Matthias Gromeier, MD

Professor of Neurosurgery
Professor in Molecular Genetics and Microbiology
Professor in Medicine
Member of the Duke Cancer Institute
Campus mail Box 3020 Med Ctr, Durham, NC 27710
Phone (919) 668-6205
Email address grome001@mc.duke.edu

I am a classically trained virologist with a focus on molecular mechanisms of RNA virus pathogenesis. My career is dedicated to unraveling RNA virus:host relations and devising methods of exploiting them for cancer immunotherapy and vaccine design. My background is in translation regulation and mRNA metabolism, viral RNA sensing and innate immunity, and cancer immunology and immunotherapy. Basic mechanistic research in my laboratory is supporting an ambitious clinical translational research program with active multi-center clinical trials in several cancer indications. 

Education and Training

  • Postdoctoral Associate, Molecular Genetics & Microbiology, State University of New York, Stony Brook, 1996 - 1999
  • Postdoctoral fellow, Molecular Genetics & Microbiology, State University of New York, Stony Brook, 1993 - 1996
  • M.D., University of Hamburg (Germany), 1992

Publications

Lawson, Sarah K., Elena Y. Dobrikova, Mayya Shveygert, and Matthias Gromeier. “p38α mitogen-activated protein kinase depletion and repression of signal transduction to translation machinery by miR-124 and -128 in neurons.” Mol Cell Biol 33, no. 1 (January 2013): 127–35. https://doi.org/10.1128/MCB.00695-12.

PMID
23109423
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Barton, Kelly L., Katherine Misuraca, Francisco Cordero, Elena Dobrikova, Hooney D. Min, Matthias Gromeier, David G. Kirsch, and Oren J. Becher. “PD-0332991, a CDK4/6 inhibitor, significantly prolongs survival in a genetically engineered mouse model of brainstem glioma.” Plos One 8, no. 10 (2013): e77639. https://doi.org/10.1371/journal.pone.0077639.

PMID
24098593
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Dobrikova, Elena Y., Christian Goetz, Robert W. Walters, Sarah K. Lawson, James O. Peggins, Karen Muszynski, Sheryl Ruppel, et al. “Attenuation of neurovirulence, biodistribution, and shedding of a poliovirus:rhinovirus chimera after intrathalamic inoculation in Macaca fascicularis.” J Virol 86, no. 5 (March 2012): 2750–59. https://doi.org/10.1128/JVI.06427-11.

PMID
22171271
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Goetz, Christian, Elena Dobrikova, Mayya Shveygert, Mikhail Dobrikov, and Matthias Gromeier. “Oncolytic poliovirus against malignant glioma.” Future Virol 6, no. 9 (September 2011): 1045–58. https://doi.org/10.2217/fvl.11.76.

PMID
21984883
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Dobrikov, Mikhail, Elena Dobrikova, Mayya Shveygert, and Matthias Gromeier. “Phosphorylation of eukaryotic translation initiation factor 4G1 (eIF4G1) by protein kinase C{alpha} regulates eIF4G1 binding to Mnk1.” Mol Cell Biol 31, no. 14 (July 2011): 2947–59. https://doi.org/10.1128/MCB.05589-11.

PMID
21576361
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Wang, Eric S., Elena Dobrikova, Christian Goetz, Andrew T. Dufresne, and Matthias Gromeier. “Adaptation of an ICAM-1-tropic enterovirus to the mouse respiratory tract.” J Virol 85, no. 11 (June 2011): 5606–17. https://doi.org/10.1128/JVI.01502-10.

PMID
21450825
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Goetz, Christian, Richard G. Everson, Linda C. Zhang, and Matthias Gromeier. “MAPK signal-integrating kinase controls cap-independent translation and cell type-specific cytotoxicity of an oncolytic poliovirus.” Mol Ther 18, no. 11 (November 2010): 1937–46. https://doi.org/10.1038/mt.2010.145.

PMID
20648000
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Shveygert, Mayya, Constanze Kaiser, Shelton S. Bradrick, and Matthias Gromeier. “Regulation of eukaryotic initiation factor 4E (eIF4E) phosphorylation by mitogen-activated protein kinase occurs through modulation of Mnk1-eIF4G interaction.” Mol Cell Biol 30, no. 21 (November 2010): 5160–67. https://doi.org/10.1128/MCB.00448-10.

PMID
20823271
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Neplioueva, Valentina, Elena Y. Dobrikova, Neelanjan Mukherjee, Jack D. Keene, and Matthias Gromeier. “Tissue type-specific expression of the dsRNA-binding protein 76 and genome-wide elucidation of its target mRNAs.” Plos One 5, no. 7 (July 23, 2010): e11710. https://doi.org/10.1371/journal.pone.0011710.

PMID
20668518
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Goetz, Christian, and Matthias Gromeier. “Preparing an oncolytic poliovirus recombinant for clinical application against glioblastoma multiforme.” Cytokine Growth Factor Rev 21, no. 2–3 (April 2010): 197–203. https://doi.org/10.1016/j.cytogfr.2010.02.005.

PMID
20299272
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Pages