Matthias Gromeier, MD

Professor of Neurosurgery
Professor in Molecular Genetics and Microbiology
Professor in Medicine
Member of the Duke Cancer Institute
Campus mail Box 3020 Med Ctr, Durham, NC 27710
Phone (919) 668-6205
Email address grome001@mc.duke.edu

Neuro-Oncology
Protein Synthesis Regulation
Signal Transduction
Growth & Proliferation Control in Cancer
Oncolytic Viruses
Viral Neuropathogenesis
Immunization Vectors

Education and Training

  • Postdoctoral Associate, Molecular Genetics & Microbiology, State University of New York at Stony Brook, 1996 - 1999
  • Postdoctoral fellow, Molecular Genetics & Microbiology, State University of New York at Stony Brook, 1993 - 1996
  • M.D., University of Hamburg (Germany), 1992

Publications

Bryant, JD, Brown, MC, Dobrikov, MI, Dobrikova, EY, Gemberling, SL, Zhang, Q, and Gromeier, M. "Regulation of HIF-1α during Hypoxia by DAP5-Induced Translation of PHD2." Molecular and cellular biology (March 12, 2018).

PMID
29530922
Full Text

Gromeier, M, and Nair, SK. "Recombinant Poliovirus for Cancer Immunotherapy." Annual review of medicine 69 (January 2018): 289-299.

PMID
29414253
Full Text

Chandramohan, V, Bryant, JD, Piao, H, Keir, ST, Lipp, ES, Lefaivre, M, Perkinson, K, Bigner, DD, Gromeier, M, and McLendon, RE. "Validation of an Immunohistochemistry Assay for Detection of CD155, the Poliovirus Receptor, in Malignant Gliomas." Archives of pathology & laboratory medicine 141, no. 12 (December 2017): 1697-1704.

PMID
28829151
Full Text

Brown, MC, Holl, EK, Boczkowski, D, Dobrikova, E, Mosaheb, M, Chandramohan, V, Bigner, DD, Gromeier, M, and Nair, SK. "Cancer immunotherapy with recombinant poliovirus induces IFN-dominant activation of dendritic cells and tumor antigen-specific CTLs." Science translational medicine 9, no. 408 (September 2017).

PMID
28931654
Full Text

Brown, MC, and Gromeier, M. "MNK Controls mTORC1:Substrate Association through Regulation of TELO2 Binding with mTORC1." Cell reports 18, no. 6 (February 2017): 1444-1457.

PMID
28178522
Full Text

Holl, EK, Brown, MC, Boczkowski, D, McNamara, MA, George, DJ, Bigner, DD, Gromeier, M, and Nair, SK. "Recombinant oncolytic poliovirus, PVSRIPO, has potent cytotoxic and innate inflammatory effects, mediating therapy in human breast and prostate cancer xenograft models." Oncotarget 7, no. 48 (November 2016): 79828-79841.

PMID
27806313
Full Text

Brown, MC, and Gromeier, M. "Cytotoxic and immunogenic mechanisms of recombinant oncolytic poliovirus." Current opinion in virology 13 (August 2015): 81-85. (Review)

PMID
26083317
Full Text

Brown, MC, and Gromeier, M. "Oncolytic immunotherapy through tumor-specific translation and cytotoxicity of poliovirus." Discovery medicine 19, no. 106 (May 2015): 359-365. (Review)

PMID
26105699
Scholars@Duke

Brown, MC, Dobrikova, EY, Dobrikov, MI, Walton, RW, Gemberling, SL, Nair, SK, Desjardins, A, Sampson, JH, Friedman, HS, Friedman, AH, Tyler, DS, Bigner, DD, and Gromeier, M. "Oncolytic polio virotherapy of cancer." Cancer 120, no. 21 (November 2014): 3277-3286. (Review)

PMID
24939611
Full Text

Brown, MC, Bryant, JD, Dobrikova, EY, Shveygert, M, Bradrick, SS, Chandramohan, V, Bigner, DD, and Gromeier, M. "Induction of viral, 7-methyl-guanosine cap-independent translation and oncolysis by mitogen-activated protein kinase-interacting kinase-mediated effects on the serine/arginine-rich protein kinase." Journal of virology 88, no. 22 (November 2014): 13135-13148.

PMID
25187541
Full Text

Pages