Rodger Alan Liddle, MD

Professor of Medicine
Faculty Network Member of the Duke Institute for Brain Sciences
Member of the Duke Cancer Institute
Campus mail 1033A GSRB-1 Bldg, Durham, NC 27710
Phone (919) 681-6380
Email address

Our laboratory has two major research interests:

Enteroendocrine Cell Biology

Enteroendocrine cells (EECs) are sensory cells of the gut that send signals throughout the body.  They have the ability to sense food and nutrients in the lumen of the intestine and secrete hormones into the blood.  Our laboratory has had a longstanding interest in two types of EECs that regulate satiety and signal the brain to stop eating.   Cholecystokinin (CCK) is secreted from EECs of the upper small intestine and regulates the ingestion and digestion of food through effects on the stomach, gallbladder, pancreas and brain.  Peptide YY (PYY) is secreted from EECs of the small intestine and colon and regulates satiety.  We recently demonstrated that CCK and PYY cells not only secrete hormones but are directly connected to nerves through unique cellular processes called ‘neuropods’.  Our laboratory is devoted to understanding EECs signaling and its role in disease.


Pancreatitis is an inflammatory disease of the pancreas compounded by intrapancreaatic activation of digestive enzymes.  Our laboratory is studying the influence of nerves on the development of pancreatitis. Neurogenic inflammation results from the release of bioactive substances from sensory neurons in the pancreas causing vasodilatation, edema, and inflammatory cell infiltration producing tissue necrosis. Our goal is to identify the agents that activate sensory neurons, characterize the receptors on sensory nerves that mediate these actions, and determine the effects of neural stimulation on pancreatic injury with the long-term objective of developing strategies to reduce neurogenic inflammation to treat pancreatitis. 

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Education and Training

  • Gastroenterology Fellowship, Gastroenterology, University of California - San Francisco, 1981 - 1984
  • Residency, Generalinternal Medicine, University of California - San Francisco, 1979 - 1981
  • Internship, General Internal Medicine, University of California - San Francisco, 1978 - 1979
  • M.D., Vanderbilt University, 1978
  • B.S., University of Utah, 1972


Farooq, Ahmad, Liliana Hernandez, Sandip M. Swain, Rafiq A. Shahid, Joelle M-J Romac, Steven R. Vigna, and Rodger A. Liddle. “Initiation and severity of experimental pancreatitis are modified by phosphate.” Am J Physiol Gastrointest Liver Physiol 322, no. 6 (June 1, 2022): G561–70.

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Swain, Sandip M., Joelle M-J Romac, Steven R. Vigna, and Rodger A. Liddle. “Piezo1-mediated stellate cell activation causes pressure-induced pancreatic fibrosis in mice.” Jci Insight 7, no. 8 (April 22, 2022).

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Farooq, Ahmad, Courtney M. Richman, Sandip M. Swain, Rafiq A. Shahid, Steven R. Vigna, and Rodger A. Liddle. “The Role of Phosphate in Alcohol-Induced Experimental Pancreatitis.” Gastroenterology 161, no. 3 (September 2021): 982-995.e2.

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Swain, S. M., J. M. Romac, S. R. Vigna, and R. A. Liddle. “Piezo1 Channel Opening Induces Stellate Cell Activation and Pressure-induced Pancreatic Fibrosis.” In Pancreas, 50:1101–1101, 2021.


Sokratian, Arpine, Julia Ziaee, Kaela Kelly, Allison Chang, Nicole Bryant, Shijie Wang, Enquan Xu, et al. “Heterogeneity in α-synuclein fibril activity correlates to disease phenotypes in Lewy body dementia.” Acta Neuropathol 141, no. 4 (April 2021): 547–64.

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Ye, Lihua, Munhyung Bae, Chelsi D. Cassilly, Sairam V. Jabba, Daniel W. Thorpe, Alyce M. Martin, Hsiu-Yi Lu, et al. “Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways.” Cell Host Microbe 29, no. 2 (February 10, 2021): 179-196.e9.

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Liddle, Rodger A. “Chemical pancreatectomy: an unconventional approach to preventing autodigestion in pancreatitis.” J Clin Invest 131, no. 3 (February 1, 2021).

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Swain, Sandip M., and Rodger A. Liddle. “Piezo1 acts upstream of TRPV4 to induce pathological changes in endothelial cells due to shear stress.” J Biol Chem 296 (January 2021): 100171.

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