Matthias Gromeier, MD

Professor of Neurosurgery
Professor in Molecular Genetics and Microbiology
Professor in Medicine
Member of the Duke Cancer Institute
Campus mail Box 3020 Med Ctr, Durham, NC 27710
Phone (919) 668-6205
Email address grome001@mc.duke.edu

I am a classically trained virologist with a focus on molecular mechanisms of RNA virus pathogenesis. My career is dedicated to unraveling RNA virus:host relations and devising methods of exploiting them for cancer immunotherapy and vaccine design. My background is in translation regulation and mRNA metabolism, viral RNA sensing and innate immunity, and cancer immunology and immunotherapy. Basic mechanistic research in my laboratory is supporting an ambitious clinical translational research program with active multi-center clinical trials in several cancer indications. 

Education and Training

  • Postdoctoral Associate, Molecular Genetics & Microbiology, State University of New York, Stony Brook, 1996 - 1999
  • Postdoctoral fellow, Molecular Genetics & Microbiology, State University of New York, Stony Brook, 1993 - 1996
  • M.D., University of Hamburg (Germany), 1992

Publications

Bradrick, Shelton S., Elena Y. Dobrikova, Constanze Kaiser, Mayya Shveygert, and Matthias Gromeier. “Poly(A)-binding protein is differentially required for translation mediated by viral internal ribosome entry sites.” Rna 13, no. 9 (September 2007): 1582–93. https://doi.org/10.1261/rna.556107.

PMID
17652408
Full Text

Florez de Sessions, Paola, Elena Dobrikova, and Matthias Gromeier. “Genetic adaptation to untranslated region-mediated enterovirus growth deficits by mutations in the nonstructural proteins 3AB and 3CD.” J Virol 81, no. 16 (August 2007): 8396–8405. https://doi.org/10.1128/JVI.00321-07.

PMID
17537861
Full Text

Campbell, Stephanie A., Matthew Mulvey, Ian Mohr, and Matthias Gromeier. “Attenuation of herpes simplex virus neurovirulence with picornavirus cis-acting genetic elements.” J Virol 81, no. 2 (January 2007): 791–99. https://doi.org/10.1128/JVI.00714-06.

PMID
17079296
Full Text

Merrill, Melinda K., and Matthias Gromeier. “The double-stranded RNA binding protein 76:NF45 heterodimer inhibits translation initiation at the rhinovirus type 2 internal ribosome entry site.” J Virol 80, no. 14 (July 2006): 6936–42. https://doi.org/10.1128/JVI.00243-06.

PMID
16809299
Full Text

Dobrikova, Elena Y., Rachel N. Grisham, Constanze Kaiser, Jennifer Lin, and Matthias Gromeier. “Competitive translation efficiency at the picornavirus type 1 internal ribosome entry site facilitated by viral cis and trans factors.” J Virol 80, no. 7 (April 2006): 3310–21. https://doi.org/10.1128/JVI.80.7.3310-3321.2006.

PMID
16537598
Full Text

Merrill, Melinda K., Elena Y. Dobrikova, and Matthias Gromeier. “Cell-type-specific repression of internal ribosome entry site activity by double-stranded RNA-binding protein 76.” J Virol 80, no. 7 (April 2006): 3147–56. https://doi.org/10.1128/JVI.80.7.3147-3156.2006.

PMID
16537583
Full Text

Ochiai, Hidenobu, Stephanie A. Campbell, Gary E. Archer, Tracy A. Chewning, Eugenia Dragunsky, Alexander Ivanov, Matthias Gromeier, and John H. Sampson. “Targeted therapy for glioblastoma multiforme neoplastic meningitis with intrathecal delivery of an oncolytic recombinant poliovirus.” Clin Cancer Res 12, no. 4 (February 15, 2006): 1349–54. https://doi.org/10.1158/1078-0432.CCR-05-1595.

PMID
16489093
Full Text

Dufresne, A. T., and M. Gromeier. “Understanding polio: New insights from a cold virus.” Microbe 1, no. 1 (January 1, 2006): 13–18.

Scholars@Duke

Pages