Rodger Alan Liddle, MD

Professor of Medicine
Faculty Network Member of the Duke Institute for Brain Sciences
Member of the Duke Cancer Institute
Campus mail 1033A GSRB-1 Bldg, Durham, NC 27710
Phone (919) 681-6380
Email address rodger.liddle@duke.edu

Our laboratory has two major research interests:

Enteroendocrine Cell Biology

Enteroendocrine cells (EECs) are sensory cells of the gut that send signals throughout the body.  They have the ability to sense food and nutrients in the lumen of the intestine and secrete hormones into the blood.  Our laboratory has had a longstanding interest in two types of EECs that regulate satiety and signal the brain to stop eating.   Cholecystokinin (CCK) is secreted from EECs of the upper small intestine and regulates the ingestion and digestion of food through effects on the stomach, gallbladder, pancreas and brain.  Peptide YY (PYY) is secreted from EECs of the small intestine and colon and regulates satiety.  We recently demonstrated that CCK and PYY cells not only secrete hormones but are directly connected to nerves through unique cellular processes called ‘neuropods’.  Our laboratory is devoted to understanding EECs signaling and its role in disease.

Pancreatitis

Pancreatitis is an inflammatory disease of the pancreas compounded by intrapancreaatic activation of digestive enzymes.  Our laboratory is studying the influence of nerves on the development of pancreatitis. Neurogenic inflammation results from the release of bioactive substances from sensory neurons in the pancreas causing vasodilatation, edema, and inflammatory cell infiltration producing tissue necrosis. Our goal is to identify the agents that activate sensory neurons, characterize the receptors on sensory nerves that mediate these actions, and determine the effects of neural stimulation on pancreatic injury with the long-term objective of developing strategies to reduce neurogenic inflammation to treat pancreatitis. 

Visit our lab page.

Education and Training

  • Gastroenterology Fellowship, Gastroenterology, University of California - San Francisco, 1981 - 1984
  • Residency, Generalinternal Medicine, University of California - San Francisco, 1979 - 1981
  • Internship, General Internal Medicine, University of California - San Francisco, 1978 - 1979
  • M.D., Vanderbilt University, 1978
  • B.S., University of Utah, 1972

Publications

Sokratian, Arpine, Julia Ziaee, Kaela Kelly, Allison Chang, Nicole Bryant, Shijie Wang, Enquan Xu, et al. “Heterogeneity in α-synuclein fibril activity correlates to disease phenotypes in Lewy body dementia.” Acta Neuropathol 141, no. 4 (April 2021): 547–64. https://doi.org/10.1007/s00401-021-02288-1.

PMID
33641009
Full Text

Ye, Lihua, Munhyung Bae, Chelsi D. Cassilly, Sairam V. Jabba, Daniel W. Thorpe, Alyce M. Martin, Hsiu-Yi Lu, et al. “Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways.” Cell Host Microbe 29, no. 2 (February 10, 2021): 179-196.e9. https://doi.org/10.1016/j.chom.2020.11.011.

PMID
33352109
Full Text

Liddle, Rodger A. “Chemical pancreatectomy: an unconventional approach to preventing autodigestion in pancreatitis.” J Clin Invest 131, no. 3 (February 1, 2021). https://doi.org/10.1172/JCI146210.

PMID
33529161
Full Text

Swain, Sandip M., and Rodger A. Liddle. “Piezo1 acts upstream of TRPV4 to induce pathological changes in endothelial cells due to shear stress.” J Biol Chem, December 9, 2020. https://doi.org/10.1074/jbc.RA120.015059.

PMID
33298523
Full Text

Swain, Sandip M., Joelle M-J Romac, Rafiq A. Shahid, Stephen J. Pandol, Wolfgang Liedtke, Steven R. Vigna, and Rodger A. Liddle. “TRPV4 channel opening mediates pressure-induced pancreatitis initiated by Piezo1 activation.” J Clin Invest 130, no. 5 (May 1, 2020): 2527–41. https://doi.org/10.1172/JCI134111.

PMID
31999644
Full Text

Ye, Lihua, Olaf Mueller, Jennifer Bagwell, Michel Bagnat, Rodger A. Liddle, and John F. Rawls. “High fat diet induces microbiota-dependent silencing of enteroendocrine cells.” Elife 8 (December 3, 2019). https://doi.org/10.7554/eLife.48479.

PMID
31793875
Full Text

Chiang, Ryan S., Ahmad Farooq, Alice Parish, Donna Niedzwiecki, Matthew R. Kappus, Yuval Patel, Rodger A. Liddle, and Andrew J. Muir. “1089 Hypophosphatemia in Patients With Alcoholic Hepatitis.” In American Journal of Gastroenterology, 114:S615–16. Ovid Technologies (Wolters Kluwer Health), 2019. https://doi.org/10.14309/01.ajg.0000593888.05451.17.

Full Text

Pages