Scott Michael Palmer, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Vice-Chair for Research in the Department of Medicine
Professor in Immunology
Professor in Population Health Sciences
Core Faculty in Innovation & Entrepreneurship
Campus mail 2085 Msrb2 2 Genome Ct, Durham, NC 27710
Phone (919) 684-0245
Email address scott.palmer@duke.edu

Dr. Palmer leads a successful program of clinical, basic and translational research in transplantation and advanced lung diseases. He currently directs the pulmonary research program at the Duke Clinical Research Institute (DCRI) and serves as Vice Chair for Research in the Department of Medicine.

Dr. Palmer has over 150 peer reviewed publications, received numerous awards, including election into the American Society for Clinical Investigation (ASCI) in 2012, chaired many sessions at national and international meetings, serves regularly on NIH study sections, and is on the editorial board of many prominent journals. He is also Associate Director of the Clinical Research Training Program at Duke and has personally mentored over 40 pre-and post-doctoral trainees, many of whom are now engaged in their own successful research careers.

His scientific accomplishments include the first human studies to demonstrate the importance of innate immunity in transplant rejection and completion of a prospective multicenter study that improved CMV prevention after lung transplantation.

Current basic projects in the lab are studying the role of the matrix in the activation of innate immunity in pulmonary transplant rejection, and epithelial injury and repair in the development of toxin induced bronchiolitis obliterans. Translational and human projects are studying predictors of lung transplant survival in the UNOS database, immune monitoring to predict CMV infection and acute rejection after lung transplantation, and the use of novel inhaled antibiotics in lung transplantation. The lab is also using cutting edge whole exome genetic sequencing to identify genetic predictors of transplant rejection.

Dr. Palmer also leads trials coordinated through the DCRI that study the natural history and investigate new treatments for idiopathic pulmonary fibrosis (IPF), chronic lung transplant rejection, and posttransplant cytomegalovirus infection.

Education and Training

  • Fellow, Pulmonary Medicine, Medicine, Duke University, 1996 - 1999
  • Medical Resident, Medicine, Duke University, 1993 - 1996
  • M.H.S., Duke University, 2000
  • M.D., Duke University, 1993

Publications

Hostetler, Haley P., Megan L. Neely, Elizabeth Lydon, Lara A. Danziger-Isakov, Jamie L. Todd, and Scott M. Palmer. “Immunity to varicella, measles, and mumps in patients evaluated for lung transplantation.” In American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2021. https://doi.org/10.1111/ajt.16602.

PMID
33840158
Full Text

Shino, Michael Y., Ning Li, Jamie L. Todd, Megan L. Neely, Heather Kopetskie, Michelle L. Sever, Jerry Kirchner, et al. “Correlation between BAL CXCR3 Chemokines and Lung Allograft Histopathologies: A Multi-Center Study.” Am J Transplant, April 11, 2021. https://doi.org/10.1111/ajt.16601.

PMID
33840162
Full Text

Zaffiri, Lorenzo, Courtney Frankel, Erika J. Bush, Megan L. Neely, Elizabeth N. Pavlisko, Irina L. Mokrova, Micah A. Luftig, and Scott M. Palmer. “Evidence of Epstein-Barr virus heterogeneous gene expression in adult lung transplant recipients with posttransplant lymphoproliferative disorder.” J Med Virol, March 11, 2021. https://doi.org/10.1002/jmv.26936.

PMID
33704812
Full Text

Halpern, Samantha E., Alec McConnell, Sarah B. Peskoe, Vignesh Raman, Oliver K. Jawitz, Ashley Y. Choi, Megan L. Neely, Scott M. Palmer, and Matthew G. Hartwig. “A three-tier system for evaluation of organ procurement organizations' willingness to pursue and utilize nonideal donor lungs.” Am J Transplant 21, no. 3 (March 2021): 1269–77. https://doi.org/10.1111/ajt.16347.

PMID
33048423
Full Text

Masci, Anna Maria, Scott White, Ben Neely, Maryanne Ardini-Polaske, Carol B. Hill, Ravi S. Misra, Bruce Aronow, et al. “Ontology-guided segmentation and object identification for developmental mouse lung immunofluorescent images.” Bmc Bioinformatics 22, no. 1 (February 23, 2021): 82. https://doi.org/10.1186/s12859-021-04008-8.

PMID
33622235
Full Text

Neely, Megan L., Scott M. Palmer, and Laurie D. Snyder. “Primary graft dysfunction and health-related quality of life after transplantation: The good, the bad, and the missing.” Am J Transplant 21, no. 2 (February 2021): 456–57. https://doi.org/10.1111/ajt.16313.

PMID
32957167
Full Text

Hostetler, H. P., M. L. Neely, F. L. Kelly, J. A. Belperio, M. Budev, J. M. Reynolds, P. D. Shah, et al. “Intragraft Hyaluronan Increases in Association with Acute Lung Transplant Rejection.” Transplantation Direct, January 1, 2021. https://doi.org/10.1097/TXD.0000000000001138.

Full Text

Mosher, Christopher L., Jeremy M. Weber, Courtney W. Frankel, Megan L. Neely, and Scott M. Palmer. “Risk factors for mortality in lung transplant recipients aged ≥65 years: A retrospective cohort study of 5,815 patients in the scientific registry of transplant recipients.” J Heart Lung Transplant 40, no. 1 (January 2021): 42–55. https://doi.org/10.1016/j.healun.2020.10.009.

PMID
33208278
Full Text

Stanfield, Brent A., Todd Purves, Scott Palmer, Bruce Sullenger, Karen Welty-Wolf, Krista Haines, Suresh Agarwal, and George Kasotakis. “IL-10 and class 1 histone deacetylases act synergistically and independently on the secretion of proinflammatory mediators in alveolar macrophages.” Plos One 16, no. 1 (2021): e0245169. https://doi.org/10.1371/journal.pone.0245169.

PMID
33471802
Full Text

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