Robert Matthew Tighe, MD

Assistant Professor of Medicine
Campus mail Duke Box 2629, Durham, NC 27710
Phone (919) 684-4894
Email address robert.tighe@duke.edu

The research focus of my laboratory is to identify susceptibility factors and candidate pathways relevant to host biological responses to environmental pollutants. By carefully dissecting these links, we will gain insight into how environmental pollutants acutely induce respiratory symptoms and exacerbate chronic lung diseases. This can lead to targeted therapeutics and/or identify susceptible populations.

The central hypothesis of my research is that macrophages are key regulators of the biologic responses to environmental pollutants and the development of pulmonary fibrosis. My laboratory has pioneered the identification of novel pulmonary macrophage subsets and has defined their function in lung injury and repair. In both published work and areas of active investigation, we have identified macrophage subsets with unique genetic programming and function after challenges with environmental exposures such as ozone, wood smoke and silica. Since macrophages have both detrimental and protective functions, identifying these subsets offers the opportunity to understand their unique programing and function. This could allow development of targeted therapeutics that take advantage of these functions, polarize the immune responses and alleviate respiratory disease.

Education and Training

  • Fellowship, Pulmonary And Critical Care, Duke University School of Medicine, 2006 - 2010
  • Resident, Internal Medicine, Boston University, 2002 - 2006
  • M.D., University of Tennessee, Memphis, 2002

Publications

Tighe, RM, Birukova, A, Yaeger, MJ, Reece, SW, and Gowdy, KM. "Euthanasia- and Lavage-mediated Effects on Bronchoalveolar Measures of Lung Injury and Inflammation." American Journal of Respiratory Cell and Molecular Biology 59, no. 2 (August 2018): 257-266.

PMID
29481287
Full Text

Kilburg-Basnyat, B, Reece, SW, Crouch, MJ, Luo, B, Boone, AD, Yaeger, M, Hodge, M, Psaltis, C, Hannan, JL, Manke, J, Armstrong, ML, Reisdorph, N, Tighe, RM, Shaikh, SR, and Gowdy, KM. "Specialized Pro-Resolving Lipid Mediators Regulate Ozone-Induced Pulmonary and Systemic Inflammation." Toxicological Sciences : an Official Journal of the Society of Toxicology 163, no. 2 (June 2018): 466-477.

PMID
29471542
Full Text

Que, LG, Yang, Z, Lugogo, NL, Katial, RK, Shoemaker, SA, Troha, JM, Rodman, DM, Tighe, RM, and Kraft, M. "Effect of the S-nitrosoglutathione reductase inhibitor N6022 on bronchial hyperreactivity in asthma." Immunity, Inflammation and Disease 6, no. 2 (June 2018): 322-331.

PMID
29642282
Full Text

Garantziotis, S, and Tighe, RM. "Inflammation Gets on the Lung's Nerves: IL-17 and Neuroendocrine Cells Mediate Ozone Responses in Obesity." American Journal of Respiratory Cell and Molecular Biology 58, no. 3 (March 2018): 284-285.

PMID
29493325
Full Text

Tighe, RM, and Garantziotis, S. "Hyaluronan interactions with innate immunity in lung biology." Matrix Biology : Journal of the International Society for Matrix Biology (February 2, 2018). (Review)

PMID
29410190
Full Text

Espenschied, ST, Tighe, RM, and Gowdy, KM. "Flow Cytometry for the Immunotoxicologist." Methods in Molecular Biology (Clifton, N.J.) 1803 (January 2018): 183-197.

PMID
29882140
Full Text

Yu, Y-RA, and Tighe, RM. "Isolation and Characterization of Human Lung Myeloid Cells." Methods in Molecular Biology (Clifton, N.J.) 1809 (January 2018): 111-119.

PMID
29987786
Full Text

Potts-Kant, EN, Li, Z, Tighe, RM, Lindsey, JY, Frush, BW, Foster, WM, and Hollingsworth, JW. "Retraction notice to NAD(P)H:QUINONE OXIOREDUCTASE 1 PROTECTS LUNGS FROM OXIDANT-INDUCED EMPHYSEMA IN MICE [FRB 52/3 (2012) 705 - 715]." Free Radical Biology & Medicine 113 (December 2017): 580-null.

PMID
29162264
Full Text

Suwanpradid, J, Shih, M, Pontius, L, Yang, B, Birukova, A, Guttman-Yassky, E, Corcoran, DL, Que, LG, Tighe, RM, and MacLeod, AS. "Arginase1 Deficiency in Monocytes/Macrophages Upregulates Inducible Nitric Oxide Synthase To Promote Cutaneous Contact Hypersensitivity." Journal of Immunology (Baltimore, Md. : 1950) 199, no. 5 (September 2017): 1827-1834.

PMID
28747341
Full Text

Trempus, CS, Song, W, Lazrak, A, Yu, Z, Creighton, JR, Young, BM, Heise, RL, Yu, YR, Ingram, JL, Tighe, RM, Matalon, S, and Garantziotis, S. "A novel role for primary cilia in airway remodeling." American Journal of Physiology. Lung Cellular and Molecular Physiology 313, no. 2 (August 2017): L328-L338.

PMID
28473325
Full Text

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