Neil Ross MacIntyre, MD

Professor of Medicine
Campus mail 1120 Hosp North, Durham, NC 27710
Phone (919) 681-2720
Email address macin001@mc.duke.edu

1) Mechanical Ventilation and respiratory failure. Current projects involve studying patient-ventilator interactions during modes of support that require patient activity. The focus is on ventilatory muscle function during these assisted modes. Other projects include evaluating respiratory system mechanics in acute respiratory failure and the role of ECMO in the adult. Duke is also one of several institutions in the NIH ARDS Network, a consortium designed to perform multi-center trials.

2) Diffusing capacity of the lung for carbon monoxide. Current projects involve using a rapidly responding gas analyzer to measure lung diffusing capacity in discrete regions of the lung. These analyses are being extended into mechanically ventilated patients.

3) COPD. Current projects involve studying the physiology of cardio-respiratory conditioning in patients with obstructive lung disease and the role of pulmonary rehabilitation in improving COPD outcomes. Duke is also a member of two NIH sponsored multicenter programs: the COPDgene project correlating genetic profiles with physiologic/clinical phenotypes; and the NIH LOTT project evaluating the role of oxygen therapy in exercise and sleep hypoxemia.

4) Aerosol delivery systems. The current project is the development of a prototype aerosol generating catheter that can be directly inserted into the airways. Studies are being conducted in both ex vivo animal lungs and in mechanically ventilated patients.

Education and Training

  • M.D., Cornell University, 1972

Publications

Giovacchini, Coral X., Anne M. Mathews, Brian R. Lawlor, and Neil R. MacIntyre. “Titrating Oxygen Requirements During Exercise: Evaluation of a Standardized Single Walk Test Protocol..” Chest 153, no. 4 (April 2018): 922–28. https://doi.org/10.1016/j.chest.2017.11.009.

PMID
29170035
Full Text

Zapol, Warren M., H Cecil Charles, Andrew R. Martin, Rui C. Sá, Binglan Yu, Fumito Ichinose, Neil MacIntyre, et al. “Pulmonary Delivery of Therapeutic and Diagnostic Gases..” J Aerosol Med Pulm Drug Deliv 31, no. 2 (April 2018): 78–87. https://doi.org/10.1089/jamp.2017.1431.

PMID
29451844
Full Text

MacIntyre, Neil R., Michael Gentile, John Davies, Stephen Bergin, Craig Rackley, and Anne Mathews. “Airway pressure release ventilation: a step forward?.” Intensive Care Med 44, no. 2 (February 2018). https://doi.org/10.1007/s00134-017-5012-9.

PMID
29230522
Full Text

Paul, D. W., D. K. Lagat, N. MacIntyre, J. R. Egger, D. M. Murdoch, L. G. Que, and P. S. Kussin. “Validation of spirometry prediction equations in western Kenya..” Int J Tuberc Lung Dis 22, no. 1 (January 1, 2018): 112–18. https://doi.org/10.5588/ijtld.17.0005.

PMID
29297435
Full Text

Narewski, E. R., A. L. Blackford, M. R. Lammi, A. L. Fuhlbrigge, X. Soler, R. Albert, G. J. Criner, et al. “Clinical differences in COPD patients with variable patterns of hypoxemia.” Chronic Obstructive Pulmonary Diseases 5, no. 3 (January 1, 2018): 167–78. https://doi.org/10.15326/jcopdf.5.3.2017.0175.

Full Text

MacIntyre, Neil R., Andrew G. Miller, Michael A. Gentile, and John D. Davies. “Airway Pressure Release Ventilation Letter-Reply..” Respir Care 63, no. 1 (January 2018): 128–29. https://doi.org/10.4187/respcare.06014.

PMID
29237871
Full Text

Yusen, Roger D., Gerard J. Criner, Alice L. Sternberg, David H. Au, Anne L. Fuhlbrigge, Richard K. Albert, Richard Casaburi, et al. “The Long-Term Oxygen Treatment Trial for Chronic Obstructive Pulmonary Disease: Rationale, Design, and Lessons Learned..” Ann Am Thorac Soc 15, no. 1 (January 2018): 89–101. https://doi.org/10.1513/AnnalsATS.201705-374SD.

PMID
29087741
Full Text

Boueiz, Adel, Yale Chang, Michael H. Cho, George R. Washko, Raul San José Estépar, Russell P. Bowler, James D. Crapo, et al. “Lobar Emphysema Distribution Is Associated With 5-Year Radiological Disease Progression..” Chest 153, no. 1 (January 2018): 65–76. https://doi.org/10.1016/j.chest.2017.09.022.

PMID
28943279
Full Text

Culver, Bruce H., Brian L. Graham, Allan L. Coates, Jack Wanger, Cristine E. Berry, Patricia K. Clarke, Teal S. Hallstrand, et al. “Recommendations for a Standardized Pulmonary Function Report. An Official American Thoracic Society Technical Statement..” Am J Respir Crit Care Med 196, no. 11 (December 1, 2017): 1463–72. https://doi.org/10.1164/rccm.201710-1981ST.

PMID
29192835
Full Text

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