Matthias Gromeier, MD

Professor of Neurosurgery
Professor in Molecular Genetics and Microbiology
Professor in Medicine
Member of the Duke Cancer Institute
Campus mail Box 3020 Med Ctr, Durham, NC 27710
Phone (919) 668-6205
Email address grome001@mc.duke.edu

I am a classically trained virologist with a focus on molecular mechanisms of RNA virus pathogenesis. My career is dedicated to unraveling RNA virus:host relations and devising methods of exploiting them for cancer immunotherapy and vaccine design. My background is in translation regulation and mRNA metabolism, viral RNA sensing and innate immunity, and cancer immunology and immunotherapy. Basic mechanistic research in my laboratory is supporting an ambitious clinical translational research program with active multi-center clinical trials in several cancer indications. 

Education and Training

  • Postdoctoral Associate, Molecular Genetics & Microbiology, State University of New York, Stony Brook, 1996 - 1999
  • Postdoctoral fellow, Molecular Genetics & Microbiology, State University of New York, Stony Brook, 1993 - 1996
  • M.D., University of Hamburg (Germany), 1992

Publications

McKay, Zachary P., Michael C. Brown, and Matthias Gromeier. “Aryl Hydrocarbon Receptor Signaling Controls CD155 Expression on Macrophages and Mediates Tumor Immunosuppression.” J Immunol, January 27, 2021. https://doi.org/10.4049/jimmunol.2000792.

PMID
33504618
Full Text

Gromeier, Matthias, Michael C. Brown, Gao Zhang, Xiang Lin, Yeqing Chen, Zhi Wei, Nike Beaubier, et al. “Very low mutation burden is a feature of inflamed recurrent glioblastomas responsive to cancer immunotherapy.” Nat Commun 12, no. 1 (January 13, 2021): 352. https://doi.org/10.1038/s41467-020-20469-6.

PMID
33441554
Full Text

Mosaheb, Mubeen, Daniel Landi, Elena Dobrikova, Michael Brown, Yuanfan Yang, Jana Cable, Hideho Okada, et al. “GENETICALLY STABLE POLIOVIRUS VECTOR CARRYING H3.3K27M ANTIGEN FOR TREATMENT OF DIFFUSE MIDLINE GLIOMA BY INTRAMUSCULAR INJECTION.” In Neuro Oncology, 22:472–472, 2020.

Scholars@Duke

Hariharan, Seethalakshmi, Michelle Bowie, Janell Hostettler, Kristen Roso, Yiping He, Martin A. Roskoski, Casey Charbonneau, et al. “INTERPLAY BETWEEN IDH1 AND ATRX MUTATIONS GOVERN INNATE IMMUNE RESPONSES IN GLIOMAS.” In Neuro Oncology, 22:108–108, 2020.

Scholars@Duke

Yang, Yuanfan, Michael Brown, Matthias Gromeier, and Darell Bigner. “ONCOLYTIC POLIOVIRUS AS A PROBE FOR MECHANISMS OF IMMUNE RESISTANCE IN GLIOBLASTOMA.” In Neuro Oncology, 22:231–231, 2020.

Scholars@Duke

Mosaheb, Mubeen M., Michael C. Brown, Elena Y. Dobrikova, Mikhail I. Dobrikov, and Matthias Gromeier. “Harnessing virus tropism for dendritic cells for vaccine design.” Curr Opin Virol 44 (October 2020): 73–80. https://doi.org/10.1016/j.coviro.2020.07.012.

PMID
32771959
Full Text

Kastan, Jonathan P., Elena Y. Dobrikova, Jeffrey D. Bryant, and Matthias Gromeier. “CReP mediates selective translation initiation at the endoplasmic reticulum.” Sci Adv 6, no. 23 (June 2020): eaba0745. https://doi.org/10.1126/sciadv.aba0745.

PMID
32537501
Full Text

Frazier, Victoria N., Eda Holl, Michael Brown, David Boczkowski, Karenia Landa, Shelley Hwang, Matthias Gromeier, and Smita K. Nair. “Oncolytic poliovirus immunotherapy for breast cancer.” In Journal of Immunology, Vol. 204, 2020.

Scholars@Duke

Thompson, Eric M., Eric Thompson, Wafa Hassen, Meredith McDonald, Daniel Picard, Michael Brown, Elena Dobrikova, and Matthias Gromeier. “Poliovirus Oncolytic Activity in Medulloblastoma is Mediated by Oxidative Stress.” In Journal of Neurosurgery, 132:115–115. AMER ASSOC NEUROLOGICAL SURGEONS, 2020.

Scholars@Duke

Farrow, N. E., G. M. Beasley, A. S. MacLeod, M. A. Sarah, A. Cognetta, M. Gromeier, M. A. Selim, D. D. Bigner, R. McLendon, and M. J. Whitley. “Expression of CD155, PD-1 and PD-L1 in Non-Melanoma Skin Cancer: Implications for Treatment of Advanced Disease.” In Annals of Surgical Oncology, 27:S204–S204. SPRINGER, 2020.

Scholars@Duke

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