Matthew A. Sparks, MD

Associate Professor of Medicine
Campus mail 2 Genome Court, Msrb2 Room 1013, Box 103015, Durham, NC 27710
Phone (919) 684-9737
Email address matthew.sparks@duke.edu

I serve as the Program Director for the Nephrology Fellowship Program. My goal is to work with each fellow to ensure they develop a successful career in whatever direction they choose. I am the lead for the newly established Society for Early Education Scholars (SEEDS) in the Department of Medicine. The SEEDS Program is a year-long mentored education program designed for fellows planning careers as clinician educators or education scholars.

Nephrology Fellowship Program

My laboratory is interested in understanding how both the renin-angiotensin and prostanoid systems regulate blood pressure by altering blood flow to the kidney. We use a combination of physiologic and molecular techniques in genetically modified mice to probe questions about how changes in the micro circulation in the kidney alter sodium excretion. The overarching goal of this research is to identify novel mechanisms to target drug therapy for patients with hypertension. My research has been funded by the Department of Veterans Affairs Office of Research and Development and the American Heart Association. We also explore the link between pulmonary hypertension and CKD.

Sparks Laboratory Website

I'm also interested finding ways to promote medical education. My focus is on leveraging social media to enhance learning in nephrology. I serve as program director for the Nephrology Social Media Collective (NSMC) internship and member of the board of directors of nephrology journal club (NephJC), a non-profit organization dedicated to enhancing free online medical education in nephrology. I am also co-founder and advisory board member of the first nephrology blog associated with a journal- AJKD blog, the official blog of the American Journal of Kidney Diseases. Co-creator of the popular educational project NephMadness. Past deputy editor of Renal Fellow Network where I continue to remain as faculty lead. I am currently a member of the Nephrology Board of the American Board of Internal Medicine, the Scientific and Clinical Education Lifelong learning Committee Chair, Kidney in Cardiovascular Disease Council of the American Heart Association and am a fellow of the American Society of Nephrology, the American Heart Association, and the National Kidney Foundation. 

I serve as Education Director for KIDNEYcon- a yearly hands-on conference dedicated to advances in nephrology held in Little Rock, AR each April.

Listen to my podcast "The Nephron Segment"

@Nephro_Sparks on Twitter

Education and Training

  • Fellow in Nephrology, Medicine, Duke University School of Medicine, 2007 - 2011
  • Chief Resident, Medicine, University of Arkansas for Medical Sciences, College of Medicine, 2006 - 2007
  • Resident, Medicine, University of Arkansas for Medical Sciences, College of Medicine, 2003 - 2006
  • M.D., University of Arkansas for Medical Sciences, College of Medicine, 2003

Publications

Dimke, Henrik, Matthew A. Sparks, Benjamin R. Thomson, Sebastian Frische, Thomas M. Coffman, and Susan E. Quaggin. “Tubulovascular cross-talk by vascular endothelial growth factor a maintains peritubular microvasculature in kidney.” J Am Soc Nephrol 26, no. 5 (May 2015): 1027–38. https://doi.org/10.1681/ASN.2014010060.

PMID
25385849
Full Text

Sparks, Matthew A., Edgar V. Lerma, Warren Kupin, Paul J. Phelan, Kenar D. Jhaveri, and Joel Topf. “NephMadness 2015: nephrology as a cornerstone of medicine.” Am J Kidney Dis 65, no. 3 (March 2015): 375–77. https://doi.org/10.1053/j.ajkd.2014.12.002.

PMID
25704043
Full Text

Zhang, Jiandong, Mehul B. Patel, Robert Griffiths, Alice Mao, Young-soo Song, Norah S. Karlovich, Matthew A. Sparks, et al. “Tumor necrosis factor-α produced in the kidney contributes to angiotensin II-dependent hypertension.” Hypertension 64, no. 6 (December 2014): 1275–81. https://doi.org/10.1161/HYPERTENSIONAHA.114.03863.

PMID
25185128
Full Text

Malone, Andrew F., Paul J. Phelan, Gentzon Hall, Umran Cetincelik, Alison Homstad, Andrea S. Alonso, Ruiji Jiang, et al. “Rare hereditary COL4A3/COL4A4 variants may be mistaken for familial focal segmental glomerulosclerosis.” Kidney Int 86, no. 6 (December 2014): 1253–59. https://doi.org/10.1038/ki.2014.305.

PMID
25229338
Full Text

Gbadegesin, Rasheed A., Gentzon Hall, Adebowale Adeyemo, Nils Hanke, Irini Tossidou, James Burchette, Guanghong Wu, et al. “Mutations in the gene that encodes the F-actin binding protein anillin cause FSGS.” J Am Soc Nephrol 25, no. 9 (September 2014): 1991–2002. https://doi.org/10.1681/ASN.2013090976.

PMID
24676636
Full Text

Sparks, Matthew A., Steven D. Crowley, Susan B. Gurley, Maria Mirotsou, and Thomas M. Coffman. “Classical Renin-Angiotensin system in kidney physiology.” Compr Physiol 4, no. 3 (July 2014): 1201–28. https://doi.org/10.1002/cphy.c130040.

PMID
24944035
Full Text

Zhang, Jian-dong, Mehul B. Patel, Robert Griffiths, Paul C. Dolber, Phillip Ruiz, Matthew A. Sparks, Johannes Stegbauer, et al. “Type 1 angiotensin receptors on macrophages ameliorate IL-1 receptor-mediated kidney fibrosis.” J Clin Invest 124, no. 5 (May 2014): 2198–2203. https://doi.org/10.1172/JCI61368.

PMID
24743144
Full Text

Wang, Liming, Yuping Tang, William Eisner, Matthew A. Sparks, Anne F. Buckley, and Robert F. Spurney. “Augmenting podocyte injury promotes advanced diabetic kidney disease in Akita mice.” Biochem Biophys Res Commun 444, no. 4 (February 21, 2014): 622–27. https://doi.org/10.1016/j.bbrc.2014.01.115.

PMID
24491571
Full Text

Malone, A. F., P. J. Phelan, G. Hall, U. Cetincelik, A. Homstad, A. S. Alonso, R. Jiang, et al. “Rare hereditary COL4A3/COL4A4 variants may be mistaken for familial focal segmental glomerulosclerosis.” Kidney International 86, no. 6 (January 1, 2014): 1253–59. https://doi.org/10.1038/ki.2014.305.

Full Text

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