Robert Matthew Tighe, MD

Associate Professor of Medicine
Assistant Professor
Campus mail Duke Box 2629, Durham, NC 27710
Phone (919) 684-4894
Email address robert.tighe@duke.edu

The research focus of my laboratory is to identify susceptibility factors and candidate pathways relevant to host biological responses to environmental pollutants. By carefully dissecting these links, we will gain insight into how environmental pollutants acutely induce respiratory symptoms and exacerbate chronic lung diseases. This can lead to targeted therapeutics and/or identify susceptible populations.

The central hypothesis of my research is that macrophages are key regulators of the biologic responses to environmental pollutants and the development of pulmonary fibrosis. My laboratory has pioneered the identification of novel pulmonary macrophage subsets and has defined their function in lung injury and repair. In both published work and areas of active investigation, we have identified macrophage subsets with unique genetic programming and function after challenges with environmental exposures such as ozone, wood smoke and silica. Since macrophages have both detrimental and protective functions, identifying these subsets offers the opportunity to understand their unique programing and function. This could allow development of targeted therapeutics that take advantage of these functions, polarize the immune responses and alleviate respiratory disease.

Education and Training

  • Fellowship, Pulmonary And Critical Care, Duke University School of Medicine, 2006 - 2010
  • Resident, Internal Medicine, Boston University, 2002 - 2006
  • M.D., University of Tennessee Health Science Center, 2002

Publications

Wang, Ziyi, Leith Rankine, Elianna A. Bier, David Mummy, Junlan Lu, Alex Church, Robert M. Tighe, et al. “Using hyperpolarized 129Xe gas-exchange MRI to model the regional airspace, membrane, and capillary contributions to diffusing capacity.” J Appl Physiol (1985) 130, no. 5 (May 1, 2021): 1398–1409. https://doi.org/10.1152/japplphysiol.00702.2020.

PMID
33734831
Full Text

Novak, Caymen M., Robert M. Tighe, and Megan N. Ballinger. “What Is "Normal" When Examining Myeloid Cells in Human Airways?” Am J Respir Crit Care Med 203, no. 8 (April 15, 2021): 931–32. https://doi.org/10.1164/rccm.202010-3932ED.

PMID
33181037
Full Text

McCumber, Alexander W., Yeon Ji Kim, Omoanghe Samuel Isikhuemhen, Robert M. Tighe, and Claudia K. Gunsch. “The environment shapes swine lung bacterial communities.” Sci Total Environ 758 (March 1, 2021): 143623. https://doi.org/10.1016/j.scitotenv.2020.143623.

PMID
33243510
Full Text

Reece, Sky W., Sanjay Varikuti, Brita Kilburg-Basnyat, Katelyn Dunigan-Russell, Myles X. Hodge, Bin Luo, Jennifer H. Madenspacher, et al. “Scavenger Receptor BI Attenuates IL-17A-dependent Neutrophilic Inflammation in Asthma.” Am J Respir Cell Mol Biol, March 1, 2021. https://doi.org/10.1165/rcmb.2020-0007OC.

PMID
33647226
Full Text

Gowdy, K. M., B. Kilburg-Basnyat, M. X. Hodge, S. W. Reece, V. Yermalitsk, S. S. Davies, J. Manke, et al. “Novel Mechanisms of Ozone-Induced Pulmonary Inflammation and Resolution, and the Potential Protective Role of Scavenger Receptor BI.” Res Rep Health Eff Inst, no. 204 (March 2021): 1–49.

PMID
33998222
Scholars@Duke

Pederson, William P., Jaime M. Cyphert-Daly, Robert M. Tighe, Loretta G. Que, and Julie G. Ledford. “Genetic variation in surfactant protein-A2 alters responses to ozone.” Plos One 16, no. 2 (2021): e0247504. https://doi.org/10.1371/journal.pone.0247504.

PMID
33617569
Full Text

Bedoya, Armando, Roy A. Pleasants, Joel C. Boggan, Danielle Seaman, Anne Reihman, Lauren Howard, Robert Kundich, Karen Welty-Wolf, and Robert M. Tighe. “Interstitial lung disease in a veterans affairs regional network; a retrospective cohort study.” Plos One 16, no. 3 (2021): e0247316. https://doi.org/10.1371/journal.pone.0247316.

PMID
33735247
Full Text

Wagner, James G., Christina E. Barkauskas, Aaron Vose, Ryan P. Lewandowski, Jack R. Harkema, and Robert M. Tighe. “Repetitive Ozone Exposures and Evaluation of Pulmonary Inflammation and Remodeling in Diabetic Mouse Strains.” Environ Health Perspect 128, no. 11 (November 2020): 117009. https://doi.org/10.1289/EHP7255.

PMID
33253011
Full Text

Chotirmall, Sanjay H., Fernando J. Martinez, Paul T. Schumacker, Colin R. Cooke, Nitin Seam, Laurent Brochard, Robert M. Tighe, Bruce D. Levy, Diane Gern, and Jadwiga A. Wedzicha. “Life at the Editorial "COVID Frontline". The American Thoracic Society Journal Family.” Am J Respir Crit Care Med 201, no. 12 (June 15, 2020): 1457–59. https://doi.org/10.1164/rccm.202005-1516ED.

PMID
32356668
Full Text

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