Michael Arthur Hauser, PhD

Professor in Medicine
Associate Research Professor in Molecular Genetics and Microbiology
Member of Duke Molecular Physiology Institute
Campus mail 2016 Genome Science Research Bldg I, Durham, NC 27710
Phone (919) 684-3508
Email address mike.hauser@duke.edu

Dr. Hauser has a strong interest in ocular genetics. Genomic studies at the Center for Human Genetics have identified multiple linkage peaks and susceptibility genes in primary open angle glaucoma (POAG) and age related macular degeneration (AMD). Dr. Hauser has recently accepted a 20% appointment at the Singapore Eye Research INstitute and the Duke/National University of Singapore.  In collaboration with multiple collaborators in Singapore, and Dr. Rand Allingham at the Duke Eye Center, Dr. Hauser is currently conducting a genome wide association study for glaucoma in individuals of African ancestry. These investigations include large datasets collected in Ghana, Nigeria, and South Africa.  
 
Dr. Hauser is also involved in collaborative investigations into the genetics of post-tramatic stress disorder in US veterans from Iraq and Afghanistan.   Major collaborators include Dr. Allison Ashley Koch, Dr. Jean Beckham, Dr. Christine Marx and the MIRECC Collaborative group at the Durham Veteran's Administration.  We have published a genome wide association study, as well as numerous investigations into candidate genes.  Epigenomic DNA methylation analysis and gene expression analysis of 3500 individuals is currently ongoing. 

Education and Training

  • Ph.D., Johns Hopkins University, 1990

Publications

Kimbrel, Nathan A., Michael A. Hauser, Melanie Garrett, Allison Ashley-Koch, Yutao Liu, Michelle F. Dennis, Rebecca C. Klein, Rebecca C. Veterans Affairs Mid-Atlantic Mental Illness Research, Education, and Clinical Center Workgroup, and Jean C. Beckham. “EFFECT OF THE APOE ε4 ALLELE AND COMBAT EXPOSURE ON PTSD AMONG IRAQ/AFGHANISTAN-ERA VETERANS.” Depress Anxiety 32, no. 5 (May 2015): 307–15. https://doi.org/10.1002/da.22348.

PMID
25709077
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Aung, Tin, Mineo Ozaki, Takanori Mizoguchi, R Rand Allingham, Zheng Li, Aravind Haripriya, Satoko Nakano, et al. “A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome.” Nat Genet 47, no. 4 (April 2015): 387–92. https://doi.org/10.1038/ng.3226.

PMID
25706626
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Springelkamp, Henriët, Aniket Mishra, Pirro G. Hysi, Puya Gharahkhani, René Höhn, Chiea-Chuen Khor, Jessica N. Cooke Bailey, et al. “Meta-analysis of Genome-Wide Association Studies Identifies Novel Loci Associated With Optic Disc Morphology.” Genet Epidemiol 39, no. 3 (March 2015): 207–16. https://doi.org/10.1002/gepi.21886.

PMID
25631615
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Williams, Susan E. I., Trevor R. Carmichael, R Rand Allingham, Michael Hauser, and Michele Ramsay. “The genetics of POAG in black South Africans: a candidate gene association study.” Sci Rep 5 (February 11, 2015): 8378. https://doi.org/10.1038/srep08378.

PMID
25669751
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Liu, Yutao, Melanie E. Garrett, Michelle F. Dennis, Kimberly T. Green, Kimberly T. VA Mid-Atlantic MIRECC Registry Workgroup, Allison E. Ashley-Koch, Michael A. Hauser, Jean C. Beckham, and Nathan A. Kimbrel. “An examination of the association between 5-HTTLPR, combat exposure, and PTSD diagnosis among U.S. veterans.” Plos One 10, no. 3 (2015): e0119998. https://doi.org/10.1371/journal.pone.0119998.

PMID
25793742
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Abu-Amero, Khaled K., Inas Helwa, Abdulrahman Al-Muammar, Shelby Strickland, Michael A. Hauser, R Rand Allingham, and Yutao Liu. “Screening of the Seed Region of MIR184 in Keratoconus Patients from Saudi Arabia.” Biomed Res Int 2015 (2015): 604508. https://doi.org/10.1155/2015/604508.

PMID
26380287
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Abu-Amero, K. K., I. Helwa, A. Al-Muammar, S. Strickland, M. A. Hauser, R. R. Allingham, and Y. Liu. “Case-control association between CCT-associated variants and keratoconus in a Saudi Arabian population.” Journal of Negative Results in Biomedicine, 2015. https://doi.org/10.1186/s12952-015-0029-5.

Full Text

Cheng, Ching-Yu, R Rand Allingham, Tin Aung, Yih-Chung Tham, Michael A. Hauser, Eranga N. Vithana, Chiea Chuen Khor, and Tien Yin Wong. “Association of common SIX6 polymorphisms with peripapillary retinal nerve fiber layer thickness: the Singapore Chinese Eye Study.” Invest Ophthalmol Vis Sci 56, no. 1 (December 23, 2014): 478–83. https://doi.org/10.1167/iovs.14-15863.

PMID
25537207
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Liu, Yutao, Melanie E. Garrett, Brian L. Yaspan, Jessica Cooke Bailey, Stephanie J. Loomis, Murray Brilliant, Donald L. Budenz, et al. “DNA copy number variants of known glaucoma genes in relation to primary open-angle glaucoma.” Invest Ophthalmol Vis Sci 55, no. 12 (November 20, 2014): 8251–58. https://doi.org/10.1167/iovs.14-15712.

PMID
25414181
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Roses, Allen D., Michael W. Lutz, Ann M. Saunders, Dmitry Goldgaber, Robert Saul, Scott S. Sundseth, P Anthony Akkari, et al. “African-American TOMM40'523-APOE haplotypes are admixture of West African and Caucasian alleles.” Alzheimers Dement 10, no. 6 (November 2014): 592-601.e2. https://doi.org/10.1016/j.jalz.2014.06.009.

PMID
25260913
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