Samira Musah, PhD

Assistant Professor in the Department of Biomedical Engineering
Assistant Professor - Track V in Medicine
Affiliate of the Regeneration Next Initiative
Campus mail 101 Science Dr., Box 90281, Durham, NC 27708
Email address samira.musah@duke.edu

The Musah Lab is interested in understanding how molecular signals and biophysical forces can function either synergistically or independently to guide organ development and physiology, and how these processes can be therapeutically harnessed to treat human disease. Given the escalating medical crisis in nephrology as growing number of patients suffer from kidney disease that can lead to organ failure, the Musah Lab focuses on engineering stem cell fate for applications in human kidney disease, extra-renal complications, and therapeutic development. Dr. Musah’s research interests include stem cell biology and regenerative medicine, molecular and cellular basis of human organ development and disease progression, organ engineering, patient-specific disease models, biomarker identification, therapeutic discovery, tissue and organ transplantation, microphysiological systems including Organ Chips (organs-on-chips) and organoids, matrix biology, mechanotransduction and disease biophysics.

Education and Training

  • Ph.D., University of Wisconsin at Madison, 2013

Publications

Musah, Samira, Nikolaos Dimitrakakis, Diogo M. Camacho, George M. Church, and Donald E. Ingber. “Directed differentiation of human induced pluripotent stem cells into mature kidney podocytes and establishment of a Glomerulus Chip..” Nature Protocols 13, no. 7 (July 2018): 1662–85. https://doi.org/10.1038/s41596-018-0007-8.

PMID
29995874
Full Text

Musah, Samira, Akiko Mammoto, Thomas C. Ferrante, Sauveur S. F. Jeanty, Mariko Hirano-Kobayashi, Tadanori Mammoto, Kristen Roberts, et al. “Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip..” Nature Biomedical Engineering 1 (January 2017). https://doi.org/10.1038/s41551-017-0069.

PMID
29038743
Full Text

Musah, Samira, Paul J. Wrighton, Yefim Zaltsman, Xiaofen Zhong, Stefan Zorn, Matthew B. Parlato, Cheston Hsiao, et al. “Substratum-induced differentiation of human pluripotent stem cells reveals the coactivator YAP is a potent regulator of neuronal specification..” Proceedings of the National Academy of Sciences of the United States of America 111, no. 38 (September 8, 2014): 13805–10. https://doi.org/10.1073/pnas.1415330111.

PMID
25201954
Full Text

Musah, Samira, Stephen A. Morin, Paul J. Wrighton, Daniel B. Zwick, Song Jin, and Laura L. Kiessling. “Glycosaminoglycan-binding hydrogels enable mechanical control of human pluripotent stem cell self-renewal..” Acs Nano 6, no. 11 (November 2012): 10168–77. https://doi.org/10.1021/nn3039148.

PMID
23005914
Full Text

Musah, Samira, and Laura L. Kiessling. “Synthetic polymer scaffold supports human embryonic stem cell adhesion and proliferation in defined conditions.” In Abstracts of Papers of the American Chemical Society, Vol. 244. AMER CHEMICAL SOC, 2012.

Scholars@Duke

Derda, Ratmir, Samira Musah, Brendan P. Orner, Joseph R. Klim, Lingyin Li, and Laura L. Kiessling. “High-throughput discovery of synthetic surfaces that support proliferation of pluripotent cells..” Journal of the American Chemical Society 132, no. 4 (February 2010): 1289–95. https://doi.org/10.1021/ja906089g.

PMID
20067240
Full Text

Kikandi, S. N., S. Musah, K. Lee, J. Hassani, S. Rajan, A. Zhou, and O. A. Sadik. “Comparative studies of quercetin interactions with monophosphate nucleotides using UV-Vis spectroscopy and electrochemical techniques.” Electroanalysis 19, no. 19–20 (October 1, 2007): 2131–40. https://doi.org/10.1002/elan.200703954.

Full Text

Musah, Samira. “Building an artificial kidney from human stem cells,” n.d.

Scholars@Duke