Robert John Mentz, MD

Associate Professor of Medicine
Associate Professor in Population Health Sciences
Member in the Duke Clinical Research Institute
Campus mail Np-8062, Dcri. PO Box 17969, Durham, NC 27715
Phone (919) 668-7121
Email address

I am a cardiologist with a clinical and research interest in heart failure, including advanced therapies such as cardiac transplantation and mechanical assist devices or “heart pumps." I became a heart failure cardiologist in order to help patients manage their chronic disease over many months and years. I consider myself strongly committed to compassionate patient care with a focus on quality of life and patient preference.

My research interests are focused on treating co-morbid diseases in heart failure patients and improving outcomes across the cardiovascular spectrum through clinical trials and outcomes research. Below, you will find my specific research interests:

  •     Co-morbidity characterization (diabetes, sleep apnea, renal failure) in heart failure.
  •     Phenotypic characterization and risk prognostication of patients with heart failure.
  •     Role of surrogate and nonfatal endpoints in clinical heart failure trials.
  •     Biomarkers in heart failure.
  •     Novel pharmacological and non-pharmacological approaches to heart failure.
  •     Improving site-based heart failure research.
In Their Words

Education and Training

  • Fellowship, Advanced Heart Failure, Duke University School of Medicine, 2012 - 2013
  • Fellowship, Clinical Cardiology, Duke University School of Medicine, 2010 - 2012
  • Resident, Internal Medicine, Brigham and Women's Hospital, 2008 - 2010
  • Intern, Internal Medicine, Brigham and Women's Hospital, 2007 - 2008
  • M.D., Emory University, 2003


Mentz, Robert J., Vera Bittner, Aijing Z. Starr, Jerome L. Fleg, Gordon Moe, Ann M. Swank, Meredith Fitz-Gerald, et al. “Race, Exercise Training and Outcomes in Chronic Heart Failure.” Circulation 126, no. 21 (November 20, 2012).


Zannad, Faiez, Wendy Gattis Stough, Patrick Rossignol, Johann Bauersachs, John J. V. McMurray, Karl Swedberg, Allan D. Struthers, et al. “Mineralocorticoid receptor antagonists for heart failure with reduced ejection fraction: integrating evidence into clinical practice..” Eur Heart J 33, no. 22 (November 2012): 2782–95.

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Vaduganathan, Muthiah, Andrew P. Ambrosy, Stephen J. Greene, Robert J. Mentz, Haris P. Subacius, Aldo P. Maggioni, Karl Swedberg, et al. “Predictive value of low relative lymphocyte count in patients hospitalized for heart failure with reduced ejection fraction: insights from the EVEREST trial..” Circ Heart Fail 5, no. 6 (November 2012): 750–58.

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Mentz, Robert J., Juan-Carlos Kaski, Gheorghe-Andrei Dan, Sidney Goldstein, Norman Stockbridge, Angeles Alonso-Garcia, Luis M. Ruilope, et al. “Implications of geographical variation on clinical outcomes of cardiovascular trials..” Am Heart J 164, no. 3 (September 2012): 303–12.

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Gheorghiade, M., G. Lan, H. Subacius, R. J. Mentz, A. Shah, M. A. Konstam, F. Zannad, K. Swedberg, and A. Maggioni. “Baseline hemoglobin predicts post-discharge events in patients admitted for worsening heart failure with reduced ejection fraction in the EVEREST trial.” In European Heart Journal, 33:645–645, 2012.


Mentz, R. J., P. J. Schulte, D. W. Kitzman, M. Fiuzat, W. E. Kraus, I. L. Pina, S. J. Keteyian, et al. “Beta-Blocker Selectivity in Heart Failure (HF) Patients With Chronic Obstructive Pulmonary Disease (COPD): Insights from HF-A Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION).” In Journal of Cardiac Failure, 18:S63–S63. Elsevier BV, 2012.

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Mentz, Robert J., Philip H. Schmidt, Mary J. Kwasny, Andrew P. Ambrosy, Christopher M. O’Connor, Marvin A. Konstam, Faiez Zannad, Aldo P. Maggioni, Karl Swedberg, and Mihai Gheorghiade. “The impact of chronic obstructive pulmonary disease in patients hospitalized for worsening heart failure with reduced ejection fraction: an analysis of the EVEREST Trial..” J Card Fail 18, no. 7 (July 2012): 515–23.

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