Michael Arthur Hauser, PhD

Professor in Medicine
Associate Research Professor in Molecular Genetics and Microbiology
Member of Duke Molecular Physiology Institute
Campus mail 2016 Genome Science Research Bldg I, Durham, NC 27710
Phone (919) 684-3508
Email address mike.hauser@duke.edu

Dr. Hauser has a strong interest in ocular genetics. Genomic studies at the Center for Human Genetics have identified multiple linkage peaks and susceptibility genes in primary open angle glaucoma (POAG) and age related macular degeneration (AMD). Dr. Hauser has recently accepted a 20% appointment at the Singapore Eye Research INstitute and the Duke/National University of Singapore.  In collaboration with multiple collaborators in Singapore, and Dr. Rand Allingham at the Duke Eye Center, Dr. Hauser is currently conducting a genome wide association study for glaucoma in individuals of African ancestry. These investigations include large datasets collected in Ghana, Nigeria, and South Africa.  
 
Dr. Hauser is also involved in collaborative investigations into the genetics of post-tramatic stress disorder in US veterans from Iraq and Afghanistan.   Major collaborators include Dr. Allison Ashley Koch, Dr. Jean Beckham, Dr. Christine Marx and the MIRECC Collaborative group at the Durham Veteran's Administration.  We have published a genome wide association study, as well as numerous investigations into candidate genes.  Epigenomic DNA methylation analysis and gene expression analysis of 3500 individuals is currently ongoing. 

Education and Training

  • Ph.D., Johns Hopkins University, 1990

Publications

Bailey, Jessica N Cooke, Brian L. Yaspan, Louis R. Pasquale, Michael A. Hauser, Jae H. Kang, Stephanie J. Loomis, Murray Brilliant, et al. “Hypothesis-independent pathway analysis implicates GABA and acetyl-CoA metabolism in primary open-angle glaucoma and normal-pressure glaucoma.” Hum Genet 133, no. 10 (October 2014): 1319–30. https://doi.org/10.1007/s00439-014-1468-7.

PMID
25037249
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Guffanti, G., A. E. Ashley-Koch, A. L. Roberts, M. E. Garrett, N. Solovieff, A. Ratanatharathorn, I. De Vivo, et al. “No association between RORA polymorphisms and PTSD in two independent samples.” Mol Psychiatry 19, no. 10 (October 2014): 1056–57. https://doi.org/10.1038/mp.2014.19.

PMID
25048002
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Hysi, Pirro G., Ching-Yu Cheng, Henriët Springelkamp, Stuart Macgregor, Jessica N Cooke Bailey, Robert Wojciechowski, Veronique Vitart, et al. “Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma.” Nat Genet 46, no. 10 (October 2014): 1126–30. https://doi.org/10.1038/ng.3087.

PMID
25173106
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Gharahkhani, Puya, Kathryn P. Burdon, Rhys Fogarty, Shiwani Sharma, Alex W. Hewitt, Sarah Martin, Matthew H. Law, et al. “Common variants near ABCA1, AFAP1 and GMDS confer risk of primary open-angle glaucoma.” Nat Genet 46, no. 10 (October 2014): 1120–25. https://doi.org/10.1038/ng.3079.

PMID
25173105
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Springelkamp, Henriët, René Höhn, Aniket Mishra, Pirro G. Hysi, Chiea-Chuen Khor, Stephanie J. Loomis, Jessica N Cooke Bailey, et al. “Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process.” Nat Commun 5 (September 22, 2014): 4883. https://doi.org/10.1038/ncomms5883.

PMID
25241763
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Li, Yi-Ju, Mollie A. Minear, Xuejun Qin, Jacqueline Rimmler, Michael A. Hauser, R Rand Allingham, Robert P. Igo, et al. “Mitochondrial polymorphism A10398G and Haplogroup I are associated with Fuchs' endothelial corneal dystrophy.” Invest Ophthalmol Vis Sci 55, no. 7 (June 10, 2014): 4577–84. https://doi.org/10.1167/iovs.13-13517.

PMID
24917144
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Kang, J. H., S. J. Loomis, B. L. Yaspan, J. C. Bailey, R. N. Weinreb, R. K. Lee, P. R. Lichter, et al. “Vascular tone pathway polymorphisms in relation to primary open-angle glaucoma.” Eye (Lond) 28, no. 6 (June 2014): 662–71. https://doi.org/10.1038/eye.2014.42.

PMID
24603425
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Liu, Jian, Lindsay M. Wallace, Sara E. Garwick-Coppens, Darcée D. Sloboda, Carol S. Davis, Chady H. Hakim, Michael A. Hauser, Susan V. Brooks, Jerry R. Mendell, and Scott Q. Harper. “RNAi-mediated Gene Silencing of Mutant Myotilin Improves Myopathy in LGMD1A Mice.” Mol Ther Nucleic Acids 3 (April 29, 2014): e160. https://doi.org/10.1038/mtna.2014.13.

PMID
24781192
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Nongpiur, Monisha E., Chiea Chuen Khor, Hongyan Jia, Belinda K. Cornes, Li-Jia Chen, Chunyan Qiao, K Saidas Nair, et al. “ABCC5, a gene that influences the anterior chamber depth, is associated with primary angle closure glaucoma.” Plos Genet 10, no. 3 (March 2014): e1004089. https://doi.org/10.1371/journal.pgen.1004089.

PMID
24603532
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Moylan, Cynthia A., Herbert Pang, Andrew Dellinger, Ayako Suzuki, Melanie E. Garrett, Cynthia D. Guy, Susan K. Murphy, et al. “Hepatic gene expression profiles differentiate presymptomatic patients with mild versus severe nonalcoholic fatty liver disease.” Hepatology 59, no. 2 (February 2014): 471–82. https://doi.org/10.1002/hep.26661.

PMID
23913408
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