Robert John Mentz, MD

Associate Professor of Medicine
Associate Professor in Population Health Sciences
Member in the Duke Clinical Research Institute
Campus mail Np-8062, Dcri. PO Box 17969, Durham, NC 27715
Phone (919) 668-7121
Email address

I am a cardiologist with a clinical and research interest in heart failure, including advanced therapies such as cardiac transplantation and mechanical assist devices or “heart pumps." I became a heart failure cardiologist in order to help patients manage their chronic disease over many months and years. I consider myself strongly committed to compassionate patient care with a focus on quality of life and patient preference.

My research interests are focused on treating co-morbid diseases in heart failure patients and improving outcomes across the cardiovascular spectrum through clinical trials and outcomes research. Below, you will find my specific research interests:

  •     Co-morbidity characterization (diabetes, sleep apnea, renal failure) in heart failure.
  •     Phenotypic characterization and risk prognostication of patients with heart failure.
  •     Role of surrogate and nonfatal endpoints in clinical heart failure trials.
  •     Biomarkers in heart failure.
  •     Novel pharmacological and non-pharmacological approaches to heart failure.
  •     Improving site-based heart failure research.
In Their Words

Education and Training

  • Fellowship, Advanced Heart Failure, Duke University School of Medicine, 2012 - 2013
  • Fellowship, Clinical Cardiology, Duke University School of Medicine, 2010 - 2012
  • Resident, Internal Medicine, Brigham and Women's Hospital, 2008 - 2010
  • Intern, Internal Medicine, Brigham and Women's Hospital, 2007 - 2008
  • M.D., Emory University, 2003


Bethel, M Angelyn, Rishi A. Patel, Peter Merrill, Yuliya Lokhnygina, John B. Buse, Robert J. Mentz, Neha J. Pagidipati, et al. “Cardiovascular outcomes with glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes: a meta-analysis..” Lancet Diabetes Endocrinol 6, no. 2 (February 2018): 105–13.

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Pastva, Amy M., Pamela W. Duncan, Gordon R. Reeves, M Benjamin Nelson, David J. Whellan, Christopher M. O’Connor, Joel D. Eggebeen, et al. “Strategies for supporting intervention fidelity in the rehabilitation therapy in older acute heart failure patients (REHAB-HF) trial..” Contemp Clin Trials 64 (January 2018): 118–27.

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Luo, Nancy, Haolin Xu, Hani Jneid, Gregg C. Fonarow, Renato D. Lopes, Christopher B. Granger, Anne B. Curtis, et al. “High Use of Oral Anticoagulation in Eligible Patients Discharged With Heart Failure and Atrial Fibrillation Irrespective of Ejection Fraction: Insights From the AHA Get With The Guidelines- Atrial Fibrillation Program.” In Circulation, Vol. 136. LIPPINCOTT WILLIAMS & WILKINS, 2017.


Vaduganathan, Muthiah, Robert J. Mentz, Haris Subacius, Ravi B. Patel, Neal A. Chatterjee, Stephen J. Greene, Andrew P. Ambrosy, et al. “Sudden Cardiac Death Risk After Hospitalization for Heart Failure: Insights From EVEREST.” In Circulation, Vol. 136. LIPPINCOTT WILLIAMS & WILKINS, 2017.


Greene, Stephen, Nancy Luo, Robert J. Mentz, Chantelle Hardy, Warren K. Laskey, Paul A. Heidenreich, Clyde W. Yancy, et al. “Home-Time as a Novel Post-Discharge Outcome for Patients Hospitalized With Heart Failure.” In Circulation, Vol. 136. LIPPINCOTT WILLIAMS & WILKINS, 2017.


Ambrosy, Andrew P., Hillary Mulder, Adrian Coles, William E. Krauss, Carolyn S. Lam, Peter A. Mccullough, Ileana Pina, et al. “Renal Function and Exercise Training in Ambulatory Heart Failure Patients With a Reduced Ejection Fraction - Findings From the HF-ACTION Randomized Controlled Trial.” In Circulation, Vol. 136. LIPPINCOTT WILLIAMS & WILKINS, 2017.


Greene, Stephen J., Adrian F. Hernandez, Jie-Lena Sun, Javed Butler, Paul W. Armstrong, Justin A. Ezekowitz, Faiez Zannad, et al. “Country Income Level, Protocol Completion, and Trial Endpoints Among Patients With Acute Heart Failure: Insights From the ASCEND-HF Trial.” In Circulation, Vol. 136. LIPPINCOTT WILLIAMS & WILKINS, 2017.


Cerbin, Lukasz P., Andrew P. Ambrosy, and Robert J. Mentz. “Building the case for aerobic exercise in ambulatory patients with heart failure and a reduced ejection fraction..” Am Heart J 192 (October 2017).

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Holman, Rury R., M Angelyn Bethel, Robert J. Mentz, Vivian P. Thompson, Yuliya Lokhnygina, John B. Buse, Juliana C. Chan, et al. “Effects of Once-Weekly Exenatide on Cardiovascular Outcomes in Type 2 Diabetes..” N Engl J Med 377, no. 13 (September 28, 2017): 1228–39.

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Butler, Javed, Kevin J. Anstrom, G Michael Felker, Michael M. Givertz, Andreas P. Kalogeropoulos, Marvin A. Konstam, Douglas L. Mann, et al. “Efficacy and Safety of Spironolactone in Acute Heart Failure: The ATHENA-HF Randomized Clinical Trial..” Jama Cardiol 2, no. 9 (September 1, 2017): 950–58.

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