Robert Matthew Tighe, MD

Assistant Professor of Medicine
Campus mail Duke Box 2629, Durham, NC 27710
Phone (919) 684-4894
Email address robert.tighe@duke.edu

The research focus of my laboratory is to identify susceptibility factors and candidate pathways relevant to host biological responses to environmental pollutants. By carefully dissecting these links, we will gain insight into how environmental pollutants acutely induce respiratory symptoms and exacerbate chronic lung diseases. This can lead to targeted therapeutics and/or identify susceptible populations.

The central hypothesis of my research is that macrophages are key regulators of the biologic responses to environmental pollutants and the development of pulmonary fibrosis. My laboratory has pioneered the identification of novel pulmonary macrophage subsets and has defined their function in lung injury and repair. In both published work and areas of active investigation, we have identified macrophage subsets with unique genetic programming and function after challenges with environmental exposures such as ozone, wood smoke and silica. Since macrophages have both detrimental and protective functions, identifying these subsets offers the opportunity to understand their unique programing and function. This could allow development of targeted therapeutics that take advantage of these functions, polarize the immune responses and alleviate respiratory disease.

Education and Training

  • M.D., University of Tennessee, Memphis, 2002

Publications

Suwanpradid, J, Shih, M, Pontius, L, Yang, B, Birukova, A, Guttman-Yassky, E, Corcoran, DL, Que, LG, Tighe, RM, and MacLeod, AS. "Arginase1 Deficiency in Monocytes/Macrophages Upregulates Inducible Nitric Oxide Synthase To Promote Cutaneous Contact Hypersensitivity." Journal of immunology (Baltimore, Md. : 1950) 199, no. 5 (September 2017): 1827-1834.

PMID
28747341
Full Text

Trempus, CS, Song, W, Lazrak, A, Yu, Z, Creighton, JR, Young, BM, Heise, RL, Yu, YR, Ingram, JL, Tighe, RM, Matalon, S, and Garantziotis, S. "A novel role for primary cilia in airway remodeling." American journal of physiology. Lung cellular and molecular physiology 313, no. 2 (August 2017): L328-L338.

PMID
28473325
Full Text

Frush, BW, Li, Z, Stiles, JV, Cotter, SF, Shofer, SL, Foster, WM, Hollingsworth, JW, and Tighe, RM. "Ozone primes alveolar macrophage-derived innate immunity in healthy human subjects." The Journal of allergy and clinical immunology 138, no. 4 (October 2016): 1213-1215.e1.

PMID
27325435
Full Text

Tighe, RM, Li, Z, Potts, EN, Frush, S, Liu, N, Gunn, MD, Foster, WM, Noble, PW, and Hollingsworth, JW. "Erratum: Ozone inhalation promotes CX3CR1-dependent maturation of resident lung macrophages that limit oxidative stress and inflammation (Journal of Immunology (2011) 187 (4800-4808))." Journal of Immunology 196, no. 5 (March 1, 2016): 2424-.

Full Text

Harkema, JR, Jackson-Humbles, DN, Lewandowski, RP, Wagner, JG, and Tighe, RM. "Rapid Onset Of Ozone-Induced Pulmonary Fibrosis In Diabetic Kkay Mice." 2016.

Scholars@Duke

Yu, Y-RA, Hotten, DF, Malakhau, Y, Volker, E, Ghio, AJ, Noble, PW, Kraft, M, Hollingsworth, JW, Gunn, MD, and Tighe, RM. "Flow Cytometric Analysis of Myeloid Cells in Human Blood, Bronchoalveolar Lavage, and Lung Tissues." American journal of respiratory cell and molecular biology 54, no. 1 (January 2016): 13-24.

PMID
26267148
Full Text

Pinilla-Vera, M, Xiong, Z, Zhao, Y, Zhao, J, Donahoe, MP, Barge, S, Horne, WT, Kolls, JK, McVerry, BJ, Birukova, A, Tighe, RM, Foster, WM, Hollingsworth, J, Ray, A, Mallampalli, R, Ray, P, and Lee, JS. "Full Spectrum of LPS Activation in Alveolar Macrophages of Healthy Volunteers by Whole Transcriptomic Profiling." PloS one 11, no. 7 (January 2016): e0159329-.

PMID
27434537
Full Text

Birukova, A, Li, Z, Hollingsworth, JW, and Tighe, RM. "Marco Regulates The In Vivo Response To Low Molecular Weight Hyaluronan Fragments." 2016.

Scholars@Duke

Michaud, GC, Channick, CL, Marion, CR, Tighe, RM, Town, JA, Luks, AM, Richards, JB, Kher, S, Mota, P, Hong, G, West, NE, Rackley, C, Neilans, L, Rodriguez-Lopez, J, DuBrock, H, Kennedy, CC, Kelm, DJ, and Thomson, CC. "ATS Core Curriculum 2015. Part I: Adult Pulmonary Medicine." Annals of the American Thoracic Society 12, no. 9 (September 2015): 1387-1397.

PMID
26372804
Full Text

Yu, Y, Hotten, D, Birukova, A, Volker, E, Ghio, AJ, Noble, PW, Kraft, M, Hollingsworth, JW, Gunn, MD, and Tighe, RM. "Flow Cytometry Of Human Bronchoalveolar Lavage Fluid And Lung Tissue Identifies Interstitial Macrophages." 2015.

Scholars@Duke

Pages