Education and Training
- Ph.D., Duke University, 2002
Meng, K, Shim, P, Wang, Q, Zhao, S, Gu, T, Kahsai, AW, Ahn, S, and Chen, X. "Design, synthesis, and functional assessment of Cmpd-15 derivatives as negative allosteric modulators for the β2-adrenergic receptor." Bioorganic & medicinal chemistry (March 15, 2018).
Liu, X, Ahn, S, Kahsai, AW, Meng, K-C, Latorraca, NR, Pani, B, Venkatakrishnan, AJ, Masoudi, A, Weis, WI, Dror, RO, Chen, X, Lefkowitz, RJ, and Kobilka, BK. "Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure." Nature 548, no. 7668 (August 16, 2017): 480-484.
Ahn, S, Kahsai, AW, Pani, B, Wang, Q-T, Zhao, S, Wall, AL, Strachan, RT, Staus, DP, Wingler, LM, Sun, LD, Sinnaeve, J, Choi, M, Cho, T, Xu, TT, Hansen, GM, Burnett, MB, Lamerdin, JE, Bassoni, DL, Gavino, BJ, Husemoen, G, Olsen, EK, Franch, T, Costanzi, S, Chen, X, and Lefkowitz, RJ. "Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library." Proceedings of the National Academy of Sciences of the United States of America 114, no. 7 (February 2017): 1708-1713.
Kahsai, AW, Wisler, JW, Lee, J, Ahn, S, Cahill Iii, TJ, Dennison, SM, Staus, DP, Thomsen, ARB, Anasti, KM, Pani, B, Wingler, LM, Desai, H, Bompiani, KM, Strachan, RT, Qin, X, Alam, SM, Sullenger, BA, and Lefkowitz, RJ. "Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor." Nature chemical biology 12, no. 9 (September 2016): 709-716.
Staus, DP, Strachan, RT, Manglik, A, Pani, B, Kahsai, AW, Kim, TH, Wingler, LM, Ahn, S, Chatterjee, A, Masoudi, A, Kruse, AC, Pardon, E, Steyaert, J, Weis, WI, Prosser, RS, Kobilka, BK, Costa, T, and Lefkowitz, RJ. "Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation." Nature 535, no. 7612 (July 13, 2016): 448-452.
Strachan, RT, Sun, J-P, Rominger, DH, Violin, JD, Ahn, S, Rojas Bie Thomsen, A, Zhu, X, Kleist, A, Costa, T, and Lefkowitz, RJ. "Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR)." The Journal of biological chemistry 289, no. 20 (May 2014): 14211-14224.
Staus, DP, Wingler, LM, Strachan, RT, Rasmussen, SGF, Pardon, E, Ahn, S, Steyaert, J, Kobilka, BK, and Lefkowitz, RJ. "Regulation of β2-adrenergic receptor function by conformationally selective single-domain intrabodies." Mol Pharmacol 85, no. 3 (March 2014): 472-481.
Aristotelous, T, Ahn, S, Shukla, AK, Gawron, S, Sassano, MF, Kahsai, AW, Wingler, LM, Zhu, X, Tripathi-Shukla, P, Huang, XP, Riley, J, Besnard, J, Read, KD, Roth, BL, Gilbert, IH, Hopkins, AL, Lefkowitz, RJ, and Navratilova, I. "Discovery of β2 adrenergic receptor ligands using biosensor fragment screening of tagged wild-type receptor." ACS Medicinal Chemistry Letters 4, no. 10 (October 10, 2013): 1005-1010.
Weiss, DR, Ahn, S, Sassano, MF, Kruse, AC, Karpiak, J, Roth, BL, Kobilka, BK, Shoichet, BK, and Lefkowitz, RJ. "G-protein coupled receptors in virtual screening: Functional fidelity and selectivity." April 7, 2013.
Jiangbo, W, Ahn, S, Kahsai, AW, Rong, L, Jie, R, Kun, H, Xiaoqing, S, and Xin, C. "Synthesis of beta(2)-AR Agonist BI-167107." CHINESE JOURNAL OF ORGANIC CHEMISTRY 33, no. 3 (March 2013): 634-639.