Seungkirl Ahn, PhD

Publications

Liu, Xiangyu, Ali Masoudi, Alem W. Kahsai, Li-Yin Huang, Biswaranjan Pani, Dean P. Staus, Paul J. Shim, et al. “Mechanism of β2AR regulation by an intracellular positive allosteric modulator.” Science 364, no. 6447 (June 28, 2019): 1283–87. https://doi.org/10.1126/science.aaw8981.

PMID
31249059
Full Text

Luttrell, Louis M., Jialu Wang, Bianca Plouffe, Jeffrey S. Smith, Lama Yamani, Suneet Kaur, Pierre-Yves Jean-Charles, et al. “Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9.” Sci Signal 11, no. 549 (September 25, 2018). https://doi.org/10.1126/scisignal.aat7650.

PMID
30254056
Full Text

Choi, Minjung, Dean P. Staus, Laura M. Wingler, Seungkirl Ahn, Biswaranjan Pani, William D. Capel, and Robert J. Lefkowitz. “G protein-coupled receptor kinases (GRKs) orchestrate biased agonism at the β2-adrenergic receptor.” Sci Signal 11, no. 544 (August 21, 2018). https://doi.org/10.1126/scisignal.aar7084.

PMID
30131371
Full Text

Ahn, Seungkirl, Biswaranjan Pani, Alem W. Kahsai, Eva K. Olsen, Gitte Husemoen, Mikkel Vestergaard, Lei Jin, et al. “Small-Molecule Positive Allosteric Modulators of the β2-Adrenoceptor Isolated from DNA-Encoded Libraries.” Mol Pharmacol 94, no. 2 (August 2018): 850–61. https://doi.org/10.1124/mol.118.111948.

PMID
29769246
Full Text

Meng, Kaicheng, Paul Shim, Qingtin Wang, Shuai Zhao, Ting Gu, Alem W. Kahsai, Seungkirl Ahn, and Xin Chen. “Design, synthesis, and functional assessment of Cmpd-15 derivatives as negative allosteric modulators for the β2-adrenergic receptor.” Bioorg Med Chem 26, no. 9 (May 15, 2018): 2320–30. https://doi.org/10.1016/j.bmc.2018.03.023.

PMID
29588128
Full Text

Liu, Xiangyu, Seungkirl Ahn, Alem W. Kahsai, Kai-Cheng Meng, Naomi R. Latorraca, Biswaranjan Pani, A. J. Venkatakrishnan, et al. “Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure.” Nature 548, no. 7668 (August 24, 2017): 480–84. https://doi.org/10.1038/nature23652.

PMID
28813418
Full Text

Ahn, Seungkirl, Alem W. Kahsai, Biswaranjan Pani, Qin-Ting Wang, Shuai Zhao, Alissa L. Wall, Ryan T. Strachan, et al. “Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library.” Proc Natl Acad Sci U S A 114, no. 7 (February 14, 2017): 1708–13. https://doi.org/10.1073/pnas.1620645114.

PMID
28130548
Full Text

Kahsai, Alem W., James W. Wisler, Jungmin Lee, Seungkirl Ahn, Thomas J. Cahill Iii, S Moses Dennison, Dean P. Staus, et al. “Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor.” Nat Chem Biol 12, no. 9 (September 2016): 709–16. https://doi.org/10.1038/nchembio.2126.

PMID
27398998
Full Text

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