Sana Mustapha Al-Khatib, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 7521 N Pavilion Bldg, Durham, NC 27715
Phone (919) 668-8649
Email address alkha001@mc.duke.edu

Dr. Sana M. Al-Khatib is a tenured Professor of Medicine at Duke University Medical Center, a board-certified clinical electrophysiologist and an experienced clinical researcher in cardiac arrhythmias.  As a graduate of the NIH-funded Clinical Research Training Program, she is one of a few electrophysiologists nationwide with expertise in quantitative research methods. Her clinical expertise is in sudden cardiac death prevention, atrial fibrillation and ventricular arrhythmias, and implantable cardiac devices. Her research expertise lies in the design and conduct of clinical trials, outcomes research, and cost-effectiveness analyses. She is a recipient of a National Heart, Lung and Blood Institute’s R-01 grant titled “Implantable Cardioverter Defibrillator Therapy in Patients with Heart Failure” (2009-2013) and of an American Heart Association Career Development Award (2002-2006). She is a Co-Principal Investigator on an NHLBI-funded T-32 Postdoctoral Training in Cardiovascular Clinical Research and on several Agency of Healthcare Research and Quality sponsored R-01 grants including the “Duke Cardiovascular Center for Education and Research on Therapeutics.” She has more than 130 publications in peer-reviewed journals. She has established several collaborative research efforts both within and outside her institution. The goals of these collaborations are to synergize efforts aimed at improving the survival and quality of life of patients at risk for sudden cardiac death and those with atrial and ventricular arrhythmias through clinical trials and outcomes-based research and to evaluate study design and data analysis in order to improve the quality of research done in these arenas. Dr. Al-Khatib is an Associate Editor for the American Heart Journal and is on the Editorial Board for the Journal of Cardiovascular Electrophysiology. Dr. Al-Khatib serves on multiple national committees including the Heart Rhythm Society Board of Trustees, the Heart Rhythm Society Health Policy committee, the Heart Rhythm Society Legislative subcommittee, the Heart Rhythm Society Program Planning committee, the American College of Cardiology ICD Registry Steering committee, and the National Quality Forum Cardiovascular Steering committee.

In Their Words

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1996 - 2000
  • Medical Resident, Medicine, Duke University, 1993 - 1996
  • M.D., American University of Beirut (Lebannon), 1993

Publications

Pokorney, SD, Al-Khatib, SM, Sun, J-L, Schulte, P, O'Connor, CM, Teerlink, JR, Armstrong, PW, Ezekowitz, JA, Starling, RC, Voors, AA, Velazquez, EJ, Hernandez, AF, and Mentz, RJ. "Sudden cardiac death after acute heart failure hospital admission: insights from ASCEND-HF." December 20, 2017.

PMID
29266564
Full Text

Zeitler, EP, Al-Khatib, SM, Friedman, DJ, Han, JY, Poole, JE, Bardy, GH, Bigger, JT, Buxton, AE, Moss, AJ, Lee, KL, Dorian, P, Cappato, R, Kadish, AH, Kudenchuk, PJ, Mark, DB, Inoue, LYT, and Sanders, GD. "Predicting appropriate shocks in patients with heart failure: Patient level meta-analysis from SCD-HeFT and MADIT II." November 2017.

PMID
28744959
Full Text

Al-Khatib, SM, and Pokorney, SD. "Primary Prevention Implantable Cardioverter Defibrillators in Patients With Nonischemic Cardiomyopathy: Diminishing Returns With Advancing Age?." Circulation 136, no. 19 (November 2017): 1781-1783.

PMID
29109194
Full Text

Al-Khatib, SM, Gillis, AM, and Curtis, AB. "The Centers for Medicare and Medicaid Services' Decision to Reconsider Coverage Indications for ICDs: Where to Now?." Circulation (October 25, 2017).

PMID
29070501
Full Text

Pokorney, SD, Mi, X, Lewis, RK, Greiner, M, Epstein, LM, Carrillo, RG, Zeitler, EP, Al-Khatib, SM, Hegland, DD, and Piccini, JP. "Outcomes Associated With Extraction Versus Capping and Abandoning Pacing and Defibrillator Leads." Circulation 136, no. 15 (October 2017): 1387-1395.

PMID
28830879
Full Text

Zeitler, EP, Friedman, DJ, Daubert, JP, Al-Khatib, SM, Solomon, SD, Biton, Y, McNitt, S, Zareba, W, Moss, AJ, and Kutyifa, V. "Reply: The Benefit of Cardiac Resynchronization Therapy Is Not Hindered by the Number of Comorbidities." Journal of the American College of Cardiology 70, no. 16 (October 2017): 2097-2098. (Letter)

PMID
29025566
Full Text

Friedman, DJ, Al-Khatib, SM, Zeitler, EP, Han, J, Bardy, GH, Poole, JE, Bigger, JT, Buxton, AE, Moss, AJ, Lee, KL, Steinman, R, Dorian, P, Cappato, R, Kadish, AH, Kudenchuk, PJ, Mark, DB, Inoue, LYT, and Sanders, GD. "New York Heart Association class and the survival benefit from primary prevention implantable cardioverter defibrillators: A pooled analysis of 4 randomized controlled trials." September 2017.

PMID
28888266
Full Text

Al-Khatib, SM, Friedman, DJ, Hess, PL, Pun, PH, and Sanders, GD. "Do Implantable Cardioverter-Defibrillators Lower the Risk of Sudden Death and Total Mortality in Patients with End-Stage Renal Disease?." Current Cardiovascular Risk Reports 11, no. 9 (September 2017).

Full Text

Friedman, DJ, Black-Maier, EW, Barnett, AS, Pokorney, SD, Al-Khatib, SM, Jackson, KP, Bahnson, TD, Ellis, CR, Atwater, BD, Lewis, RK, and Piccini, JP. "LAA Electrical Isolation for Treatment of Recurrent Atrial Fibrillation." JACC: Clinical Electrophysiology (September 2017).

Full Text

Crowley, MJ, Al-Khatib, SM, Wang, TY, Khazanie, P, Kressin, NR, Krumholz, HM, Kiefe, CI, Wells, BL, O'Brien, SM, Peterson, ED, and Sanders, GD. "How well does early-career investigators' cardiovascular outcomes research training align with funded outcomes research?." American Heart Journal (September 2017).

Full Text

Pages