Marilyn Jo Telen, MD

Professor of Medicine
Wellcome Clinical Distinguished Professor of Medicine in Honor of R. Wayne Rundles, M.D.
Associate Professor of Pathology
Member of the Duke Cancer Institute
Affiliate, Duke Global Health Institute
Campus mail 333 Med Sci Res Bldg, Durham, NC 27710
Phone (919) 684-5378
Email address marilyn.telen@duke.edu

Dr. Telen is recognized as an expert in the biochemistry and molecular genetics of blood group antigens and the pathophysiological mechanisms of vaso-occlusion in sickle cell disease. She is the Director of the Duke Comprehensive Sickle Cell Center.

Dr. Telen's laboratory focuses on structure/function analysis of membrane proteins expressed by erythroid cells, as well as the role of these proteins in non-erythroid cells. Proteins are also studied in transfectant systems, and research focuses especially on adhesion receptors. The goals of this work are (1) to understand the mechanism and role of red cell adhesion to leukocytes and endothelium in sickle cell disease; (2) to understand the signaling mechanisms leading to activation (and inactivation) of red cell adhesion molecules; (3) to understand the molecular basis of blood group antigen expression, and (4) to understand the interactions of erythroid membrane proteins with other cells and with extracellular matrix..

Recent investigations have focused on the role of signaling pathways in the upregulation of sickle red cell adhesion. Present studies include (1) investigation of beta-adrenergic signaling pathway responsible for activation of B-CAM/LU and LW adhesion receptors; (2) understanding how nitric oxide and ATP downregulate sickle red cell adhesion; (3) studying the effect of these processes in animal models.

Dr. Telen is also involved in a large multicenter study looking for genetic polymorphisms that affect clinical outcomes in sickle cell disease, as well as a multi-center study investigating the mechanisms and treatment of pulmonary hypertension in sickle cell disease.

Key Words:

Adhesion molecules
Erythrocyte membrane
Sickle cell disease
Transfusion medicine
Immunohematology
CD44
B-CAM/LU
Genetic polymorphisms

Education and Training

  • Fellowship, Hematology/ Oncology, Duke University School of Medicine, 1980 - 1983
  • Resident, Medicine, State University of New York - Buffalo, 1977 - 1980
  • Intern, Medicine, State University of New York - Buffalo, 1977 - 1978
  • M.D., New York University, 1977

Publications

Haynes, B. F., M. J. Telen, M. J. PalkerTJ, E. Harden, and R. M. Scearce. “Monoclonal antibody defines human cell surface protein p80 on intrathymic T cells.” J Immunol 132, no. 5 (May 1984): 2678.

PMID
6425411
Scholars@Duke

Haynes, B. F., E. A. Harden, M. J. Telen, M. E. Hemler, J. L. Strominger, T. J. Palker, R. M. Scearce, and G. S. Eisenbarth. “Differentiation of human T lymphocytes. I. Acquisition of a novel human cell surface protein (p80) during normal intrathymic T cell maturation.” J Immunol 131, no. 3 (September 1983): 1195–1200.

PMID
6224850
Scholars@Duke

Telen, M. J., G. S. Eisenbarth, and B. F. Haynes. “Human erythrocyte antigens. Regulation of expression of a novel erythrocyte surface antigen by the inhibitor Lutheran In(Lu) gene.” The Journal of Clinical Investigation 71, no. 6 (June 1983): 1878–86. https://doi.org/10.1172/jci110943.

PMID
6863545
Full Text

TELEN, M. J., G. S. EISENBARTH, and B. F. HAYNES. “CHARACTERIZATION AND DISTRIBUTION OF A LUTHERAN ERYTHROCYTE ANTIGEN AS DEFINED BY A MONOCLONAL-ANTIBODY.” Clinical Research 30, no. 2 (January 1, 1982): A331–A331.

Scholars@Duke

EISENBARTH, G. S., M. J. TELEN, C. PETERSON, T. REIMAN, and B. F. HAYNES. “CHARACTERIZATION OF A NOVEL CELL-SURFACE GLYCOPROTEIN COEXPRESSED ON CELLS BEARING THE INSULIN-RECEPTOR AND SELECTIVELY EXPRESSED ON PANCREATIC-ISLET CELLS.” Clinical Research 30, no. 2 (January 1, 1982): A391–A391.

Scholars@Duke

Telen, Marilyn, and Joseph Bundy. “RNA-sequencing of isolated cell populations expressing human APOL1 G2 risk variant reveals molecular correlates of sickle cell nephropathy in zebrafish podocytes.,” n.d.

Scholars@Duke

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