Michael August Blazing, MD

Associate Professor of Medicine
Campus mail 7412HOSP North, Durham, NC 27710
Phone (919) 681-3945
Email address blazi001@mc.duke.edu

General focus: My research interests are in primary and secondary prevention of cardiovascular disease. Specifically, I am looking at compliance issues within the cardiology division and in the University as a whole with regard to evidence based treatment and secondary prevention of cardiovascular disease. I am using both retrospective and prospective collection of discharge data to try and analyze these trends. In the future, we hope to begin clinical trials with regard to various issues which are outstanding in primary and secondary prevention. Some of the issues include treatment of hypercholesterolemia in elderly patients, differences between the various statins with regard to affects on lipid profiles, and early treatment of hypercholesterolemia after MI.

As part of my work, I have served as a consultant with various drug companies with regard to focusing on active issues and treatment of hypercholesterolemia.

Key words: Primary prevention, secondary prevention, hyperlipidemia, homocysteine, and hypertension.

In Their Words

Education and Training

  • M.D., University of California San Francisco, School of Medicine, 1987

Publications

Oyama, Kazuma, Robert P. Giugliano, Michael A. Blazing, Jeong-Gun Park, Andrew M. Tershakovec, Marc S. Sabatine, Christopher P. Cannon, and Eugene Braunwald. “Baseline Low-Density Lipoprotein Cholesterol and Clinical Outcomes of Combining Ezetimibe With Statin Therapy in IMPROVE-IT.” J Am Coll Cardiol 78, no. 15 (October 12, 2021): 1499–1507. https://doi.org/10.1016/j.jacc.2021.08.011.

PMID
34620406
Full Text

Goyal, Akash, Tony Schibler, Brooke Alhanti, Karen L. Hannan, Christopher B. Granger, Michael A. Blazing, Renato D. Lopes, et al. “Assessment of North American Clinical Research Site Performance During the Start-up of Large Cardiovascular Clinical Trials.” Jama Netw Open 4, no. 7 (July 1, 2021): e2117963. https://doi.org/10.1001/jamanetworkopen.2021.17963.

PMID
34297072
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Giugliano, Robert P., Baris Gencer, Stephen D. Wiviott, Jeong-Gun Park, Charles S. Fuchs, Wolfram Goessling, Thomas A. Musliner, et al. “Prospective Evaluation of Malignancy in 17,708 Patients Randomized to Ezetimibe Versus Placebo: Analysis From IMPROVE-IT.” Jacc Cardiooncol 2, no. 3 (September 2020): 385–96. https://doi.org/10.1016/j.jaccao.2020.07.008.

PMID
34396246
Full Text

Shah, Nishant P., Neha J. Pajidipati, Robert W. McGarrah, Ann Marie Navar, Sreekanth Vemulapalli, Michael A. Blazing, Svati H. Shah, Adrian F. Hernandez, and Manesh R. Patel. “Lipoprotein (a): An Update on a Marker of Residual Risk and Associated Clinical Manifestations.” Am J Cardiol 126 (July 1, 2020): 94–102. https://doi.org/10.1016/j.amjcard.2020.03.043.

PMID
32336532
Full Text

Loungani, Rahul S., Michael R. Rehorn, L Kristin Newby, Jason N. Katz, Igor Klem, Robert J. Mentz, W Schuyler Jones, et al. “A care pathway for the cardiovascular complications of COVID-19: Insights from an institutional response.” Am Heart J 225 (July 2020): 3–9. https://doi.org/10.1016/j.ahj.2020.04.024.

PMID
32417526
Full Text

Bach, Richard G., Christopher P. Cannon, and Michael A. Blazing. “Interpreting the Benefit of Simvastatin-Ezetimibe in Patients 75 Years or Older-Reply.” Jama Cardiol 5, no. 2 (February 1, 2020): 235–36. https://doi.org/10.1001/jamacardio.2019.5241.

PMID
31895449
Full Text

Bach, Richard G., Christopher P. Cannon, Robert P. Giugliano, Jennifer A. White, Yuliya Lokhnygina, Erin A. Bohula, Robert M. Califf, Eugene Braunwald, and Michael A. Blazing. “Effect of Simvastatin-Ezetimibe Compared With Simvastatin Monotherapy After Acute Coronary Syndrome Among Patients 75 Years or Older: A Secondary Analysis of a Randomized Clinical Trial.” Jama Cardiol 4, no. 9 (September 1, 2019): 846–54. https://doi.org/10.1001/jamacardio.2019.2306.

PMID
31314050
Full Text

Qamar, Arman, Robert P. Giugliano, Erin A. Bohula, Jeong-Gun Park, Petr Jarolim, Sabina A. Murphy, Michael A. Blazing, et al. “Biomarkers and Clinical Cardiovascular Outcomes With Ezetimibe in the IMPROVE-IT Trial.” J Am Coll Cardiol 74, no. 8 (August 27, 2019): 1057–68. https://doi.org/10.1016/j.jacc.2019.06.038.

PMID
31439215
Full Text

Sharma, Abhinav, Jie-Lena Sun, Yuliya Lokhnygina, Matthew T. Roe, Tariq Ahmad, Nihar R. Desai, and Michael A. Blazing. “Patient Phenotypes, Cardiovascular Risk, and Ezetimibe Treatment in Patients After Acute Coronary Syndromes (from IMPROVE-IT).” Am J Cardiol 123, no. 8 (April 15, 2019): 1193–1201. https://doi.org/10.1016/j.amjcard.2019.01.034.

PMID
30739657
Full Text

Cholesterol Treatment Trialists’ Collaboration, Rui. “Efficacy and safety of statin therapy in older people: a meta-analysis of individual participant data from 28 randomised controlled trials.” Lancet 393, no. 10170 (February 2, 2019): 407–15. https://doi.org/10.1016/S0140-6736(18)31942-1.

PMID
30712900
Full Text

Pages