Steve M Taylor, MD

Associate Professor of Medicine
Assistant Research Professor of Global Health
Campus mail 303 Research Drive, Sands Building #301, Durham, NC 27710
Phone (919) 684-8111
Email address steve.taylor@duke.edu

My lab website has a fuller description of my research activities: https://sites.duke.edu/taylorlab/.

I am principally interested in field and translational studies of falciparum malaria. These interests fall along several lines:

1) Epidemiology. Falciparum malaria is an immense problem whose contours are difficult to discern in hyperendemic regions like much of sub-Saharan Africa. I am involved in field applications of molecular genetic techniques to better define the burden of parasitemia in endemic areas and the partitioning and flux of parasite populations. We are working on techniques to generate and parse high-dimensional genomic data to better understand the structure of these parasite populations. Ultimately the goal of these investigations is to inform measures to control malaria and contain distinct parasite populations.

2) Pathogenesis. Severe malaria is a lethal disease; it is the cause of most of the 400,000 malaria deaths annually in African children. In these children, sickle-trait hemoglobin confers >90% protection from severe, life-threatening malaria. Several lines of evidence support the hypothesis that this dramatic protection results from the inability of the parasite to export parasite-derived proteins to the surface of the infected human red blood cell. We are investigating the molecular genetic correlates of this phenomenon in in vitro and ex vivo systems in order to identify mechanisms by which sickle-trait neutralizes the parasite. By leveraging this naturally-occurring model of malaria protection we hope to ultimately identify druggable targets for future antiparasitic or adjunctive therapies.

3) Diagnostics. In the field, clinical practice guidelines now recommend parasitologic diagnosis of malaria prior to treatment. Parasite detection can be confirmed by traditional microscopy or by rapid immunochromatographic tests, but each of these approaches is potentially undermined by limits of detection, operator error, and the monoplex nature of parasite testing in settings with complex pathogen epidemiology. With collaborators in Biomedical Engineering at the Pratt School of Engineering, we are developing PCR-free multiplex detection assays that utilize robust, rapid, and scalable nanoengineered platforms that target multiple bloodborne tropical pathogens in a single assay. The ultimate goal of this project is to enhance the clinical management of febrile illness in the tropics.

4) Prevention. In malaria-endemic Africa, high-risk groups that suffer disproportionate malaria morbidity clearly benefit from antimalarial chemoprevention; these groups include pregnant women across Africa and children under 5 in West Africa. African children with sickle-cell anemia also suffer significant malaria morbidity, but chemoprevention regimens that are recommended for them lack a compelling evidence base. With partners in Malawi and Kenya, we are testing new approaches to malaria chemoprevention in both pregnant women and in children with sickle-cell anemia. The goal of these projects is to enhance public health guidelines for the routine care of these high-risk groups and reduce the burden of malaria in African children.

The ultimate goals of these translational studies of falciparum malaria in children and pregnant women is to integrate epidemiologic, clinical, and molecular genetic models of disease in order to inform the rational design of medical and public health interventions to reduce the awful burden of malaria.

Education and Training

  • Gillings School of Global Public Health - Postdoctoral Fellow, Department Of Epidemiology, University of North Carolina at Chapel Hill, 2008 - 2012
  • Fellowship, Infectious Diseases & International Health, Duke University School of Medicine, 2007 - 2012
  • Internship/Residency, Medicine, Yale University School of Medicine, 2004 - 2007
  • M.D., Duke University School of Medicine, 2004
  • M.P.H., University of North Carolina at Chapel Hill, 2003
  • B.S., Duke University, 1998

Publications

Ter Kuile, FO, and Taylor, SM. "Gilding the Lily? Enhancing Antenatal Malaria Prevention in HIV-Infected Women." The Journal of infectious diseases 216, no. 1 (July 2017): 4-6.

PMID
28329047
Full Text

Levitt, B, Obala, A, Langdon, S, Corcoran, D, O'Meara, WP, and Taylor, SM. "Overlap Extension Barcoding for the Next Generation Sequencing and Genotyping of Plasmodium falciparum in Individual Patients in Western Kenya." Scientific reports 7 (January 24, 2017): 41108-.

PMID
28117350
Full Text

Nkhoma, M, Ashorn, P, Ashorn, U, Dewey, KG, Gondwe, A, Mbotwa, J, Rogerson, S, Taylor, SM, and Maleta, K. "Providing lipid-based nutrient supplement during pregnancy does not reduce the risk of maternal P falciparum parasitaemia and reproductive tract infections: a randomised controlled trial." BMC pregnancy and childbirth 17, no. 1 (January 17, 2017): 35-.

PMID
28095801
Full Text

Ngo, HT, Gandra, N, Fales, AM, Taylor, SM, and Vo-Dinha, T. "DNA detection and single nucleotide mutation identification using SERS for molecular diagnostics and global health." January 1, 2017.

Full Text

Abel, L, Wafula, RN, Evans, D, Taylor, SM, O'Meara, WP, and Obala, AA. "IMPLICATIONS OF REDUCED SUSCEPTIBILITY TO INSECTICIDES IN MALARIA VECTORS IN AN AREA WITH HIGH ITN COVERAGE." 2017.

Scholars@Duke

Liu, Y, Mwapasa, V, Khairallah, C, Thwai, KL, Kalilani-Phiri, L, Ter Kuile, FO, Meshnick, SR, and Taylor, SM. "Rapid Diagnostic Test Performance Assessed Using Latent Class Analysis for the Diagnosis of Plasmodium falciparum Placental Malaria." The American journal of tropical medicine and hygiene 95, no. 4 (October 2016): 835-839.

PMID
27527628
Full Text

Madanitsa, M, Kalilani, L, Mwapasa, V, van Eijk, AM, Khairallah, C, Ali, D, Pace, C, Smedley, J, Thwai, K-L, Levitt, B, Wang, D, Kang'ombe, A, Faragher, B, Taylor, SM, Meshnick, S, and Ter Kuile, FO. "Scheduled Intermittent Screening with Rapid Diagnostic Tests and Treatment with Dihydroartemisinin-Piperaquine versus Intermittent Preventive Therapy with Sulfadoxine-Pyrimethamine for Malaria in Pregnancy in Malawi: An Open-Label Randomized Controlled Trial." PLoS medicine 13, no. 9 (September 13, 2016): e1002124-.

PMID
27622558
Full Text

Ngo, HT, Gandra, N, Fales, AM, Taylor, SM, and Vo-Dinh, T. "Sensitive DNA detection and SNP discrimination using ultrabright SERS nanorattles and magnetic beads for malaria diagnostics." Biosensors & bioelectronics 81 (July 2016): 8-14.

PMID
26913502
Full Text

Liu, Y, Griffin, JB, Muehlenbachs, A, Rogerson, SJ, Bailis, AJ, Sharma, R, Sullivan, DJ, Tshefu, AK, Landis, SH, Kabongo, J-MM, Taylor, SM, and Meshnick, SR. "Diagnosis of placental malaria in poorly fixed and processed placental tissue." Malaria Journal 15, no. 1 (May 10, 2016): 272-.

PMID
27165119
Full Text

Doctor, SM, Liu, Y, Whitesell, A, Thwai, KL, Taylor, SM, Janko, M, Emch, M, Kashamuka, M, Muwonga, J, Tshefu, A, and Meshnick, SR. "Malaria surveillance in the Democratic Republic of the Congo: comparison of microscopy, PCR, and rapid diagnostic test." Diagnostic microbiology and infectious disease 85, no. 1 (May 2016): 16-18.

PMID
26915637
Full Text

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