Scott Michael Palmer, MD

Professor of Medicine
Vice-Chair for Research in the Department of Medicine
Member in the Duke Clinical Research Institute
Professor in Immunology
Professor in Population Health Sciences
Core Faculty in Innovation & Entrepreneurship
Campus mail 2085 Msrb2 2 Genome Ct, Durham, NC 27710
Phone (919) 684-0245
Email address

Dr. Palmer leads a successful program of clinical, basic and translational research in transplantation and advanced lung diseases. He currently directs the pulmonary research program at the Duke Clinical Research Institute (DCRI) and serves as Vice Chair for Research in the Department of Medicine.

Dr. Palmer has over 150 peer reviewed publications, received numerous awards, including election into the American Society for Clinical Investigation (ASCI) in 2012, chaired many sessions at national and international meetings, serves regularly on NIH study sections, and is on the editorial board of many prominent journals. He is also Associate Director of the Clinical Research Training Program at Duke and has personally mentored over 40 pre-and post-doctoral trainees, many of whom are now engaged in their own successful research careers.

His scientific accomplishments include the first human studies to demonstrate the importance of innate immunity in transplant rejection and completion of a prospective multicenter study that improved CMV prevention after lung transplantation.

Current basic projects in the lab are studying the role of the matrix in the activation of innate immunity in pulmonary transplant rejection, and epithelial injury and repair in the development of toxin induced bronchiolitis obliterans. Translational and human projects are studying predictors of lung transplant survival in the UNOS database, immune monitoring to predict CMV infection and acute rejection after lung transplantation, and the use of novel inhaled antibiotics in lung transplantation. The lab is also using cutting edge whole exome genetic sequencing to identify genetic predictors of transplant rejection.

Dr. Palmer also leads trials coordinated through the DCRI that study the natural history and investigate new treatments for idiopathic pulmonary fibrosis (IPF), chronic lung transplant rejection, and posttransplant cytomegalovirus infection.

Education and Training

  • Fellow, Pulmonary Medicine, Medicine, Duke University, 1996 - 1999
  • Medical Resident, Medicine, Duke University, 1993 - 1996
  • M.H.S., Duke University, 2000
  • M.D., Duke University, 1993


Shino, Michael Y., Ning Li, Jamie L. Todd, Megan L. Neely, Jerry Kirchner, Heather Kopetskie, Michelle L. Sever, et al. “Correlation between BAL CXCR3 chemokines and lung allograft histopathologies: A multicenter study.” Am J Transplant 21, no. 10 (October 2021): 3401–10.

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Hostetler, Haley P., Megan L. Neely, Elizabeth Lydon, Lara A. Danziger-Isakov, Jamie L. Todd, and Scott M. Palmer. “Immunity to varicella, measles, and mumps in patients evaluated for lung transplantation.” In Am J Transplant, 21:2864–70, 2021.

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Zaffiri, Lorenzo, Courtney Frankel, Erika J. Bush, Megan L. Neely, Elizabeth N. Pavlisko, Irina L. Mokrova, Micah A. Luftig, and Scott M. Palmer. “Evidence of Epstein-Barr virus heterogeneous gene expression in adult lung transplant recipients with posttransplant lymphoproliferative disorder.” J Med Virol 93, no. 8 (August 2021): 5040–47.

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Eichenberger, Emily M., Felicia Ruffin, Michael Dagher, Reginald Lerebours, Sin-Ho Jung, Batu Sharma-Kuinkel, Andrew N. Macintyre, et al. “Bacteremia in solid organ transplant recipients as compared to immunocompetent patients: Acute phase cytokines and outcomes in a prospective, matched cohort study.” Am J Transplant 21, no. 6 (June 2021): 2113–22.

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Ghio, Andrew J., Joleen M. Soukup, Lisa A. Dailey, Victor L. Roggli, Alvin L. Crumbliss, and Scott M. Palmer. “Diacetyl exposure disrupts iron homeostasis in animals and cells.” Inhal Toxicol 33, no. 6–8 (May 2021): 268–74.

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Schneeberger, P. H., C. Zhang, J. Santilli, Z. Wijesinha, L. Levy, B. Chen, W. Xu, et al. “The Pulmonary Microbiome after Lung Transplantation is Associated with Gastroesophageal Reflux Disease, Inflammation, and Allograft Dysfunction.” In Journal of Heart and Lung Transplantation, 40:S59–60, 2021.


Levy, L., M. Ahmed, E. Huszti, C. K. Zhang, S. E. Hunter, K. M. Boonstra, A. T. Sage, et al. “Bronchoalveolar Bile Acids are Associated with Acute Rejection, Inflammation, and Allograft Survival: A Multi-Center Study.” In Journal of Heart and Lung Transplantation, 40:S62–63, 2021.


Hostetler, Haley P., Megan L. Neely, Francine L. Kelly, John A. Belperio, Marie Budev, John M. Reynolds, Pali D. Shah, et al. “Intragraft Hyaluronan Increases in Association With Acute Lung Transplant Rejection.” Transplant Direct 7, no. 4 (April 2021): e685.

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Halpern, Samantha E., Alec McConnell, Sarah B. Peskoe, Vignesh Raman, Oliver K. Jawitz, Ashley Y. Choi, Megan L. Neely, Scott M. Palmer, and Matthew G. Hartwig. “A three-tier system for evaluation of organ procurement organizations' willingness to pursue and utilize nonideal donor lungs.” Am J Transplant 21, no. 3 (March 2021): 1269–77.

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