Stephen Greene, MD

Assistant Professor of Medicine
Member in the Duke Clinical Research Institute
Email address stephen.greene@duke.edu

I am a cardiologist with a clinical and research interest in heart failure. I take care of patients with various types of heart failure, including patients who are best treated with medications and patients who receive advanced therapies like heart transplantation and mechanical assist devices. I became a heart failure cardiologist to help patients manage their heart conditions and best achieve their goals for their health. I am strongly committed to helping patients thoroughly understand their medical conditions and helping them make informed medical decisions aligned with their preferences.

My research interests are focused on strategies and therapies to improve outcomes and quality of life for patients with heart failure. This involves research through clinical trials and through examining data from real-world clinical practice. Below, you will find my specific research interests:

  • Use and dosing of evidence-based heart failure medications
  • Management of worsening heart failure outside the hospital
  • Novel pharmacological and non-pharmacological approaches to heart failure
  • Improving outcomes following a hospitalization for heart failure
  • Surrogate and nonfatal endpoints in heart failure clinical trials
  • Clinical trial design and operations
  • Improving site-based heart failure research

Education and Training

  • Fellowship, Cardiology, Duke University School of Medicine, 2015 - 2020
  • Residency, Internal Medicine, Northwestern University, 2012 - 2015
  • M.D., Northwestern University, Feinberg School of Medicine, 2012

Publications

Pierce, Jacob B., Robert J. Mentz, Jie-Lena Sun, Brooke Alhanti, David J. Whellan, William E. Kraus, Ileana L. Piña, Mona Fiuzat, Christopher M. O’Connor, and Stephen J. Greene. “Titration of medical therapy and clinical outcomes among patients with heart failure with reduced ejection fraction: findings from the HF-ACTION trial.” J Card Fail, June 7, 2022. https://doi.org/10.1016/j.cardfail.2022.05.010.

PMID
35688408
Full Text

Shah, Anand, Robert J. Mentz, Jie-Lena Sun, Vishal N. Rao, Brooke Alhanti, Vanessa Blumer, Randall Starling, Javed Butler, and Stephen J. Greene. “Emergency Department Visits Versus Hospital Readmissions Among Patients Hospitalized for Heart Failure.” J Card Fail 28, no. 6 (June 2022): 916–23. https://doi.org/10.1016/j.cardfail.2021.11.025.

PMID
34987009
Full Text

Pierce, Jacob B., Robert J. Mentz, Jie-Lena Sun, Brooke Alhanti, David J. Whellan, William E. Kraus, Ileana L. Piña, Mona Fiuzat, Christopher M. O’Connor, and Stephen J. Greene. “Titration of medical therapy and clinical outcomes among patients with heart failure with reduced ejection fraction: Findings from the HF-ACTION trial.” Am Heart J 251 (May 29, 2022): 115–26. https://doi.org/10.1016/j.ahj.2022.05.018.

PMID
35640729
Full Text

Minhas, Abdul Mannan Khan, Husam M. Salah, Muhammad Shahzeb Khan, Vishal N. Rao, Ryan J. Tedford, Yogesh N. V. Reddy, Melissa C. Caughey, et al. “Most Common Causes of Hospitalization Associated with Inpatient Mortality in the United States Between 2005-2018.” Am J Med Sci 363, no. 5 (May 2022): 459–61. https://doi.org/10.1016/j.amjms.2022.01.009.

PMID
35090870
Full Text

Khan, Muhammad Shahzeb, Adam D. DeVore, G Michael Felker, Javed Butler, Gregg C. Fonarow, and Stephen J. Greene. “Reply: Revisited Metformin Therapy in Heart Failure With Preserved Ejection Fraction.” Jacc Heart Fail 10, no. 5 (May 2022): 366–67. https://doi.org/10.1016/j.jchf.2022.02.013.

PMID
35483801
Full Text

Jain, Vardhman, Abdul Mannan Khan Minhas, Safi U. Khan, Stephen J. Greene, Ambarish Pandey, Harriette G. C. Van Spall, Gregg C. Fonarow, Robert J. Mentz, Javed Butler, and Muhammad Shahzeb Khan. “Trends in HF Hospitalizations Among Young Adults in the United States From 2004 to 2018.” Jacc Heart Fail 10, no. 5 (May 2022): 350–62. https://doi.org/10.1016/j.jchf.2022.01.021.

PMID
35483798
Full Text

Greene, Stephen J., Xi Tan, Yu-Chen Yeh, Mark Bernauer, Omer Zaidi, Mei Yang, and Javed Butler. “Factors associated with non-use and sub-target dosing of medical therapy for heart failure with reduced ejection fraction.” Heart Fail Rev 27, no. 3 (May 2022): 741–53. https://doi.org/10.1007/s10741-021-10077-x.

PMID
33471236
Full Text

Minhas, Abdul Mannan Khan, Sardar Hassan Ijaz, Shakeel Jamal, Sourbha S. Dani, Muhammad Shahzeb Khan, Stephen J. Greene, Marat Fudim, et al. “Trends in Characteristics and Outcomes in Primary Heart Failure Hospitalizations Among Older Population in the United States, 2004 to 2018.” Circ Heart Fail 15, no. 5 (May 2022): e008943. https://doi.org/10.1161/CIRCHEARTFAILURE.121.008943.

PMID
35078346
Full Text

Ijaz, Sardar Hassan, Shakeel Jamal, Abdul Mannan Khan Minhas, Abu Baker Sheikh, Salik Nazir, Muhammad Shahzeb Khan, Anum S. Minhas, et al. “Trends in Characteristics and Outcomes of Peripartum Cardiomyopathy Hospitalizations in the United States Between 2004 and 2018.” Am J Cardiol 168 (April 1, 2022): 142–50. https://doi.org/10.1016/j.amjcard.2021.12.034.

PMID
35074213
Full Text

Vaduganathan, Muthiah, Stephen J. Greene, Shuaiqi Zhang, Nicole Solomon, Karen Chiswell, Adam D. Devore, Javed Butler, et al. “Projected Clinical Benefits of Implementation of SGLT-2 Inhibitors Among Medicare Beneficiaries Hospitalized for Heart Failure.” J Card Fail 28, no. 4 (April 2022): 554–63. https://doi.org/10.1016/j.cardfail.2021.11.010.

PMID
34785402
Full Text

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