Robert Frank Spurney, MD

Professor of Medicine
Member of the Duke Cancer Institute
Campus mail Box 103015, Duke University Medical Center, Durham, NC 27710
Phone (919) 684-9729
Email address spurn002@mc.duke.edu

Dr. Spurney’s research has focused on the role of G protein coupled receptors (GPCRs) in regulating cellular physiology both in normal and disease states as well as the regulatory mechanisms that modulate GPCR responsiveness at the molecular level. These studies have centered on two major themes. The first investigates the role of GPCR signaling pathways in regulating podocyte function using cultured podocytes and transgenic animals models. The second area of research involves the role of GPCR kinases (GRKs) and arrestin scaffolding proteins in modulating GPCR signaling in bone forming osteoblasts using cultured osteoblast cell lines as well as genetically modified mice including transgenic models and knockout animals. The long-term goal of these studies is to identify novel therapeutic targets that may useful for treating disease processes such as glomerulonephritis and osteoporosis.

Please see the Duke Nephrology Division website for more detailed information.

Education and Training

  • Fellow in Nephrology, Medicine, Duke University, 1987 - 1990
  • Senior Assistant Resident, Medicine, Duke University, 1986 - 1987
  • Resident in Pathology, Pathology, Duke University, 1985 - 1986
  • Medical Resident, Medicine, Duke University, 1983 - 1985
  • M.D., Ohio State University, 1983

Publications

Wang, Liming, Yuping Tang, Anne F. Buckley, and Robert F. Spurney. “Blockade of the natriuretic peptide clearance receptor attenuates proteinuria in a mouse model of focal segmental glomerulosclerosis.” Physiol Rep 9, no. 21 (November 2021): e15095. https://doi.org/10.14814/phy2.15095.

PMID
34755480
Full Text

Ren, Jiafa, Yuemei Xu, Xiaohan Lu, Liming Wang, Shintaro Ide, Gentzon Hall, Tomokazu Souma, Jamie R. Privratsky, Robert F. Spurney, and Steven D. Crowley. “Twist1 in podocytes ameliorates podocyte injury and proteinuria by limiting CCL2-dependent macrophage infiltration.” Jci Insight 6, no. 15 (August 9, 2021). https://doi.org/10.1172/jci.insight.148109.

PMID
34369383
Full Text

Lane, Brandon M., Susan Murray, Katherine Benson, Agnieszka Bierzynska, Megan Chryst-Stangl, Liming Wang, Guanghong Wu, et al. “A Rare Autosomal Dominant Variant in Regulator of Calcineurin Type 1 (RCAN1) Gene Confers Enhanced Calcineurin Activity and May Cause FSGS.” J Am Soc Nephrol, April 16, 2021. https://doi.org/10.1681/ASN.2020081234.

PMID
33863784
Full Text

Hall, Gentzon, G Michelle Ducasa, Brandon M. Lane, Max Lagas, Maria E. Kovalik, Olivia G. Gregory, Guanghong Wu, et al. “THE LMX1 beta R246Q MUTATION INDUCES PODOCYTE INJURY THROUGH DYSREGULATION OF CHOLESTEROL TRANSPORT GENE EXPRESSION.” In Nephrology Dialysis Transplantation, Vol. 34. OXFORD UNIV PRESS, 2019.

Scholars@Duke

Hall, Gentzon, Sidharth K. Sethi, Brandon M. Lane, Matthew G. Sampson, Olivia G. Gregory, Maria E. Kovalik, Megan Chryst-Stangl, et al. “A NOVEL HETEROZYGOUS MISSENSE MUTATION OF WILMS' TUMOR 1 MAY CAUSE FSGS THROUGH DYSREGULATED EXPRESSION OF ARHGAP24.” In Nephrology Dialysis Transplantation, Vol. 34. OXFORD UNIV PRESS, 2019.

Scholars@Duke

Wang, Liming, Jae-Hyung Chang, Anne F. Buckley, and Robert F. Spurney. “Knockout of TRPC6 promotes insulin resistance and exacerbates glomerular injury in Akita mice.” Kidney Int 95, no. 2 (February 2019): 321–32. https://doi.org/10.1016/j.kint.2018.09.026.

PMID
30665571
Full Text

Wang, Liming, Anne F. Buckley, and Robert F. Spurney. “Regulation of cofilin phosphorylation in glomerular podocytes by testis specific kinase 1 (TESK1).” Sci Rep 8, no. 1 (August 16, 2018): 12286. https://doi.org/10.1038/s41598-018-30115-3.

PMID
30115939
Full Text

Hall, Gentzon, Brandon M. Lane, Kamal Khan, Igor Pediaditakis, Jianqiu Xiao, Guanghong Wu, Liming Wang, et al. “The Human FSGS-Causing ANLN R431C Mutation Induces Dysregulated PI3K/AKT/mTOR/Rac1 Signaling in Podocytes.” J Am Soc Nephrol 29, no. 8 (August 2018): 2110–22. https://doi.org/10.1681/ASN.2017121338.

PMID
30002222
Full Text

Wang, Liming, Yonggang Sha, Jingyi Bai, William Eisner, Matthew A. Sparks, Anne F. Buckley, and Robert F. Spurney. “Podocyte-specific knockout of cyclooxygenase 2 exacerbates diabetic kidney disease.” Am J Physiol Renal Physiol 313, no. 2 (August 1, 2017): F430–39. https://doi.org/10.1152/ajprenal.00614.2016.

PMID
28490532
Full Text

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