Rodger Alan Liddle, MD

Professor of Medicine
Member of the Duke Institute for Brain Sciences
Member of the Duke Cancer Institute
Campus mail 1033A GSRB-1 Bldg, Durham, NC 27710
Phone (919) 681-6380
Email address rodger.liddle@duke.edu

Our laboratory has two major research interests:

Enteroendocrine Cell Biology

Enteroendocrine cells (EECs) are sensory cells of the gut that send signals throughout the body.  They have the ability to sense food and nutrients in the lumen of the intestine and secrete hormones into the blood.  Our laboratory has had a longstanding interest in two types of EECs that regulate satiety and signal the brain to stop eating.   Cholecystokinin (CCK) is secreted from EECs of the upper small intestine and regulates the ingestion and digestion of food through effects on the stomach, gallbladder, pancreas and brain.  Peptide YY (PYY) is secreted from EECs of the small intestine and colon and regulates satiety.  We recently demonstrated that CCK and PYY cells not only secrete hormones but are directly connected to nerves through unique cellular processes called ‘neuropods’.  Our laboratory is devoted to understanding EECs signaling and its role in disease.

Pancreatitis

Pancreatitis is an inflammatory disease of the pancreas compounded by intrapancreaatic activation of digestive enzymes.  Our laboratory is studying the influence of nerves on the development of pancreatitis. Neurogenic inflammation results from the release of bioactive substances from sensory neurons in the pancreas causing vasodilatation, edema, and inflammatory cell infiltration producing tissue necrosis. Our goal is to identify the agents that activate sensory neurons, characterize the receptors on sensory nerves that mediate these actions, and determine the effects of neural stimulation on pancreatic injury with the long-term objective of developing strategies to reduce neurogenic inflammation to treat pancreatitis. 

Visit our lab page.

Education and Training

  • Gastroenterology Fellowship, Gastroenterology, University of California - San Francisco, 1981 - 1984
  • Residency, Generalinternal Medicine, University of California - San Francisco, 1979 - 1981
  • Internship, General Internal Medicine, University of California - San Francisco, 1978 - 1979
  • M.D., Vanderbilt University, 1978
  • B.S., University of Utah, 1972

Publications

"Editorial introductions." Current Opinion in Gastroenterology 33, no. 5 (September 2017): v-v.

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Ye, L, and Liddle, RA. "Gastrointestinal hormones and the gut connectome." Current opinion in endocrinology, diabetes, and obesity 24, no. 1 (February 2017): 9-14.

PMID
27820704
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Liddle, RA. "Location, Location, Location . . . It Is Important in Pancreatitis, Too." Cellular and molecular gastroenterology and hepatology 3, no. 1 (January 2017): 6-7.

PMID
28174753
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Kanju, P, Chen, Y, Lee, W, Yeo, M, Lee, SH, Romac, J, Shahid, R, Fan, P, Gooden, DM, Simon, SA, Spasojevic, I, Mook, RA, Liddle, RA, Guilak, F, and Liedtke, WB. "Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain." Scientific reports 6 (June 2016): 26894-.

PMID
27247148
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Anderson, MA, Akshintala, V, Albers, KM, Amann, ST, Belfer, I, Brand, R, Chari, S, Cote, G, Davis, BM, Frulloni, L, Gelrud, A, Guda, N, Humar, A, Liddle, RA, Slivka, A, Gupta, RS, Szigethy, E, Talluri, J, Wassef, W, Wilcox, CM, Windsor, J, Yadav, D, and Whitcomb, DC. "Mechanism, assessment and management of pain in chronic pancreatitis: Recommendations of a multidisciplinary study group." Pancreatology : official journal of the International Association of Pancreatology (IAP) .. [et al.] 16, no. 1 (January 2016): 83-94.

PMID
26620965
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Bohórquez, D, Haque, F, Medicetty, S, and Liddle, RA. "Correlative Confocal and 3D Electron Microscopy of a Specific Sensory Cell." Journal of visualized experiments : JoVE, no. 101 (July 19, 2015): e52918-.

PMID
26273796
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Bohórquez, DV, and Liddle, RA. "The gut connectome: making sense of what you eat." The Journal of clinical investigation 125, no. 3 (March 2, 2015): 888-890.

PMID
25729849
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Shahid, RA, Wang, DQ-H, Fee, BE, McCall, SJ, Romac, JM-J, Vigna, SR, and Liddle, RA. "Endogenous elevation of plasma cholecystokinin does not prevent gallstones." European journal of clinical investigation 45, no. 3 (March 2015): 237-246.

PMID
25641074
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Morozko, EL, Nishio, A, Ingham, NJ, Chandra, R, Fitzgerald, T, Martelletti, E, Borck, G, Wilson, E, Riordan, GP, Wangemann, P, Forge, A, Steel, KP, Liddle, RA, Friedman, TB, and Belyantseva, IA. "ILDR1 null mice, a model of human deafness DFNB42, show structural aberrations of tricellular tight junctions and degeneration of auditory hair cells." Human molecular genetics 24, no. 3 (February 2015): 609-624.

PMID
25217574
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Bohórquez, DV, Shahid, RA, Erdmann, A, Kreger, AM, Wang, Y, Calakos, N, Wang, F, and Liddle, RA. "Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells." Journal of Clinical Investigation 125, no. 2 (February 2015): 782-786.

PMID
25555217
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