Michael Aaron Morse, MD

Professor of Medicine
Professor in the Department of Surgery
Member of the Duke Cancer Institute
Campus mail Duke Box 3233, Durham, NC 27710
Phone (919) 681-3480
Email address morse004@mc.duke.edu

We are studying the use of immune therapies to treat various cancers, including gastrointestinal, breast, and lung cancers and melanoma. These therapies include vaccines based on dendritic cells developed in our laboratory as well as vaccines based on peptides, viral vectors, and DNA plasmids. Our group is also a national leader in the development and use of laboratory assays for demonstrating immunologic responses to cancer vaccines. Finally, we are developing immunotherapies based on adoptive transfer of tumor and viral antigen-specific T cells.

Our current clinical trials include phase I and II studies of immunotherapy for: patients with metastatic malignancies expressing CEA, pancreatic cancer, colorectal cancer, breast cancer, and ovarian cancer, and leukemias following HSCT. My clinical area of expertise is in gastrointestinal oncology, in particular, the treatment of hepatic malignancies, and malignant melanoma.

Key words: dendritic cells, immunotherapy, vaccines, T cells, gastrointestinal oncology, melanoma, hepatoma

Education and Training

  • Fellow in Hematology-Oncology, Medicine, Duke University, 1993 - 1996
  • Medical Resident, Medicine, University of Washington, 1990 - 1993
  • M.D., Yale University, 1990

Grants

Publications

Wang, Jie, Takuya Osada, Michael A. Morse, Frank Calzone, Hai Yan, Dung Thai, and H Kim Lyerly. “Targeting the glucagon receptor signaling pathway as a novel strategy to counteract PI3K inhibitor induced hyperglycemia while sustaining tumor PI3K inhibition.” Leuk Lymphoma 62, no. 7 (July 2021): 1761–64. https://doi.org/10.1080/10428194.2021.1881504.

PMID
33576297
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Devi, Gayathri R., Pascal Finetti, Michael A. Morse, Seayoung Lee, Alexandre de Nonneville, Steven Van Laere, Jesse Troy, Joseph Geradts, Shannon McCall, and Francois Bertucci. “Expression of X-Linked Inhibitor of Apoptosis Protein (XIAP) in Breast Cancer Is Associated with Shorter Survival and Resistance to Chemotherapy.” Cancers (Basel) 13, no. 11 (June 4, 2021). https://doi.org/10.3390/cancers13112807.

PMID
34199946
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Strickler, John H., Christel N. Rushing, Hope E. Uronis, Michael A. Morse, Donna Niedzwiecki, Gerard C. Blobe, Ashley N. Moyer, et al. “Cabozantinib and Panitumumab for RAS Wild-Type Metastatic Colorectal Cancer.” Oncologist 26, no. 6 (June 2021): 465-e917. https://doi.org/10.1002/onco.13678.

PMID
33469991
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Smith, V. L., R. C. Bentley, M. A. Morse, and A. A. Pendse. “Unique presentation of a gastrointestinal stromal tumor, epithelioid type, with a dual copy loss of SDHA gene as a liver primary.” Human Pathology: Case Reports 22 (November 1, 2020). https://doi.org/10.1016/j.ehpc.2020.200427.

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Crosby, Erika J., Amy C. Hobeika, Donna Niedzwiecki, Christel Rushing, David Hsu, Peter Berglund, Jonathan Smith, et al. “Long-term survival of patients with stage III colon cancer treated with VRP-CEA(6D), an alphavirus vector that increases the CD8+ effector memory T cell to Treg ratio.” J Immunother Cancer 8, no. 2 (November 2020). https://doi.org/10.1136/jitc-2020-001662.

PMID
33177177
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Eads, Jennifer R., Diane Reidy-Lagunes, Heloisa P. Soares, Jennifer A. Chan, Lowell B. Anthony, Thorvardur R. Halfdanarson, Boris G. Naraev, et al. “Differential Diagnosis of Diarrhea in Patients With Neuroendocrine Tumors.” Pancreas 49, no. 9 (October 2020): 1123–30. https://doi.org/10.1097/MPA.0000000000001658.

PMID
32991344
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Crosby, Erika J., Chaitanya R. Acharya, Anthony-Fayez Haddad, Christopher A. Rabiola, Gangjun Lei, Jun-Ping Wei, Xiao-Yi Yang, et al. “Stimulation of Oncogene-Specific Tumor-Infiltrating T Cells through Combined Vaccine and αPD-1 Enable Sustained Antitumor Responses against Established HER2 Breast Cancer.” Clin Cancer Res 26, no. 17 (September 1, 2020): 4670–81. https://doi.org/10.1158/1078-0432.CCR-20-0389.

PMID
32732224
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Strosberg, Jonathan, Pamela L. Kunz, Andrew Hendifar, James Yao, David Bushnell, Matthew H. Kulke, Richard P. Baum, et al. “Impact of liver tumour burden, alkaline phosphatase elevation, and target lesion size on treatment outcomes with 177Lu-Dotatate: an analysis of the NETTER-1 study.” Eur J Nucl Med Mol Imaging 47, no. 10 (September 2020): 2372–82. https://doi.org/10.1007/s00259-020-04709-x.

PMID
32123969
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Kim, Richard D., Nilofer S. Azad, Michael A. Morse, Elizabeth Poplin, Amit Mahipal, Benjamin Tan, Sharon A. Mavroukakis, et al. “Phase II Study of Ensituximab, a Novel Chimeric Monoclonal Antibody, in Adults with Unresectable, Metastatic Colorectal Cancer.” Clinical Cancer Research : An Official Journal of the American Association for Cancer Research 26, no. 14 (July 2020): 3557–64. https://doi.org/10.1158/1078-0432.ccr-20-0426.

PMID
32303539
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Pages