Matthew Hirschey, PhD

Associate Professor of Medicine
Associate Professor in Pharmacology and Cancer Biology
Member of Sarah W. Stedman Nutrition and Metabolism Center
Member of the Duke Cancer Institute
Campus mail 104775, Room 50-201, Durham, NC 27701
Phone (919) 479-2315
Email address matthew.hirschey@duke.edu

The Hirschey Lab in the Duke Molecular Physiology Institute, and the Departments of Medicine and Pharmacology & Cancer Biology at Duke University studies different aspects of metabolic control, mitochondrial signaling, and cellular processes regulating human health and disease.

Education and Training

  • Ph.D., University of California Santa Barbara, 2006

Publications

Mills, Christine A., Xianxi Wang, Dhaval P. Bhatt, Paul A. Grimsrud, Jacob Peter Matson, Debojyoti Lahiri, Daniel J. Burke, Jeanette Gowen Cook, Matthew D. Hirschey, and Michael J. Emanuele. “Sirtuin 5 Is Regulated by the SCFCyclin F Ubiquitin Ligase and Is Involved in Cell Cycle Control.” Mol Cell Biol 41, no. 2 (January 25, 2021). https://doi.org/10.1128/MCB.00269-20.

PMID
33168699
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Gonzalez-Hunt, Claudia P., Anthony L. Luz, Ian T. Ryde, Elena A. Turner, Olga R. Ilkayeva, Dhaval P. Bhatt, Matthew D. Hirschey, and Joel N. Meyer. “Multiple metabolic changes mediate the response of Caenorhabditis elegans to the complex I inhibitor rotenone.” Toxicology 447 (January 15, 2021): 152630. https://doi.org/10.1016/j.tox.2020.152630.

PMID
33188857
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Madonna, Megan C., Joy E. Duer, Joyce V. Lee, Jeremy Williams, Baris Avsaroglu, Caigang Zhu, Riley Deutsch, et al. “In Vivo Optical Metabolic Imaging of Long-Chain Fatty Acid Uptake in Orthotopic Models of Triple-Negative Breast Cancer.” Cancers (Basel) 13, no. 1 (January 5, 2021). https://doi.org/10.3390/cancers13010148.

PMID
33466329
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Enriquez-Hesles, Elisa, Daniel L. Smith, Nazif Maqani, Margaret B. Wierman, Matthew D. Sutcliffe, Ryan D. Fine, Agata Kalita, et al. “A cell-nonautonomous mechanism of yeast chronological aging regulated by caloric restriction and one-carbon metabolism.” J Biol Chem 296 (December 2, 2020): 100125. https://doi.org/10.1074/jbc.RA120.015402.

PMID
33460918
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Enriquez-Hesles, Elisa, Daniel L. Smith, Nazif Maqani, Margaret B. Wierman, Matthew D. Sutcliffe, Ryan D. Fine, Agata Kalita, et al. “A cell non-autonomous mechanism of yeast chronological aging regulated by caloric restriction and one-carbon metabolism.” J Biol Chem, November 26, 2020. https://doi.org/10.1074/jbc.RA120.015402.

PMID
33243834
Full Text

Madonna, Megan, Joy Duer, Joyce Lee, Jeremy Williams, Baris Avsaroglu, Caigang Zhu, Riley Deutsch, et al. “In vivo optical metabolic imaging of long-chain fatty acid uptake in orthotopic models of triple negative breast cancer,” November 2, 2020. https://doi.org/10.1101/2020.11.02.365288.

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Huynh, Frank K., Brett S. Peterson, Kristin A. Anderson, Zhihong Lin, Aeowynn J. Coakley, Fiara M. S. Llaguno, Thi-Tina N. Nguyen, et al. “β-Cell-specific ablation of sirtuin 4 does not affect nutrient-stimulated insulin secretion in mice.” Am J Physiol Endocrinol Metab 319, no. 4 (October 1, 2020): E805–13. https://doi.org/10.1152/ajpendo.00170.2020.

PMID
32865009
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Fox, Douglas B., Nina Marie G. Garcia, Brock J. McKinney, Ryan Lupo, Laura C. Noteware, Rachel Newcomb, Juan Liu, Jason W. Locasale, Matthew D. Hirschey, and James V. Alvarez. “NRF2 activation promotes the recurrence of dormant tumour cells through regulation of redox and nucleotide metabolism.” Nat Metab 2, no. 4 (April 2020): 318–34. https://doi.org/10.1038/s42255-020-0191-z.

PMID
32691018
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Naiman, Shoshana, Frank K. Huynh, Reuven Gil, Yair Glick, Yael Shahar, Noga Touitou, Liat Nahum, et al. “SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα.” Cell Rep 29, no. 12 (December 17, 2019): 4127-4143.e8. https://doi.org/10.1016/j.celrep.2019.11.067.

PMID
31851938
Full Text

Pages