Robert Matthew Tighe, MD

Associate Professor of Medicine
Assistant Professor
Campus mail Duke Box 2629, Durham, NC 27710
Phone (919) 684-4894
Email address robert.tighe@duke.edu

The research focus of my laboratory is to identify susceptibility factors and candidate pathways relevant to host biological responses to environmental pollutants. By carefully dissecting these links, we will gain insight into how environmental pollutants acutely induce respiratory symptoms and exacerbate chronic lung diseases. This can lead to targeted therapeutics and/or identify susceptible populations.

The central hypothesis of my research is that macrophages are key regulators of the biologic responses to environmental pollutants and the development of pulmonary fibrosis. My laboratory has pioneered the identification of novel pulmonary macrophage subsets and has defined their function in lung injury and repair. In both published work and areas of active investigation, we have identified macrophage subsets with unique genetic programming and function after challenges with environmental exposures such as ozone, wood smoke and silica. Since macrophages have both detrimental and protective functions, identifying these subsets offers the opportunity to understand their unique programing and function. This could allow development of targeted therapeutics that take advantage of these functions, polarize the immune responses and alleviate respiratory disease.

Education and Training

  • Fellowship, Pulmonary And Critical Care, Duke University School of Medicine, 2006 - 2010
  • Resident, Internal Medicine, Boston University, 2002 - 2006
  • M.D., University of Tennessee Health Science Center, 2002

Publications

McCumber, Alexander W., Yeon Ji Kim, Omoanghe Samuel Isikhuemhen, Robert M. Tighe, and Claudia K. Gunsch. “The environment shapes swine lung bacterial communities.” Sci Total Environ 758 (March 1, 2021): 143623. https://doi.org/10.1016/j.scitotenv.2020.143623.

PMID
33243510
Full Text

Wagner, James G., Christina E. Barkauskas, Aaron Vose, Ryan P. Lewandowski, Jack R. Harkema, and Robert M. Tighe. “Repetitive Ozone Exposures and Evaluation of Pulmonary Inflammation and Remodeling in Diabetic Mouse Strains.” Environ Health Perspect 128, no. 11 (November 2020): 117009. https://doi.org/10.1289/EHP7255.

PMID
33253011
Full Text

Chotirmall, Sanjay H., Fernando J. Martinez, Paul T. Schumacker, Colin R. Cooke, Nitin Seam, Laurent Brochard, Robert M. Tighe, Bruce D. Levy, Diane Gern, and Jadwiga A. Wedzicha. “Life at the Editorial "COVID Frontline". The American Thoracic Society Journal Family.” Am J Respir Crit Care Med 201, no. 12 (June 15, 2020): 1457–59. https://doi.org/10.1164/rccm.202005-1516ED.

PMID
32356668
Full Text

Hussain, Salik, Collin G. Johnson, Joseph Sciurba, Xianglin Meng, Vandy P. Stober, Caini Liu, Jaime M. Cyphert-Daly, et al. “TLR5 participates in the TLR4 receptor complex and promotes MyD88-dependent signaling in environmental lung injury.” Elife 9 (January 28, 2020). https://doi.org/10.7554/eLife.50458.

PMID
31989925
Full Text

Mummy, D., L. Rankine, Z. Wang, E. Bier, C. Rackley, L. D. Morrison, J. Mammarappallil, B. Driehuys, and R. M. Tighe. “Hyperpolarized 129Xe Magnetic Resonance Imaging Is Sensitive to Therapy Response in Idiopathic Pulmonary Fibrosis.” In American Journal of Respiratory and Critical Care Medicine, Vol. 201, 2020.

Scholars@Duke

Yang, Z., J. M. Daly, J. L. Ingram, F. Holguin, R. M. Tighe, and L. G. Que. “Deficiency in Paraoxonase 2 Increases Airway Hyper Responsiveness After Ozone Exposure in Mice.” In American Journal of Respiratory and Critical Care Medicine, Vol. 201, 2020.

Scholars@Duke

Ihrie, M., V. L. McQuade, C. V. Lacuesta, R. M. Tighe, L. G. Que, A. Hedge, J. K. Walker, and J. L. Ingram. “Chronic Leptin Administration in Lean, Allergen-Challenged Female Mice Promotes Small Airway Closure and Airway Fibrosis.” In American Journal of Respiratory and Critical Care Medicine, Vol. 201, 2020.

Scholars@Duke

Daly, J. M., Z. Yang, J. L. Ingram, K. M. Luginbuhl, A. Varanko, R. M. Tighe, A. Chilkoti, and L. G. Que. “Glucagon Like Peptide 1 Attenuates Airway Hyperresponsiveness in a Mouse Model of Obese Allergic Asthma.” In American Journal of Respiratory and Critical Care Medicine, Vol. 201, 2020.

Scholars@Duke

Pages