Rodger Alan Liddle, MD

Professor of Medicine
Faculty Network Member of the Duke Institute for Brain Sciences
Member of the Duke Cancer Institute
Campus mail 1033A GSRB-1 Bldg, Durham, NC 27710
Phone (919) 681-6380
Email address

Our laboratory has two major research interests:

Enteroendocrine Cell Biology

Enteroendocrine cells (EECs) are sensory cells of the gut that send signals throughout the body.  They have the ability to sense food and nutrients in the lumen of the intestine and secrete hormones into the blood.  Our laboratory has had a longstanding interest in two types of EECs that regulate satiety and signal the brain to stop eating.   Cholecystokinin (CCK) is secreted from EECs of the upper small intestine and regulates the ingestion and digestion of food through effects on the stomach, gallbladder, pancreas and brain.  Peptide YY (PYY) is secreted from EECs of the small intestine and colon and regulates satiety.  We recently demonstrated that CCK and PYY cells not only secrete hormones but are directly connected to nerves through unique cellular processes called ‘neuropods’.  Our laboratory is devoted to understanding EECs signaling and its role in disease.


Pancreatitis is an inflammatory disease of the pancreas compounded by intrapancreaatic activation of digestive enzymes.  Our laboratory is studying the influence of nerves on the development of pancreatitis. Neurogenic inflammation results from the release of bioactive substances from sensory neurons in the pancreas causing vasodilatation, edema, and inflammatory cell infiltration producing tissue necrosis. Our goal is to identify the agents that activate sensory neurons, characterize the receptors on sensory nerves that mediate these actions, and determine the effects of neural stimulation on pancreatic injury with the long-term objective of developing strategies to reduce neurogenic inflammation to treat pancreatitis. 

Visit our lab page.

Education and Training

  • Gastroenterology Fellowship, Gastroenterology, University of California - San Francisco, 1981 - 1984
  • Residency, Generalinternal Medicine, University of California - San Francisco, 1979 - 1981
  • Internship, General Internal Medicine, University of California - San Francisco, 1978 - 1979
  • M.D., Vanderbilt University, 1978
  • B.S., University of Utah, 1972


Liddle, RA. "Neuropods." Cellular and Molecular Gastroenterology and Hepatology (January 30, 2019). (Review)

Full Text

Liddle, RA. "Parkinson's disease from the gut." Brain Research 1693, no. Pt B (August 2018): 201-206.

Full Text

Liddle, RA. "Interactions of Gut Endocrine Cells with Epithelium and Neurons." Comprehensive Physiology 8, no. 3 (June 18, 2018): 1019-1030.

Full Text

Romac, JM-J, Shahid, RA, Swain, SM, Vigna, SR, and Liddle, RA. "Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis." Nature Communications 9, no. 1 (April 30, 2018): 1715-null.

Full Text

Liddle, RA. "Regulation of Pancreatic Secretion." In Physiology of the Gastrointestinal Tract: Sixth Edition, 895-929. March 28, 2018.

Full Text

Kalloo, A, and Liddle, R. "Editorial introductions." Current Opinion in Gastroenterology 33, no. 5 (September 1, 2017): v-null.

Full Text

Chandra, R, Hiniker, A, Kuo, Y-M, Nussbaum, RL, and Liddle, RA. "α-Synuclein in gut endocrine cells and its implications for Parkinson's disease." Jci Insight 2, no. 12 (June 15, 2017).

Full Text

Himmerkus, N, Gong, Y, Friedman, T, Liddle, RA, Baker, LA, Hou, J, and Bleich, M. "Water impermeability of the thick ascending limb of Henle's loop and the collecting duct depends on ILDR1 expression." March 2017.


Ye, L, and Liddle, RA. "Gastrointestinal hormones and the gut connectome." Current Opinion in Endocrinology, Diabetes, and Obesity 24, no. 1 (February 2017): 9-14. (Review)

Full Text

Diamond, P, Kenny, M, and Liddle, R. "Introduction: The progressive Dilemma in British politics." Political Quarterly 88, no. 1 (January 1, 2017): 6-12.

Full Text