Sana Mustapha Al-Khatib, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 7521 N Pavilion Bldg, Durham, NC 27715
Phone (919) 668-8649
Email address alkha001@mc.duke.edu

Dr. Sana M. Al-Khatib is a tenured Professor of Medicine at Duke University Medical Center, a board-certified clinical electrophysiologist and an experienced clinical researcher in cardiac arrhythmias.  As a graduate of the NIH-funded Clinical Research Training Program, she is one of a few electrophysiologists nationwide with expertise in quantitative research methods. Her clinical expertise is in sudden cardiac death prevention, atrial fibrillation and ventricular arrhythmias, and implantable cardiac devices. Her research expertise lies in the design and conduct of clinical trials, outcomes research, and cost-effectiveness analyses. She is a recipient of a National Heart, Lung and Blood Institute’s R-01 grant titled “Implantable Cardioverter Defibrillator Therapy in Patients with Heart Failure” (2009-2013) and of an American Heart Association Career Development Award (2002-2006). She is a Co-Principal Investigator on an NHLBI-funded T-32 Postdoctoral Training in Cardiovascular Clinical Research and on several Agency of Healthcare Research and Quality sponsored R-01 grants including the “Duke Cardiovascular Center for Education and Research on Therapeutics.” She has more than 130 publications in peer-reviewed journals. She has established several collaborative research efforts both within and outside her institution. The goals of these collaborations are to synergize efforts aimed at improving the survival and quality of life of patients at risk for sudden cardiac death and those with atrial and ventricular arrhythmias through clinical trials and outcomes-based research and to evaluate study design and data analysis in order to improve the quality of research done in these arenas. Dr. Al-Khatib is an Associate Editor for the American Heart Journal and is on the Editorial Board for the Journal of Cardiovascular Electrophysiology. Dr. Al-Khatib serves on multiple national committees including the Heart Rhythm Society Board of Trustees, the Heart Rhythm Society Health Policy committee, the Heart Rhythm Society Legislative subcommittee, the Heart Rhythm Society Program Planning committee, the American College of Cardiology ICD Registry Steering committee, and the National Quality Forum Cardiovascular Steering committee.

In Their Words

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1996 - 2000
  • Medical Resident, Medicine, Duke University, 1993 - 1996
  • M.D., American University of Beirut (Lebannon), 1993

Publications

Pokorney, SD, Bloom, D, Granger, CB, Thomas, KL, Al-Khatib, SM, Roettig, ML, Anderson, J, Heflin, MT, and Granger, BB. "Exploring patient-provider decision-making for use of anticoagulation for stroke prevention in atrial fibrillation: Results of the INFORM-AF study." European Journal of Cardiovascular Nursing : Journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology 18, no. 4 (April 2019): 280-288.

PMID
30418049
Full Text

Pokorney, SD, Gersh, BJ, Ahmad, A, Al-Khatib, SM, Blank, M, Coylewright, M, DiBattiste, P, Healey, JS, Hedrich, O, Hylek, EM, Kline-Rogers, E, Peterson, ED, Mendys, P, Mirro, MJ, Naccarelli, G, Patel, P, Ruff, CT, Rutman, H, Stockbridge, N, Temple, R, and Granger, CB. "Stroke prevention in atrial fibrillation: Closing the gap." American Heart Journal 210 (April 2019): 29-38.

PMID
30731371
Full Text

Levine, GN, O'Gara, PT, Beckman, JA, Al-Khatib, SM, Birtcher, KK, Cigarroa, JE, de Las Fuentes, L, Deswal, A, Fleisher, LA, Gentile, F, Goldberger, ZD, Hlatky, MA, Joglar, JA, Piano, MR, and Wijeysundera, DN. "Recent Innovations, Modifications, and Evolution of ACC/AHA Clinical Practice Guidelines: An Update for Our Constituencies: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines." Circulation (March 20, 2019): CIR0000000000000651-null.

PMID
30892927
Full Text

Levine, GN, O'Gara, PT, Beckman, JA, Al-Khatib, SM, Birtcher, KK, Cigarroa, JE, de Las Fuentes, L, Deswal, A, Fleisher, LA, Gentile, F, Goldberger, ZD, Hlatky, MA, Joglar, JA, Piano, MR, and Wijeysundera, DN. "Recent Innovations, Modifications, and Evolution of ACC/AHA Clinical Practice Guidelines: An Update for Our Constituencies: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines." Journal of the American College of Cardiology (March 16, 2019).

PMID
30904245
Full Text

Al-Khatib, SM, and Granger, CB. "The changing epidemiology of ventricular arrhythmias and sudden cardiac death: Is it a reality?." Heart Rhythm 16, no. 3 (March 2019): 367-368.

PMID
30291915
Full Text

Hohnloser, SH, Fudim, M, Alexander, JH, Wojdyla, DM, Ezekowitz, JA, Hanna, M, Atar, D, Hijazi, Z, Bahit, MC, Al-Khatib, SM, Lopez-Sendon, JL, Wallentin, L, Granger, CB, and Lopes, RD. "Efficacy and Safety of Apixaban versus Warfarin in Patients with Atrial Fibrillation and Extremes in Body Weight: Insights from the ARISTOTLE Trial." Circulation (February 18, 2019).

PMID
30773022
Full Text

Pun, PH, Dupre, ME, Starks, MA, Tyson, C, Vellano, K, Svetkey, LP, Hansen, S, Frizzelle, BG, McNally, B, Jollis, JG, Al-Khatib, SM, Granger, CB, and CARES Surveillance Group, . "Outcomes for Hemodialysis Patients Given Cardiopulmonary Resuscitation for Cardiac Arrest at Outpatient Dialysis Clinics." Journal of the American Society of Nephrology : Jasn (February 7, 2019).

PMID
30733235
Full Text

Cocoros, NM, Pokorney, SD, Haynes, K, Garcia, C, Al-Khalidi, HR, Al-Khatib, SM, Archdeacon, P, Goldsack, JC, Harkins, T, Lin, ND, Martin, D, McCall, D, Nair, V, Parlett, L, Temple, R, McMahill-Walraven, C, Granger, CB, and Platt, R. "FDA-Catalyst-Using FDA's Sentinel Initiative for large-scale pragmatic randomized trials: Approach and lessons learned during the planning phase of the first trial." Clinical Trials (London, England) 16, no. 1 (February 2019): 90-97.

PMID
30445835
Full Text

Goldstein, SA, Mentz, RJ, Hellkamp, AS, Randolph, TC, Fonarow, GC, Hernandez, A, Yancy, CW, and Al-Khatib, SM. "Timing of cardiac resynchronization therapy device implantation in heart failure patients and its association with outcomes." Clinical Cardiology 42, no. 2 (February 2019): 256-263.

PMID
30548280
Full Text

Fanaroff, AC, Clare, R, Pieper, KS, Mahaffey, KW, Melloni, C, Green, JB, Alexander, JH, Jones, WS, Harrison, RW, Mehta, RH, Povsic, TJ, Moreira, HG, Al-Khatib, SM, Roe, MT, Kong, DF, Mathews, R, Tricoci, P, Holman, RR, Wallentin, L, Held, C, Califf, RM, Alexander, KP, and Lopes, RD. "Frequency, Regional Variation, and Predictors of Undetermined Cause of Death in Cardiometabolic Clinical Trials: A Pooled Analysis of 9259 Deaths in 9 Trials." Circulation 139, no. 7 (February 2019): 863-873.

PMID
30586739
Full Text

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