Patrick Hank Pun, MD

Associate Professor of Medicine
Member of the Duke Clinical Research Institute
Campus mail Duke Box 17969, Durham, NC 27705
Phone (919) 668-8529

My current research interest is in understanding the mechanisms of cardiovascular disease among patients with chronic kidney disease, with a particular focus on the epidemic of sudden cardiac death. The ultimate goal is to reduce the impact of sudden death through improved risk stratification and novel risk mitigation therapies. Current investigations are focused on identifying novel genetic and biomarker risk factors among CKD patients, understanding the interplay of hemodialysis-specific exposures in the development of arrhythmias, and examining the risks and benefits of implantable cardioverter defibrillators among CKD patients using clinical trial and registry data.

Education and Training

  • Fellow in Nephrology, Medicine, Duke University, 2004 - 2007
  • Medical Resident, Medicine, Duke University, 2001 - 2004
  • M.D., Vanderbilt University, 2001

Publications

Pun, PH. "Dialysate potassium concentration: Should mass balance trump electrophysiology?." Seminars in Dialysis (July 19, 2018).

PMID
30027592
Full Text

Pun, PH, and Wyatt, CM. "Utility of implantable cardioverter defibrillators in chronic kidney disease." Kidney International 93, no. 5 (May 2018): 1028-1030.

PMID
29559162
Full Text

Pun, PH, Dupre, M, Anderson, M, Hansen, SM, Tyson, C, Frizzelle, B, Vellano, K, Jollis, J, McNally, B, and Granger, C. "CHARACTERISTICS OF CARDIAC ARREST AND BYSTANDER RESUSCITATION WITHIN OUTPATIENT DIALYSIS CLINICS IN NORTH CAROLINA." March 2018.

Full Text

Pun, PH, and Middleton, JP. "Dialysate Potassium, Dialysate Magnesium, and Hemodialysis Risk." Journal of the American Society of Nephrology : JASN 28, no. 12 (December 2017): 3441-3451. (Review)

PMID
28993507
Full Text

Pun, PH, Goldstein, BA, Gallis, JA, Middleton, JP, and Svetkey, LP. "Serum Potassium Levels and Risk of Sudden Cardiac Death Among Patients With Chronic Kidney Disease and Significant Coronary Artery Disease." Kidney International Reports 2, no. 6 (November 2017): 1122-1131.

PMID
29270520
Full Text

Al-Khatib, SM, Friedman, DJ, Hess, PL, Pun, PH, and Sanders, GD. "Do Implantable Cardioverter-Defibrillators Lower the Risk of Sudden Death and Total Mortality in Patients with End-Stage Renal Disease?." Current Cardiovascular Risk Reports 11, no. 9 (September 2017).

Full Text

Makar, MS, and Pun, PH. "Sudden Cardiac Death Among Hemodialysis Patients." American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation 69, no. 5 (May 2017): 684-695. (Review)

PMID
28223004
Full Text

Pun, PH, Sheng, S, Sanders, G, DeVore, AD, Friedman, D, Fonarow, GC, Heidenreich, PA, Yancy, CW, Hernandez, AF, and Al-Khatib, SM. "Prescription of Guideline-Recommended Implantable Cardioverter Defibrillator and Cardiac Resynchronization Therapy Among Patients Hospitalized With Heart Failure and Varying Degrees of Renal Function." The American journal of cardiology 119, no. 6 (March 2017): 886-892.

PMID
28160975
Full Text

Wang, H, Pun, PH, Kwee, L, Craig, D, Haynes, C, Chryst-Ladd, M, Svetkey, LP, Patel, UD, Hauser, ER, Pollak, MR, Kraus, WE, and Shah, SH. "Apolipoprotein L1 Genetic Variants Are Associated with Chronic Kidney Disease but Not with Cardiovascular Disease in a Population Referred for Cardiac Catheterization." Cardiorenal Medicine 7, no. 2 (February 2017): 96-103.

PMID
28611783
Full Text

Pun, PH, Abdalla, S, Block, GA, Chertow, GM, Correa-Rotter, R, Dehmel, B, Drüeke, TB, Floege, J, Goodman, WG, Herzog, CA, London, GM, Mahaffey, KW, Moe, SM, Parfrey, PS, Wheeler, DC, and Middleton, JP. "Cinacalcet, dialysate calcium concentration, and cardiovascular events in the EVOLVE trial." Hemodialysis international. International Symposium on Home Hemodialysis 20, no. 3 (July 2016): 421-431.

PMID
26564024
Full Text

Pages