Michael August Blazing, MD

Associate Professor of Medicine
Campus mail 7412HOSP North, Durham, NC 27710
Phone (919) 681-3945
Email address blazi001@mc.duke.edu

General focus: My research interests are in primary and secondary prevention of cardiovascular disease. Specifically, I am looking at compliance issues within the cardiology division and in the University as a whole with regard to evidence based treatment and secondary prevention of cardiovascular disease. I am using both retrospective and prospective collection of discharge data to try and analyze these trends. In the future, we hope to begin clinical trials with regard to various issues which are outstanding in primary and secondary prevention. Some of the issues include treatment of hypercholesterolemia in elderly patients, differences between the various statins with regard to affects on lipid profiles, and early treatment of hypercholesterolemia after MI.

As part of my work, I have served as a consultant with various drug companies with regard to focusing on active issues and treatment of hypercholesterolemia.

Key words: Primary prevention, secondary prevention, hyperlipidemia, homocysteine, and hypertension.

In Their Words

Education and Training

  • M.D., University of California, San Francisco, School of Medicine, 1987

Publications

Blazing, Michael A., Robert P. Giugliano, Christopher P. Cannon, Thomas A. Musliner, Andrew M. Tershakovec, Jennifer A. White, Craig Reist, Amy McCagg, Eugene Braunwald, and Robert M. Califf. “Evaluating cardiovascular event reduction with ezetimibe as an adjunct to simvastatin in 18,144 patients after acute coronary syndromes: final baseline characteristics of the IMPROVE-IT study population..” Am Heart J 168, no. 2 (August 2014): 205-12.e1. https://doi.org/10.1016/j.ahj.2014.05.004.

PMID
25066560
Full Text

Patel, Mahesh J., and Michael A. Blazing. “Inflammation and atherosclerosis: disease modulating therapies..” Curr Treat Options Cardiovasc Med 15, no. 6 (December 2013): 681–95. https://doi.org/10.1007/s11936-013-0268-z.

PMID
23979859
Full Text

Cholesterol Treatment Trialists’ (CTT) Collaborators, C., B. Mihaylova, J. Emberson, L. Blackwell, A. Keech, J. Simes, E. H. Barnes, et al. “The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials..” Lancet 380, no. 9841 (August 11, 2012): 581–90. https://doi.org/10.1016/S0140-6736(12)60367-5.

PMID
22607822
Full Text

Cholesterol Treatment Trialists’ (CTT) Collaboration, Colin, Jonathan R. Emberson, Patricia M. Kearney, Lisa Blackwell, Connie Newman, Christina Reith, Neeraj Bhala, et al. “Lack of effect of lowering LDL cholesterol on cancer: meta-analysis of individual data from 175,000 people in 27 randomised trials of statin therapy..” Plos One 7, no. 1 (2012). https://doi.org/10.1371/journal.pone.0029849.

PMID
22276132
Full Text

Preiss, David, Sreenivasa Rao Kondapally Seshasai, Paul Welsh, Sabina A. Murphy, Jennifer E. Ho, David D. Waters, David A. DeMicco, et al. “Risk of incident diabetes with intensive-dose compared with moderate-dose statin therapy: a meta-analysis..” Jama 305, no. 24 (June 22, 2011): 2556–64. https://doi.org/10.1001/jama.2011.860.

PMID
21693744
Full Text

Keefe, Francis J., Rebecca A. Shelby, Tamara J. Somers, Indira Varia, Michael Blazing, Sandra J. Waters, Daphne McKee, et al. “Effects of coping skills training and sertraline in patients with non-cardiac chest pain: a randomized controlled study..” Pain 152, no. 4 (April 2011): 730–41. https://doi.org/10.1016/j.pain.2010.08.040.

PMID
21324590
Full Text

Cholesterol Treatment Trialists’ (CTT) Collaboration, R., C. Baigent, L. Blackwell, J. Emberson, L. E. Holland, C. Reith, N. Bhala, et al. “Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials..” Lancet 376, no. 9753 (November 13, 2010): 1670–81. https://doi.org/10.1016/S0140-6736(10)61350-5.

PMID
21067804
Full Text

Kong, Melissa H., Linda K. Shaw, Christopher O’Connor, Robert M. Califf, Michael A. Blazing, and Sana M. Al-Khatib. “Is rhythm-control superior to rate-control in patients with atrial fibrillation and diastolic heart failure?.” Ann Noninvasive Electrocardiol 15, no. 3 (July 2010): 209–17. https://doi.org/10.1111/j.1542-474X.2010.00365.x.

PMID
20645962
Full Text

Califf, Robert M., Yuliya Lokhnygina, Christopher P. Cannon, Michael E. Stepanavage, Carolyn H. McCabe, Thomas A. Musliner, Richard C. Pasternak, et al. “An update on the IMProved reduction of outcomes: Vytorin Efficacy International Trial (IMPROVE-IT) design..” Am Heart J 159, no. 5 (May 2010): 705–9. https://doi.org/10.1016/j.ahj.2010.03.004.

PMID
20435175
Full Text

Pages