Rodger Alan Liddle, MD

Professor of Medicine
Member of the Duke Institute for Brain Sciences
Member of the Duke Cancer Institute
Campus mail 1033A GSRB-1 Bldg, Durham, NC 27710
Phone (919) 681-6380
Email address rodger.liddle@duke.edu

Our laboratory has two major research interests:

Enteroendocrine Cell Biology

Enteroendocrine cells (EECs) are sensory cells of the gut that send signals throughout the body.  They have the ability to sense food and nutrients in the lumen of the intestine and secrete hormones into the blood.  Our laboratory has had a longstanding interest in two types of EECs that regulate satiety and signal the brain to stop eating.   Cholecystokinin (CCK) is secreted from EECs of the upper small intestine and regulates the ingestion and digestion of food through effects on the stomach, gallbladder, pancreas and brain.  Peptide YY (PYY) is secreted from EECs of the small intestine and colon and regulates satiety.  We recently demonstrated that CCK and PYY cells not only secrete hormones but are directly connected to nerves through unique cellular processes called ‘neuropods’.  Our laboratory is devoted to understanding EECs signaling and its role in disease.

Pancreatitis

Pancreatitis is an inflammatory disease of the pancreas compounded by intrapancreaatic activation of digestive enzymes.  Our laboratory is studying the influence of nerves on the development of pancreatitis. Neurogenic inflammation results from the release of bioactive substances from sensory neurons in the pancreas causing vasodilatation, edema, and inflammatory cell infiltration producing tissue necrosis. Our goal is to identify the agents that activate sensory neurons, characterize the receptors on sensory nerves that mediate these actions, and determine the effects of neural stimulation on pancreatic injury with the long-term objective of developing strategies to reduce neurogenic inflammation to treat pancreatitis. 

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Education and Training

  • Gastroenterology Fellowship, Gastroenterology, University of California - San Francisco, 1981 - 1984
  • Residency, Generalinternal Medicine, University of California - San Francisco, 1979 - 1981
  • Internship, General Internal Medicine, University of California - San Francisco, 1978 - 1979
  • M.D., Vanderbilt University, 1978
  • B.S., University of Utah, 1972

Publications

Liddle, RA. "Parkinson's disease from the gut." Brain Research 1693, no. Pt B (August 2018): 201-206.

PMID
29360467
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Liddle, RA. "Interactions of Gut Endocrine Cells with Epithelium and Neurons." Comprehensive Physiology 8, no. 3 (June 18, 2018): 1019-1030.

PMID
29978902
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Romac, JM-J, Shahid, RA, Swain, SM, Vigna, SR, and Liddle, RA. "Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis." Nature Communications 9, no. 1 (April 30, 2018): 1715-null.

PMID
29712913
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Liddle, RA. "Regulation of Pancreatic Secretion." In Physiology of the Gastrointestinal Tract: Sixth Edition, 895-929. March 28, 2018.

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"Editorial introductions." Current Opinion in Gastroenterology 33, no. 5 (September 2017): v-v.

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Chandra, R, Hiniker, A, Kuo, Y-M, Nussbaum, RL, and Liddle, RA. "α-Synuclein in gut endocrine cells and its implications for Parkinson's disease." Jci Insight 2, no. 12 (June 15, 2017).

PMID
28614796
Full Text

Himmerkus, N, Gong, Y, Friedman, T, Liddle, RA, Baker, LA, Hou, J, and Bleich, M. "Water impermeability of the thick ascending limb of Henle's loop and the collecting duct depends on ILDR1 expression." March 2017.

Scholars@Duke

Ye, L, and Liddle, RA. "Gastrointestinal hormones and the gut connectome." Current Opinion in Endocrinology, Diabetes, and Obesity 24, no. 1 (February 2017): 9-14. (Review)

PMID
27820704
Full Text

Liddle, RA. "Location, Location, Location . . . It Is Important in Pancreatitis, Too." Cellular and molecular gastroenterology and hepatology 3, no. 1 (January 2017): 6-7.

PMID
28174753
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Diamond, P, Kenny, M, and Liddle, R. "Introduction: The Progressive Dilemma in British Politics." The Political Quarterly 88, no. 1 (January 2017): 6-12.

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