Matthias Gromeier, MD

Professor of Neurosurgery
Professor in Molecular Genetics and Microbiology
Professor in Medicine
Member of the Duke Cancer Institute
Campus mail Box 3020 Med Ctr, Durham, NC 27710
Phone (919) 668-6205
Email address grome001@mc.duke.edu

I am a classically trained virologist with a focus on molecular mechanisms of RNA virus pathogenesis. My career is dedicated to unraveling RNA virus:host relations and devising methods of exploiting them for cancer immunotherapy and vaccine design. My background is in translation regulation and mRNA metabolism, viral RNA sensing and innate immunity, and cancer immunology and immunotherapy. Basic mechanistic research in my laboratory is supporting an ambitious clinical translational research program with active multi-center clinical trials in several cancer indications. 

Education and Training

  • Postdoctoral Associate, Molecular Genetics & Microbiology, State University of New York, Stony Brook, 1996 - 1999
  • Postdoctoral fellow, Molecular Genetics & Microbiology, State University of New York, Stony Brook, 1993 - 1996
  • M.D., University of Hamburg (Germany), 1992

Publications

Thompson, Eric M., Michael Brown, Elena Dobrikova, Vijay Ramaswamy, Michael D. Taylor, Roger McLendon, Jennifer Sanks, Vidya Chandramohan, Darell Bigner, and Matthias Gromeier. “Poliovirus Receptor (CD155) Expression in Pediatric Brain Tumors Mediates Oncolysis of Medulloblastoma and Pleomorphic Xanthoastrocytoma.” J Neuropathol Exp Neurol 77, no. 8 (August 1, 2018): 696–702. https://doi.org/10.1093/jnen/nly045.

PMID
29878245
Full Text

Desjardins, Annick, Matthias Gromeier, James E. Herndon, Nike Beaubier, Dani P. Bolognesi, Allan H. Friedman, Henry S. Friedman, et al. “Recurrent Glioblastoma Treated with Recombinant Poliovirus.” N Engl J Med 379, no. 2 (July 12, 2018): 150–61. https://doi.org/10.1056/NEJMoa1716435.

PMID
29943666
Full Text

Landa, Karenia, Eda Holl, Michael Brown, James Herndon, Lars Grimm, Jeremy Force, Darell Bigner, Shelley Hwang, Matthias Gromeier, and Smita Nair. “Abstract LB-302: Oncolytic poliovirus-mediated inflammation and immunity in breast cancer.” In Immunology. American Association for Cancer Research, 2018. https://doi.org/10.1158/1538-7445.am2018-lb-302.

Full Text

Bryant, Jeffrey D., Michael C. Brown, Mikhail I. Dobrikov, Elena Y. Dobrikova, Sarah L. Gemberling, Qing Zhang, and Matthias Gromeier. “Regulation of Hypoxia-Inducible Factor 1α during Hypoxia by DAP5-Induced Translation of PHD2.” Mol Cell Biol 38, no. 11 (June 1, 2018). https://doi.org/10.1128/MCB.00647-17.

PMID
29530922
Full Text

Ashley, David M., Eric M. Thompson, Daniel Landi, Annick Desjardins, Allan H. Friedman, Stevie Threatt, James E. Herndon, et al. “PHASE 1B STUDY POLIO VACCINE SABIN-RHINOVIRUS POLIOVIRUS (PVSRIPO) FOR RECURRENT MALIGNANT GLIOMA IN CHILDREN.” In Neuro Oncology, 20:93–93. OXFORD UNIV PRESS INC, 2018.

Scholars@Duke

Force, Jeremy, Eda Holl, Michael Brown, Paul Kelly Marcom, Lars Grimm, David Boczkowski, Victoria Frazier, et al. “Recombinant oncolytic poliovirus combined with checkpoint blockade for breast cancer therapy.” In Journal of Clinical Oncology, 36:e12641–e12641. American Society of Clinical Oncology (ASCO), 2018. https://doi.org/10.1200/jco.2018.36.15_suppl.e12641.

Full Text

Evans, Myron K., Michael C. Brown, Joseph Geradts, Xuhui Bao, Timothy J. Robinson, Mohit Kumar Jolly, Peter B. Vermeulen, et al. “XIAP Regulation by MNK Links MAPK and NFκB Signaling to Determine an Aggressive Breast Cancer Phenotype.” Cancer Res 78, no. 7 (April 1, 2018): 1726–38. https://doi.org/10.1158/0008-5472.CAN-17-1667.

PMID
29351901
Full Text

Chandramohan, Vidyalakshmi, Jeffrey D. Bryant, Hailan Piao, Stephen T. Keir, Eric S. Lipp, Michaela Lefaivre, Kathryn Perkinson, Darell D. Bigner, Matthias Gromeier, and Roger E. McLendon. “Validation of an Immunohistochemistry Assay for Detection of CD155, the Poliovirus Receptor, in Malignant Gliomas.” Arch Pathol Lab Med 141, no. 12 (December 2017): 1697–1704. https://doi.org/10.5858/arpa.2016-0580-OA.

PMID
28829151
Full Text

Bryant, Jeffrey, Michael Brown, and Matthias Gromeier. “Chemotherapy enhances oncolytic recombinant poliovirus efficacy.” In Journal for Immunotherapy of Cancer, Vol. 5. BMC, 2017.

Scholars@Duke

Pages