Robert Matthew Tighe, MD

Associate Professor of Medicine
Assistant Professor
Campus mail Duke Box 2629, Durham, NC 27710
Phone (919) 684-4894
Email address robert.tighe@duke.edu

The research focus of my laboratory is to identify susceptibility factors and candidate pathways relevant to host biological responses to environmental pollutants. By carefully dissecting these links, we will gain insight into how environmental pollutants acutely induce respiratory symptoms and exacerbate chronic lung diseases. This can lead to targeted therapeutics and/or identify susceptible populations.

The central hypothesis of my research is that macrophages are key regulators of the biologic responses to environmental pollutants and the development of pulmonary fibrosis. My laboratory has pioneered the identification of novel pulmonary macrophage subsets and has defined their function in lung injury and repair. In both published work and areas of active investigation, we have identified macrophage subsets with unique genetic programming and function after challenges with environmental exposures such as ozone, wood smoke and silica. Since macrophages have both detrimental and protective functions, identifying these subsets offers the opportunity to understand their unique programing and function. This could allow development of targeted therapeutics that take advantage of these functions, polarize the immune responses and alleviate respiratory disease.

Education and Training

  • Fellowship, Pulmonary And Critical Care, Duke University School of Medicine, 2006 - 2010
  • Resident, Internal Medicine, Boston University, 2002 - 2006
  • M.D., University of Tennessee Health Science Center, 2002

Publications

Tighe, Robert M., and Sweta M. Patel. “Human Immunodeficiency Virus, Smoking, and Chronic Obstructive Pulmonary Disease: A Case of T Cells Stuck in the Wrong Place?” Am J Respir Cell Mol Biol 65, no. 5 (November 2021): 464–65. https://doi.org/10.1165/rcmb.2021-0295ED.

PMID
34370962
Full Text

Mummy, David G., Elianna A. Bier, Ziyi Wang, Jennifer Korzekwinski, Lake Morrison, Christina Barkauskas, H Page McAdams, Robert M. Tighe, Bastiaan Driehuys, and Joseph G. Mammarappallil. “Hyperpolarized 129Xe MRI and Spectroscopy of Gas-Exchange Abnormalities in Nonspecific Interstitial Pneumonia.” Radiology 301, no. 1 (October 2021): 211–20. https://doi.org/10.1148/radiol.2021204149.

PMID
34313473
Full Text

Vose, Aaron, Matthew McCravy, Anastasiya Birukova, Zhonghui Yang, John W. Hollingsworth, Loretta G. Que, and Robert M. Tighe. “Wood smoke particle exposure in mice reduces the severity of influenza infection.” Toxicol Appl Pharmacol 426 (September 1, 2021): 115645. https://doi.org/10.1016/j.taap.2021.115645.

PMID
34271066
Full Text

Yaeger, Michael J., Sky W. Reece, Brita Kilburg-Basnyat, Miles X. Hodge, Anandita Pal, Katelyn Dunigan-Russell, Bin Luo, et al. “Sex Differences in Pulmonary Eicosanoids and Specialized Pro-Resolving Mediators in Response to Ozone Exposure.” Toxicol Sci 183, no. 1 (August 30, 2021): 170–83. https://doi.org/10.1093/toxsci/kfab081.

PMID
34175951
Full Text

Reece, Sky W., Sanjay Varikuti, Brita Kilburg-Basnyat, Katelyn Dunigan-Russell, Myles X. Hodge, Bin Luo, Jennifer H. Madenspacher, et al. “Scavenger Receptor BI Attenuates IL-17A-Dependent Neutrophilic Inflammation in Asthma.” Am J Respir Cell Mol Biol 64, no. 6 (June 2021): 698–708. https://doi.org/10.1165/rcmb.2020-0007OC.

PMID
33647226
Full Text

Wang, Ziyi, Leith Rankine, Elianna A. Bier, David Mummy, Junlan Lu, Alex Church, Robert M. Tighe, et al. “Using hyperpolarized 129Xe gas-exchange MRI to model the regional airspace, membrane, and capillary contributions to diffusing capacity.” J Appl Physiol (1985) 130, no. 5 (May 1, 2021): 1398–1409. https://doi.org/10.1152/japplphysiol.00702.2020.

PMID
33734831
Full Text

Vose, A., B. P. Patel, A. Bedoya, R. M. Tighe, and S. L. Shofer. “Impulse Oscillometry Identifies Small Airways Pathology Among Obese Patients Otherwise Missed by Traditional Spirometry.” In American Journal of Respiratory and Critical Care Medicine, Vol. 203, 2021.

Scholars@Duke

Mummy, D., A. Swaminathan, K. Yarnall, J. Mammarappallil, B. Driehuys, and R. M. Tighe. “Hyperpolarized Xe-129 MRI Features Identify Functional Differences That Do Not Correlate with Chest CT in Patients with Idiopathic Pulmonary Fibrosis.” In American Journal of Respiratory and Critical Care Medicine, Vol. 203, 2021.

Scholars@Duke

Vose, A., M. S. Mccravy, Z. Yang, L. G. Que, J. W. Hollingsworth, and R. M. Tighe. “Woodsmoke Particle Exposure in Mice Confers Protective Benefit Against PR8 Influenza Virus.” In American Journal of Respiratory and Critical Care Medicine, Vol. 203, 2021.

Scholars@Duke

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