Matthias Gromeier, MD

Professor of Neurosurgery
Professor in Molecular Genetics and Microbiology
Professor in Medicine
Member of the Duke Cancer Institute
Campus mail Box 3020 Med Ctr, Durham, NC 27710
Phone (919) 668-6205
Email address grome001@mc.duke.edu

Neuro-Oncology
Protein Synthesis Regulation
Signal Transduction
Growth & Proliferation Control in Cancer
Oncolytic Viruses
Viral Neuropathogenesis
Immunization Vectors

Education and Training

  • Postdoctoral Associate, Molecular Genetics & Microbiology, State University of New York at Stony Brook, 1996 - 1999
  • Postdoctoral fellow, Molecular Genetics & Microbiology, State University of New York at Stony Brook, 1993 - 1996
  • M.D., University of Hamburg (Germany), 1992

Publications

Walton, RW, Brown, MC, Sacco, MT, and Gromeier, M. "Engineered Oncolytic Poliovirus PVSRIPO Subverts MDA5-Dependent Innate Immune Responses in Cancer Cells.(Accepted)" Journal of Virology 92, no. 19 (October 2018).

PMID
29997212
Full Text

Dobrikov, MI, Dobrikova, EY, and Gromeier, M. "Ribosomal RACK1:Protein Kinase C βII Modulates Intramolecular Interactions between Unstructured Regions of Eukaryotic Initiation Factor 4G (eIF4G) That Control eIF4E and eIF3 Binding.(Accepted)" Molecular and Cellular Biology 38, no. 19 (October 2018).

PMID
30012864
Full Text

Dobrikov, MI, Dobrikova, EY, and Gromeier, M. "Ribosomal RACK1:Protein Kinase C βII Phosphorylates Eukaryotic Initiation Factor 4G1 at S1093 To Modulate Cap-Dependent and -Independent Translation Initiation.(Accepted)" Molecular and Cellular Biology 38, no. 19 (October 2018).

PMID
30012863
Full Text

Desjardins, A, Gromeier, M, Herndon, JE, Beaubier, N, Bolognesi, DP, Friedman, AH, Friedman, HS, McSherry, F, Muscat, AM, Nair, S, Peters, KB, Randazzo, D, Sampson, JH, Vlahovic, G, Harrison, WT, McLendon, RE, Ashley, D, and Bigner, DD. "Recurrent Glioblastoma Treated with Recombinant Poliovirus." The New England Journal of Medicine 379, no. 2 (July 2018): 150-161.

PMID
29943666
Full Text

Bryant, JD, Brown, MC, Dobrikov, MI, Dobrikova, EY, Gemberling, SL, Zhang, Q, and Gromeier, M. "Regulation of Hypoxia-Inducible Factor 1α during Hypoxia by DAP5-Induced Translation of PHD2." Molecular and Cellular Biology 38, no. 11 (June 2018).

PMID
29530922
Full Text

Evans, MK, Brown, MC, Geradts, J, Bao, X, Robinson, TJ, Jolly, MK, Vermeulen, PB, Palmer, GM, Gromeier, M, Levine, H, Morse, MA, Van Laere, SJ, and Devi, GR. "XIAP Regulation by MNK Links MAPK and NFκB Signaling to Determine an Aggressive Breast Cancer Phenotype." Cancer Research 78, no. 7 (April 2018): 1726-1738.

PMID
29351901
Full Text

Gromeier, M, and Nair, SK. "Recombinant Poliovirus for Cancer Immunotherapy." Annual review of medicine 69 (January 2018): 289-299.

PMID
29414253
Full Text

Chandramohan, V, Bryant, JD, Piao, H, Keir, ST, Lipp, ES, Lefaivre, M, Perkinson, K, Bigner, DD, Gromeier, M, and McLendon, RE. "Validation of an Immunohistochemistry Assay for Detection of CD155, the Poliovirus Receptor, in Malignant Gliomas." Archives of pathology & laboratory medicine 141, no. 12 (December 2017): 1697-1704.

PMID
28829151
Full Text

Brown, MC, Holl, EK, Boczkowski, D, Dobrikova, E, Mosaheb, M, Chandramohan, V, Bigner, DD, Gromeier, M, and Nair, SK. "Cancer immunotherapy with recombinant poliovirus induces IFN-dominant activation of dendritic cells and tumor antigen-specific CTLs." Science Translational Medicine 9, no. 408 (September 2017).

PMID
28931654
Full Text

Brown, MC, and Gromeier, M. "MNK Controls mTORC1:Substrate Association through Regulation of TELO2 Binding with mTORC1." Cell Reports 18, no. 6 (February 2017): 1444-1457.

PMID
28178522
Full Text

Pages