Michael Aaron Morse, MD

Professor of Medicine
Professor in the Department of Surgery
Member of the Duke Cancer Institute
Campus mail Duke Box 3233, Durham, NC 27710
Phone (919) 681-3480
Email address morse004@mc.duke.edu

We are studying the use of immune therapies to treat various cancers, including gastrointestinal, breast, and lung cancers and melanoma. These therapies include vaccines based on dendritic cells developed in our laboratory as well as vaccines based on peptides, viral vectors, and DNA plasmids. Our group is also a national leader in the development and use of laboratory assays for demonstrating immunologic responses to cancer vaccines. Finally, we are developing immunotherapies based on adoptive transfer of tumor and viral antigen-specific T cells.

Our current clinical trials include phase I and II studies of immunotherapy for: patients with metastatic malignancies expressing CEA, pancreatic cancer, colorectal cancer, breast cancer, and ovarian cancer, and leukemias following HSCT. My clinical area of expertise is in gastrointestinal oncology, in particular, the treatment of hepatic malignancies, and malignant melanoma.

Key words: dendritic cells, immunotherapy, vaccines, T cells, gastrointestinal oncology, melanoma, hepatoma

Education and Training

  • Fellow In Hematology Oncology, Medicine, Duke University, 1993 - 1996
  • Medical Resident, Medicine, University of Washington, 1990 - 1993
  • M.D., Yale University, 1990

Grants

Publications

Le, DT, Hubbard-Lucey, VM, Morse, MA, Heery, CR, Dwyer, A, Marsilje, TH, Brodsky, AN, Chan, E, Deming, DA, Diaz, LA, Fridman, WH, Goldberg, RM, Hamilton, SR, Housseau, F, Jaffee, EM, Kang, SP, Krishnamurthi, SS, Lieu, CH, Messersmith, W, Sears, CL, Segal, NH, Yang, A, Moss, RA, Cha, E, O'Donnell-Tormey, J, Roach, N, Davis, AQD, McAbee, KE, Worrall, S, and Benson, AB. "A Blueprint to Advance Colorectal Cancer Immunotherapies." Cancer immunology research (October 16, 2017).

PMID
29038296
Full Text

Osada, T, Kaneko, K, Gwin, WR, Morse, MA, Hobeika, A, Pogue, BW, Hartman, ZC, Hughes, PF, Haystead, T, and Lyerly, HK. "In Vivo Detection of HSP90 Identifies Breast Cancers with Aggressive Behavior." Clinical cancer research : an official journal of the American Association for Cancer Research (October 9, 2017).

PMID
28993342
Full Text

Jiang, N, Qiao, G, Wang, X, Morse, MA, Gwin, WR, Zhou, L, Song, Y, Zhao, Y, Chen, F, Zhou, X, Huang, L, Hobeika, A, Yi, X, Xia, X, Guan, Y, Song, J, Ren, J, and Lyerly, HK. "Dendritic Cell/Cytokine-Induced Killer Cell Immunotherapy Combined with S-1 in Patients with Advanced Pancreatic Cancer: A Prospective Study." Clinical cancer research : an official journal of the American Association for Cancer Research 23, no. 17 (September 2017): 5066-5073.

PMID
28611200
Full Text

Overman, MJ, McDermott, R, Leach, JL, Lonardi, S, Lenz, H-J, Morse, MA, Desai, J, Hill, A, Axelson, M, Moss, RA, Goldberg, MV, Cao, ZA, Ledeine, J-M, Maglinte, GA, Kopetz, S, and André, T. "Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study." The Lancet. Oncology 18, no. 9 (September 2017): 1182-1191.

PMID
28734759
Full Text

Riedel, RF, Meadows, KL, Lee, PH, Morse, MA, Uronis, HE, Blobe, GC, George, DJ, Crawford, J, Niedzwiecki, D, Rushing, CN, Arrowood, CC, and Hurwitz, HI. "Phase I study of pazopanib plus TH-302 in advanced solid tumors." Cancer chemotherapy and pharmacology 79, no. 3 (March 2017): 611-619.

PMID
28238078
Full Text

Clark, JI, Wong, MKK, Kaufman, HL, Daniels, GA, Morse, MA, McDermott, DF, Agarwala, SS, Lewis, LD, Stewart, JH, Vaishampayan, U, Curti, B, Gonzalez, R, Lutzky, J, Rudraptna, V, Cranmer, LD, Jeter, JM, Hauke, RJ, Miletello, G, Milhem, MM, Amin, A, Richart, JM, Fishman, M, Hallmeyer, S, Patel, SP, Van Veldhuizen, P, Agarwal, N, Taback, B, Treisman, JS, Ernstoff, MS, Perritt, JC, Hua, H, Rao, TB, Dutcher, JP, and Aung, S. "Impact of Sequencing Targeted Therapies With High-dose Interleukin-2 Immunotherapy: An Analysis of Outcome and Survival of Patients With Metastatic Renal Cell Carcinoma From an On-going Observational IL-2 Clinical Trial: PROCLAIMSM." Clinical genitourinary cancer 15, no. 1 (February 2017): 31-41.e4.

PMID
27916626
Full Text

Ren, J, Gwin, WR, Zhou, X, Wang, X, Huang, H, Jiang, N, Zhou, L, Agarwal, P, Hobeika, A, Crosby, E, Hartman, ZC, Morse, MA, H Eng, K, and Lyerly, HK. "Adaptive T cell responses induced by oncolytic Herpes Simplex Virus-granulocyte macrophage-colony-stimulating factor therapy expanded by dendritic cell and cytokine-induced killer cell adoptive therapy." Oncoimmunology 6, no. 4 (January 2017): e1264563-.

PMID
28507788
Full Text

Osada, T, Morse, MA, Hobeika, A, Diniz, MA, Gwin, WR, Hartman, Z, Wei, J, Guo, H, Yang, X-Y, Liu, C-X, Kaneko, K, Broadwater, G, and Lyerly, HK. "Vaccination targeting human HER3 alters the phenotype of infiltrating T cells and responses to immune checkpoint inhibition." Oncoimmunology 6, no. 6 (January 2017): e1315495-.

PMID
28680745
Full Text

Pishvaian, M, Morse, MA, McDevitt, J, Norton, JD, Ren, S, Robbie, GJ, Ryan, PC, Soukharev, S, Bao, H, and Denlinger, CS. "Phase 1 Dose Escalation Study of MEDI-565, a Bispecific T-Cell Engager that Targets Human Carcinoembryonic Antigen, in Patients With Advanced Gastrointestinal Adenocarcinomas." Clinical colorectal cancer 15, no. 4 (December 2016): 345-351.

PMID
27591895
Full Text

Alva, A, Daniels, GA, Wong, MKK, Kaufman, HL, Morse, MA, McDermott, DF, Clark, JI, Agarwala, SS, Miletello, G, Logan, TF, Hauke, RJ, Curti, B, Kirkwood, JM, Gonzalez, R, Amin, A, Fishman, M, Agarwal, N, Lowder, JN, Hua, H, Aung, S, and Dutcher, JP. "Contemporary experience with high-dose interleukin-2 therapy and impact on survival in patients with metastatic melanoma and metastatic renal cell carcinoma." Cancer immunology, immunotherapy : CII 65, no. 12 (December 2016): 1533-1544.

PMID
27714434
Full Text

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