Patrick Hank Pun, MD

Associate Professor of Medicine
Member of the Duke Clinical Research Institute
Campus mail Duke Box 17969, Durham, NC 27705
Phone (919) 668-8529

My current research interest is in understanding the mechanisms of cardiovascular disease among patients with chronic kidney disease, with a particular focus on the epidemic of sudden cardiac death. The ultimate goal is to reduce the impact of sudden death through improved risk stratification and novel risk mitigation therapies. Current investigations are focused on identifying novel genetic and biomarker risk factors among CKD patients, understanding the interplay of hemodialysis-specific exposures in the development of arrhythmias, and examining the risks and benefits of implantable cardioverter defibrillators among CKD patients using clinical trial and registry data.

Education and Training

  • Fellow in Nephrology, Medicine, Duke University, 2004 - 2007
  • Medical Resident, Medicine, Duke University, 2001 - 2004
  • M.D., Vanderbilt University, 2001

Publications

Pun, Patrick H., and Sana M. Al-Khatib. “Implantable Defibrillators for Primary Prevention of Sudden Death in Patients on Dialysis..” Am J Kidney Dis 74, no. 6 (December 2019): 857–60. https://doi.org/10.1053/j.ajkd.2019.05.002.

PMID
31257051
Full Text

Pun, Patrick H., Matthew E. Dupre, Monique A. Starks, Clark Tyson, Kimberly Vellano, Laura P. Svetkey, Steen Hansen, et al. “Outcomes for Hemodialysis Patients Given Cardiopulmonary Resuscitation for Cardiac Arrest at Outpatient Dialysis Clinics..” J Am Soc Nephrol, February 7, 2019. https://doi.org/10.1681/ASN.2018090911.

PMID
30733235
Full Text

Massicotte-Azarniouch, David, John Paul Kuwornu, Megan K. McCallum, Nisha Bansal, Ngan Lam, Amber O. Molnar, Patrick Pun, Deborah Zimmerman, Amit X. Garg, and Manish M. Sood. “The Association of Kidney Function and Albuminuria With the Risk and Outcomes of Syncope: A Population-Based Cohort Study..” Can J Cardiol 34, no. 12 (December 2018): 1631–40. https://doi.org/10.1016/j.cjca.2018.08.033.

PMID
30527152
Full Text

Pun, Patrick H. “Dialysate potassium concentration: Should mass balance trump electrophysiology?.” Semin Dial 31, no. 6 (November 2018): 569–75. https://doi.org/10.1111/sdi.12738.

PMID
30027592
Full Text

Pun, Patrick Hank, Matthew Dupre, Monique Anderson, Steen M. Hansen, Clark Tyson, Brian Frizzelle, Kimberly Vellano, James Jollis, Bryan McNally, and Christopher Granger. “CHARACTERISTICS OF CARDIAC ARREST AND BYSTANDER RESUSCITATION WITHIN OUTPATIENT DIALYSIS CLINICS IN NORTH CAROLINA.” In Journal of the American College of Cardiology, 71:A303–A303. Elsevier BV, 2018. https://doi.org/10.1016/s0735-1097(18)30844-1.

Full Text

Pun, Patrick H., Benjamin A. Goldstein, John A. Gallis, John P. Middleton, and Laura P. Svetkey. “Serum Potassium Levels and Risk of Sudden Cardiac Death Among Patients With Chronic Kidney Disease and Significant Coronary Artery Disease..” Kidney Int Rep 2, no. 6 (November 2017): 1122–31. https://doi.org/10.1016/j.ekir.2017.07.001.

PMID
29270520
Full Text

Al-Khatib, S. M., D. J. Friedman, P. L. Hess, P. H. Pun, and G. D. Sanders. “Do Implantable Cardioverter-Defibrillators Lower the Risk of Sudden Death and Total Mortality in Patients with End-Stage Renal Disease?.” Current Cardiovascular Risk Reports 11, no. 9 (September 1, 2017). https://doi.org/10.1007/s12170-017-0551-8.

Full Text

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