Mary Elizabeth Anne Sunday, MD, PhD

Professor of Pathology
Professor in Cell Biology
Professor of Medicine
Professor in Pediatrics
Member of the Duke Cancer Institute
Campus mail Davison Bldg., 2nd Floor, Durham, NC 27710
Phone (919) 681-4945
Email address mary.sunday@duke.edu

Oxygen (O2) is essential for life, but excessive oxygen causes tissue injury, scarring, aging, and death. We are studying mechanisms of injury mediated by O2-sensing pulmonary neuroendocrine cells, especially gastrin-releasing peptide (GRP). GRP secretion is induced by O2-related (oxidant) injury, leading to acute and chronic lung injury and pulmonary fibrosis (PF). Our key model is PF due to ionizing radiation to the thorax. This is clinically relevant to PF triggered by many environmental exposures or autoimmune diseases, as well as idiopathic pulmonary fibrosis (IPF). There is no cure for PF. We seek to reverse fibrotic responses in lung.

Education and Training

  • Research Fellow, Pathology, Children's Hospital Boston, 1986 - 1987
  • Research & Clinical Fellow, Pathology, Madigan Army Medical Center, 1985 - 1987
  • Research Fellow, Medicine, Massachusetts General Hospital, 1983 - 1987
  • Resident, Anatomic Pathology, Pathology, Madigan Army Medical Center, 1983 - 1985
  • Intern, Internal Medicine, Johns Hopkins University, 1982 - 1983
  • Ph.D., Harvard University , 1982
  • M.D., Harvard University , 1982
  • B.S., University of Toronto (Canada), 1976

Publications

Tighe, RM, Heck, K, Soderblom, E, Zhou, S, Birukova, A, Young, K, Rouse, D, Vidas, J, Komforti, MK, Toomey, CB, Cuttitta, F, and Sunday, ME. "Immediate Release of Gastrin-Releasing Peptide Mediates Delayed Radiation-Induced Pulmonary Fibrosis." The American Journal of Pathology (March 18, 2019).

PMID
30898588
Full Text

Shirey, KA, Sunday, ME, Lai, W, Patel, MC, Blanco, JCG, Cuttitta, F, and Vogel, SN. "Novel role of gastrin releasing peptide-mediated signaling in the host response to influenza infection." Mucosal Immunology 12, no. 1 (January 2019): 223-231.

PMID
30327535
Full Text

Ashcraft, KA, Miles, D, Sunday, ME, Choudhury, KR, Young, KH, Palmer, GM, Patel, P, Woska, EC, Zhang, R, Oldham, M, Dewhirst, MW, and Koontz, BF. "Development and Preliminary Evaluation of a Murine Model of Chronic Radiation-Induced Proctitis." International Journal of Radiation Oncology, Biology, Physics 101, no. 5 (August 2018): 1194-1201.

PMID
30012529
Full Text

Lugogo, N, Francisco, D, Addison, KJ, Manne, A, Pederson, W, Ingram, JL, Green, CL, Suratt, BT, Lee, JJ, Sunday, ME, Kraft, M, and Ledford, JG. "Obese asthmatic patients have decreased surfactant protein A levels: Mechanisms and implications." The Journal of Allergy and Clinical Immunology 141, no. 3 (March 2018): 918-926.e3.

PMID
28624607
Full Text

Mathews, JA, Krishnamoorthy, N, Kasahara, DI, Hutchinson, J, Cho, Y, Brand, JD, Williams, AS, Wurmbrand, AP, Ribeiro, L, Cuttitta, F, Sunday, ME, Levy, BD, and Shore, SA. "Augmented Responses to Ozone in Obese Mice Require IL-17A and Gastrin-Releasing Peptide." American Journal of Respiratory Cell and Molecular Biology 58, no. 3 (March 2018): 341-351.

PMID
28957638
Full Text

Bao, EL, Chystsiakova, A, Brahmajothi, MV, Sunday, ME, Pavlisko, EN, Wempe, MF, and Auten, RL. "Bronchopulmonary dysplasia impairs L-type amino acid transporter-1 expression in human and baboon lung." Pediatric pulmonology 51, no. 10 (October 2016): 1048-1056.

PMID
26918397
Full Text

Ingram, JL, Slade, D, Church, TD, Francisco, D, Heck, K, Sigmon, RW, Ghio, M, Murillo, A, Firszt, R, Lugogo, NL, Que, L, Sunday, ME, and Kraft, M. "Role of Matrix Metalloproteinases-1 and -2 in Interleukin-13-Suppressed Elastin in Airway Fibroblasts in Asthma." American Journal of Respiratory Cell and Molecular Biology 54, no. 1 (January 2016): 41-50.

PMID
26074138
Full Text

Ledford, JG, Goto, H, Potts, EN, Degan, S, Wei Chu, H, Voelker, DR, Sunday, ME, Cianciolo, GJ, Foster, WM, Kraft, M, and Wright, JR. "Correction: SP-A Preserves Airway Homeostasis during Mycoplasma pneumoniae Infection in Mice." Journal of Immunology (Baltimore, Md. : 1950) 195, no. 6 (September 2015): 2917-2918.

PMID
26342104
Full Text

Zhou, S, Degan, S, Potts, EN, Foster, WM, and Sunday, ME. "Correction: NPAS3 is a trachealess homolog critical for lung development and homeostasis (Proceedings of the National Academy of Sciences of the United States of America (2009) 106 (11691-11696) DOI: 10.1073/pnas.0902426106)." Proceedings of the National Academy of Sciences of the United States of America 112, no. 29 (July 21, 2015): E3970-null.

Full Text

"Retraction for Zhou et al., Gastrin-releasing peptide blockade as a broad-spectrum anti-inflammatory therapy for asthma." Proceedings of the National Academy of Sciences 112, no. 14 (April 7, 2015): E1813-E1813.

Full Text

Pages