Mary Elizabeth Anne Sunday, MD, PhD

Professor of Pathology
Professor in Cell Biology
Professor of Medicine
Professor in Pediatrics
Member of the Duke Cancer Institute
Campus mail Davison Bldg., 2nd Floor, Durham, NC 27710
Phone (919) 681-4945
Email address mary.sunday@duke.edu

Oxygen (O2) is essential for life, but excessive oxygen causes tissue injury, scarring, aging, and death. We are studying mechanisms of injury mediated by O2-sensing pulmonary neuroendocrine cells, especially gastrin-releasing peptide (GRP). GRP secretion is induced by O2-related (oxidant) injury, leading to acute and chronic lung injury and pulmonary fibrosis (PF). Our key model is PF due to ionizing radiation to the thorax. This is clinically relevant to PF triggered by many environmental exposures or autoimmune diseases, as well as idiopathic pulmonary fibrosis (IPF). There is no cure for PF. We seek to reverse fibrotic responses in lung.

Education and Training

  • Research Fellow, Pathology, Children's Hospital Boston, 1986 - 1987
  • Research & Clinical Fellow, Pathology, Madigan Army Medical Center, 1985 - 1987
  • Research Fellow, Medicine, Massachusetts General Hospital, 1983 - 1987
  • Resident, Anatomic Pathology, Pathology, Madigan Army Medical Center, 1983 - 1985
  • Intern, Internal Medicine, Johns Hopkins University, 1982 - 1983
  • Ph.D., Harvard University, 1982
  • M.D., Harvard University, 1982
  • B.S., University of Toronto (Canada), 1976

Publications

Mathews, JA, Krishnamoorthy, N, Kasahara, DI, Hutchinson, J, Cho, Y, Brand, JD, Williams, AS, Wurmbrand, AP, Ribeiro, L, Cuttitta, F, Sunday, ME, Levy, BD, and Shore, SA. "Augmented Responses to Ozone in Obese Mice Require IL-17A and Gastrin-releasing Peptide." American journal of respiratory cell and molecular biology (September 28, 2017).

PMID
28957638
Full Text

Lugogo, N, Francisco, D, Addison, KJ, Manne, A, Pederson, W, Ingram, JL, Green, CL, Suratt, BT, Lee, JJ, Sunday, ME, Kraft, M, and Ledford, JG. "Obese asthmatic patients have decreased surfactant protein A levels: Mechanisms and implications." The Journal of allergy and clinical immunology (June 14, 2017).

PMID
28624607
Full Text

Bao, EL, Chystsiakova, A, Brahmajothi, MV, Sunday, ME, Pavlisko, EN, Wempe, MF, and Auten, RL. "Bronchopulmonary dysplasia impairs L-type amino acid transporter-1 expression in human and baboon lung." Pediatric pulmonology 51, no. 10 (October 2016): 1048-1056.

PMID
26918397
Full Text

Ingram, JL, Slade, D, Church, TD, Francisco, D, Heck, K, Sigmon, RW, Ghio, M, Murillo, A, Firszt, R, Lugogo, NL, Que, L, Sunday, ME, and Kraft, M. "Role of Matrix Metalloproteinases-1 and -2 in Interleukin-13-Suppressed Elastin in Airway Fibroblasts in Asthma." American journal of respiratory cell and molecular biology 54, no. 1 (January 2016): 41-50.

PMID
26074138
Full Text

Ledford, JG, Goto, H, Potts, EN, Degan, S, Wei Chu, H, Voelker, DR, Sunday, ME, Cianciolo, GJ, Foster, WM, Kraft, M, and Wright, JR. "Correction: SP-A Preserves Airway Homeostasis during Mycoplasma pneumoniae Infection in Mice." Journal of immunology (Baltimore, Md. : 1950) 195, no. 6 (September 2015): 2917-2918.

PMID
26342104
Full Text

"Correction for Zhou et al., NPAS3 is a trachealess homolog critical for lung development and homeostasis: Fig. 4." Proceedings of the National Academy of Sciences 112, no. 29 (July 21, 2015): E3970-E3970.

Full Text

"Retraction for Zhou et al., Gastrin-releasing peptide blockade as a broad-spectrum anti-inflammatory therapy for asthma." Proceedings of the National Academy of Sciences 112, no. 14 (April 7, 2015): E1813-E1813.

Full Text

Zhou, S, Nissao, E, Jackson, IL, Leong, W, Dancy, L, Cuttitta, F, Vujaskovic, Z, and Sunday, ME. "Radiation-induced lung injury is mitigated by blockade of gastrin-releasing peptide." Am J Pathol 182, no. 4 (April 2013): 1248-1254.

PMID
23395092
Full Text

Lin, R, Degan, S, Theriot, BS, Fischer, BM, Strachan, RT, Liang, J, Pierce, RA, Sunday, ME, Noble, PW, Kraft, M, Brody, AR, and Walker, JKL. "Chronic treatment in vivo with β-adrenoceptor agonists induces dysfunction of airway β(2) -adrenoceptors and exacerbates lung inflammation in mice." Br J Pharmacol 165, no. 7 (April 2012): 2365-2377.

PMID
22013997
Full Text

Ingram, JL, Huggins, MJ, Church, TD, Li, Y, Francisco, DC, Degan, S, Firszt, R, Beaver, DM, Lugogo, NL, Wang, Y, Sunday, ME, Noble, PW, and Kraft, M. "Airway fibroblasts in asthma manifest an invasive phenotype." Am J Respir Crit Care Med 183, no. 12 (June 15, 2011): 1625-1632.

PMID
21471104
Full Text

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