Endocrinology, Metabolism, and Nutrition

Mark A. Herman, MD

Assistant Professor of Medicine
Assistant Research Professor in Pharmacology and Cancer Biology
Member of Duke Molecular Physiology Institute
Campus mail 300 N. Duke Street, Carmichael Building, Durham, NC 27701
Email address mark.herman@duke.edu

Education and Training

  • Endocrinology Fellowship, Beth Israel Deaconess Medical Center, 2003 - 2006
  • Internal Medicine Residency, University of Texas Southwestern Medical Center at Dallas Southwestern Medical School, 2000 - 2003
  • M.D., University of Texas Southwestern Medical Center at Dallas Southwestern Medical School, 2000

Grants

Publications

Kumar, A, Katz, LS, Schulz, AM, Kim, M, Honig, LB, Li, L, Davenport, B, Homann, D, Garcia-Ocaña, A, Herman, MA, Haynes, CM, Chipuk, JE, and Scott, DK. "Activation of Nrf2 Is Required for Normal and ChREBPα-Augmented Glucose-Stimulated β-Cell Proliferation." Diabetes 67, no. 8 (August 2018): 1561-1575.

PMID
29764859
Full Text

Rotroff, DM, Yee, SW, Zhou, K, Marvel, SW, Shah, HS, Jack, JR, Havener, TM, Hedderson, MM, Kubo, M, Herman, MA, Gao, H, Mychaleckyi, JC, McLeod, HL, Doria, A, Giacomini, KM, Pearson, ER, Wagner, MJ, Buse, JB, Motsinger-Reif, AA, MetGen Investigators, , and ACCORD/ACCORDion Investigators, . "Genetic Variants in CPA6 and PRPF31 Are Associated With Variation in Response to Metformin in Individuals With Type 2 Diabetes." Diabetes 67, no. 7 (July 2018): 1428-1440.

PMID
29650774
Full Text

Bu, P, Chen, K-Y, Xiang, K, Johnson, C, Crown, SB, Rakhilin, N, Ai, Y, Wang, L, Xi, R, Astapova, I, Han, Y, Li, J, Barth, BB, Lu, M, Gao, Z, Mines, R, Zhang, L, Herman, M, Hsu, D, Zhang, G-F, and Shen, X. "Aldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis." Cell metabolism 27, no. 6 (June 2018): 1249-1262.e4.

PMID
29706565
Full Text

White, PJ, McGarrah, RW, Grimsrud, PA, Tso, S-C, Yang, W-H, Haldeman, JM, Grenier-Larouche, T, An, J, Lapworth, AL, Astapova, I, Hannou, SA, George, T, Arlotto, M, Olson, LB, Lai, M, Zhang, G-F, Ilkayeva, O, Herman, MA, Wynn, RM, Chuang, DT, and Newgard, CB. "The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase." Cell Metabolism 27, no. 6 (June 2018): 1281-1293.e7.

PMID
29779826
Full Text

Jiang, ZG, Tapper, EB, Kim, M, Connelly, MA, Krawczyk, SA, Yee, EU, Herman, MA, Mukamal, KJ, and Lai, M. "Genetic Determinants of Circulating Lipoproteins in Nonalcoholic Fatty Liver Disease." Journal of Clinical Gastroenterology 52, no. 5 (May 2018): 444-451.

PMID
28362682
Full Text

Herman, MA, Hannou, SA, McKeown, NM, and Haslam, DE. "Fructose metabolism and metabolic disease." The Journal of clinical investigation 128, no. 2 (February 1, 2018): 545-555. (Review)

Full Text

McKeown, NM, Dashti, HS, Ma, J, Haslam, DE, Kiefte-de Jong, JC, Smith, CE, Tanaka, T, Graff, M, Lemaitre, RN, Rybin, D, Sonestedt, E, Frazier-Wood, AC, Mook-Kanamori, DO, Li, Y, Wang, CA, Leermakers, ETM, Mikkilä, V, Young, KL, Mukamal, KJ, Cupples, LA, Schulz, C-A, Chen, T-A, Li-Gao, R, Huang, T, Oddy, WH, Raitakari, O, Rice, K, Meigs, JB, Ericson, U, Steffen, LM, Rosendaal, FR, Hofman, A, Kähönen, M, Psaty, BM, Brunkwall, L, Uitterlinden, AG, Viikari, J, Siscovick, DS, Seppälä, I, North, KE, Mozaffarian, D, Dupuis, J, Orho-Melander, M, Rich, SS, de Mutsert, R, Qi, L, Pennell, CE, Franco, OH, Lehtimäki, T, and Herman, MA. "Sugar-sweetened beverage intake associations with fasting glucose and insulin concentrations are not modified by selected genetic variants in a ChREBP-FGF21 pathway: a meta-analysis." Diabetologia 61, no. 2 (February 2018): 317-330.

PMID
29098321
Full Text

Kim, M, Astapova, II, Flier, SN, Hannou, SA, Doridot, L, Sargsyan, A, Kou, HH, Fowler, AJ, Liang, G, and Herman, MA. "Intestinal, but not hepatic, ChREBP is required for fructose tolerance." JCI insight 2, no. 24 (December 21, 2017).

PMID
29263303
Full Text

Ter Horst, KW, Gilijamse, PW, Demirkiran, A, van Wagensveld, BA, Ackermans, MT, Verheij, J, Romijn, JA, Nieuwdorp, M, Maratos-Flier, E, Herman, MA, and Serlie, MJ. "The FGF21 response to fructose predicts metabolic health and persists after bariatric surgery in obese humans." Molecular metabolism 6, no. 11 (November 2017): 1493-1502.

PMID
29107295
Full Text

Fisher, FM, Kim, M, Doridot, L, Cunniff, JC, Parker, TS, Levine, DM, Hellerstein, MK, Hudgins, LC, Maratos-Flier, E, and Herman, MA. "A critical role for ChREBP-mediated FGF21 secretion in hepatic fructose metabolism." Molecular metabolism 6, no. 1 (January 2017): 14-21.

PMID
28123933
Full Text

Pages