Michael August Blazing, MD

Associate Professor of Medicine
Campus mail 7412HOSP North, Durham, NC 27710
Phone (919) 681-3945
Email address blazi001@mc.duke.edu

General focus: My research interests are in primary and secondary prevention of cardiovascular disease. Specifically, I am looking at compliance issues within the cardiology division and in the University as a whole with regard to evidence based treatment and secondary prevention of cardiovascular disease. I am using both retrospective and prospective collection of discharge data to try and analyze these trends. In the future, we hope to begin clinical trials with regard to various issues which are outstanding in primary and secondary prevention. Some of the issues include treatment of hypercholesterolemia in elderly patients, differences between the various statins with regard to affects on lipid profiles, and early treatment of hypercholesterolemia after MI.

As part of my work, I have served as a consultant with various drug companies with regard to focusing on active issues and treatment of hypercholesterolemia.

Key words: Primary prevention, secondary prevention, hyperlipidemia, homocysteine, and hypertension.

In Their Words

Education and Training

  • M.D., University of California, San Francisco, School of Medicine, 1987

Publications

Giugliano, Robert P., Christopher P. Cannon, Michael A. Blazing, José C. Nicolau, Ramón Corbalán, Jindřich Špinar, Jeong-Gun Park, et al. “Benefit of Adding Ezetimibe to Statin Therapy on Cardiovascular Outcomes and Safety in Patients With Versus Without Diabetes Mellitus: Results From IMPROVE-IT (Improved Reduction of Outcomes: Vytorin Efficacy International Trial)..” Circulation 137, no. 15 (April 10, 2018): 1571–82. https://doi.org/10.1161/CIRCULATIONAHA.117.030950.

PMID
29263150
Full Text

Bohula, Erin A., Stephen D. Wiviott, Robert P. Giugliano, Michael A. Blazing, Jeong-Gun Park, Sabina A. Murphy, Jennifer A. White, et al. “Prevention of Stroke with the Addition of Ezetimibe to Statin Therapy in Patients With Acute Coronary Syndrome in IMPROVE-IT (Improved Reduction of Outcomes: Vytorin Efficacy International Trial)..” Circulation 136, no. 25 (December 19, 2017): 2440–50. https://doi.org/10.1161/CIRCULATIONAHA.117.029095.

PMID
28972004
Full Text

Kato, Eri Toda, Christopher P. Cannon, Michael A. Blazing, Erin Bohula, Sema Guneri, Jennifer A. White, Sabina A. Murphy, Jeong-Gun Park, Eugene Braunwald, and Robert P. Giugliano. “Efficacy and Safety of Adding Ezetimibe to Statin Therapy Among Women and Men: Insight From IMPROVE-IT (Improved Reduction of Outcomes: Vytorin Efficacy International Trial)..” J Am Heart Assoc 6, no. 11 (November 18, 2017). https://doi.org/10.1161/JAHA.117.006901.

PMID
29151034
Full Text

Stanifer, John W., David M. Charytan, Jennifer White, Yuliya Lokhnygina, Christopher P. Cannon, Matthew T. Roe, and Michael A. Blazing. “Benefit of Ezetimibe Added to Simvastatin in Reduced Kidney Function..” J Am Soc Nephrol 28, no. 10 (October 2017): 3034–43. https://doi.org/10.1681/ASN.2016090957.

PMID
28507057
Full Text

Fanaroff, Alexander C., Matthew T. Roe, Robert M. Clare, Yuliya Lokhnygina, Ann Marie Navar, Robert P. Giugliano, Stephen D. Wiviott, Andrew M. Tershakovec, Eugene Braunwald, and Michael A. Blazing. “Competing Risks of Cardiovascular Versus Noncardiovascular Death During Long-Term Follow-Up After Acute Coronary Syndromes..” J Am Heart Assoc 6, no. 9 (September 18, 2017). https://doi.org/10.1161/JAHA.117.005840.

PMID
28923989
Full Text

Giugliano, Robert P., Stephen D. Wiviott, Michael A. Blazing, Gaetano M. De Ferrari, Jeong-Gun Park, Sabina A. Murphy, Jennifer A. White, Andrew M. Tershakovec, Christopher P. Cannon, and Eugene Braunwald. “Long-term Safety and Efficacy of Achieving Very Low Levels of Low-Density Lipoprotein Cholesterol : A Prespecified Analysis of the IMPROVE-IT Trial..” Jama Cardiol 2, no. 5 (May 1, 2017): 547–55. https://doi.org/10.1001/jamacardio.2017.0083.

PMID
28291866
Full Text

Pokharel, Yashashwi, Khaja Chinnakondepalli, Katherine Vilain, Kaijun Wang, Daniel B. Mark, Glenn Davies, Michael A. Blazing, et al. “Impact of Ezetimibe on the Rate of Cardiovascular-Related Hospitalizations and Associated Costs Among Patients With a Recent Acute Coronary Syndrome: Results From the IMPROVE-IT Trial (Improved Reduction of Outcomes: Vytorin Efficacy International Trial)..” Circ Cardiovasc Qual Outcomes 10, no. 5 (May 2017). https://doi.org/10.1161/CIRCOUTCOMES.116.003201.

PMID
28506979
Full Text

Bohula, Erin A., David A. Morrow, Robert P. Giugliano, Michael A. Blazing, Ping He, Jeong-Gun Park, Sabina A. Murphy, et al. “Atherothrombotic Risk Stratification and Ezetimibe for Secondary Prevention..” J Am Coll Cardiol 69, no. 8 (February 28, 2017): 911–21. https://doi.org/10.1016/j.jacc.2016.11.070.

PMID
28231942
Full Text

Eisen, Alon, Christopher P. Cannon, Michael A. Blazing, Erin A. Bohula, Jeong-Gun Park, Sabina A. Murphy, Jennifer A. White, Robert P. Giugliano, Eugene Braunwald, and Eugene IMPROVE-IT (IMProved Reduction of Outcomes: Vytorin Efficacy International Trial) Investigators. “The benefit of adding ezetimibe to statin therapy in patients with prior coronary artery bypass graft surgery and acute coronary syndrome in the IMPROVE-IT trial..” Eur Heart J 37, no. 48 (December 21, 2016): 3576–84. https://doi.org/10.1093/eurheartj/ehw377.

PMID
27569841
Full Text

Blazing, Michael A., Robert P. Giugliano, James A. de Lemos, Christopher P. Cannon, Andrew Tonkin, Christie M. Ballantyne, Basil S. Lewis, et al. “On-treatment analysis of the Improved Reduction of Outcomes: Vytorin Efficacy International Trial (IMPROVE-IT)..” Am Heart J 182 (December 2016): 89–96. https://doi.org/10.1016/j.ahj.2016.09.004.

PMID
27914504
Full Text

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