Rebekah Ryanne Wu, MD

Associate Professor of Medicine
Member of Duke Center for Applied Genomics and Precision Medicine
Campus mail 304 Research Drive, Box 90141, Durham, NC 27708
Phone (919) 684-5479
Email address ryanne.wu@duke.edu

Dr. Wu is an internal medicine physician and health services researcher. Her main research interest is studying the implementation of precision medicine applications to improve clinical care. She is involved in projects currently looking at a patient-facing family history risk assessment tool, MeTree, which provides individualized risk stratification and clinical decision support recommendations to clinicians and patients. In addition she is also involved in a large scale sequencing program in Singapore looking at the intersection of family health history and genomics to better understand how these data elements can complement one another and create more precise risk predictions.  She is a member of NHGRI's IGNITE network as a co-investigator on a multi-site pragmatic clinical trial of the impact of pharmacogenetic testing on management of depression and acute, and chronic pain.  She is the implementation science advisor for the VA's Pharmacogenomic Testing for Veterans (PHASER) program, which is working to complete preemptive PGx testing on up to 250,000 Veterans by 2024.

Education and Training

  • Chief Resident, Internal Medicine, Georgetown University School of Medicine, 2009 - 2010
  • Resident, Internal Medicine, Georgetown University School of Medicine, 2006 - 2009
  • M.D., University of North Carolina, Chapel Hill, School of Medicine, 2006

Publications

Dong, Olivia M., Megan C. Roberts, R Ryanne Wu, Corrine I. Voils, Nina Sperber, Kara L. Gavin, Jill Bates, et al. “Evaluation of the Veterans Affairs Pharmacogenomic Testing for Veterans (PHASER) clinical program at initial test sites.” Pharmacogenomics 22, no. 17 (November 2021): 1121–33. https://doi.org/10.2217/pgs-2021-0089.

PMID
34704830
Full Text

Yoon, Sungwon, Hendra Goh, Si Ming Fung, Shihui Tang, David Matchar, Geoffrey S. Ginsburg, Lori A. Orlando, Joanne Ngeow, and Rebekah Ryanne Wu. “Experience and Perceptions of a Family Health History Risk Assessment Tool among Multi-Ethnic Asian Breast Cancer Patients.” J Pers Med 11, no. 10 (October 19, 2021). https://doi.org/10.3390/jpm11101046.

PMID
34683187
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Levy, Kenneth D., Kathryn Blake, Colette Fletcher-Hoppe, James Franciosi, Daisuke Goto, James K. Hicks, Ann M. Holmes, et al. “Correction: Opportunities to implement a sustainable genomic medicine program: lessons learned from the IGNITE Network.” Genet Med 23, no. 10 (October 2021): 2020. https://doi.org/10.1038/s41436-020-01054-0.

PMID
33288881
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Bylstra, Yasmin, Weng Khong Lim, Sylvia Kam, Koei Wan Tham, R Ryanne Wu, Jing Xian Teo, Sonia Davila, et al. “Correction to: Family history assessment significantly enhances delivery of precision medicine in the genomics era.” Genome Med 13, no. 1 (July 5, 2021): 109. https://doi.org/10.1186/s13073-021-00916-9.

PMID
34225778
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Ginsburg, Geoffrey S., Larisa H. Cavallari, Hrishikesh Chakraborty, Rhonda M. Cooper-DeHoff, Paul R. Dexter, Michael T. Eadon, Bart S. Ferket, et al. “Establishing the value of genomics in medicine: the IGNITE Pragmatic Trials Network.” Genet Med 23, no. 7 (July 2021): 1185–91. https://doi.org/10.1038/s41436-021-01118-9.

PMID
33782552
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Fung, Si Ming, R Ryanne Wu, Rachel A. Myers, Jasper Goh, Geoffrey S. Ginsburg, David Matchar, Lori A. Orlando, and Joanne Ngeow. “Clinical implementation of an oncology-specific family health history risk assessment tool.” Hered Cancer Clin Pract 19, no. 1 (March 20, 2021): 20. https://doi.org/10.1186/s13053-021-00177-y.

PMID
33743786
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Bylstra, Yasmin, Weng Khong Lim, Sylvia Kam, Koei Wan Tham, R Ryanne Wu, Jing Xian Teo, Sonia Davila, et al. “Family history assessment significantly enhances delivery of precision medicine in the genomics era.” Genome Med 13, no. 1 (January 7, 2021): 3. https://doi.org/10.1186/s13073-020-00819-1.

PMID
33413596
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Orlando, Lori A., R Ryanne Wu, Rachel A. Myers, Joan Neuner, Catherine McCarty, Irina V. Haller, Melissa Harry, et al. “At the intersection of precision medicine and population health: an implementation-effectiveness study of family health history based systematic risk assessment in primary care.” Bmc Health Serv Res 20, no. 1 (November 7, 2020): 1015. https://doi.org/10.1186/s12913-020-05868-1.

PMID
33160339
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Wu, R Ryanne, Rehena Sultana, Yasmin Bylstra, Saumya Jamuar, Sonia Davila, Weng Khong Lim, Geoffrey S. Ginsburg, et al. “Evaluation of family health history collection methods impact on data and risk assessment outcomes.” Prev Med Rep 18 (June 2020): 101072. https://doi.org/10.1016/j.pmedr.2020.101072.

PMID
32181122
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Bylstra, Y., S. Davila, W. K. Lim, R. Wu, J. X. Teo, S. Kam, T. Lysaght, et al. “Implementation of genomics in medical practice to deliver precision medicine for an Asian population.” Npj Genomic Medicine 4, no. 1 (December 1, 2019). https://doi.org/10.1038/s41525-019-0085-8.

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