Olga Ilkayeva, PhD

Assistant Professor in Medicine
Member of Duke Molecular Physiology Institute
Campus mail 300 N Duke St, 48-205, Durham, NC 27701
Phone (919) 479-2370

Education and Training

  • Ph.D., University of Texas Southwestern Medical Center, Medical School, 2002

Publications

Zhao, Yuxing, Brian J. Altman, Jonathan L. Coloff, Catherine E. Herman, Sarah R. Jacobs, Heather L. Wieman, Jessica A. Wofford, et al. “Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1.” Mol Cell Biol 27, no. 12 (June 2007): 4328–39. https://doi.org/10.1128/MCB.00153-07.

PMID
17371841
Full Text

Power, R. A., M. W. Hulver, J. Y. Zhang, J. Dubois, R. M. Marchand, O. Ilkayeva, D. M. Muoio, and R. L. Mynatt. “Carnitine revisited: potential use as adjunctive treatment in diabetes.” Diabetologia 50, no. 4 (April 2007): 824–32. https://doi.org/10.1007/s00125-007-0605-4.

PMID
17310372
Full Text

Zhang, Yong-Mei, Shigeru Chohnan, Kristopher G. Virga, Robert D. Stevens, Olga R. Ilkayeva, Brett R. Wenner, James R. Bain, et al. “Chemical knockout of pantothenate kinase reveals the metabolic and genetic program responsible for hepatic coenzyme A homeostasis.” Chem Biol 14, no. 3 (March 2007): 291–302. https://doi.org/10.1016/j.chembiol.2007.01.013.

PMID
17379144
Full Text

Thyfault, John P., Melanie G. Cree, Donghai Zheng, Jennifer J. Zwetsloot, Edward B. Tapscott, Timothy R. Koves, Olga Ilkayeva, Robert R. Wolfe, Deborah M. Muoio, and G Lynis Dohm. “Contraction of insulin-resistant muscle normalizes insulin action in association with increased mitochondrial activity and fatty acid catabolism.” Am J Physiol Cell Physiol 292, no. 2 (February 2007): C729–39. https://doi.org/10.1152/ajpcell.00311.2006.

PMID
17050616
Full Text

Joseph, Jamie W., Mette V. Jensen, Olga Ilkayeva, Ferdinando Palmieri, Cristina Alárcon, Christopher J. Rhodes, and Christopher B. Newgard. “The mitochondrial citrate/isocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion.” J Biol Chem 281, no. 47 (November 24, 2006): 35624–32. https://doi.org/10.1074/jbc.M602606200.

PMID
17001083
Full Text

Ronnebaum, Sarah M., Olga Ilkayeva, Shawn C. Burgess, Jamie W. Joseph, Danhong Lu, Robert D. Stevens, Thomas C. Becker, A Dean Sherry, Christopher B. Newgard, and Mette V. Jensen. “A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion.” J Biol Chem 281, no. 41 (October 13, 2006): 30593–602. https://doi.org/10.1074/jbc.M511908200.

PMID
16912049
Full Text

Jensen, Mette V., Jamie W. Joseph, Olga Ilkayeva, Shawn Burgess, Danhong Lu, Sarah M. Ronnebaum, Matthew Odegaard, Thomas C. Becker, A Dean Sherry, and Christopher B. Newgard. “Compensatory responses to pyruvate carboxylase suppression in islet beta-cells. Preservation of glucose-stimulated insulin secretion.” J Biol Chem 281, no. 31 (August 4, 2006): 22342–51. https://doi.org/10.1074/jbc.M604350200.

PMID
16740637
Full Text

Koves, Timothy R., Ping Li, Jie An, Takayuki Akimoto, Dorothy Slentz, Olga Ilkayeva, G Lynis Dohm, Zhen Yan, Christopher B. Newgard, and Deborah M. Muoio. “Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency.” J Biol Chem 280, no. 39 (September 30, 2005): 33588–98. https://doi.org/10.1074/jbc.M507621200.

PMID
16079133
Full Text

Hammond, Linda E., Susanne Neschen, Anthony J. Romanelli, Gary W. Cline, Olga R. Ilkayeva, Gerald I. Shulman, Deborah M. Muoio, and Rosalind A. Coleman. “Mitochondrial glycerol-3-phosphate acyltransferase-1 is essential in liver for the metabolism of excess acyl-CoAs.” J Biol Chem 280, no. 27 (July 8, 2005): 25629–36. https://doi.org/10.1074/jbc.M503181200.

PMID
15878874
Full Text

Pages