Patrick Hank Pun, MD

Associate Professor of Medicine
Member of the Duke Clinical Research Institute
Campus mail Duke Box 17969, Durham, NC 27705
Phone (919) 668-8529

My current research interest is in understanding the mechanisms of cardiovascular disease among patients with chronic kidney disease, with a particular focus on the epidemic of sudden cardiac death. The ultimate goal is to reduce the impact of sudden death through improved risk stratification and novel risk mitigation therapies. Current investigations are focused on identifying novel genetic and biomarker risk factors among CKD patients, understanding the interplay of hemodialysis-specific exposures in the development of arrhythmias, and examining the risks and benefits of implantable cardioverter defibrillators among CKD patients using clinical trial and registry data.

Education and Training

  • Fellow in Nephrology, Medicine, Duke University, 2004 - 2007
  • Medical Resident, Medicine, Duke University, 2001 - 2004
  • M.D., Vanderbilt University, 2001

Publications

Al-Khatib, S. M., D. J. Friedman, P. L. Hess, P. H. Pun, and G. D. Sanders. “Do Implantable Cardioverter-Defibrillators Lower the Risk of Sudden Death and Total Mortality in Patients with End-Stage Renal Disease?” Current Cardiovascular Risk Reports 11, no. 9 (September 1, 2017). https://doi.org/10.1007/s12170-017-0551-8.

Full Text

Pun, Patrick H., Shubin Sheng, Gillian Sanders, Adam D. DeVore, Daniel Friedman, Gregg C. Fonarow, Paul A. Heidenreich, Clyde W. Yancy, Adrian F. Hernandez, and Sana M. Al-Khatib. “Prescription of Guideline-Recommended Implantable Cardioverter Defibrillator and Cardiac Resynchronization Therapy Among Patients Hospitalized With Heart Failure and Varying Degrees of Renal Function.” Am J Cardiol 119, no. 6 (March 15, 2017): 886–92. https://doi.org/10.1016/j.amjcard.2016.11.043.

PMID
28160975
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Wang, Hanghang, Patrick H. Pun, Lydia Kwee, Damian Craig, Carol Haynes, Megan Chryst-Ladd, Laura P. Svetkey, et al. “Apolipoprotein L1 Genetic Variants Are Associated with Chronic Kidney Disease but Not with Cardiovascular Disease in a Population Referred for Cardiac Catheterization.” Cardiorenal Med 7, no. 2 (February 2017): 96–103. https://doi.org/10.1159/000453458.

PMID
28611783
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Wang, Hanghang, Patrick Pun, Lydia Kwee, Damian Craig, Carol Hanynes, Elizabeth Hauser, Simon Gregory, et al. “Genetic Modifiers of Renal Dysfunction in African-American APOL1 Carriers Identified Through a Genome-Wide Screen.” In Circulation, Vol. 134, 2016.

Scholars@Duke

Pun, Patrick H., Safa Abdalla, Geoffrey A. Block, Glenn M. Chertow, Ricardo Correa-Rotter, Bastian Dehmel, Tilman B. Drüeke, et al. “Cinacalcet, dialysate calcium concentration, and cardiovascular events in the EVOLVE trial.” Hemodial Int 20, no. 3 (July 2016): 421–31. https://doi.org/10.1111/hdi.12382.

PMID
26564024
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Pun, Patrick H., Anne S. Hellkamp, Gillian D. Sanders, John P. Middleton, Stephen C. Hammill, Hussein R. Al-Khalidi, Lesley H. Curtis, Gregg C. Fonarow, and Sana M. Al-Khatib. “Primary prevention implantable cardioverter defibrillators in end-stage kidney disease patients on dialysis: a matched cohort study.” Nephrol Dial Transplant 30, no. 5 (May 2015): 829–35. https://doi.org/10.1093/ndt/gfu274.

PMID
25404241
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Hess, Paul L., Anne S. Hellkamp, Eric D. Peterson, Gillian D. Sanders, Hussein R. Al-Khalidi, Lesley H. Curtis, Bradley G. Hammill, et al. “Survival after primary prevention implantable cardioverter-defibrillator placement among patients with chronic kidney disease.” Circ Arrhythm Electrophysiol 7, no. 5 (October 2014): 793–99. https://doi.org/10.1161/CIRCEP.114.001455.

PMID
25038119
Full Text

Pun, Patrick H., Sana M. Al-Khatib, Joo Yoon Han, Rex Edwards, Gust H. Bardy, J Thomas Bigger, Alfred E. Buxton, et al. “Implantable cardioverter-defibrillators for primary prevention of sudden cardiac death in CKD: a meta-analysis of patient-level data from 3 randomized trials.” Am J Kidney Dis 64, no. 1 (July 2014): 32–39. https://doi.org/10.1053/j.ajkd.2013.12.009.

PMID
24518128
Full Text

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