Patrick Hank Pun, MD

Associate Professor of Medicine
Member of the Duke Clinical Research Institute
Campus mail Duke Box 17969, Durham, NC 27705
Phone (919) 668-8529

My current research interest is in understanding the mechanisms of cardiovascular disease among patients with chronic kidney disease, with a particular focus on the epidemic of sudden cardiac death. The ultimate goal is to reduce the impact of sudden death through improved risk stratification and novel risk mitigation therapies. Current investigations are focused on identifying novel genetic and biomarker risk factors among CKD patients, understanding the interplay of hemodialysis-specific exposures in the development of arrhythmias, and examining the risks and benefits of implantable cardioverter defibrillators among CKD patients using clinical trial and registry data.

Education and Training

  • Fellow in Nephrology, Medicine, Duke University, 2004 - 2007
  • Medical Resident, Medicine, Duke University, 2001 - 2004
  • M.D., Vanderbilt University, 2001

Publications

Assimon, Magdalene M., Patrick H. Pun, Sana M. Al-Khatib, M Alan Brookhart, Bradley N. Gaynes, Wolfgang C. Winkelmayer, and Jennifer E. Flythe. “Proton pump inhibitors may enhance the risk of citalopram- and escitalopram-associated sudden cardiac death among patients receiving hemodialysis.” Pharmacoepidemiol Drug Saf 31, no. 6 (June 2022): 670–79. https://doi.org/10.1002/pds.5428.

PMID
35285107
Full Text

Assimon, Magdalene M., Patrick H. Pun, Lily Chin-Hua Wang, Sana M. Al-Khatib, M Alan Brookhart, David J. Weber, Wolfgang C. Winkelmayer, and Jennifer E. Flythe. “Analysis of Respiratory Fluoroquinolones and the Risk of Sudden Cardiac Death Among Patients Receiving Hemodialysis.” Jama Cardiol 7, no. 1 (January 1, 2022): 75–83. https://doi.org/10.1001/jamacardio.2021.4234.

PMID
34668928
Full Text

Rymer, Jennifer A., Shuang Li, Patrick H. Pun, Laine Thomas, and Tracy Y. Wang. “Racial Disparities in Invasive Management for Patients With Acute Myocardial Infarction With Chronic Kidney Disease.” Circ Cardiovasc Interv 15, no. 1 (January 2022): e011171. https://doi.org/10.1161/CIRCINTERVENTIONS.121.011171.

PMID
34915722
Full Text

Hein, Aaron M., Julia J. Scialla, Jie-Lena Sun, Stephen J. Greene, Linda K. Shaw, Karen Chiswell, Patrick H. Pun, and Robert J. Mentz. “Estimated Glomerular Filtration Rate Variability in Patients With Heart Failure and Chronic Kidney Disease.” J Card Fail 27, no. 11 (November 2021): 1175–84. https://doi.org/10.1016/j.cardfail.2021.04.016.

PMID
33971291
Full Text

Lunyera, Joseph, Robert M. Clare, Karen Chiswell, Julia J. Scialla, Patrick H. Pun, Kevin L. Thomas, Monique A. Starks, and Clarissa J. Diamantidis. “Racial Differences in AKI Incidence Following Percutaneous Coronary Intervention.” J Am Soc Nephrol 32, no. 3 (March 2021): 654–62. https://doi.org/10.1681/ASN.2020040502.

PMID
33443096
Full Text

Pun, Patrick H., Sean D. Pokorney, and Christopher B. Granger. “Warfarin for Atrial Fibrillation Stroke Prophylaxis in Advanced Kidney Disease: If You Are Not Confused, You Are Not Thinking Clearly.” Jacc Clin Electrophysiol 6, no. 13 (December 14, 2020): 1669–71. https://doi.org/10.1016/j.jacep.2020.07.020.

PMID
33334445
Full Text

Pun, Patrick H., Craig S. Parzynski, Daniel J. Friedman, Gillian Sanders, Jeptha P. Curtis, and Sana M. Al-Khatib. “Trends in Use and In-Hospital Outcomes of Subcutaneous Implantable Cardioverter Defibrillators in Patients Undergoing Long-Term Dialysis.” Clin J Am Soc Nephrol 15, no. 11 (November 6, 2020): 1622–30. https://doi.org/10.2215/CJN.07920520.

PMID
32967922
Full Text

Hofacker, Samuel A., Matthew E. Dupre, Kimberly Vellano, Bryan McNally, Monique Anderson Starks, Myles Wolf, Laura P. Svetkey, and Patrick H. Pun. “Association between patient race and staff resuscitation efforts after cardiac arrest in outpatient dialysis clinics: A study from the CARES surveillance group.” Resuscitation 156 (November 2020): 42–50. https://doi.org/10.1016/j.resuscitation.2020.07.036.

PMID
32860854
Full Text

Pages