Robert Frank Spurney, MD

Professor of Medicine
Member of the Duke Cancer Institute
Campus mail Box 103015, Duke University Medical Center, Durham, NC 27710
Phone (919) 684-9729
Email address spurn002@mc.duke.edu

Dr. Spurney’s research has focused on the role of G protein coupled receptors (GPCRs) in regulating cellular physiology both in normal and disease states as well as the regulatory mechanisms that modulate GPCR responsiveness at the molecular level. These studies have centered on two major themes. The first investigates the role of GPCR signaling pathways in regulating podocyte function using cultured podocytes and transgenic animals models. The second area of research involves the role of GPCR kinases (GRKs) and arrestin scaffolding proteins in modulating GPCR signaling in bone forming osteoblasts using cultured osteoblast cell lines as well as genetically modified mice including transgenic models and knockout animals. The long-term goal of these studies is to identify novel therapeutic targets that may useful for treating disease processes such as glomerulonephritis and osteoporosis.

Please see the Duke Nephrology Division website for more detailed information.

Education and Training

  • Fellow in Nephrology, Medicine, Duke University, 1987 - 1990
  • Senior Assistant Resident, Medicine, Duke University, 1986 - 1987
  • Resident in Pathology, Pathology, Duke University, 1985 - 1986
  • Medical Resident, Medicine, Duke University, 1983 - 1985
  • M.D., Ohio State University, 1983

Publications

Wang, L, Sha, Y, Bai, J, Eisner, W, Sparks, MA, Buckley, AF, and Spurney, RF. "Podocyte-specific knockout of cyclooxygenase 2 exacerbates diabetic kidney disease." American journal of physiology. Renal physiology 313, no. 2 (August 2017): F430-F439.

PMID
28490532
Full Text

Hall, G, and Spurney, RF. "Losing their footing: Rac1 signaling causes podocyte detachment and FSGS." Kidney international 92, no. 2 (August 2017): 283-285.

PMID
28709595
Full Text

Johnson, SA, and Spurney, RF. "Twenty years after ACEIs and ARBs: emerging treatment strategies for diabetic nephropathy." American journal of physiology. Renal physiology 309, no. 10 (November 2015): F807-F820. (Review)

PMID
26336162
Full Text

Wang, L, Jirka, G, Rosenberg, PB, Buckley, AF, Gomez, JA, Fields, TA, Winn, MP, and Spurney, RF. "Gq signaling causes glomerular injury by activating TRPC6." The Journal of clinical investigation 125, no. 5 (May 2015): 1913-1926.

PMID
25844902
Full Text

Hall, G, Gbadegesin, RA, Lavin, P, Wu, G, Liu, Y, Oh, EC, Wang, L, Spurney, RF, Eckel, J, Lindsey, T, Homstad, A, Malone, AF, Phelan, PJ, Shaw, A, Howell, DN, Conlon, PJ, Katsanis, N, and Winn, MP. "A novel missense mutation of Wilms' Tumor 1 causes autosomal dominant FSGS." Journal of the American Society of Nephrology : JASN 26, no. 4 (April 2015): 831-843.

PMID
25145932
Full Text

Gbadegesin, RA, Hall, G, Adeyemo, A, Hanke, N, Tossidou, I, Burchette, J, Wu, G, Homstad, A, Sparks, MA, Gomez, J, Jiang, R, Alonso, A, Lavin, P, Conlon, P, Korstanje, R, Stander, MC, Shamsan, G, Barua, M, Spurney, R, Singhal, PC, Kopp, JB, Haller, H, Howell, D, Pollak, MR, Shaw, AS, Schiffer, M, and Winn, MP. "Mutations in the gene that encodes the F-actin binding protein anillin cause FSGS." Journal of the American Society of Nephrology : JASN 25, no. 9 (September 2014): 1991-2002.

PMID
24676636
Full Text

Hall, G, Rowell, J, Farinelli, F, Gbadegesin, RA, Lavin, P, Wu, G, Homstad, A, Malone, A, Lindsey, T, Jiang, R, Spurney, R, Tomaselli, GF, Kass, DA, and Winn, MP. "Phosphodiesterase 5 inhibition ameliorates angiontensin II-induced podocyte dysmotility via the protein kinase G-mediated downregulation of TRPC6 activity." American journal of physiology. Renal physiology 306, no. 12 (June 2014): F1442-F1450.

PMID
24740790
Full Text

Ortiz-Melo, DI, and Spurney, RF. "Special deLIVERy: podocyte injury promotes renal angiotensin II generation from liver-derived angiotensinogen." Kidney international 85, no. 5 (May 2014): 1009-1011.

PMID
24786873
Full Text

Wang, L, Tang, Y, Eisner, W, Sparks, MA, Buckley, AF, and Spurney, RF. "Augmenting podocyte injury promotes advanced diabetic kidney disease in Akita mice." Biochemical and Biophysical Research Communications 444, no. 4 (February 21, 2014): 622-627.

Full Text

Wang, L, Tang, Y, Eisner, W, Sparks, MA, Buckley, AF, and Spurney, RF. "Augmenting podocyte injury promotes advanced diabetic kidney disease in Akita mice." Biochemical and biophysical research communications 444, no. 4 (February 2014): 622-627.

PMID
24491571
Full Text

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