Seungkirl Ahn, PhD

Publications

Wang, J., A. Seungkirl, A. W. Kahsai, R. Liu, J. Ren, K. Hu, X. Sun, and X. Chen. “Synthesis of β2-AR agonist BI-167107.” Chinese Journal of Organic Chemistry 33, no. 3 (March 1, 2013): 634–39. https://doi.org/10.6023/cjoc201211015.

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Heitzler, Domitille, Guillaume Durand, Nathalie Gallay, Aurélien Rizk, Seungkirl Ahn, Jihee Kim, Jonathan D. Violin, et al. “Competing G protein-coupled receptor kinases balance G protein and β-arrestin signaling.” Mol Syst Biol 8 (June 26, 2012): 590. https://doi.org/10.1038/msb.2012.22.

PMID
22735336
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Rajagopal, Sudarshan, Seungkirl Ahn, David H. Rominger, William Gowen-MacDonald, Christopher M. Lam, Scott M. Dewire, Jonathan D. Violin, and Robert J. Lefkowitz. “Quantifying ligand bias at seven-transmembrane receptors.” Mol Pharmacol 80, no. 3 (September 2011): 367–77. https://doi.org/10.1124/mol.111.072801.

PMID
21610196
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Kahsai, Alem W., Kunhong Xiao, Sudarshan Rajagopal, Seungkirl Ahn, Arun K. Shukla, Jinpeng Sun, Terrence G. Oas, and Robert J. Lefkowitz. “Multiple ligand-specific conformations of the β2-adrenergic receptor.” Nat Chem Biol 7, no. 10 (August 21, 2011): 692–700. https://doi.org/10.1038/nchembio.634.

PMID
21857662
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Hara, Makoto R., Jeffrey J. Kovacs, Erin J. Whalen, Sudarshan Rajagopal, Ryan T. Strachan, Wayne Grant, Aaron J. Towers, et al. “A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1.” Nature 477, no. 7364 (August 21, 2011): 349–53. https://doi.org/10.1038/nature10368.

PMID
21857681
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Nobles, Kelly N., Kunhong Xiao, Seungkirl Ahn, Arun K. Shukla, Christopher M. Lam, Sudarshan Rajagopal, Ryan T. Strachan, et al. “Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin.” Sci Signal 4, no. 185 (August 9, 2011): ra51. https://doi.org/10.1126/scisignal.2001707.

PMID
21868357
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Shukla, Arun K., Jihee Kim, Seungkirl Ahn, Kunhong Xiao, Sudha K. Shenoy, Wolfgang Liedtke, and Robert J. Lefkowitz. “Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4.” J Biol Chem 285, no. 39 (September 24, 2010): 30115–25. https://doi.org/10.1074/jbc.M110.141549.

PMID
20650893
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Rajagopal, Sudarshan, Jihee Kim, Seungkirl Ahn, Stewart Craig, Christopher M. Lam, Norma P. Gerard, Craig Gerard, and Robert J. Lefkowitz. “Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7.” Proc Natl Acad Sci U S A 107, no. 2 (January 12, 2010): 628–32. https://doi.org/10.1073/pnas.0912852107.

PMID
20018651
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Kim, Jihee, Seungkirl Ahn, Keshava Rajagopal, and Robert J. Lefkowitz. “Independent beta-arrestin2 and Gq/protein kinase Czeta pathways for ERK stimulated by angiotensin type 1A receptors in vascular smooth muscle cells converge on transactivation of the epidermal growth factor receptor.” J Biol Chem 284, no. 18 (May 1, 2009): 11953–62. https://doi.org/10.1074/jbc.M808176200.

PMID
19254952
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