Mary Elizabeth Anne Sunday, MD, PhD

Professor of Pathology
Professor in Cell Biology
Professor of Medicine
Professor in Pediatrics
Member of the Duke Cancer Institute
Campus mail Davison Bldg., 2nd Floor, Durham, NC 27710
Phone (919) 681-4945
Email address mary.sunday@duke.edu

Oxygen (O2) is essential for life, but excessive oxygen causes tissue injury, scarring, aging, and death. We are studying mechanisms of injury mediated by O2-sensing pulmonary neuroendocrine cells, especially gastrin-releasing peptide (GRP). GRP secretion is induced by O2-related (oxidant) injury, leading to acute and chronic lung injury and pulmonary fibrosis (PF). Our key model is PF due to ionizing radiation to the thorax. This is clinically relevant to PF triggered by many environmental exposures or autoimmune diseases, as well as idiopathic pulmonary fibrosis (IPF). There is no cure for PF. We seek to reverse fibrotic responses in lung.

Education and Training

  • Research Fellow, Pathology, Children's Hospital Boston, 1986 - 1987
  • Research & Clinical Fellow, Pathology, Madigan Army Medical Center, 1985 - 1987
  • Research Fellow, Medicine, Massachusetts General Hospital, 1983 - 1987
  • Resident, Anatomic Pathology, Pathology, Madigan Army Medical Center, 1983 - 1985
  • Intern, Internal Medicine, Johns Hopkins University, 1982 - 1983
  • Ph.D., Harvard University , 1982
  • M.D., Harvard University , 1982
  • B.S., University of Toronto (Canada), 1976

Publications

Sunday, M. E. “Corrigendum: Oxygen, gastrin-releasing peptide, and pediatric lung disease: Life in the balance [Front Pediatr, 2, 72 (2014)] doi: 10.3389/fped.2014.00072.” Frontiers in Pediatrics 2, no. OCT (October 1, 2014). https://doi.org/10.3389/fped.2014.00102.

Full Text

Zhou, Shutang, Esther Nissao, Isabel L. Jackson, Wei Leong, Lindsay Dancy, Frank Cuttitta, Zeljko Vujaskovic, and Mary E. Sunday. “Radiation-induced lung injury is mitigated by blockade of gastrin-releasing peptide..” The American Journal of Pathology 182, no. 4 (April 2013): 1248–54. https://doi.org/10.1016/j.ajpath.2012.12.024.

PMID
23395092
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Lin, Rui, Simone Degan, Barbara S. Theriot, Bernard M. Fischer, Ryan T. Strachan, Jiurong Liang, Richard A. Pierce, et al. “Chronic treatment in vivo with β-adrenoceptor agonists induces dysfunction of airway β(2) -adrenoceptors and exacerbates lung inflammation in mice..” British Journal of Pharmacology 165, no. 7 (April 2012): 2365–77. https://doi.org/10.1111/j.1476-5381.2011.01725.x.

PMID
22013997
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Ingram, Jennifer L., Molly J. Huggins, Tony D. Church, Yuejuan Li, Dave C. Francisco, Simone Degan, Rafael Firszt, et al. “Airway fibroblasts in asthma manifest an invasive phenotype..” American Journal of Respiratory and Critical Care Medicine 183, no. 12 (June 2011): 1625–32. https://doi.org/10.1164/rccm.201009-1452OC.

PMID
21471104
Full Text

Zhou, Shutang, Simone Degan, Erin N. Potts, W Michael Foster, and Mary E. Sunday. “NPAS3 is a trachealess homolog critical for lung development and homeostasis..” Proceedings of the National Academy of Sciences of the United States of America 106, no. 28 (July 6, 2009): 11691–96. https://doi.org/10.1073/pnas.0902426106.

PMID
19581591
Full Text

Ledford, Julie G., Hisatsugu Goto, Erin N. Potts, Simone Degan, Hong Wei Chu, Dennis R. Voelker, Mary E. Sunday, et al. “SP-A preserves airway homeostasis during Mycoplasma pneumoniae infection in mice..” Journal of Immunology (Baltimore, Md. : 1950) 182, no. 12 (June 2009): 7818–27. https://doi.org/10.4049/jimmunol.0900452.

PMID
19494306
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Zaas, David W., Zachary D. Swan, Bethany J. Brown, Guojie Li, Scott H. Randell, Simone Degan, Mary E. Sunday, Jo Rae Wright, and Soman N. Abraham. “Counteracting signaling activities in lipid rafts associated with the invasion of lung epithelial cells by Pseudomonas aeruginosa..” The Journal of Biological Chemistry 284, no. 15 (April 2009): 9955–64. https://doi.org/10.1074/jbc.M808629200.

PMID
19211560
Full Text

Degan, Simone, Giselle Y. Lopez, Katharine Kevill, and Mary E. Sunday. “Gastrin-releasing peptide, immune responses, and lung disease..” Annals of the New York Academy of Sciences 1144 (November 2008): 136–47. https://doi.org/10.1196/annals.1418.022.

PMID
19076373
Full Text

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