Sana Mustapha Al-Khatib, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 7521 N Pavilion Bldg, Durham, NC 27715
Phone (919) 668-8649
Email address alkha001@duke.edu

Dr. Sana M. Al-Khatib is a tenured Professor of Medicine at Duke University Medical Center, a board-certified clinical electrophysiologist and an experienced clinical researcher in cardiac arrhythmias.  As a graduate of the NIH-funded Clinical Research Training Program, she is one of a few electrophysiologists nationwide with expertise in quantitative research methods. Her clinical expertise is in sudden cardiac death prevention, atrial fibrillation and ventricular arrhythmias, and implantable cardiac devices. Her research expertise lies in the design and conduct of clinical trials, outcomes research, and cost-effectiveness analyses. She is a recipient of a National Heart, Lung and Blood Institute’s R-01 grant titled “Implantable Cardioverter Defibrillator Therapy in Patients with Heart Failure” (2009-2013) and of an American Heart Association Career Development Award (2002-2006). She is a Co-Principal Investigator on an NHLBI-funded T-32 Postdoctoral Training in Cardiovascular Clinical Research and on several Agency of Healthcare Research and Quality sponsored R-01 grants including the “Duke Cardiovascular Center for Education and Research on Therapeutics.” She has more than 130 publications in peer-reviewed journals. She has established several collaborative research efforts both within and outside her institution. The goals of these collaborations are to synergize efforts aimed at improving the survival and quality of life of patients at risk for sudden cardiac death and those with atrial and ventricular arrhythmias through clinical trials and outcomes-based research and to evaluate study design and data analysis in order to improve the quality of research done in these arenas. Dr. Al-Khatib is an Associate Editor for the American Heart Journal and is on the Editorial Board for the Journal of Cardiovascular Electrophysiology. Dr. Al-Khatib serves on multiple national committees including the Heart Rhythm Society Board of Trustees, the Heart Rhythm Society Health Policy committee, the Heart Rhythm Society Legislative subcommittee, the Heart Rhythm Society Program Planning committee, the American College of Cardiology ICD Registry Steering committee, and the National Quality Forum Cardiovascular Steering committee.

In Their Words

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1996 - 2000
  • Medical Resident, Medicine, Duke University, 1993 - 1996
  • M.D., American University of Beirut (Lebanon), 1993

Publications

Allen LaPointe, Nancy M., Fatima Ali-Ahmed, Frederik Dalgaard, Andrzej S. Kosinski, Gillian Sanders Schmidler, and Sana M. Al-Khatib. “Cardiac resynchronization therapy outcomes with left ventricular lead concordant with latest mechanical activation: A meta-analysis.” Pacing Clin Electrophysiol, June 10, 2022. https://doi.org/10.1111/pace.14549.

PMID
35687711
Full Text

Mastoris, Ioannis, Harriette GC Van Spall, Seth H. Sheldon, Rhea C. Pimentel, Leslie Steinkamp, Zubair Shah, Sana M. Al-Khatib, Jagmeet P. Singh, and Andrew J. Sauer. “Emerging Implantable-Device Technology for Patients at the Intersection of Electrophysiology and Heart Failure Interdisciplinary Care.” J Card Fail 28, no. 6 (June 2022): 991–1015. https://doi.org/10.1016/j.cardfail.2021.11.006.

PMID
34774748
Full Text

Assimon, Magdalene M., Patrick H. Pun, Sana M. Al-Khatib, M Alan Brookhart, Bradley N. Gaynes, Wolfgang C. Winkelmayer, and Jennifer E. Flythe. “Proton pump inhibitors may enhance the risk of citalopram- and escitalopram-associated sudden cardiac death among patients receiving hemodialysis.” Pharmacoepidemiol Drug Saf 31, no. 6 (June 2022): 670–79. https://doi.org/10.1002/pds.5428.

PMID
35285107
Full Text

Zeitler, Emily P., Andrea M. Austin, Christopher G. Leggett, Lauren G. Gilstrap, Daniel J. Friedman, Jonathan S. Skinner, and Sana M. Al-Khatib. “Reply: Complications and Mortality Following CRT-D vs ICD.” Jacc Heart Fail 10, no. 6 (June 2022): 444–45. https://doi.org/10.1016/j.jchf.2022.04.005.

PMID
35654530
Full Text

Althouse, Andrew D., Sandeep Kumar Jain, Alaa Shalaby, Madhurmeet Singh, Raul Weiss, Larissa Myaskovsky, Sana M. Al-Khatib, and Samir Saba. “Feasibility of a Randomized Clinical Trial of Cardiac Resynchronization Therapy With or Without an Implantable Defibrillator in Older Patients.” Circ Arrhythm Electrophysiol 15, no. 4 (April 2022): e010795. https://doi.org/10.1161/CIRCEP.121.010795.

PMID
35357219
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Friedman, Daniel J., Li Qin, Craig Parzynski, E Kevin Heist, Andrea M. Russo, Isuru Ranasinghe, Emily P. Zeitler, et al. “Longitudinal Outcomes of Subcutaneous or Transvenous Implantable Cardioverter-Defibrillators in Older Patients.” J Am Coll Cardiol 79, no. 11 (March 22, 2022): 1050–59. https://doi.org/10.1016/j.jacc.2021.12.033.

PMID
35300816
Full Text

Lala, Anuradha, Upasana Tayal, Carine E. Hamo, Quentin Youmans, Sana M. Al-Khatib, Biykem Bozkurt, Melinda B. Davis, et al. “Sex Differences in Heart Failure.” J Card Fail 28, no. 3 (March 2022): 477–98. https://doi.org/10.1016/j.cardfail.2021.10.006.

PMID
34774749
Full Text

Bicong, Li, John Carson Allen, Kelly Arps, Sana M. Al-Khatib, Tristram D. Bahnson, James P. Daubert, Camille Frazier-Mills, et al. “Leadless pacemaker implantation after lead extraction for cardiac implanted electronic device infection.” J Cardiovasc Electrophysiol 33, no. 3 (March 2022): 464–70. https://doi.org/10.1111/jce.15363.

PMID
35029307
Full Text

Zeitler, Emily P., Andrea M. Austin, Christopher G. Leggett, Lauren G. Gilstrap, Daniel J. Friedman, Jonathan S. Skinner, and Sana M. Al-Khatib. “Complications and Mortality Following CRT-D Versus ICD Implants in Older Medicare Beneficiaries With Heart Failure.” Jacc Heart Fail 10, no. 3 (March 2022): 147–57. https://doi.org/10.1016/j.jchf.2021.10.012.

PMID
35241242
Full Text

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