Shiao-Wen David Hsu, MD

Associate Professor of Medicine
William Dalton Family Assistant Professor of Medical Oncology, in the School of Medicine
Member of the Duke Cancer Institute
Campus mail Dept of Medicine, Box 3233, Durham, NC 27710
Phone (919) 681-3480
Email address shiaowen.hsu@duke.edu

Education and Training

  • Fellow in Hematology-Oncology, Medicine, Duke University, 2004 - 2007
  • Medical Resident, Medicine, University of Texas at Dallas, 2001 - 2004
  • M.D., University of North Carolina at Chapel Hill, 2001

Publications

Wang, Jiangbo, Robert A. Mook, Xiu-Rong Ren, Qingfu Zhang, Genevieve Jing, Min Lu, Ivan Spasojevic, H Kim Lyerly, David Hsu, and Wei Chen. “Identification of DK419, a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth..” Bioorg Med Chem 26, no. 20 (November 1, 2018): 5435–42. https://doi.org/10.1016/j.bmc.2018.09.016.

PMID
30274939
Full Text

Bu, Pengcheng, Kai-Yuan Chen, Kun Xiang, Christelle Johnson, Scott B. Crown, Nikolai Rakhilin, Yiwei Ai, et al. “Aldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis..” Cell Metab 27, no. 6 (June 5, 2018): 1249-1262.e4. https://doi.org/10.1016/j.cmet.2018.04.003.

PMID
29706565
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Lu, Min, Amelia S. Zessin, Wayne Glover, and David S. Hsu. “Activation of the mTOR Pathway by Oxaliplatin in the Treatment of Colorectal Cancer Liver Metastasis..” Plos One 12, no. 1 (2017). https://doi.org/10.1371/journal.pone.0169439.

PMID
28060954
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Zhang, Tian, Rengasamy Boominathan, Brad Foulk, Chandra Rao, Gabor Kemeny, John H. Strickler, James L. Abbruzzese, et al. “Development of a Novel c-MET-Based CTC Detection Platform..” Mol Cancer Res 14, no. 6 (June 2016): 539–47. https://doi.org/10.1158/1541-7786.MCR-16-0011.

PMID
26951228
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Mi, Jing, Partha Ray, Jenny Liu, Chien-Tsun Kuan, Jennifer Xu, David Hsu, Bruce A. Sullenger, Rebekah R. White, and Bryan M. Clary. “In Vivo Selection Against Human Colorectal Cancer Xenografts Identifies an Aptamer That Targets RNA Helicase Protein DHX9..” Mol Ther Nucleic Acids 5 (April 26, 2016). https://doi.org/10.1038/mtna.2016.27.

PMID
27115840
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Tang, Xiaohu, Jianli Wu, Chien-Kuang Ding, Min Lu, Melissa M. Keenan, Chao-Chieh Lin, Chih-An Lin, et al. “Cystine Deprivation Triggers Programmed Necrosis in VHL-Deficient Renal Cell Carcinomas..” Cancer Res 76, no. 7 (April 1, 2016): 1892–1903. https://doi.org/10.1158/0008-5472.CAN-15-2328.

PMID
26833124
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Bu, Pengcheng, Lihua Wang, Kai-Yuan Chen, Nikolai Rakhilin, Jian Sun, Adria Closa, Kuei-Ling Tung, et al. “miR-1269 promotes metastasis and forms a positive feedback loop with TGF-β..” Nat Commun 6 (April 15, 2015). https://doi.org/10.1038/ncomms7879.

PMID
25872451
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Ganapathi, Asvin M., Paul J. Speicher, Brian R. Englum, Anthony W. Castleberry, John Migaly, David S. Hsu, and Christopher R. Mantyh. “Adjuvant chemotherapy for t1 node-positive colon cancers provides significant survival benefit..” Dis Colon Rectum 57, no. 12 (December 2014): 1341–48. https://doi.org/10.1097/DCR.0000000000000245.

PMID
25379998
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Rangwala, Fatima, Johanna C. Bendell, Mark F. Kozloff, Christy C. Arrowood, Andrew Dellinger, Jennifer Meadows, Sandra Tourt-Uhlig, et al. “Phase I study of capecitabine, oxaliplatin, bevacizumab, and everolimus in advanced solid tumors..” Invest New Drugs 32, no. 4 (August 2014): 700–709. https://doi.org/10.1007/s10637-014-0089-2.

PMID
24711126
Full Text

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