Stuart Johnston Knechtle, MD

Professor of Surgery
William R. Kenan, Jr. Distinguished Professor
Adjunct Professor in the Department of Medicine
Member in the Duke Clinical Research Institute
Email address stuart.knechtle@duke.edu

During my career as an academic surgeon, I have had the privilege of leading and/or participating in a diverse portfolio of hypothesis-driven research projects.  These projects have centered on the immunology of surgery and transplantation, including both cellular and antibody-mediated immune responses.  During my training I studied the response of hyper-sensitized recipients to allogeneic liver transplantation, and am currently studying means of reducing immunologic memory that might allow more successful transplantation in sensitized recipients.  This immune response involves pathways of coagulation, antibody-mediated rejection, and cellular rejection and current work in my lab involves these three pathways.  The other major focuses of my work have been co-stimulation blockade and immune cell depletion as approaches to immunologic unresponsiveness or tolerance.  My research group has been involved in translational and clinical research to develop these mechanistic tools for the benefit of human organ transplant recipients.

Recent Publications

Knechtle SJ, Shaw JM, Hering BJ, Kraemer K, Madsen JC. Translational impact of NIH-funded nonhuman primate research in transplantation. Sci Transl Med. 2019 Jul 10;11(500). pii: eaau0143. Reprint | Full Text

Education and Training

  • Transplant Fellow, Surgery, University of Wisconsin - Madison, 1989 - 1991
  • Residency, Surgery, Duke University School of Medicine, 1982 - 1989
  • M.D., Cornell University, Weill Medical College, 1982

Publications

Kalayoglu, M., A. M. D’Alessandro, S. J. Knechtle, H. W. Sollinger, J. D. Pirsch, R. M. Hoffmann, and F. O. Belzer. “State of the art of liver transplantation in the USA.” Transplant Proc 25, no. 4 Suppl 3 (August 1993): 47.

PMID
8351716
Scholars@Duke

Pirsch, J. D., A. M. D’Alessandro, S. J. Knechtle, H. W. Sollinger, F. O. Belzer, and M. Kalayoglu. “Effect of cyclosporine on renal function in survivors of liver transplantation after 1 year.” Transplant Proc 25, no. 4 Suppl 3 (August 1993): 13–14.

PMID
8351705
Scholars@Duke

Pirsch, J. D., A. M. D’Alessandro, S. J. Knechtle, M. Kalayoglu, H. W. Sollinger, and F. O. Belzer. “Renal transplantation in the cyclosporine era.” Transplant Proc 25, no. 4 Suppl 3 (August 1993): 15–16.

PMID
8351706
Scholars@Duke

Burlingham, W. J., J. H. Fechner, L. D. DeVito, H. W. Sollinger, S. J. Knechtle, and A. P. Grailer. “Human interleukin-2 and lymphoproliferative (T-helper cell) responses to soluble HLA class I antigens in vitro: I. Specificity for polymorphic domains.” Tissue Antigens 42, no. 1 (July 1993): 35–38. https://doi.org/10.1111/j.1399-0039.1993.tb02163.x.

PMID
8248892
Full Text

D’Alessandro, A. M., R. J. Ploeg, S. J. Knechtle, J. D. Pirsch, M. D. Stegall, R. Hoffmann, H. W. Sollinger, F. O. Belzer, and M. Kalayoglu. “Retransplantation of the liver--a seven-year experience.” Transplantation 55, no. 5 (May 1993): 1083–87. https://doi.org/10.1097/00007890-199305000-00028.

PMID
8497886
Full Text

Ploeg, R. J., A. M. D’Alessandro, S. J. Knechtle, M. D. Stegall, J. D. Pirsch, R. M. Hoffmann, T. Sasaki, H. W. Sollinger, F. O. Belzer, and M. Kalayoglu. “Risk factors for primary dysfunction after liver transplantation--a multivariate analysis.” Transplantation 55, no. 4 (April 1993): 807–13. https://doi.org/10.1097/00007890-199304000-00024.

PMID
8475556
Full Text

Ploeg, R. J., A. M. D’Alessandro, M. D. Stegall, M. Wojtowycz, I. A. Sproat, S. J. Knechtle, J. D. Pirsch, H. W. Sollinger, F. O. Belzer, and M. Kalayoglu. “Effect of surgical and spontaneous portasystemic shunts on liver transplantation.” Transplant Proc 25, no. 2 (April 1993): 1946–48.

PMID
8470237
Scholars@Duke

Belzer, F. O., J. H. Southard, A. M. D’Alessandro, S. J. Knechtle, H. W. Sollinger, and M. Kalayoglu. “Update on preservation of liver grafts.” Transplant Proc 25, no. 2 (April 1993): 2010–11.

PMID
8470259
Scholars@Duke

Knechtle, S. J., M. F. Fleming, K. L. Barry, D. Steen, J. D. Pirsch, A. M. D’Alessandro, M. Kalayoglu, and F. O. Belzer. “Liver transplantation in alcoholics: assessment of psychological health and work activity.” Transplant Proc 25, no. 2 (April 1993): 1916–18.

PMID
8470225
Scholars@Duke

Ploeg, R. J., A. M. D’Alessandro, S. J. Knechtle, M. D. Stegall, J. D. Pirsch, R. M. Hoffmann, T. Sasaki, H. W. Sollinger, F. O. Belzer, and M. Kalayoglu. “Malfunction of the liver after transplantation: an analysis of potential risk factors.” Transplant Proc 25, no. 1 Pt 2 (February 1993): 1659–61.

PMID
8442228
Scholars@Duke

Pages