Steve M Taylor, MD

Associate Professor of Medicine
Assistant Research Professor of Global Health
Campus mail 303 Research Drive, Sands Building #301, Durham, NC 27710
Phone (919) 684-8111
Email address steve.taylor@duke.edu

My lab website has a fuller description of my research activities: https://sites.duke.edu/taylorlab/.

I am principally interested in field and translational studies of falciparum malaria. These interests fall along several lines:

1) Epidemiology. Falciparum malaria is an immense problem whose contours are difficult to discern in hyperendemic regions like much of sub-Saharan Africa. I am involved in field applications of molecular genetic techniques to better define the burden of parasitemia in endemic areas and the partitioning and flux of parasite populations. We are working on techniques to generate and parse high-dimensional genomic data to better understand the structure of these parasite populations. Ultimately the goal of these investigations is to inform measures to control malaria and contain distinct parasite populations.

2) Pathogenesis. Severe malaria is a lethal disease; it is the cause of most of the 400,000 malaria deaths annually in African children. In these children, sickle-trait hemoglobin confers >90% protection from severe, life-threatening malaria. Several lines of evidence support the hypothesis that this dramatic protection results from the inability of the parasite to export parasite-derived proteins to the surface of the infected human red blood cell. We are investigating the molecular genetic correlates of this phenomenon in in vitro and ex vivo systems in order to identify mechanisms by which sickle-trait neutralizes the parasite. By leveraging this naturally-occurring model of malaria protection we hope to ultimately identify druggable targets for future antiparasitic or adjunctive therapies.

3) Diagnostics. In the field, clinical practice guidelines now recommend parasitologic diagnosis of malaria prior to treatment. Parasite detection can be confirmed by traditional microscopy or by rapid immunochromatographic tests, but each of these approaches is potentially undermined by limits of detection, operator error, and the monoplex nature of parasite testing in settings with complex pathogen epidemiology. With collaborators in Biomedical Engineering at the Pratt School of Engineering, we are developing PCR-free multiplex detection assays that utilize robust, rapid, and scalable nanoengineered platforms that target multiple bloodborne tropical pathogens in a single assay. The ultimate goal of this project is to enhance the clinical management of febrile illness in the tropics.

4) Prevention. In malaria-endemic Africa, high-risk groups that suffer disproportionate malaria morbidity clearly benefit from antimalarial chemoprevention; these groups include pregnant women across Africa and children under 5 in West Africa. African children with sickle-cell anemia also suffer significant malaria morbidity, but chemoprevention regimens that are recommended for them lack a compelling evidence base. With partners in Malawi and Kenya, we are testing new approaches to malaria chemoprevention in both pregnant women and in children with sickle-cell anemia. The goal of these projects is to enhance public health guidelines for the routine care of these high-risk groups and reduce the burden of malaria in African children.

The ultimate goals of these translational studies of falciparum malaria in children and pregnant women is to integrate epidemiologic, clinical, and molecular genetic models of disease in order to inform the rational design of medical and public health interventions to reduce the awful burden of malaria.

Education and Training

  • Gillings School of Global Public Health - Postdoctoral Fellow, Department Of Epidemiology, University of North Carolina at Chapel Hill, 2008 - 2012
  • Fellowship, Infectious Diseases & International Health, Duke University School of Medicine, 2007 - 2012
  • Internship/Residency, Medicine, Yale University School of Medicine, 2004 - 2007
  • M.D., Duke University School of Medicine, 2004
  • M.P.H., University of North Carolina at Chapel Hill, 2003
  • B.S., Duke University, 1998

Publications

Patel, JC, Mwapasa, V, Kalilani, L, Ter Kuile, FO, Khairallah, C, Thwai, KL, Meshnick, SR, and Taylor, SM. "Absence of Association Between Sickle Trait Hemoglobin and Placental Malaria Outcomes." The American journal of tropical medicine and hygiene 94, no. 5 (May 2016): 1002-1007.

