Mary Elizabeth Anne Sunday, MD, PhD

Professor of Pathology
Professor in Cell Biology
Professor of Medicine
Professor in Pediatrics
Campus mail Davison Bldg., 2nd Floor, Durham, NC 27710
Phone (919) 681-4945
Email address mary.sunday@duke.edu

Oxygen (O2) is essential for life, but excessive oxygen causes tissue injury, scarring, aging, and death. We are studying mechanisms of injury mediated by O2-sensing pulmonary neuroendocrine cells, especially gastrin-releasing peptide (GRP). GRP secretion is induced by O2-related (oxidant) injury, leading to acute and chronic lung injury and pulmonary fibrosis (PF). Our key model is PF due to ionizing radiation to the thorax. This is clinically relevant to PF triggered by many environmental exposures or autoimmune diseases, as well as idiopathic pulmonary fibrosis (IPF). There is no cure for PF. We seek to reverse fibrotic responses in lung.

Education and Training

  • Research Fellow, Pathology, Children's Hospital, Boston, 1986 - 1987
  • Research & Clinical Fellow, Pathology, Madigan Army Medical Center, 1985 - 1987
  • Research Fellow, Medicine, Massachusetts General Hospital, 1983 - 1987
  • Resident, Anatomic Pathology, Pathology, Madigan Army Medical Center, 1983 - 1985
  • Intern, Internal Medicine, Johns Hopkins University, 1982 - 1983
  • Ph.D., Harvard University , 1982
  • M.D., Harvard University , 1982
  • B.S., University of Toronto (Canada), 1976

Publications

Lee, Matt K., Gloria S. Pryhuber, Margaret A. Schwarz, Susan M. Smith, Zdena Pavlova, and Mary E. Sunday. “Developmental regulation of p66Shc is altered by bronchopulmonary dysplasia in baboons and humans..” Am J Respir Crit Care Med 171, no. 12 (June 15, 2005): 1384–94. https://doi.org/10.1164/rccm.200406-776OC.

PMID
15778491
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Moore, Kimberly A., Tom Polte, Sui Huang, Bin Shi, Eben Alsberg, Mary E. Sunday, and Donald E. Ingber. “Control of basement membrane remodeling and epithelial branching morphogenesis in embryonic lung by Rho and cytoskeletal tension..” Dev Dyn 232, no. 2 (February 2005): 268–81. https://doi.org/10.1002/dvdy.20237.

PMID
15614768
Full Text

Sunday, M. E., L. Shan, and M. Subramaniam. “Immunomodulatory functions of the diffuse neuroendocrine system: Implications for bronchopulmonary dysplasia.” Endocrine Pathology 15, no. 2 (June 1, 2004): 91–106.

Scholars@Duke

Kong, Yanping, Jonathon Glickman, Meera Subramaniam, Aliakbar Shahsafaei, K. P. Allamneni, Jon C. Aster, Jeffrey Sklar, and Mary E. Sunday. “Functional diversity of notch family genes in fetal lung development..” Am J Physiol Lung Cell Mol Physiol 286, no. 5 (May 2004): L1075–83. https://doi.org/10.1152/ajplung.00438.2002.

PMID
15064243
Full Text

Shan, L., R. L. Emanuel, D. Dewald, J. S. Torday, N. Asokanathan, K. Wada, E. Wada, and M. E. Sunday. “Bombesin-like peptide receptor gene expression, regulation, and function in fetal murine lung.” American Journal of Physiology  Lung Cellular and Molecular Physiology 286, no. 1 30-1 (January 1, 2004).

Scholars@Duke

Shan, Lin, Rodica L. Emanuel, Denise Dewald, John S. Torday, Nithiananthan Asokanathan, Keiji Wada, Etsuko Wada, and Mary E. Sunday. “Bombesin-like peptide receptor gene expression, regulation, and function in fetal murine lung..” Am J Physiol Lung Cell Mol Physiol 286, no. 1 (January 2004): L165–73. https://doi.org/10.1152/ajplung.00436.2002.

PMID
12959933
Full Text

Sunday, Mary E., Lin Shan, and Meera Subramaniam. “Immunomodulatory functions of the diffuse neuroendocrine system: implications for bronchopulmonary dysplasia..” Endocr Pathol 15, no. 2 (2004): 91–106.

PMID
15299196
Scholars@Duke

Subramaniam, Meera, Kumiya Sugiyama, David H. Coy, Yanping Kong, York E. Miller, Peter F. Weller, Keiji Wada, Etsuko Wada, and Mary E. Sunday. “Bombesin-like peptides and mast cell responses: relevance to bronchopulmonary dysplasia?.” Am J Respir Crit Care Med 168, no. 5 (September 1, 2003): 601–11. https://doi.org/10.1164/rccm.200212-1434OC.

PMID
12807697
Full Text

Chang, Ling-Yi L., Meera Subramaniam, Bradley A. Yoder, Brian J. Day, Misoo C. Ellison, Mary E. Sunday, and James D. Crapo. “A catalytic antioxidant attenuates alveolar structural remodeling in bronchopulmonary dysplasia..” Am J Respir Crit Care Med 167, no. 1 (January 1, 2003): 57–64. https://doi.org/10.1164/rccm.200203-232OC.

PMID
12502477
Full Text

Haley, K. J., and M. E. Sunday. “Neuroimmunologic control of asthma.” Immunology and Allergy Clinics of North America 22, no. 4 (November 1, 2002): 807–25. https://doi.org/10.1016/S0889-8561(02)00023-1.

Full Text

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