Michael Arthur Hauser, PhD

Professor in Medicine
Associate Research Professor in Molecular Genetics and Microbiology
Member of Duke Molecular Physiology Institute
Campus mail 2016 Genome Science Research Bldg I, Durham, NC 27710
Phone (919) 684-3508
Email address mike.hauser@duke.edu

Dr. Hauser has a strong interest in ocular genetics. Genomic studies at the Center for Human Genetics have identified multiple linkage peaks and susceptibility genes in primary open angle glaucoma (POAG) and age related macular degeneration (AMD). Dr. Hauser has recently accepted a 20% appointment at the Singapore Eye Research INstitute and the Duke/National University of Singapore.  In collaboration with multiple collaborators in Singapore, and Dr. Rand Allingham at the Duke Eye Center, Dr. Hauser is currently conducting a genome wide association study for glaucoma in individuals of African ancestry. These investigations include large datasets collected in Ghana, Nigeria, and South Africa.  
 
Dr. Hauser is also involved in collaborative investigations into the genetics of post-tramatic stress disorder in US veterans from Iraq and Afghanistan.   Major collaborators include Dr. Allison Ashley Koch, Dr. Jean Beckham, Dr. Christine Marx and the MIRECC Collaborative group at the Durham Veteran's Administration.  We have published a genome wide association study, as well as numerous investigations into candidate genes.  Epigenomic DNA methylation analysis and gene expression analysis of 3500 individuals is currently ongoing. 

Education and Training

  • Ph.D., Johns Hopkins University, 1990

Publications

Khawaja, Anthony P., Jessica N. Cooke Bailey, Jae Hee Kang, R Rand Allingham, Michael A. Hauser, Murray Brilliant, Donald L. Budenz, et al. “Assessing the Association of Mitochondrial Genetic Variation With Primary Open-Angle Glaucoma Using Gene-Set Analyses.” Invest Ophthalmol Vis Sci 57, no. 11 (September 1, 2016): 5046–52. https://doi.org/10.1167/iovs.16-20017.

PMID
27661856
Full Text

Drewry, Michelle Dianne, Inas Helwa, R Rand Allingham, Michael A. Hauser, and Yutao Liu. “miRNA-Seq in four different normal human ocular tissues.” In Investigative Ophthalmology & Visual Science, Vol. 57. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2016.

Scholars@Duke

Gao, Xiaoyi Raymond, Drew Nannini, Kristen Goulee, Inas F. Aboobakar, R Rand Allingham, Michael A. Hauser, and Yutao Liu. “Differential gene expression and pathway enrichment in the human cornea and retina.” In Investigative Ophthalmology & Visual Science, Vol. 57. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2016.

Scholars@Duke

Ozaki, Mineo, Francesca Pasutto, Takanori Mizoguchi, Michael A. Hauser, Fotis Topouzis, Michael Dubina, Deepak P. Edward, Ningli Wang, Tin Aung, and Chiea Chuen Khor. “Genome-wide association study comparing patients with exfoliation syndrome and exfoliation glaucoma.” In Investigative Ophthalmology & Visual Science, Vol. 57. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2016.

Scholars@Duke

Pasquale, Louis R., Jessica Cooke Bailey, Jae H. Kang, Hugo Aschard, Michael A. Hauser, R Rand Allingham, David A. Sullivan, Jonathan L. Haines, and Janey L. Wiggs. “Testosterone pathway polymorphisms in relation to primary open angle glaucoma: an analysis stratified by sex.” In Investigative Ophthalmology & Visual Science, Vol. 57. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2016.

Scholars@Duke

Cai, Jingwen, Michelle Dianne Drewry, Kristin Perkumas, Michael Dismuke, Iris Navarro, Michael A. Hauser, W Daniel Starner, and Yutao Liu. “DNA methylation in Human SC Cells with Glaucoma.” In Investigative Ophthalmology & Visual Science, Vol. 57. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2016.

Scholars@Duke

Liu, Yutao, Jessica Cooke Bailey, Inas Helwa, W Michael Dismuke, Jingwen Cai, Michelle Drewry, Murray H. Brilliant, et al. “A Common Variant in MIR182 Is Associated With Primary Open-Angle Glaucoma in the NEIGHBORHOOD Consortium.” Invest Ophthalmol Vis Sci 57, no. 10 (August 1, 2016): 4528–35. https://doi.org/10.1167/iovs.16-19688.

PMID
27537254
Full Text

Liu, Yutao, Jessica Cooke Bailey, Inas Helwa, W Michael Dismuke, Jingwen Cai, Michelle Drewry, Murray H. Brilliant, et al. “A Common Variant in MIR182 Is Associated With Primary Open-Angle Glaucoma in the NEIGHBORHOOD Consortium.” Investigative Ophthalmology & Visual Science 57, no. 10 (August 2016): 4528–35. https://doi.org/10.1167/iovs.16-19688.

Full Text

Drewry, Michelle, Inas Helwa, R Rand Allingham, Michael A. Hauser, and Yutao Liu. “miRNA Profile in Three Different Normal Human Ocular Tissues by miRNA-Seq.” Invest Ophthalmol Vis Sci 57, no. 8 (July 1, 2016): 3731–39. https://doi.org/10.1167/iovs.16-19155.

PMID
27415791
Full Text

Roach, Allana N., Tasanee Braithwaite, Christine Carrington, Elysse Marcellin, Subash Sharma, Aroon Hingorani, Juan P. Casas, et al. “Addressing ethical challenges in the Genetics Substudy of the National Eye Survey of Trinidad and Tobago (GSNESTT).” Appl Transl Genom 9 (June 2016): 6–14. https://doi.org/10.1016/j.atg.2016.05.001.

PMID
27556007
Full Text

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