Mary Elizabeth Anne Sunday, MD, PhD

Professor of Pathology
Professor in Cell Biology
Professor of Medicine
Professor in Pediatrics
Member of the Duke Cancer Institute
Campus mail Davison Bldg., 2nd Floor, Durham, NC 27710
Phone (919) 681-4945
Email address mary.sunday@duke.edu

Oxygen (O2) is essential for life, but excessive oxygen causes tissue injury, scarring, aging, and death. We are studying mechanisms of injury mediated by O2-sensing pulmonary neuroendocrine cells, especially gastrin-releasing peptide (GRP). GRP secretion is induced by O2-related (oxidant) injury, leading to acute and chronic lung injury and pulmonary fibrosis (PF). Our key model is PF due to ionizing radiation to the thorax. This is clinically relevant to PF triggered by many environmental exposures or autoimmune diseases, as well as idiopathic pulmonary fibrosis (IPF). There is no cure for PF. We seek to reverse fibrotic responses in lung.

Education and Training

  • Research Fellow, Pathology, Children's Hospital Boston, 1986 - 1987
  • Research & Clinical Fellow, Pathology, Madigan Army Medical Center, 1985 - 1987
  • Research Fellow, Medicine, Massachusetts General Hospital, 1983 - 1987
  • Resident, Anatomic Pathology, Pathology, Madigan Army Medical Center, 1983 - 1985
  • Intern, Internal Medicine, Johns Hopkins University, 1982 - 1983
  • Ph.D., Harvard University , 1982
  • M.D., Harvard University , 1982
  • B.S., University of Toronto (Canada), 1976

Publications

Karmpaliotis, D., I. Kosmidou, E. P. Ingenito, K. Hong, A. Malhotra, M. E. Sunday, and K. J. Haley. “Angiogenic growth factors in the pathophysiology of a murine model of acute lung injury.” American Journal of Physiology  Lung Cellular and Molecular Physiology 283, no. 3 27-3 (September 1, 2002).

Scholars@Duke

Karmpaliotis, Dimitrios, Ioanna Kosmidou, Edward P. Ingenito, Kailin Hong, Atul Malhotra, Mary E. Sunday, and Kathleen J. Haley. “Angiogenic growth factors in the pathophysiology of a murine model of acute lung injury..” American Journal of Physiology. Lung Cellular and Molecular Physiology 283, no. 3 (September 2002): L585–95. https://doi.org/10.1152/ajplung.00048.2002.

PMID
12169578
Full Text

Torday, J. S., H. Sun, L. Wang, E. Torres, M. E. Sunday, and L. P. Rubin. “Erratum: Leptin mediates the parathyroid hormone-related protein paracrine stimulation of fetal lung maturation (American Journal of Physiology - Lung Cellular and Molecular (March 2002) 282 (L405-L410)).” American Journal of Physiology  Lung Cellular and Molecular Physiology 282, no. 4 26-4 (July 2, 2002).

Scholars@Duke

Moore, Kimberly A., Sui Huang, YanPing Kong, Mary E. Sunday, and Donald E. Ingber. “Control of embryonic lung branching morphogenesis by the Rho activator, cytotoxic necrotizing factor 1..” The Journal of Surgical Research 104, no. 2 (May 2002): 95–100. https://doi.org/10.1006/jsre.2002.6418.

PMID
12020126
Full Text

Cullen, Anne, Linda J. Van Marter, Elizabeth N. Allred, Marianne Moore, Richard B. Parad, and Mary E. Sunday. “Urine bombesin-like peptide elevation precedes clinical evidence of bronchopulmonary dysplasia..” American Journal of Respiratory and Critical Care Medicine 165, no. 8 (April 2002): 1093–97. https://doi.org/10.1164/ajrccm.165.8.2108044.

PMID
11956050
Full Text

Torday, J. S., H. Sun, L. Wang, E. Torres, M. E. Sunday, and L. P. Rubin. “Leptin mediates the parathyroid hormone-related protein paracrine stimulation of fetal lung maturation..” American Journal of Physiology. Lung Cellular and Molecular Physiology 282, no. 3 (March 2002): L405–10. https://doi.org/10.1152/ajplung.2002.282.3.l405.

PMID
11839533
Full Text

Sunday, M. E., K. J. Haley, R. L. Emanuel, J. S. Torday, N. Asokananthan, K. A. Sikorski, I. Tooyama, H. Kimura, T. Renda, and V. Erspamer. “Fetal alveolar epithelial cells contain [D-Ala(2)]-deltorphin I-like immunoreactivity: delta- and mu-opiate receptors mediate opposite effects in developing lung..” Am J Respir Cell Mol Biol 25, no. 4 (October 2001): 447–56. https://doi.org/10.1165/ajrcmb.25.4.4072.

PMID
11694450
Full Text

Haley, K. J., M. E. Sunday, R. Osathanondh, J. Du, C. Vathanaprida, V. V. Karpitsky, J. E. Krause, and C. M. Lilly. “Developmental expression of neurokinin A and functional neurokinin-2 receptors in lung.” American Journal of Physiology  Lung Cellular and Molecular Physiology 280, no. 6 24-6 (July 3, 2001).

Scholars@Duke

Haley, K. J., M. E. Sunday, R. Osathanondh, J. Du, C. Vathanaprida, V. V. Karpitsky, J. E. Krause, and C. M. Lilly. “Developmental expression of neurokinin A and functional neurokinin-2 receptors in lung..” American Journal of Physiology. Lung Cellular and Molecular Physiology 280, no. 6 (June 2001): L1348–58. https://doi.org/10.1152/ajplung.2001.280.6.l1348.

PMID
11350816
Full Text

Ng, Y. S., R. Rohan, M. E. Sunday, D. E. Demello, and P. A. D’Amore. “Differential expression of VEGF isoforms in mouse during development and in the adult.” Developmental Dynamics 220, no. 2 (February 10, 2001): 112–21. https://doi.org/10.1002/1097-0177(2000)9999:9999<::AID-DVDY1093>3.0.CO;2-D.

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