Olga Ilkayeva, PhD

Assistant Professor in Medicine
Member of Duke Molecular Physiology Institute
Campus mail 300 N Duke St, 48-205, Durham, NC 27701
Phone (919) 479-2370

Olga Ilkayeva, Ph.D., is the Director of the Metabolomics Core Laboratory at Duke Molecular Physiology Institute. She received her Ph.D. training in Cell Regulation from UT Southwestern Medical Center at Dallas, TX. Her postdoctoral research in the laboratory of Dr. Chris Newgard at Duke University Medical Center focused on lipid metabolism and regulation of insulin secretion. As a research scientist at the Stedman Nutrition and Metabolism Center, Dr. Ilkayeva expanded her studies to include the development of targeted mass spectrometry analyses. Currently, she works on developing and validating quantitative mass spectrometry methods used for metabolic profiling of various biological models with emphasis on diabetes, obesity, cardiovascular disease, and the role of gut microbiome in both health and disease.

Education and Training

  • Ph.D., University of Texas Southwestern Medical Center, Medical School, 2002

Publications

Eckhoff, Austin M., Ashton A. Connor, Julie K. M. Thacker, Dan G. Blazer, Harvey G. Moore, Randall P. Scheri, Sandhya A. Lagoo-Deenadayalan, et al. “A Multidimensional Bioinformatic Platform for the Study of Human Response to Surgery.” Ann Surg 275, no. 6 (June 1, 2022): 1094–1102. https://doi.org/10.1097/SLA.0000000000005429.

PMID
35258509
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Selvaraj, Senthil, Zhuxuan Fu, Philip Jones, Lydia C. Kwee, Sheryl L. Windsor, Olga Ilkayeva, Christopher B. Newgard, et al. “Metabolomic Profiling of the Effects of Dapagliflozin in Heart Failure with Reduced Ejection Fraction: DEFINE-HF.” Circulation, May 23, 2022. https://doi.org/10.1161/CIRCULATIONAHA.122.060402.

PMID
35603596
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Trub, Alec G., Gregory R. Wagner, Kristin A. Anderson, Scott B. Crown, Guo-Fang Zhang, J Will Thompson, Olga R. Ilkayeva, et al. “Statin therapy inhibits fatty acid synthase via dynamic protein modifications.” Nature Communications 13, no. 1 (May 10, 2022): 2542. https://doi.org/10.1038/s41467-022-30060-w.

PMID
35538051
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Dvergsten, Jeffrey A., Ann M. Reed, Lawrence Landerman, David S. Pisetsky, Olga Ilkayeva, and Kim M. Huffman. “Metabolomics analysis identifies a lipidomic profile in treatment-naïve juvenile dermatomyositis patients vs healthy control subjects.” Rheumatology (Oxford) 61, no. 4 (April 11, 2022): 1699–1708. https://doi.org/10.1093/rheumatology/keab520.

PMID
34185053
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Bhatt, Dhaval P., C Allie Mills, Kristin A. Anderson, Bárbara J. Henriques, Tânia G. Lucas, Sara Francisco, Juan Liu, et al. “Deglutarylation of glutaryl-CoA dehydrogenase by deacylating enzyme SIRT5 promotes lysine oxidation in mice.” J Biol Chem 298, no. 4 (April 2022): 101723. https://doi.org/10.1016/j.jbc.2022.101723.

PMID
35157847
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Williams, Ashley S., Timothy R. Koves, Yasminye D. Pettway, James A. Draper, Dorothy H. Slentz, Paul A. Grimsrud, Olga R. Ilkayeva, and Deborah M. Muoio. “Nicotinamide riboside supplementation confers marginal metabolic benefits in obese mice without remodeling the muscle acetyl-proteome.” Iscience 25, no. 1 (January 21, 2022): 103635. https://doi.org/10.1016/j.isci.2021.103635.

PMID
35028529
Full Text

Siamakpour-Reihani, Sharareh, Felicia Cao, Jing Lyu, Yi Ren, Andrew B. Nixon, Jichun Xie, Amy T. Bush, et al. “Evaluating immune response and metabolic related biomarkers pre-allogenic hematopoietic stem cell transplant in acute myeloid leukemia.” Plos One 17, no. 6 (2022): e0268963. https://doi.org/10.1371/journal.pone.0268963.

PMID
35700185
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Chandra, Rashmi, Dipendra K. Aryal, Jonathan D. Douros, Rafiq Shahid, Supriya J. Davis, Jonathan E. Campbell, Olga Ilkayeya, et al. “Ildr1 gene deletion protects against diet-induced obesity and hyperglycemia.” Plos One 17, no. 6 (2022): e0270329. https://doi.org/10.1371/journal.pone.0270329.

PMID
35749484
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Lunyera, Joseph, Clarissa J. Diamantidis, Hayden B. Bosworth, Uptal D. Patel, James Bain, Michael J. Muehlbauer, Olga Ilkayeva, et al. “Urine tricarboxylic acid cycle signatures of early-stage diabetic kidney disease.” Metabolomics 18, no. 1 (December 20, 2021): 5. https://doi.org/10.1007/s11306-021-01858-4.

PMID
34928443
Full Text

Levine, Daniel C., Hsin-Yu Kuo, Hee-Kyung Hong, Jonathan Cedernaes, Chelsea Hepler, Alexandra G. Wright, Meredith A. Sommars, et al. “NADH inhibition of SIRT1 links energy state to transcription during time-restricted feeding.” Nat Metab 3, no. 12 (December 2021): 1621–32. https://doi.org/10.1038/s42255-021-00498-1.

PMID
34903884
Full Text

Pages