Matthias Gromeier, MD

Professor of Neurosurgery
Professor in Molecular Genetics and Microbiology
Professor in Medicine
Member of the Duke Cancer Institute
Campus mail Box 3020 Med Ctr, Durham, NC 27710
Phone (919) 668-6205
Email address grome001@mc.duke.edu

I am a classically trained virologist with a focus on molecular mechanisms of RNA virus pathogenesis. My career is dedicated to unraveling RNA virus:host relations and devising methods of exploiting them for cancer immunotherapy and vaccine design. My background is in translation regulation and mRNA metabolism, viral RNA sensing and innate immunity, and cancer immunology and immunotherapy. Basic mechanistic research in my laboratory is supporting an ambitious clinical translational research program with active multi-center clinical trials in several cancer indications. 

Education and Training

  • Postdoctoral Associate, Molecular Genetics & Microbiology, State University of New York, Stony Brook, 1996 - 1999
  • Postdoctoral fellow, Molecular Genetics & Microbiology, State University of New York, Stony Brook, 1993 - 1996
  • M.D., University of Hamburg (Germany), 1992

Publications

Low, Justin T., Vidyalakshmi Chandramohan, Michelle L. Bowie, Michael C. Brown, Matthew S. Waitkus, Aaron Briley, Kevin Stevenson, et al. “Epigenetic STING silencing is developmentally conserved in gliomas and can be rescued by methyltransferase inhibition.” Cancer Cell 40, no. 5 (May 9, 2022): 439–40. https://doi.org/10.1016/j.ccell.2022.04.009.

PMID
35487217
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Yang, Yuanfan, Michael Brown, Kevin Stevenson, Giselle Lopez, Reb Kornahrens, Gao Zhang, and Matthias Gromeier. “POLIO VIROTHERAPY OF MURINE BRAIN TUMORS INDUCES MICROGLIA PROLIFERATION AND INFLAMMATION THAT IS POTENTIATED BY IMMUNE CHECKPOINT BLOCKADE.” In Neuro Oncology, 23:181–181, 2021.

Scholars@Duke

Brown, Michael, Zachary McKay, Yuanfan Yang, Darell Bigner, Smita Nair, and Matthias Gromeier. “739 Intratumor childhood vaccine-specific CD4+ T cell recall helps antitumor CD8 T cells.” In Journal for Immunotherapy of Cancer, 9:A770–A770. BMJ, 2021. https://doi.org/10.1136/jitc-2021-sitc2021.739.

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Low, Justin, Vidyalakshmi Chandramohan, Michelle Bowie, Michael Brown, Matthew Waitkus, Aaron Briley, Kevin Stevenson, et al. “STING IS SILENCED IN GBM BY PROMOTER METHYLATION THAT IS ESTABLISHED BY TISSUE OF ORIGIN.” In Neuro Oncology, 23:4–4, 2021.

Scholars@Duke

Desjardins, Annick, Matthias Gromeier, Henry Friedman, Daniel Landi, Allan Friedman, David M. Ashley, William Curry, et al. “SAFETY AND EFFICACY OF PVSRIPO IN RECURRENT GLIOBLASTOMA: LONG-TERM FOLLOW-UP AND INITIAL MULTICENTER RESULTS.” In Neuro Oncology, 23:97–97, 2021.

Scholars@Duke

Brown, Michael, Gao Zhang, Kevin Stevenson, Xiang Lin, Yeqing Chen, Zhi Wei, Nike Beaubier, et al. “TUMOR-INTRINSIC AND PERIPHERAL FEATURES ASSOCIATE WITH SURVIVAL AFTER POLIO VIROTHERAPY IN RECURRENT GBM.” In Neuro Oncology, 23:14–14, 2021.

Scholars@Duke

Kelly, Andrea True, Prakash Ambady, Michael Brown, Nicholas Butowski, Robert Cavaliere, William Curry, Annick Desjardins, et al. “LUMINOS-101: Phase 2 study of PVSRIPO with pembrolizumab in recurrent glioblastoma.” In Cancer Research, Vol. 81, 2021.

Scholars@Duke

Sloan, Andrew E., Robin Arthur Buerki, Christopher Murphy, Andrea True Kelly, Prakash Ambady, Michael Brown, Nicholas A. Butowski, et al. “LUMINOS-101: Phase 2 study of PVSRIPO with pembrolizumab in recurrent glioblastoma.” In Journal of Clinical Oncology, 39:TPS2065–TPS2065. American Society of Clinical Oncology (ASCO), 2021. https://doi.org/10.1200/jco.2021.39.15_suppl.tps2065.

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Neighbours, Lauren, Zachary P. McKay, Matthias Gromeier, Garrett Nichols, Andrea True Kelly, Daniel Corum, and Michael Brown. “Safety and efficacy of murine PVSRIPO plus anti-PD-1 immune checkpoint inhibitor (ICI) in a melanoma tumor model.” In Journal of Clinical Oncology, 39:2560–2560. American Society of Clinical Oncology (ASCO), 2021. https://doi.org/10.1200/jco.2021.39.15_suppl.2560.

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Kastan, Jonathan P., Martine W. Tremblay, Michael C. Brown, Joseph D. Trimarco, Elena Y. Dobrikova, Mikhail I. Dobrikov, and Matthias Gromeier. “Enterovirus 2Apro Cleavage of the YTHDF m6A Readers Implicates YTHDF3 as a Mediator of Type I Interferon-Driven JAK/STAT Signaling.” Mbio 12, no. 2 (April 13, 2021). https://doi.org/10.1128/mBio.00116-21.

PMID
33849973
Full Text

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