Michael Arthur Hauser, PhD

Professor in Medicine
Associate Research Professor in Molecular Genetics and Microbiology
Member of Duke Molecular Physiology Institute
Campus mail 2016 Genome Science Research Bldg I, Durham, NC 27710
Phone (919) 684-3508
Email address mike.hauser@duke.edu

Dr. Hauser has a strong interest in ocular genetics. Genomic studies at the Center for Human Genetics have identified multiple linkage peaks and susceptibility genes in primary open angle glaucoma (POAG) and age related macular degeneration (AMD). Dr. Hauser has recently accepted a 20% appointment at the Singapore Eye Research INstitute and the Duke/National University of Singapore.  In collaboration with multiple collaborators in Singapore, and Dr. Rand Allingham at the Duke Eye Center, Dr. Hauser is currently conducting a genome wide association study for glaucoma in individuals of African ancestry. These investigations include large datasets collected in Ghana, Nigeria, and South Africa.  
 
Dr. Hauser is also involved in collaborative investigations into the genetics of post-tramatic stress disorder in US veterans from Iraq and Afghanistan.   Major collaborators include Dr. Allison Ashley Koch, Dr. Jean Beckham, Dr. Christine Marx and the MIRECC Collaborative group at the Durham Veteran's Administration.  We have published a genome wide association study, as well as numerous investigations into candidate genes.  Epigenomic DNA methylation analysis and gene expression analysis of 3500 individuals is currently ongoing. 

Education and Training

  • Ph.D., Johns Hopkins University, 1990

Publications

Grassmann, Felix, Christina Kiel, Martina E. Zimmermann, Mathias Gorski, Veronika Grassmann, Klaus Stark, Klaus International AMD Genomics Consortium (IAMDGC), Iris M. Heid, and Bernhard H. F. Weber. “Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits.” Genome Med 9, no. 1 (March 27, 2017): 29. https://doi.org/10.1186/s13073-017-0418-0.

PMID
28347358
Full Text

Pasquale, Louis R., Hugues Aschard, Jae H. Kang, Jessica N Cooke Bailey, Sara Lindström, Daniel I. Chasman, William G. Christen, et al. “Age at natural menopause genetic risk score in relation to age at natural menopause and primary open-angle glaucoma in a US-based sample.” Menopause 24, no. 2 (February 2017): 150–56. https://doi.org/10.1097/GME.0000000000000741.

PMID
27760082
Full Text

Grassmann, Felix, Iris M. Heid, Bernhard H. F. Weber, and Bernhard H. F. International AMD Genomics Consortium (IAMDGC). “Recombinant Haplotypes Narrow the ARMS2/HTRA1 Association Signal for Age-Related Macular Degeneration.” Genetics 205, no. 2 (February 2017): 919–24. https://doi.org/10.1534/genetics.116.195966.

PMID
27879347
Full Text

Hauser, Michael A., Melanie E. Garrett, Yutao Liu, Michelle F. Dennis, Nathan A. Kimbrel, Nathan A. Veterans Affairs Mid-Atlantic Mental Illness Research Education And Clinical Center Workgroup, Jean C. Beckham, and Allison E. Ashley-Koch. “Further evidence for a role of the ADRB2 gene in risk for posttraumatic stress disorder.” J Psychiatr Res 84 (January 2017): 59–61. https://doi.org/10.1016/j.jpsychires.2016.09.013.

PMID
27701011
Full Text

Aboobakar, Inas F., William M. Johnson, W Daniel Stamer, Michael A. Hauser, and R Rand Allingham. “Major review: Exfoliation syndrome; advances in disease genetics, molecular biology, and epidemiology.” Exp Eye Res 154 (January 2017): 88–103. https://doi.org/10.1016/j.exer.2016.11.011.

PMID
27845061
Full Text

Bailey, Jessica Cooke, Mariusz Butkiewicz, Louis R. Pasquale, Jae H. Kang, Michael A. Hauser, Rand R. Allingham, Janey L. Wiggs, and Jonathan L. Haines. “Genome-Wide Pathway Approach to Dissecting Primary Open-Angle Glaucoma.” In Investigative Ophthalmology & Visual Science, Vol. 57. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2016.

Scholars@Duke

Aboobakar, Inas F., Xue Qin, W Daniel Starner, R Rand Allingham, and Michael A. Hauser. “A lncRNA in the LOXL1 locus modulates expression of genes relevant to exfoliation glaucoma pathobiology.” In Investigative Ophthalmology & Visual Science, Vol. 57. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2016.

Scholars@Duke

Liu, Yutao, Jessica Cooke Bailey, Inas Helwa, W Daniel Starner, Rachel W. Kuchtey, R Rand Allingham, Michael A. Hauser, Louis R. Pasquale, Jonathan L. Haines, and Laney L. Wiggs. “Association of miR-182 with High Tension Glaucoma.” In Investigative Ophthalmology & Visual Science, Vol. 57. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2016.

Scholars@Duke

Igo, Robert P., Jessica Cooke Bailey, William Scott, Rebecca J. Sardell, Margaret A. Pericak-Vance, Louis R. Pasquale, Michael A. Hauser, Terry Gaasterland, Janey L. Wiggs, and Jonathan Haines. “Genetic Association and Linkage at Putative Risk Loci for Primary Open-angle Glaucoma.” In Investigative Ophthalmology & Visual Science, Vol. 57. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2016.

Scholars@Duke

Verma, Shefali Setia, Jessica N. Cooke Bailey, Anastasia Lucas, Yuki Bradford, James G. Linneman, Michael A. Hauser, Louis R. Pasquale, et al. “Epistatic Gene-Based Interaction Analyses for Glaucoma in eMERGE and NEIGHBOR Consortium.” Plos Genet 12, no. 9 (September 2016): e1006186. https://doi.org/10.1371/journal.pgen.1006186.

PMID
27623284
Full Text

Pages