Education and Training
- Ph.D., Duke University, 2002
Wei, Huijun, Seungkirl Ahn, William G. Barnes, and Robert J. Lefkowitz. “Stable interaction between beta-arrestin 2 and angiotensin type 1A receptor is required for beta-arrestin 2-mediated activation of extracellular signal-regulated kinases 1 and 2.” J Biol Chem 279, no. 46 (November 12, 2004): 48255–61. https://doi.org/10.1074/jbc.M406205200.
Ahn, Seungkirl, Sudha K. Shenoy, Huijun Wei, and Robert J. Lefkowitz. “Differential kinetic and spatial patterns of beta-arrestin and G protein-mediated ERK activation by the angiotensin II receptor.” J Biol Chem 279, no. 34 (August 20, 2004): 35518–25. https://doi.org/10.1074/jbc.M405878200.
Ahn, Seungkirl, Huijun Wei, Tiffany Runyan Garrison, and Robert J. Lefkowitz. “Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by beta-arrestins 1 and 2.” J Biol Chem 279, no. 9 (February 27, 2004): 7807–11. https://doi.org/10.1074/jbc.C300443200.
Wei, Huijun, Seungkirl Ahn, Sudha K. Shenoy, Sadashiva S. Karnik, László Hunyady, Louis M. Luttrell, and Robert J. Lefkowitz. “Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.” Proc Natl Acad Sci U S A 100, no. 19 (September 16, 2003): 10782–87. https://doi.org/10.1073/pnas.1834556100.
Chen, Wei, Derk ten Berge, Jeff Brown, Seungkirl Ahn, Liaoyuan A. Hu, William E. Miller, Marc G. Caron, Larry S. Barak, Roel Nusse, and Robert J. Lefkowitz. “Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4.” Science 301, no. 5638 (September 5, 2003): 1391–94. https://doi.org/10.1126/science.1082808.
Ahn, Seungkirl, Christopher D. Nelson, Tiffany Runyan Garrison, William E. Miller, and Robert J. Lefkowitz. “Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference.” Proc Natl Acad Sci U S A 100, no. 4 (February 18, 2003): 1740–44. https://doi.org/10.1073/pnas.262789099.
Ahn, Seungkirl, Jihee Kim, Carmen L. Lucaveche, Mary C. Reedy, Louis M. Luttrell, Robert J. Lefkowitz, and Yehia Daaka. “Src-dependent tyrosine phosphorylation regulates dynamin self-assembly and ligand-induced endocytosis of the epidermal growth factor receptor.” J Biol Chem 277, no. 29 (July 19, 2002): 26642–51. https://doi.org/10.1074/jbc.M201499200.
Pierce, K. L., A. Tohgo, S. Ahn, M. E. Field, L. M. Luttrell, and R. J. Lefkowitz. “Epidermal growth factor (EGF) receptor-dependent ERK activation by G protein-coupled receptors: a co-culture system for identifying intermediates upstream and downstream of heparin-binding EGF shedding.” J Biol Chem 276, no. 25 (June 22, 2001): 23155–60. https://doi.org/10.1074/jbc.M101303200.
Miller, W. E., S. Maudsley, S. Ahn, K. D. Khan, L. M. Luttrell, and R. J. Lefkowitz. “beta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis.” J Biol Chem 275, no. 15 (April 14, 2000): 11312–19. https://doi.org/10.1074/jbc.275.15.11312.