Paul Kelly Marcom, MD

Associate Professor of Medicine
Member of the Duke Cancer Institute
Campus mail 10 Bryan Searle Drive, Room 461 Seeley G. Mudd Building, Durham, NC 27710
Phone (919) 684-3877
Email address marco001@mc.duke.edu

Basic Science:
-Germline and somatic genetic changes in cancer, particularly breast cancer. Ongoing efforts with Dr. Joseph R. Nevins in Department of Genetics.

Translational:
-Identification and management of individuals and families with hereditary cancer risk.
-Communication of cancer risk information to individuals and families.
-Breast cancer prevention.
-Optimizing management of early breast cancer.
-Treatment of metastatic breast cancer

Dr. Marcom's research has focused on two main areas. First, in the laboratory of Dr. Joseph Nevins in the Department of Genetics, he has been investigating alterations in cell cycle control in cancer. Primarily, these experiments have looked for primary alterations in the E2F family of genes, and their possible contribution to developing cancer. More recently, he has been involved with issues regarding genetic predisposition to developing cancer.

Investigations of cell cycle alterations have employed standard molecular biology techniques to analyze both cell lines and primary tumors for alterations in control of the retinoblastoma pathway, and consequent effects on E2F control.

Clinically, Dr. Marcom works as a medical oncologist in the multidisciplinary breast cancer clinic. He participates in clinical trials investigating new chemotherapeutic and biologic treatments. In addition, he is developing a new high risk, familial cancer clinic. This clinic will see patients and families thought to be at high risk of developing malignancies, and will interface with the forming Cancer Genetics Network. Patients and families will be counseled about their cancer risk, and identified for studying issues related to cancer genetics: determining penetrance of identified gene mutations, determining factors modifying genetic risk, prevention studies, etc. Finally, he also plans to be involved in clinical evaluation of drugs inhibiting tumor angiogenesis.

Areas of developing expertise include cell cycle alterations in malignancy, breast cancer, and hereditary cancer genetics.

Breast cancer, cell cycle, genetics, familial cancer, prognostic factors, angiogenesis

In Their Words

Education and Training

  • Fellow In Hematology Oncology, Medicine, Duke University, 1992 - 1995
  • Medical Resident, Medicine, Duke University, 1989 - 1992
  • M.D., Baylor University, 1989

Publications

Harowicz, MR, Saha, A, Grimm, LJ, Marcom, PK, Marks, JR, Hwang, ES, and Mazurowski, MA. "Can algorithmically assessed MRI features predict which patients with a preoperative diagnosis of ductal carcinoma in situ are upstaged to invasive breast cancer? (Accepted)." Journal of magnetic resonance imaging : JMRI 46, no. 5 (November 2017): 1332-1340.

PMID
28181348
Full Text

Buchanan, AH, Voils, CI, Schildkraut, JM, Fine, C, Horick, NK, Marcom, PK, Wiggins, K, and Skinner, CS. "Adherence to Recommended Risk Management among Unaffected Women with a BRCA Mutation." Journal of genetic counseling 26, no. 1 (February 2017): 79-92.

PMID
27265406
Full Text

Harowicz, MR, Robinson, TJ, Dinan, MA, Saha, A, Marks, JR, Marcom, PK, and Mazurowski, MA. "Algorithms for prediction of the Oncotype DX recurrence score using clinicopathologic data: a review and comparison using an independent dataset." Breast cancer research and treatment 162, no. 1 (February 2017): 1-10. (Review)

PMID
28064383
Full Text

Nelson, ER, Li, S, Kennedy, M, Payne, S, Kilibarda, K, Groth, J, Bowie, M, Parilla-Castellar, E, de Ridder, G, Marcom, PK, Lyes, M, Peterson, BL, Cook, M, Pizzo, SV, McDonnell, DP, and Bachelder, RE. "Chemotherapy enriches for an invasive triple-negative breast tumor cell subpopulation expressing a precursor form of N-cadherin on the cell surface." Oncotarget 7, no. 51 (December 2016): 84030-84042.

PMID
27768598
Full Text

Kamal, A, Zhang, T, Power, S, and Marcom, PK. "Is advanced imaging in early-stage breast cancer ever warranted? Reconciling clinical judgment with common quality measures." JNCCN Journal of the National Comprehensive Cancer Network 14, no. 8 (August 1, 2016): 993-998.

Full Text

Kamal, A, Zhang, T, Power, S, and Marcom, PK. "Is Advanced Imaging in Early-Stage Breast Cancer Ever Warranted? Reconciling Clinical Judgment With Common Quality Measures." Journal of the National Comprehensive Cancer Network : JNCCN 14, no. 8 (August 2016): 993-998.

PMID
27496115
Full Text

Daly, MB, Pilarski, R, Axilbund, JE, Berry, M, Buys, SS, Crawford, B, Farmer, M, Friedman, S, Garber, JE, Khan, S, Klein, C, Kohlmann, W, Kurian, A, Litton, JK, Madlensky, L, Marcom, PK, Merajver, SD, Offit, K, Pal, T, Rana, H, Reiser, G, Robson, ME, Shannon, KM, Swisher, E, Voian, NC, Weitzel, JN, Whelan, A, Wick, MJ, Wiesner, GL, Dwyer, M, Kumar, R, and Darlow, S. "Genetic/familial high-risk assessment: Breast and ovarian, version 2.2015 Featured updates to the NCCN guidelines." JNCCN Journal of the National Comprehensive Cancer Network 14, no. 2 (February 1, 2016): 153-162. (Review)

Scholars@Duke

Gradishar, WJ, Anderson, BO, Balassanian, R, Blair, SL, Burstein, HJ, Cyr, A, Elias, AD, Farrar, WB, Forero, A, Giordano, SH, Goetz, M, Goldstein, LJ, Hudis, CA, Isakoff, SJ, Marcom, PK, Mayer, IA, McCormick, B, Moran, M, Patel, SA, Pierce, LJ, Reed, EC, Salerno, KE, Schwartzberg, LS, Smith, KL, Smith, ML, Soliman, H, Somlo, G, Telli, M, Ward, JH, Shead, DA, and Kumar, R. "Breast cancer, version 1.2016 featured updates to the NCCN guidelines." JNCCN Journal of the National Comprehensive Cancer Network 13, no. 12 (December 1, 2015): 1475-1485.

Scholars@Duke

Buchanan, AH, Datta, SK, Skinner, CS, Hollowell, GP, Beresford, HF, Freeland, T, Rogers, B, Boling, J, Marcom, PK, and Adams, MB. "Randomized Trial of Telegenetics vs. In-Person Cancer Genetic Counseling: Cost, Patient Satisfaction and Attendance." Journal of genetic counseling 24, no. 6 (December 2015): 961-970.

PMID
25833335
Full Text

Mazurowski, MA, Grimm, LJ, Zhang, J, Marcom, PK, Yoon, SC, Kim, C, Ghate, SV, and Johnson, KS. "Recurrence-free survival in breast cancer is associated with MRI tumor enhancement dynamics quantified using computer algorithms." European journal of radiology 84, no. 11 (November 2015): 2117-2122.

PMID
26210095
Full Text

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