Seungkirl Ahn, PhD

Publications

Wang, Jialu, Biswaranjan Pani, Ilhan Gokhan, Xinyu Xiong, Alem W. Kahsai, Haoran Jiang, Seungkirl Ahn, Robert J. Lefkowitz, and Howard A. Rockman. “β-Arrestin-Biased Allosteric Modulator Potentiates Carvedilol-Stimulated β Adrenergic Receptor Cardioprotection.” Mol Pharmacol 100, no. 6 (December 2021): 568–79. https://doi.org/10.1124/molpharm.121.000359.

PMID
34561298
Full Text

Correction to "Unique Positive Cooperativity Between the β-Arrestin-Biased β-Blocker Carvedilol and a Small Molecule Positive Allosteric Modulator of the β2-Adrenergic Receptor".” Mol Pharmacol 100, no. 6 (December 2021): 597. https://doi.org/10.1124/molpharm.121.000363err.

PMID
34862306
Full Text

Pani, Biswaranjan, Seungkirl Ahn, Paula K. Rambarat, Shashank Vege, Alem W. Kahsai, Andrew Liu, Bruno N. Valan, Dean P. Staus, Tommaso Costa, and Robert J. Lefkowitz. “Unique Positive Cooperativity Between the β-Arrestin-Biased β-Blocker Carvedilol and a Small Molecule Positive Allosteric Modulator of the β2-Adrenergic Receptor.” Mol Pharmacol 100, no. 5 (November 2021): 513–25. https://doi.org/10.1124/molpharm.121.000363.

PMID
34580163
Full Text

Liu, Xiangyu, Ali Masoudi, Alem W. Kahsai, Li-Yin Huang, Biswaranjan Pani, Dean P. Staus, Paul J. Shim, et al. “Mechanism of β2AR regulation by an intracellular positive allosteric modulator.” Science 364, no. 6447 (June 28, 2019): 1283–87. https://doi.org/10.1126/science.aaw8981.

PMID
31249059
Full Text

Luttrell, Louis M., Jialu Wang, Bianca Plouffe, Jeffrey S. Smith, Lama Yamani, Suneet Kaur, Pierre-Yves Jean-Charles, et al. “Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9.” Sci Signal 11, no. 549 (September 25, 2018). https://doi.org/10.1126/scisignal.aat7650.

PMID
30254056
Full Text

Choi, Minjung, Dean P. Staus, Laura M. Wingler, Seungkirl Ahn, Biswaranjan Pani, William D. Capel, and Robert J. Lefkowitz. “G protein-coupled receptor kinases (GRKs) orchestrate biased agonism at the β2-adrenergic receptor.” Sci Signal 11, no. 544 (August 21, 2018). https://doi.org/10.1126/scisignal.aar7084.

PMID
30131371
Full Text

Ahn, Seungkirl, Biswaranjan Pani, Alem W. Kahsai, Eva K. Olsen, Gitte Husemoen, Mikkel Vestergaard, Lei Jin, et al. “Small-Molecule Positive Allosteric Modulators of the β2-Adrenoceptor Isolated from DNA-Encoded Libraries.” Mol Pharmacol 94, no. 2 (August 2018): 850–61. https://doi.org/10.1124/mol.118.111948.

PMID
29769246
Full Text

Meng, Kaicheng, Paul Shim, Qingtin Wang, Shuai Zhao, Ting Gu, Alem W. Kahsai, Seungkirl Ahn, and Xin Chen. “Design, synthesis, and functional assessment of Cmpd-15 derivatives as negative allosteric modulators for the β2-adrenergic receptor.” Bioorg Med Chem 26, no. 9 (May 15, 2018): 2320–30. https://doi.org/10.1016/j.bmc.2018.03.023.

PMID
29588128
Full Text

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