso-occlusion.” Br J Haematol 175, no. 5 (December 2016): 935–48. https://doi.org/10.1111/bjh.14303.

PMID
27549988
Full Text

Doss, Jennifer F., Jude C. Jonassaint, Melanie E. Garrett, Allison E. Ashley-Koch, Marilyn J. Telen, and Jen-Tsan Chi. “Phase 1 Study of a Sulforaphane-Containing Broccoli Sprout Homogenate for Sickle Cell Disease.” Plos One 11, no. 4 (2016): e0152895. https://doi.org/10.1371/journal.pone.0152895.

PMID
27071063
Full Text

Garrett, Melanie E., Karen L. Soldano, Blair R. Anderson, Marilyn J. Telen, and Allison E. Ashley-Koch. “Genome-Wide Evaluation of Epistasis with APOL1 Risk Variants in Sickle Cell Disease Nephropathy.” In Blood, Vol. 126. AMER SOC HEMATOLOGY, 2015.

Scholars@Duke

Doss, Jennifer F., David L. Corcoran, Dereje D. Jima, Marilyn J. Telen, Sandeep S. Dave, and Jen-Tsan Chi. “A comprehensive joint analysis of the long and short RNA transcriptomes of human erythrocytes.” Bmc Genomics 16 (November 16, 2015): 952. https://doi.org/10.1186/s12864-015-2156-2.

PMID
26573221
Full Text

Kanter, Julie, Marilyn J. Telen, Carolyn Hoppe, Christopher L. Roberts, Jason S. Kim, and Xiaoxi Yang. “Validation of a novel point of care testing device for sickle cell disease.” Bmc Med 13 (September 16, 2015): 225. https://doi.org/10.1186/s12916-015-0473-6.

PMID
26377572
Full Text

Anderson, Blair R., David N. Howell, Karen Soldano, Melanie E. Garrett, Nicholas Katsanis, Marilyn J. Telen, Erica E. Davis, and Allison E. Ashley-Koch. “Correction: In vivo Modeling Implicates APOL1 in Nephropathy: Evidence for Dominant Negative Effects and Epistasis under Anemic Stress.” Plos Genet 11, no. 9 (September 2015): e1005459. https://doi.org/10.1371/journal.pgen.1005459.

PMID
26379250
Full Text

Anderson, Blair R., David N. Howell, Karen Soldano, Melanie E. Garrett, Nicholas Katsanis, Marilyn J. Telen, Erica E. Davis, and Allison E. Ashley-Koch. “In vivo Modeling Implicates APOL1 in Nephropathy: Evidence for Dominant Negative Effects and Epistasis under Anemic Stress.” Plos Genet 11, no. 7 (July 2015): e1005349. https://doi.org/10.1371/journal.pgen.1005349.

PMID
26147622
Full Text

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