Nancy Bates Allen, MD

Professor of Medicine
Campus mail 4140 Purple Zone Hosp South, 201 Trent Dr., Durham, NC 27710
Phone (919) 684-2965
Email address nancy.allen@duke.edu

My clinical research interests include systemic vasculitis (Wegener's granulomatosis, microscopic polyangiitis, giant cell arteritis, Takayasu arteritis) and multi-disciplinary efforts in the areas of systemic lupus erythematosus and anti-phospholipid syndrome. Dr. E. William St. Clair and I represented Duke in both the RAVE trial, a multi-center, double-blind, controlled trial comparing rituximab with cyclophosphamide in patients with ANCA-associated vasculitis and previously the Wegener's granulomatosis etanercept trial (WGET), a multi-center effort to assess the addition of etanercept to traditional therapy in limited and severe forms of this type of vasculitis.

My area of clinical expertise is in the care of patients with all types of vasculitis, particularly Granulomatosis with Polyangiitis (formerly called Wegener's granulomatosis), Micropscopic Polyangiitis, other ANCA-associated vasculitides, giant cell arteritis, and Takayasu's arteritis. I also care for patients with systemic lupus erythematosus, anti-phospholipid syndrome, and women's health-related rheumatologic diseases. In addition I see all patients and educate trainees about all types of rheumatologic and arthritis conditions. Key words: vasculitis, systemic vasculitis, Wegener's granulomatosis, giant cell (temporal) arteritis, Takayasu arteritis, anti-phospholipid antibody syndrome.

Education and Training

  • Rheumatology Fellow, Medicine, Duke University, 1981 - 1983
  • Medical Resident, Medicine, Duke University, 1978 - 1979
  • M.D., Tufts University, 1978

Publications

Niles, J, Allen, NB, Block, JA, Koening, CL, Langford, CA, Abril, A, Lee, AS, Merkel, PA, Mertz, LE, Monach, PA, Moreland, LW, Nachman, PH, Peikert, T, Spiera, RF, Wallace, D, Erblang, F, Cascino, MD, Duncombe, P, Malik, V, and Brunetta, P. "SAFETY FOLLOWING INITIATION OF RITUXIMAB IN GRANULOMATOSIS WITH POLYANGIITIS (GPA) OR MICROSCOPIC POLYANGIITIS (MPA): INTERIM ANALYSIS OF THE RITUXIMAB IN ANCA-ASSOCIATED VASCULITIS REGISTRY (RAVER)." March 2017.

Scholars@Duke

Miloslavsky, EM, Specks, U, Merkel, PA, Seo, P, Spiera, R, Langford, CA, Hoffman, GS, Kallenberg, CGM, St Clair, EW, Tchao, NK, Viviano, L, Ding, L, Iklé, D, Villarreal, M, Jepson, B, Brunetta, P, Allen, NB, Fervenza, FC, Geetha, D, Keogh, K, Kissin, EY, Monach, PA, Peikert, T, Stegeman, C, Ytterberg, SR, Stone, JH, and Rituximab in ANCA-Associated Vasculitis-Immune Tolerance Network Research Group, . "Rituximab for the treatment of relapses in antineutrophil cytoplasmic antibody-associated vasculitis." Arthritis & rheumatology (Hoboken, N.J.) 66, no. 11 (November 2014): 3151-3159.

PMID
25047592
Full Text

Miloslavsky, EM, Specks, U, Merkel, PA, Seo, P, Spiera, R, Langford, CA, Hoffman, GS, Kallenberg, CGM, St Clair, EW, Tchao, NK, Viviano, L, Ding, L, Sejismundo, LP, Mieras, K, Iklé, D, Jepson, B, Mueller, M, Brunetta, P, Allen, NB, Fervenza, FC, Geetha, D, Keogh, K, Kissin, EY, Monach, PA, Peikert, T, Stegeman, C, Ytterberg, SR, Stone, JH, and Rituximab in ANCA-Associated Vasculitis-Immune Tolerance Network Research Group, . "Clinical outcomes of remission induction therapy for severe antineutrophil cytoplasmic antibody-associated vasculitis." Arthritis Rheum 65, no. 9 (September 2013): 2441-2449.

