Endocrinology, Metabolism, and Nutrition

Paul Grimsrud, PhD

Assistant Professor in Medicine
Member of Duke Molecular Physiology Institute
Campus mail 104775, Durham, NC 27701
Phone (919) 684-0631
Email address paul.grimsrud@duke.edu

Paul Grimsrud is an Assistant professor of Medicine—in the Division of Endocrinology, Metabolism, and Nutrition—and Proteomics Section Leader at the Duke Molecular Physiology Institute. He completed a PhD in Biochemistry at the University of Minnesota-Twin Cities and a postdoctoral fellowship at the University of Wisconsin-Madison. His research combines mass spectrometry-based proteomics with complementary biochemical approaches to characterize the regulation of metabolism and signaling by protein post-translational modifications (PTMs). He is particularly interested in mechanisms that link altered mitochondrial function to metabolic diseases, such as heart failure, type 2 diabetes, and cancer. He works with colleagues to apply quantitative PTM measurements to relevant model systems, leverage bioinformatics tools to develop testable hypotheses from large-scale data, and characterize mechanisms of PTM-mediated metabolic control.

Education and Training

  • Ph.D., University of Minnesota, Twin Cities, 2008

Grants

Publications

Bareja, Akshay, James A. Draper, Lauren H. Katz, David E. Lee, Paul A. Grimsrud, and James P. White. “Chronic caloric restriction maintains a youthful phosphoproteome in aged skeletal muscle.” Mech Ageing Dev 195 (April 2021): 111443. https://doi.org/10.1016/j.mad.2021.111443.

PMID
33529682
Full Text

Mills, Christine A., Xianxi Wang, Dhaval P. Bhatt, Paul A. Grimsrud, Jacob Peter Matson, Debojyoti Lahiri, Daniel J. Burke, Jeanette Gowen Cook, Matthew D. Hirschey, and Michael J. Emanuele. “Sirtuin 5 Is Regulated by the SCFCyclin F Ubiquitin Ligase and Is Involved in Cell Cycle Control.” Mol Cell Biol 41, no. 2 (January 25, 2021). https://doi.org/10.1128/MCB.00269-20.

PMID
33168699
Full Text

Davidson, Michael T., Paul A. Grimsrud, Ling Lai, James A. Draper, Kelsey H. Fisher-Wellman, Tara M. Narowski, Dennis M. Abraham, Timothy R. Koves, Daniel P. Kelly, and Deborah M. Muoio. “Extreme Acetylation of the Cardiac Mitochondrial Proteome Does Not Promote Heart Failure.” Circ Res 127, no. 8 (September 25, 2020): 1094–1108. https://doi.org/10.1161/CIRCRESAHA.120.317293.

PMID
32660330
Full Text

Williams, Ashley S., Timothy R. Koves, Michael T. Davidson, Scott B. Crown, Kelsey H. Fisher-Wellman, Maria J. Torres, James A. Draper, et al. “Disruption of Acetyl-Lysine Turnover in Muscle Mitochondria Promotes Insulin Resistance and Redox Stress without Overt Respiratory Dysfunction.” Cell Metab 31, no. 1 (January 7, 2020): 131-147.e11. https://doi.org/10.1016/j.cmet.2019.11.003.

PMID
31813822
Full Text

Fisher-Wellman, Kelsey H., James A. Draper, Michael T. Davidson, Ashley S. Williams, Tara M. Narowski, Dorothy H. Slentz, Olga R. Ilkayeva, et al. “Respiratory Phenomics across Multiple Models of Protein Hyperacylation in Cardiac Mitochondria Reveals a Marginal Impact on Bioenergetics.” Cell Rep 26, no. 6 (February 5, 2019): 1557-1572.e8. https://doi.org/10.1016/j.celrep.2019.01.057.

PMID
30726738
Full Text

Hershberger, Kathleen A., Dennis M. Abraham, Juan Liu, Jason W. Locasale, Paul A. Grimsrud, and Matthew D. Hirschey. “Ablation of Sirtuin5 in the postnatal mouse heart results in protein succinylation and normal survival in response to chronic pressure overload.” J Biol Chem 293, no. 27 (July 6, 2018): 10630–45. https://doi.org/10.1074/jbc.RA118.002187.

PMID
29769314
Full Text

Peterson, Brett S., Jonathan E. Campbell, Olga Ilkayeva, Paul A. Grimsrud, Matthew D. Hirschey, and Christopher B. Newgard. “Remodeling of the Acetylproteome by SIRT3 Manipulation Fails to Affect Insulin Secretion or β Cell Metabolism in the Absence of Overnutrition.” Cell Rep 24, no. 1 (July 3, 2018): 209-223.e6. https://doi.org/10.1016/j.celrep.2018.05.088.

PMID
29972782
Full Text

White, Phillip J., Robert W. McGarrah, Paul A. Grimsrud, Shih-Chia Tso, Wen-Hsuan Yang, Jonathan M. Haldeman, Thomas Grenier-Larouche, et al. “The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase.” Cell Metab 27, no. 6 (June 5, 2018): 1281-1293.e7. https://doi.org/10.1016/j.cmet.2018.04.015.

PMID
29779826
Full Text

Martin, Angelical S., Dennis M. Abraham, Kathleen A. Hershberger, Dhaval P. Bhatt, Lan Mao, Huaxia Cui, Juan Liu, et al. “Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich's ataxia cardiomyopathy model.” Jci Insight 2, no. 14 (July 20, 2017). https://doi.org/10.1172/jci.insight.93885.

PMID
28724806
Full Text

Anderson, Kristin A., Frank K. Huynh, Kelsey Fisher-Wellman, J Darren Stuart, Brett S. Peterson, Jonathan D. Douros, Gregory R. Wagner, et al. “SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion.” Cell Metabolism 25, no. 4 (April 2017): 838-855.e15. https://doi.org/10.1016/j.cmet.2017.03.003.

PMID
28380376
Full Text

Pages