Matthias Gromeier, MD

Professor of Neurosurgery
Professor in Molecular Genetics and Microbiology
Professor in Medicine
Member of the Duke Cancer Institute
Campus mail Box 3020 Med Ctr, Durham, NC 27710
Phone (919) 668-6205
Email address grome001@mc.duke.edu

I am a classically trained virologist with a focus on molecular mechanisms of RNA virus pathogenesis. My career is dedicated to unraveling RNA virus:host relations and devising methods of exploiting them for cancer immunotherapy and vaccine design. My background is in translation regulation and mRNA metabolism, viral RNA sensing and innate immunity, and cancer immunology and immunotherapy. Basic mechanistic research in my laboratory is supporting an ambitious clinical translational research program with active multi-center clinical trials in several cancer indications. 

Education and Training

  • Postdoctoral Associate, Molecular Genetics & Microbiology, State University of New York, Stony Brook, 1996 - 1999
  • Postdoctoral fellow, Molecular Genetics & Microbiology, State University of New York, Stony Brook, 1993 - 1996
  • M.D., University of Hamburg (Germany), 1992

Publications

Goetz, Christian, Richard G. Everson, Linda C. Zhang, and Matthias Gromeier. “MAPK signal-integrating kinase controls cap-independent translation and cell type-specific cytotoxicity of an oncolytic poliovirus.” Mol Ther 18, no. 11 (November 2010): 1937–46. https://doi.org/10.1038/mt.2010.145.

PMID
20648000
Full Text

Shveygert, Mayya, Constanze Kaiser, Shelton S. Bradrick, and Matthias Gromeier. “Regulation of eukaryotic initiation factor 4E (eIF4E) phosphorylation by mitogen-activated protein kinase occurs through modulation of Mnk1-eIF4G interaction.” Mol Cell Biol 30, no. 21 (November 2010): 5160–67. https://doi.org/10.1128/MCB.00448-10.

PMID
20823271
Full Text

Neplioueva, Valentina, Elena Y. Dobrikova, Neelanjan Mukherjee, Jack D. Keene, and Matthias Gromeier. “Tissue type-specific expression of the dsRNA-binding protein 76 and genome-wide elucidation of its target mRNAs.” Plos One 5, no. 7 (July 23, 2010): e11710. https://doi.org/10.1371/journal.pone.0011710.

PMID
20668518
Full Text

Goetz, Christian, and Matthias Gromeier. “Preparing an oncolytic poliovirus recombinant for clinical application against glioblastoma multiforme.” Cytokine Growth Factor Rev 21, no. 2–3 (April 2010): 197–203. https://doi.org/10.1016/j.cytogfr.2010.02.005.

PMID
20299272
Full Text

Walters, Robert W., Shelton S. Bradrick, and Matthias Gromeier. “Poly(A)-binding protein modulates mRNA susceptibility to cap-dependent miRNA-mediated repression.” Rna 16, no. 1 (January 2010): 239–50. https://doi.org/10.1261/rna.1795410.

PMID
19934229
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Dobrikova, Elena, Mayya Shveygert, Robert Walters, and Matthias Gromeier. “Herpes simplex virus proteins ICP27 and UL47 associate with polyadenylate-binding protein and control its subcellular distribution.” J Virol 84, no. 1 (January 2010): 270–79. https://doi.org/10.1128/JVI.01740-09.

PMID
19864386
Full Text

Gromeier, Matthias, Valentina Neplioueva, Neel Makherjee, Melinda Merrill, and John H. Sampson. “THE RNA-BINDING PROTEIN 76 CONTROLS GENE EXPRESSION IN GBM.” Neuro Oncology 11, no. 2 (April 1, 2009): 221–221.

Scholars@Duke

Yang, Xiaoyi, Eying Chen, Hengguang Jiang, Karen Muszynski, Raymond D. Harris, Steven L. Giardina, Matthias Gromeier, Gautam Mitra, and Gopalan Soman. “Evaluation of IRES-mediated, cell-type-specific cytotoxicity of poliovirus using a colorimetric cell proliferation assay.” J Virol Methods 155, no. 1 (January 2009): 44–54. https://doi.org/10.1016/j.jviromet.2008.09.020.

PMID
18951922
Full Text

Dobrikova, Elena Y., Trevor Broadt, Judith Poiley-Nelson, Xiaoyi Yang, Gopalan Soman, Steve Giardina, Ray Harris, and Matthias Gromeier. “Recombinant oncolytic poliovirus eliminates glioma in vivo without genetic adaptation to a pathogenic phenotype.” Mol Ther 16, no. 11 (November 2008): 1865–72. https://doi.org/10.1038/mt.2008.184.

PMID
18766173
Full Text

Pages