PMID
23754238
Full Text

Specks, U, Merkel, PA, Seo, P, Spiera, R, Langford, CA, Hoffman, GS, Kallenberg, CGM, St Clair, EW, Fessler, BJ, Ding, L, Viviano, L, Tchao, NK, Phippard, DJ, Asare, AL, Lim, N, Ikle, D, Jepson, B, Brunetta, P, Allen, NB, Fervenza, FC, Geetha, D, Keogh, K, Kissin, EY, Monach, PA, Peikert, T, Stegeman, C, Ytterberg, SR, Mueller, M, Sejismundo, LP, Mieras, K, Stone, JH, and RAVE-ITN Research Group, . "Efficacy of remission-induction regimens for ANCA-associated vasculitis." The New England Journal of Medicine 369, no. 5 (August 2013): 417-427.

PMID
23902481
Full Text

Clowse, MEB, Copland, SC, Hsieh, T-C, Chow, S-C, Hoffman, GS, Merkel, PA, Spiera, RF, Davis, JC, McCune, WJ, Ytterberg, SR, St Clair, EW, Allen, NB, Specks, U, Stone, JH, and WGET Research Group, . "Ovarian reserve diminished by oral cyclophosphamide therapy for granulomatosis with polyangiitis (Wegener's)." Arthritis Care & Research 63, no. 12 (December 2011): 1777-1781.

PMID
22127969
Full Text

Stone, JH, Merkel, PA, Seo, P, Spiera, R, Langford, CA, Hoffman, GS, Kallenberg, CGM, St Clair, EW, Fessler, BJ, Tchao, N, Webber, L, Ding, L, Sejismundo, LP, Mieras, K, Ikle, D, Phippard, DJ, Jepson, B, Lail, A, Asare, A, Lim, N, Mueller, M, Brunetta, P, Allen, NB, Fervenza, F, Geetha, D, Keogh, K, Kissin, EY, Monach, PA, Peikert, T, Stegeman, C, Ytterberg, SR, Specks, U, and Grp, RAVE-ITNR. "Extended Follow-up of Treatment with Rituximab Versus Cyclophosphamide for Remission-Induction of ANCA-Associated Vasculitis: Which Subsets Are At Greatest Risk for Flare?." October 2011.

Scholars@Duke

Silva, F, Seo, P, Schroeder, DR, Stone, JH, Merkel, PA, Hoffman, GS, Spiera, R, Sebastian, JK, Davis, JC, St Clair, EW, Allen, NB, McCune, WJ, Ytterberg, SR, Specks, U, and Wegener's Granulomatosis Etanercept Trial Research Group, . "Solid malignancies among etanercept-treated patients with granulomatosis with polyangiitis (Wegener's): long-term followup of a multicenter longitudinal cohort." Arthritis Rheum 63, no. 8 (August 2011): 2495-2503.

PMID
21484770
Full Text

Stone, JH, Merkel, PA, Spiera, R, Seo, P, Langford, CA, Hoffman, GS, Kallenberg, CGM, St Clair, EW, Turkiewicz, A, Tchao, NK, Webber, L, Ding, L, Sejismundo, LP, Mieras, K, Weitzenkamp, D, Ikle, D, Seyfert-Margolis, V, Mueller, M, Brunetta, P, Allen, NB, Fervenza, FC, Geetha, D, Keogh, KA, Kissin, EY, Monach, PA, Peikert, T, Stegeman, C, Ytterberg, SR, Specks, U, and RAVE-ITN Research Group, . "Rituximab versus cyclophosphamide for ANCA-associated vasculitis." The New England Journal of Medicine 363, no. 3 (July 2010): 221-232.

PMID
20647199
Full Text

Sebastian, JK, Voetsch, B, Stone, JH, Romay-Penabad, Z, Lo, GH, Allen, NB, Davis, JC, Hoffman, GS, McCune, WJ, St Clair, EW, Specks, U, Spiera, R, Loscalzo, J, Pierangeli, S, Merkel, PA, and Wegener's Granulomatosis Etanercept Trial Research Group, . "The frequency of anticardiolipin antibodies and genetic mutations associated with hypercoagulability among patients with Wegener's granulomatosis with and without history of a thrombotic event." The Journal of Rheumatology 34, no. 12 (December 2007): 2446-2450.

PMID
17918782
Scholars@Duke

Sebastian, JK, Voetsch, B, Stone, JH, Romay-Penabad, Z, Lo, GH, Allen, NB, Davis, JC, Hoffman, GS, McCune, WJ, St Clair, EW, Specks, U, Spiera, R, Loscalzo, J, Pierangeli, S, and Merkel, PA. "The frequency of anticardiolipin antibodies and genetic hypercoagulable factors among patients with Wegener's granulomatosis with and without a history of a thrombotic event." September 2006.

Scholars@Duke

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