Robert Matthew Tighe, MD

Assistant Professor of Medicine
Campus mail Duke Box 2629, Durham, NC 27710
Phone (919) 684-4894
Email address robert.tighe@duke.edu

The research focus of my laboratory is to identify susceptibility factors and candidate pathways relevant to host biological responses to environmental pollutants. By carefully dissecting these links, we will gain insight into how environmental pollutants acutely induce respiratory symptoms and exacerbate chronic lung diseases. This can lead to targeted therapeutics and/or identify susceptible populations.

The central hypothesis of my research is that macrophages are key regulators of the biologic responses to environmental pollutants and the development of pulmonary fibrosis. My laboratory has pioneered the identification of novel pulmonary macrophage subsets and has defined their function in lung injury and repair. In both published work and areas of active investigation, we have identified macrophage subsets with unique genetic programming and function after challenges with environmental exposures such as ozone, wood smoke and silica. Since macrophages have both detrimental and protective functions, identifying these subsets offers the opportunity to understand their unique programing and function. This could allow development of targeted therapeutics that take advantage of these functions, polarize the immune responses and alleviate respiratory disease.

Education and Training

  • Fellowship, Pulmonary And Critical Care, Duke University School of Medicine, 2006 - 2010
  • Resident, Internal Medicine, Boston University, 2002 - 2006
  • M.D., University of Tennessee Health Science Center, 2002

Publications

Hussain, Salik, Collin G. Johnson, Joseph Sciurba, Xianglin Meng, Vandy P. Stober, Caini Liu, Jaime M. Cyphert-Daly, et al. “TLR5 participates in the TLR4 receptor complex and promotes MyD88-dependent signaling in environmental lung injury.” Elife 9 (January 28, 2020). https://doi.org/10.7554/eLife.50458.

PMID
31989925
Full Text

Rankine, Leith J., Ziyi Wang, Jennifer M. Wang, Mu He, H Page McAdams, Joseph Mammarappallil, Craig R. Rackley, Bastiaan Driehuys, and Robert M. Tighe. “129Xenon Gas Exchange Magnetic Resonance Imaging as a Potential Prognostic Marker for Progression of Idiopathic Pulmonary Fibrosis.” Ann Am Thorac Soc 17, no. 1 (January 2020): 121–25. https://doi.org/10.1513/AnnalsATS.201905-413RL.

PMID
31593488
Full Text

Cyphert-Daly, Jaime M., Zhonghui Yang, Jennifer L. Ingram, Robert M. Tighe, and Loretta G. Que. “Physiologic response to chronic house dust mite exposure in mice is dependent on lot characteristics.” In J Allergy Clin Immunol, 144:1428-1432.e8, 2019. https://doi.org/10.1016/j.jaci.2019.07.019.

PMID
31369802
Full Text

Tighe, Robert M., Elizabeth F. Redente, Yen-Rei Yu, Susanne Herold, Anne I. Sperling, Jeffrey L. Curtis, Ryan Duggan, et al. “Improving the Quality and Reproducibility of Flow Cytometry in the Lung. An Official American Thoracic Society Workshop Report.” Am J Respir Cell Mol Biol 61, no. 2 (August 2019): 150–61. https://doi.org/10.1165/rcmb.2019-0191ST.

PMID
31368812
Full Text

Birukova, Anastasiya, Jaime Cyphert-Daly, Robert Ian Cumming, Yen-Rei Yu, Kymberly M. Gowdy, Loretta G. Que, and Robert M. Tighe. “Sex Modifies Acute Ozone-Mediated Airway Physiologic Responses.” Toxicol Sci, June 1, 2019. https://doi.org/10.1093/toxsci/kfz056.

PMID
30825310
Full Text

Tighe, Robert M., Karissa Heck, Erik Soderblom, Shutang Zhou, Anastasiya Birukova, Kenneth Young, Douglas Rouse, et al. “Immediate Release of Gastrin-Releasing Peptide Mediates Delayed Radiation-Induced Pulmonary Fibrosis.” Am J Pathol 189, no. 5 (May 2019): 1029–40. https://doi.org/10.1016/j.ajpath.2019.01.017.

PMID
30898588
Full Text

Lei, Beilei, Kamie Snow, Jacob Fang, Robert M. Tighe, Paloma H. Giangrande, and Francis J. Miller. “Inhalation of an RNA Aptamer Targeting Extracellular Histones Protects from Acute Lung Injury.” In Molecular Therapy, 27:334–334. CELL PRESS, 2019.

Scholars@Duke

Foster, Mary H., Jeffrey R. Ord, Emma J. Zhao, Anastasiya Birukova, Lanette Fee, Francesca M. Korte, Yohannes G. Asfaw, et al. “Silica Exposure Differentially Modulates Autoimmunity in Lupus Strains and Autoantibody Transgenic Mice.” Front Immunol 10 (2019): 2336. https://doi.org/10.3389/fimmu.2019.02336.

PMID
31632407
Full Text

Pages