Matthias Gromeier, MD

Professor of Neurosurgery
Professor in Molecular Genetics and Microbiology
Professor in Medicine
Member of the Duke Cancer Institute
Campus mail Box 3020 Med Ctr, Durham, NC 27710
Phone (919) 668-6205
Email address grome001@mc.duke.edu

Neuro-Oncology
Protein Synthesis Regulation
Signal Transduction
Growth & Proliferation Control in Cancer
Oncolytic Viruses
Viral Neuropathogenesis
Immunization Vectors

Education and Training

  • Postdoctoral Associate, Molecular Genetics & Microbiology, State University of New York at Stony Brook, 1996 - 1999
  • Postdoctoral fellow, Molecular Genetics & Microbiology, State University of New York at Stony Brook, 1993 - 1996
  • M.D., University of Hamburg (Germany), 1992

Publications

Yu, Xin, Mikhail Dobrikov, Stephen T. Keir, Matthias Gromeier, Ira H. Pastan, Ralph Reisfeld, Darell D. Bigner, and Vidyalakshmi Chandramohan. “Synergistic antitumor effects of 9.2.27-PE38KDEL and ABT-737 in primary and metastatic brain tumors..” Plos One 14, no. 1 (January 9, 2019). https://doi.org/10.1371/journal.pone.0210608.

PMID
30625226
Full Text

Dobrikov, Mikhail I., Elena Y. Dobrikova, and Matthias Gromeier. “Ribosomal RACK1:Protein Kinase C βII Modulates Intramolecular Interactions between Unstructured Regions of Eukaryotic Initiation Factor 4G (eIF4G) That Control eIF4E and eIF3 Binding..” Molecular and Cellular Biology 38, no. 19 (October 2018). https://doi.org/10.1128/MCB.00306-18.

PMID
30012864
Full Text

Dobrikov, Mikhail I., Elena Y. Dobrikova, and Matthias Gromeier. “Ribosomal RACK1:Protein Kinase C βII Phosphorylates Eukaryotic Initiation Factor 4G1 at S1093 To Modulate Cap-Dependent and -Independent Translation Initiation..” Molecular and Cellular Biology 38, no. 19 (October 2018). https://doi.org/10.1128/MCB.00304-18.

PMID
30012863
Full Text

Walton, Ross W., Michael C. Brown, Matthew T. Sacco, and Matthias Gromeier. “Engineered Oncolytic Poliovirus PVSRIPO Subverts MDA5-Dependent Innate Immune Responses in Cancer Cells..” Journal of Virology 92, no. 19 (October 2018). https://doi.org/10.1128/JVI.00879-18.

PMID
29997212
Full Text

Thompson, Eric M., Michael Brown, Elena Dobrikova, Vijay Ramaswamy, Michael D. Taylor, Roger McLendon, Jennifer Sanks, Vidya Chandramohan, Darell Bigner, and Matthias Gromeier. “Poliovirus Receptor (CD155) Expression in Pediatric Brain Tumors Mediates Oncolysis of Medulloblastoma and Pleomorphic Xanthoastrocytoma..” Journal of Neuropathology and Experimental Neurology 77, no. 8 (August 2018): 696–702. https://doi.org/10.1093/jnen/nly045.

PMID
29878245
Full Text

Desjardins, Annick, Matthias Gromeier, James E. Herndon, Nike Beaubier, Dani P. Bolognesi, Allan H. Friedman, Henry S. Friedman, et al. “Recurrent Glioblastoma Treated with Recombinant Poliovirus..” The New England Journal of Medicine 379, no. 2 (July 2018): 150–61. https://doi.org/10.1056/NEJMoa1716435.

PMID
29943666
Full Text

Bryant, Jeffrey D., Michael C. Brown, Mikhail I. Dobrikov, Elena Y. Dobrikova, Sarah L. Gemberling, Qing Zhang, and Matthias Gromeier. “Regulation of Hypoxia-Inducible Factor 1α during Hypoxia by DAP5-Induced Translation of PHD2..” Molecular and Cellular Biology 38, no. 11 (June 2018). https://doi.org/10.1128/MCB.00647-17.

PMID
29530922
Full Text

Evans, Myron K., Michael C. Brown, Joseph Geradts, Xuhui Bao, Timothy J. Robinson, Mohit Kumar Jolly, Peter B. Vermeulen, et al. “XIAP Regulation by MNK Links MAPK and NFκB Signaling to Determine an Aggressive Breast Cancer Phenotype..” Cancer Research 78, no. 7 (April 2018): 1726–38. https://doi.org/10.1158/0008-5472.can-17-1667.

PMID
29351901
Full Text

Chandramohan, Vidyalakshmi, Jeffrey D. Bryant, Hailan Piao, Stephen T. Keir, Eric S. Lipp, Michaela Lefaivre, Kathryn Perkinson, Darell D. Bigner, Matthias Gromeier, and Roger E. McLendon. “Validation of an Immunohistochemistry Assay for Detection of CD155, the Poliovirus Receptor, in Malignant Gliomas..” Archives of Pathology & Laboratory Medicine 141, no. 12 (December 2017): 1697–1704. https://doi.org/10.5858/arpa.2016-0580-OA.

PMID
28829151
Full Text

Pages