PMID
27001763
Full Text

Desai, M, Gutman, J, Taylor, SM, Wiegand, RE, Khairallah, C, Kayentao, K, Ouma, P, Coulibaly, SO, Kalilani, L, Mace, KE, Arinaitwe, E, Mathanga, DP, Doumbo, O, Otieno, K, Edgar, D, Chaluluka, E, Kamuliwo, M, Ades, V, Skarbinski, J, Shi, YP, Magnussen, P, Meshnick, S, and Ter Kuile, FO. "Impact of Sulfadoxine-Pyrimethamine Resistance on Effectiveness of Intermittent Preventive Therapy for Malaria in Pregnancy at Clearing Infections and Preventing Low Birth Weight." Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 62, no. 3 (February 2016): 323-333.

PMID
26486699
Full Text

Gutman, J, Taylor, S, Meshnick, SR, and Ter Kuile, FO. "Reply to Harrington et al." The Journal of infectious diseases 213, no. 3 (February 2016): 497-498. (Letter)

PMID
26290609
Full Text

Lopera-Mesa, TM, Doumbia, S, Konate, D, Anderson, JM, Doumbouya, M, Keita, AS, Diakite, SA, Traore, K, Krause, MA, Diouf, A, Moretz, SE, Tullo, GS, Miura, K, Gu, W, Fay, MP, Taylor, SM, Long, CA, Diakite, M, and Fairhurst, RM. "A FOUR-YEAR PROSPECTIVE STUDY OF THE IMPACT OF RED BLOOD CELL VARIANTS ON CHILDHOOD FALCIPARUM MALARIA IN SOUTHERN MALI." October 2015.

Scholars@Duke

Patel, JC, Mwapasa, V, Kalilani, L, ter Kuile, FO, Khairallah, C, Thwai, KL, Meshnick, SR, and Taylor, SM. "ABSENCE OF EFFECT OF HETEROZYGOUS HEMOGLOBIN S ON THE PREVALENCE OF PLACENTAL MALARIA AND LOW BIRTH WEIGHT." October 2015.

Scholars@Duke

Miller, RH, Hathaway, NJ, Kharabora, O, Mwandagalirwa, K, Tshefu, A, Meshnick, SR, Taylor, SM, Bailey, JA, Juliano, JJ, and Stewart, VA. "A DEEP SEQUENCING APPROACH TO ESTIMATE MALARIA COMPLEXITY OF INFECTION IN THE DEMOCRATIC REPUBLIC OF CONGO." October 2015.

Scholars@Duke

Patel, JC, Taylor, SM, Parobek, CM, Hathaway, NJ, Thwai, KL, Madanitsa, M, Mwapasa, V, Ndam, NT, ter Kuile, FO, Bailey, JA, Juliano, JJ, and Meshnick, SR. "USE OF LONG-READ DEEP-SEQUENCING TO CHARACTERIZE GENETIC DIVERSITY AND PATHOGENIC VARIANTS OF VAR2CSA IN WOMEN WITH PLACENTAL MALARIA." October 2015.

Scholars@Duke

Juliano, JJ, Barnett, E, Parobek, CM, Taylor, SM, Meshnick, SR, Stone, S, Chang, E, Fong, S, and Huang, L. "Use of Oropharyngeal Washes to Diagnose and Genotype Pneumocystis jirovecii." Open forum infectious diseases 2, no. 3 (September 2015): ofv080-.

PMID
26180832
Full Text

Gutman, J, Kalilani, L, Taylor, S, Zhou, Z, Wiegand, RE, Thwai, KL, Mwandama, D, Khairallah, C, Madanitsa, M, Chaluluka, E, Dzinjalamala, F, Ali, D, Mathanga, DP, Skarbinski, J, Shi, YP, Meshnick, S, and ter Kuile, FO. "The A581G Mutation in the Gene Encoding Plasmodium falciparum Dihydropteroate Synthetase Reduces the Effectiveness of Sulfadoxine-Pyrimethamine Preventive Therapy in Malawian Pregnant Women." The Journal of infectious diseases 211, no. 12 (June 2015): 1997-2005.

PMID
25564249
Full Text

Chandrasiri, UP, Fowkes, FJI, Richards, JS, Langer, C, Fan, Y-M, Taylor, SM, Beeson, JG, Dewey, KG, Maleta, K, Ashorn, P, and Rogerson, SJ. "The impact of lipid-based nutrient supplementation on anti-malarial antibodies in pregnant women in a randomized controlled trial." Malaria journal 14 (May 10, 2015): 193-.

PMID
25957793
Full Text

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