Stuart Johnston Knechtle, MD

Professor of Surgery
William R. Kenan, Jr. Distinguished Professor
Adjunct Professor in the Department of Medicine
Member in the Duke Clinical Research Institute
Email address stuart.knechtle@duke.edu

During my career as an academic surgeon, I have had the privilege of leading and/or participating in a diverse portfolio of hypothesis-driven research projects.  These projects have centered on the immunology of surgery and transplantation, including both cellular and antibody-mediated immune responses.  During my training I studied the response of hyper-sensitized recipients to allogeneic liver transplantation, and am currently studying means of reducing immunologic memory that might allow more successful transplantation in sensitized recipients.  This immune response involves pathways of coagulation, antibody-mediated rejection, and cellular rejection and current work in my lab involves these three pathways.  The other major focuses of my work have been co-stimulation blockade and immune cell depletion as approaches to immunologic unresponsiveness or tolerance.  My research group has been involved in translational and clinical research to develop these mechanistic tools for the benefit of human organ transplant recipients.

Recent Publications

Knechtle SJ, Shaw JM, Hering BJ, Kraemer K, Madsen JC. Translational impact of NIH-funded nonhuman primate research in transplantation. Sci Transl Med. 2019 Jul 10;11(500). pii: eaau0143. Reprint | Full Text

Education and Training

  • Transplant Fellow, Surgery, University of Wisconsin - Madison, 1989 - 1991
  • Residency, Surgery, Duke University School of Medicine, 1982 - 1989
  • M.D., Cornell University, Weill Medical College, 1982

Publications

Sollinger, H. W., S. J. Knechtle, A. Reed, A. M. D’Alessandro, M. Kalayoglu, F. O. Belzer, and J. Pirsch. “Experience with 100 consecutive simultaneous kidney-pancreas transplants with bladder drainage.” Ann Surg 214, no. 6 (December 1991): 703–11. https://doi.org/10.1097/00000658-199112000-00010.

PMID
1741650
Full Text

D’Alessandro, A. M., M. Kalayoglu, J. D. Pirsch, C. Corwith, S. J. Knechtle, A. Reed, and F. O. Belzer. “FK 506 rescue therapy for resistant rejection episodes in liver transplant recipients.” Transplant Proc 23, no. 6 (December 1991): 2987–88.

PMID
1721335
Scholars@Duke

D’Alessandro, A. M., H. W. Sollinger, M. Kalayoglu, J. D. Pirsch, A. Reed, S. J. Knechtle, and F. O. Belzer. “Indications and techniques for renal, pancreas, and liver transplantation.” Compr Ther 17, no. 11 (November 1991): 32–42.

PMID
1799960
Scholars@Duke

D’Alessandro, A. M., A. Reed, R. M. Hoffmann, H. W. Sollinger, M. Kalayoglu, S. J. Knechtle, J. D. Pirsch, and F. O. Belzer. “Results of combined hepatic, pancreaticoduodenal, and renal procurements.” Transplant Proc 23, no. 5 (October 1991): 2309–11.

PMID
1926367
Scholars@Duke

D’Alessandro, A. M., M. Kalayoglu, J. D. Pirsch, H. W. Sollinger, A. Reed, S. J. Knechtle, R. M. Hoffmann, and F. O. Belzer. “Biliary tract complications after orthotopic liver transplantation.” Transplant Proc 23, no. 3 (June 1991): 1956.

PMID
2063444
Scholars@Duke

Knechtle, S., A. D’Alessandro, A. Reed, H. Sollinger, J. Pirsch, F. Belzer, and M. Kalayoglu. “Liver retransplantation: the University of Wisconsin experience.” Transplant Proc 23, no. 3 (June 1991): 1955.

PMID
2063443
Scholars@Duke

Pirsch, J. D., M. Kalayoglu, A. M. D’Alessandro, B. J. Voss, M. J. Armbrust, A. Reed, S. J. Knechtle, H. W. Sollinger, and F. O. Belzer. “Orthotopic liver transplantation in patients 60 years of age and older.” Transplantation 51, no. 2 (February 1991): 431–33. https://doi.org/10.1097/00007890-199102000-00031.

PMID
1994539
Full Text

Reed, A., J. Pirsch, M. J. Armbrust, W. J. Burlingham, S. J. Knechtle, A. M. D’Alessandro, H. W. Sollinger, D. Lorentzen, M. Kalayoglu, and F. O. Belzer. “Multivariate analysis of donor-specific versus random transfusion protocols in haploidentical living-related transplants.” Transplantation 51, no. 2 (February 1991): 382–84. https://doi.org/10.1097/00007890-199102000-00022.

PMID
1994532
Full Text

Pirsch, J. D., M. Kalayoglu, A. M. D’Alessandro, M. J. Armbrust, A. Reed, S. J. Knechtle, H. W. Sollinger, and F. O. Belzer. “Orthotopic liver transplantation in patients over 60 years of age.” Transplant Proc 23, no. 1 Pt 2 (February 1991): 1456–57.

PMID
1989263
Scholars@Duke

D’Alessandro, A. M., M. Kalayoglu, H. W. Sollinger, R. M. Hoffmann, A. Reed, S. J. Knechtle, J. D. Pirsch, G. R. Hafez, D. Lorentzen, and F. O. Belzer. “The predictive value of donor liver biopsies on the development of primary nonfunction after orthotopic liver transplantation.” Transplant Proc 23, no. 1 Pt 2 (February 1991): 1536–37.

PMID
1989280
Scholars@Duke

Pages