Mary Elizabeth Anne Sunday, MD, PhD

Professor of Pathology
Professor in Cell Biology
Professor of Medicine
Professor in Pediatrics
Campus mail Davison Bldg., 2nd Floor, Durham, NC 27710
Phone (919) 681-4945
Email address mary.sunday@duke.edu

Oxygen (O2) is essential for life, but excessive oxygen causes tissue injury, scarring, aging, and death. We are studying mechanisms of injury mediated by O2-sensing pulmonary neuroendocrine cells, especially gastrin-releasing peptide (GRP). GRP secretion is induced by O2-related (oxidant) injury, leading to acute and chronic lung injury and pulmonary fibrosis (PF). Our key model is PF due to ionizing radiation to the thorax. This is clinically relevant to PF triggered by many environmental exposures or autoimmune diseases, as well as idiopathic pulmonary fibrosis (IPF). There is no cure for PF. We seek to reverse fibrotic responses in lung.

Education and Training

  • Research Fellow, Pathology, Children's Hospital, Boston, 1986 - 1987
  • Research & Clinical Fellow, Pathology, Madigan Army Medical Center, 1985 - 1987
  • Research Fellow, Medicine, Massachusetts General Hospital, 1983 - 1987
  • Resident, Anatomic Pathology, Pathology, Madigan Army Medical Center, 1983 - 1985
  • Intern, Internal Medicine, Johns Hopkins University, 1982 - 1983
  • Ph.D., Harvard University , 1982
  • M.D., Harvard University , 1982
  • B.S., University of Toronto (Canada), 1976

Publications

Chen, Pengcheng, Shang Wang, Kyathanahalli S. Janardhan, Rachel L. Zemans, Wenhai Deng, Peer Karmaus, Shudan Shen, et al. “Efficient CD4Cre-Mediated Conditional KRas Expression in Alveolar Macrophages and Alveolar Epithelial Cells Causes Fatal Hyperproliferative Pneumonitis..” J Immunol 203, no. 5 (September 1, 2019): 1208–17. https://doi.org/10.4049/jimmunol.1900566.

PMID
31315887
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Tighe, Robert M., Karissa Heck, Erik Soderblom, Shutang Zhou, Anastasiya Birukova, Kenneth Young, Douglas Rouse, et al. “Immediate Release of Gastrin-Releasing Peptide Mediates Delayed Radiation-Induced Pulmonary Fibrosis..” Am J Pathol 189, no. 5 (May 2019): 1029–40. https://doi.org/10.1016/j.ajpath.2019.01.017.

PMID
30898588
Full Text

Shirey, Kari Ann, Mary E. Sunday, Wendy Lai, Mira C. Patel, Jorge C. G. Blanco, Frank Cuttitta, and Stefanie N. Vogel. “Novel role of gastrin releasing peptide-mediated signaling in the host response to influenza infection..” Mucosal Immunol 12, no. 1 (January 2019): 223–31. https://doi.org/10.1038/s41385-018-0081-9.

PMID
30327535
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Ashcraft, Kathleen A., Devin Miles, Mary E. Sunday, Kingshuk Roy Choudhury, Kenneth H. Young, Gregory M. Palmer, Pranalee Patel, et al. “Development and Preliminary Evaluation of a Murine Model of Chronic Radiation-Induced Proctitis..” Int J Radiat Oncol Biol Phys 101, no. 5 (August 1, 2018): 1194–1201. https://doi.org/10.1016/j.ijrobp.2018.04.061.

PMID
30012529
Full Text

Mathews, Joel A., Nandini Krishnamoorthy, David I. Kasahara, John Hutchinson, Youngji Cho, Jeffrey D. Brand, Alison S. Williams, et al. “Augmented Responses to Ozone in Obese Mice Require IL-17A and Gastrin-Releasing Peptide..” Am J Respir Cell Mol Biol 58, no. 3 (March 2018): 341–51. https://doi.org/10.1165/rcmb.2017-0071OC.

PMID
28957638
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Lugogo, Njira, Dave Francisco, Kenneth J. Addison, Akarsh Manne, William Pederson, Jennifer L. Ingram, Cynthia L. Green, et al. “Obese asthmatic patients have decreased surfactant protein A levels: Mechanisms and implications..” J Allergy Clin Immunol 141, no. 3 (March 2018): 918-926.e3. https://doi.org/10.1016/j.jaci.2017.05.028.

PMID
28624607
Full Text

Bao, Erik L., Anastasiya Chystsiakova, Mulugu V. Brahmajothi, Mary E. Sunday, Elizabeth N. Pavlisko, Michael F. Wempe, and Richard L. Auten. “Bronchopulmonary dysplasia impairs L-type amino acid transporter-1 expression in human and baboon lung..” Pediatr Pulmonol 51, no. 10 (October 2016): 1048–56. https://doi.org/10.1002/ppul.23402.

PMID
26918397
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Ingram, Jennifer L., David Slade, Tony D. Church, Dave Francisco, Karissa Heck, R Wesley Sigmon, Michael Ghio, et al. “Role of Matrix Metalloproteinases-1 and -2 in Interleukin-13-Suppressed Elastin in Airway Fibroblasts in Asthma..” Am J Respir Cell Mol Biol 54, no. 1 (January 2016): 41–50. https://doi.org/10.1165/rcmb.2014-0290OC.

PMID
26074138
Full Text

Ledford, Julie G., Hisatsugu Goto, Erin N. Potts, Simone Degan, Hong Wei Chu, Dennis R. Voelker, Mary E. Sunday, et al. “Correction: SP-A Preserves Airway Homeostasis during Mycoplasma pneumoniae Infection in Mice..” J Immunol 195, no. 6 (September 15, 2015): 2917–18. https://doi.org/10.4049/jimmunol.1501597.

PMID
26342104
Full Text

Zhou, S., S. Degan, E. N. Potts, W. M. Foster, and M. E. Sunday. “Correction: NPAS3 is a trachealess homolog critical for lung development and homeostasis (Proceedings of the National Academy of Sciences of the United States of America (2009) 106 (11691-11696) DOI: 10.1073/pnas.0902426106).” Proceedings of the National Academy of Sciences of the United States of America 112, no. 29 (July 21, 2015). https://doi.org/10.1073/pnas.1507989112.

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