Michael Aaron Morse, MD

Professor of Medicine
Professor in the Department of Surgery
Member of the Duke Cancer Institute
Campus mail Duke Box 3233, Durham, NC 27710
Phone (919) 681-3480
Email address morse004@mc.duke.edu

We are studying the use of immune therapies to treat various cancers, including gastrointestinal, breast, and lung cancers and melanoma. These therapies include vaccines based on dendritic cells developed in our laboratory as well as vaccines based on peptides, viral vectors, and DNA plasmids. Our group is also a national leader in the development and use of laboratory assays for demonstrating immunologic responses to cancer vaccines. Finally, we are developing immunotherapies based on adoptive transfer of tumor and viral antigen-specific T cells.

Our current clinical trials include phase I and II studies of immunotherapy for: patients with metastatic malignancies expressing CEA, pancreatic cancer, colorectal cancer, breast cancer, and ovarian cancer, and leukemias following HSCT. My clinical area of expertise is in gastrointestinal oncology, in particular, the treatment of hepatic malignancies, and malignant melanoma.

Key words: dendritic cells, immunotherapy, vaccines, T cells, gastrointestinal oncology, melanoma, hepatoma

Education and Training

  • Fellow in Hematology-Oncology, Medicine, Duke University, 1993 - 1996
  • Medical Resident, Medicine, University of Washington, 1990 - 1993
  • M.D., Yale University, 1990

Publications

Marano, A. L., J. M. Clarke, M. A. Morse, A. Shah, W. Barrow, M. A. Selim, R. P. Hall, and A. R. Cardones. “Subacute cutaneous lupus erythematosus and dermatomyositis associated with anti-programmed cell death 1 therapy..” Br J Dermatol 181, no. 3 (September 2019): 580–83. https://doi.org/10.1111/bjd.17245.

PMID
30244487
Full Text

Sun, Yuanyuan, Suya Wang, Hainan Yang, Jiangping Wu, Sha Li, Guoliang Qiao, Shuo Wang, et al. “Impact of synchronized anti-PD-1 with Ad-CEA vaccination on inhibition of colon cancer growth..” Immunotherapy 11, no. 11 (August 2019): 953–66. https://doi.org/10.2217/imt-2019-0055.

PMID
31192764
Full Text

Sharma, Padmanee, Arlene Siefker-Radtke, Filippo de Braud, Umberto Basso, Emiliano Calvo, Petri Bono, Michael A. Morse, et al. “Nivolumab Alone and With Ipilimumab in Previously Treated Metastatic Urothelial Carcinoma: CheckMate 032 Nivolumab 1 mg/kg Plus Ipilimumab 3 mg/kg Expansion Cohort Results..” J Clin Oncol 37, no. 19 (July 1, 2019): 1608–16. https://doi.org/10.1200/JCO.19.00538.

PMID
31100038
Full Text

Zhao, Y., G. Qiao, X. Wang, Y. Song, X. Zhou, N. Jiang, L. Zhou, et al. “Combination of DC/CIK adoptive T cell immunotherapy with chemotherapy in advanced non-small-cell lung cancer (NSCLC) patients: a prospective patients' preference-based study (PPPS)..” Clin Transl Oncol 21, no. 6 (June 2019): 721–28. https://doi.org/10.1007/s12094-018-1968-3.

PMID
30374838
Full Text

Morse, Michael A., Michael J. Overman, Leighanne Hartman, Taline Khoukaz, Edith Brutcher, Heinz-Josef Lenz, Ajlan Atasoy, Tong Shangguan, Huanyu Zhao, and Bassel El-Rayes. “Safety of Nivolumab plus Low-Dose Ipilimumab in Previously Treated Microsatellite Instability-High/Mismatch Repair-Deficient Metastatic Colorectal Cancer..” Oncologist, May 30, 2019. https://doi.org/10.1634/theoncologist.2019-0129.

PMID
31147488
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Crosby, Erika J., William Gwin, Kimberly Blackwell, Paul K. Marcom, Serena Chang, Holden T. Maecker, Gloria Broadwater, et al. “Vaccine-Induced Memory CD8+ T Cells Provide Clinical Benefit in HER2 Expressing Breast Cancer: A Mouse to Human Translational Study..” Clin Cancer Res 25, no. 9 (May 1, 2019): 2725–36. https://doi.org/10.1158/1078-0432.CCR-18-3102.

PMID
30635338
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Wang, Xiaoli, Shuo Wang, Michael A. Morse, Ni Jiang, Yanjie Zhao, Yuguang Song, Lei Zhou, et al. “Prospective randomized comparative study on rivaroxaban and LMWH for prophylaxis of post-apheresis thrombosis in adoptive T cell immunotherapy cancer patients..” J Thromb Thrombolysis 47, no. 4 (May 2019): 505–11. https://doi.org/10.1007/s11239-019-01844-7.

PMID
30903459
Full Text

Lv, Shuzhen, Shuo Wang, Guoliang Qiao, Xiaoli Wang, Xinna Zhou, Fengcai Yan, Yanping Li, et al. “Functional CD3+CD8+PD1- T Cell Accumulation and PD-L1 Expression Increases During Tumor Invasion in DCIS of the Breast..” Clin Breast Cancer, April 16, 2019. https://doi.org/10.1016/j.clbc.2019.04.001.

PMID
31101455
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Chawla, Sant P., Howard Bruckner, Michael A. Morse, Nupur Assudani, Frederick L. Hall, and Erlinda M. Gordon. “A Phase I-II Study Using Rexin-G Tumor-Targeted Retrovector Encoding a Dominant-Negative Cyclin G1 Inhibitor for Advanced Pancreatic Cancer..” Mol Ther Oncolytics 12 (March 29, 2019): 56–67. https://doi.org/10.1016/j.omto.2018.12.005.

PMID
30705966
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